1ahb A 2.2 BS01 FMP A 1 Y70 I71 G109 Y111 I155 R163 E189 Y70 I71 G109 Y111 I155 R163 E189 I71 E160 R163 I71 E160 R163 3.2.2.22 0006952,0016787,0017148,0030598,0035821,0090729 P16094 8075985 339 DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLLLPSVSGAGRYLLMHLFNYDGKTITVAVDVTNVYIMGYLADTTSYFFNEPAAELASQYVFRDARRKITLPYSGNYERLQIAAGKPREKIPIGLPALDSAISTLLHYDSTAAAGALLVLIQTTAEAARFKYIEQQIQERAYRDEVPSLATISLENSWSGLSKQIQLAQGNNGIFRTPIVLVDNKGNRVQITNVTSKVVTSNIQLLLNTRNI 1j1s A 2.0 BS01 FMP A 1 Y72 V73 G120 Y122 I170 E175 R178 E204 Y72 V73 G120 Y122 I170 E175 R178 E204 V73 E175 R178 V73 E175 R178 3.2.2.22 0016787,0017148,0030598,0035821,0051607,0090729 P23339 701 INTITFDAGNATINKYATFMESLRNEAKDPSLKCYGIPMLPNTNSTIKYLLVKLQGASLKTITLMLRRNNLYVMGYSDPYDNKCRYHIFNDIKGTEYSDVENTLCPSSNPRVAKPINYNGLYPTLEKKAGVTSRNEVQLGIQILSSDIGKISGQGSFTEKIEAKFLLVAIQMVSEAARFKYIENQVKTNFNRDFSPNDKVLDLEENWGKISTAIHNSKNGALPKPLELKNADGTKWIVLRVDEIKPDVGLLNYVNGTCQAT 1pag A 2.8 BS01 FMP A 1 Y72 V73 S121 R122 Y123 R179 Q205 Y72 V73 S121 R122 Y123 R179 Q205 V73 E176 R179 V73 E176 R179 3.2.2.22 0016787,0017148,0030598,0035821,0051607,0090729 P10297 8411176 263 VNTIIYNVGSTTISKYATFLNDLRNEAKDPSLKCYGIPMLPNTNTNPKYVLVELQGSNKKTITLMLRRNNLYVMGYSDPFETNKCRYHIFNDISGTERQDVETTLCPNANSRVSKNINFDSRYPTLESKAGVKSRSQVQLGIQILDSNIGKISGVMSFTEKTEAEFLLVAIQMVSEAARFKYIENQVKTNFNRAFNPNPKVLNLQETWGKISTAIHDAKNGVLPKPLELVDASGAKWIVLRVDEIKPDVALLNYVGGSCQTT 1pag B 2.8 BS01 FMP B 1 Y72 V73 S121 R122 Y123 I171 R179 Q205 Y72 V73 S121 R122 Y123 I171 R179 Q205 V73 E176 R179 V73 E176 R179 3.2.2.22 0016787,0017148,0030598,0035821,0051607,0090729 P10297 8411176 263 VNTIIYNVGSTTISKYATFLNDLRNEAKDPSLKCYGIPMLPNTNTNPKYVLVELQGSNKKTITLMLRRNNLYVMGYSDPFETNKCRYHIFNDISGTERQDVETTLCPNANSRVSKNINFDSRYPTLESKAGVKSRSQVQLGIQILDSNIGKISGVMSFTEKTEAEFLLVAIQMVSEAARFKYIENQVKTNFNRAFNPNPKVLNLQETWGKISTAIHDAKNGVLPKPLELVDASGAKWIVLRVDEIKPDVALLNYVGGSCQTT 1t8s A 2.6 BS01 FMP A 1 N205 R381 W383 M404 E405 D428 K436 N174 R350 W352 M373 E374 D397 K405 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 501 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s A 2.6 BS02 FMP B 1 H188 Y189 H157 Y158 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 502 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s B 2.6 BS01 FMP A 1 H188 Y189 H157 Y158 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 501 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKEGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s B 2.6 BS02 FMP B 1 N205 C306 G307 R381 W383 D403 M404 E405 D428 K436 N174 C275 G276 R350 W352 D372 M373 E374 D397 K405 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 502 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKEGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s C 2.6 BS01 FMP C 1 N205 G307 R381 W383 I402 D403 M404 E405 D428 K436 N174 G276 R350 W352 I371 D372 M373 E374 D397 K405 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 503 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s C 2.6 BS02 FMP D 1 H188 Y189 H157 Y158 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 504 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s D 2.6 BS01 FMP C 1 H188 Y189 H157 Y158 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 503 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s D 2.6 BS02 FMP D 1 N205 R381 W383 D403 M404 E405 D428 K436 N174 R350 W352 D372 M373 E374 D397 K405 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 504 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s E 2.6 BS01 FMP E 1 N205 R381 W383 D403 M404 E405 D428 K436 N174 R350 W352 D372 M373 E374 D397 K405 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 505 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 1t8s F 2.6 BS01 FMP F 1 N205 C306 R381 W383 M404 E405 D428 K436 N174 C275 R350 W352 M373 E374 D397 K405 3.2.2.4 0003824,0005737,0005829,0008714,0009116,0016787,0044209,0046033 P0AE12 15296732 506 LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVILDRSMSAGLTRYFPTTFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR 3rti A 2.8 BS01 FMP A 1 Y80 V81 G121 N122 Y123 I172 E177 R180 Y75 V76 G116 N117 Y118 I167 E172 R175 V81 E177 R180 V76 E172 R175 3.2.2.22 0017148,0030598 -logKd/Ki=7.37, Ki=0.043uM P02879 1433290 301 YPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPP