1a69 A 2.1 BS01 FMB A 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 Ki=5uM -logKd/Ki=5.30, Ki=5uM P0ABP8 9653038 240 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1a69 B 2.1 BS01 FMB B 1 M64 S90 F159 V178 E179 M180 E181 M64 S90 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 Ki=5uM P0ABP8 9653038 240 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1a69 C 2.1 BS01 FMB C 1 S90 C91 G92 F159 V178 M180 E181 D204 S90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R213 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 Ki=5uM -logKd/Ki=5.30, Ki=5uM P0ABP8 9653038 240 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTTAAERQTTFNDMIKIALESVLLGDK 1jdz A 2.0 BS02 FMB A 1 I64 T89 T90 G91 V179 E180 M181 E182 I62 T87 T88 G89 V177 E178 M179 E180 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 270 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz B 2.0 BS02 FMB B 1 I64 T89 T90 G91 M181 E182 D205 I62 T87 T88 G89 M179 E180 D203 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 275 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz B 2.0 BS03 FMB C 1 H5 R43 H3 R41 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 280 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz C 2.0 BS02 FMB C 1 I64 T89 T90 G91 V179 M181 E182 D205 I62 T87 T88 G89 V177 M179 E180 D203 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 280 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1pr1 A 2.3 BS02 FMB A 1 M64 R87 S90 C91 G92 F159 V178 M180 E181 D204 M64 R87 S90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 R206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=5uM -logKd/Ki=5.30, Ki=5uM P0ABP9 12937174 245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHRQTTFNDMIKIALESVLLGDK 1pr1 B 2.3 BS02 FMB B 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 M64 S90 C91 G92 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=5uM P0ABP9 12937174 246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr1 C 2.3 BS02 FMB C 1 S90 C91 G92 F159 V178 E179 M180 E181 D204 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=5uM P0ABP9 12937174 247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1tc1 A 1.41 BS01 FMB A 1 D115 K143 F164 V165 D102 K130 F151 V152 E111 D112 D115 F164 R177 E98 D99 D102 F151 R164 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 ic50>2mM -logKd/Ki=2.70, IC50>2mM Q4DRC4 9790669 900 YEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCRALCDFNVPVRMEFICVSSYVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYLYHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIVVLRPE 1tc1 B 1.41 BS01 FMB B 1 D115 K143 F164 V165 D111 K139 F160 V161 E111 D112 D115 F164 R177 E107 D108 D111 F160 R173 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 ic50>2mM Q4DRC4 9790669 901 YEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYLYHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIVVLRPEVY