1wco N -1.00 BS03 FDF L 1 I1 X2 A3 I4 A5 L6 C7 P9 G10 I1 X2 A3 I4 A5 L6 C7 P9 G10 ? 0005576,0042742 P29559 15361862 101 ITAISLCPPGCKPGALMGCNMKPAPCNCSIHVSK 3cke A 2.4 BS01 FDF A 1 Y67 F87 D90 F153 L184 N219 W308 R314 Y315 Y55 F75 D78 F141 L172 N207 W286 R292 Y293 Y67 F87 F153 K181 W308 Y55 F75 F141 K169 W286 4.2.3.9 0016829,0045483,0046872 -logKd/Ki=6.10, Ki=0.8uM Q9UR08 18385128 400 SLEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWNFPNEKARKKFVAAGFSRVTCLYFPKALDDRIHFACRLLTVLFLIDDLLEYMSFEEGSAYNEKLIPISRGDVLPDRSIPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRARPMGLGGYLEYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSKHLSVVNDIYSYEKELYTLCTSVQILAQEADVTAEAAKRVLFVMCREWELRHQLLVARLSAEGLETPGLAAYVEGLEYQMSGNELWSQTTLRYSV 3cke B 2.4 BS01 FDF B 1 F87 D90 F153 R314 F75 D78 F141 R294 Y67 F87 F153 K181 W308 Y55 F75 F141 K169 W288 4.2.3.9 0016829,0045483,0046872 Q9UR08 18385128 401 SLEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWNFPNEKARKKFVAAGFSRVTCLYFPKALDDRIHFACRLLTVLFLIDDLLEYMSFEEGSAYNEKLIPISRGDVLPDRSIPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRARPMGLGGYLEYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSKHLSVVNDIYSYEKELYTSILCTSVQILAQEADVTAEAAKRVLFVMCREWELRHQLLVARLSAEGLETPGLAAYVEGLEYQMSGNELWSQTTLRYSV 3cke C 2.4 BS01 FDF C 1 F87 D90 F153 L184 N219 R314 Y315 F75 D78 F141 L172 N207 R292 Y293 Y67 F87 F153 K181 W308 Y55 F75 F141 K169 W286 4.2.3.9 0016829,0045483,0046872 Q9UR08 18385128 402 SLEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWNFPNEKARKKFVAAGFSRVTCLYFPKALDDRIHFACRLLTVLFLIDDLLEYMSFEEGSAYNEKLIPISRGDVLPDRSIPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRARPMGLGGYLEYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSKHLSVVNDIYSYEKELYTLCTSVQILAQEADVTAEAAKRVLFVMCREWELRHQLLVARLSAEGLETPGLAAYVEGLEYQMSGNELWSQTTLRYSV 6wkd A 2.2 BS01 FDF A 1 F76 F77 Y146 R173 I177 N219 W308 R314 Y315 F68 F69 Y138 R158 I162 N204 W273 R279 Y280 F76 F77 I177 R314 F68 F69 I162 R279 4.2.3.7 0016829,0017000,0046872,0050467 Q55012 32786410 401 IPLPGRQSPDHARAEAEQLAWPRSLGLIRSDAAAERHLRGGYADLASRFYPHATGADLDLGVDLMSWFFLFDDLFDGPRGENPEDTKQLTDQVAAALDGPLPDTAPPIAHGFADIWRRTCEGMTPAWCARSARHWRNYFDGYVDEAESRFAAQYLAMRRHTIGVQPTVDLAERAGRFEVPHRVFDSAVMSAMLQIAVDVNLLLNDIASLNMVMIRSVSHMQNEVRARLEQYLLLESCLPKVGEIYQLDTAEREALERYRTDAVRTVIRGSYDWHRSSGRY 6wkf A 2.5 BS01 FDF A 1 Y76 F77 D80 R173 I177 N219 Y67 F68 D71 R155 I159 N201 Y76 F77 D80 D84 R157 R173 I177 N219 S223 K226 W308 H309 Y67 F68 D71 D75 R147 R155 I159 N201 S205 K208 W268 H269 4.2.3.7 0016829,0017000,0046872,0050467 Q55012 32786410 401 PLPGRQSPDHARAEAEQLAWPRSLGLIRSDAAAERHLRGGYADLASRFYPHATGADLDLGVDLMSWYFLFDDLFDPRGENPEDTKQLTDQVAAALDGPLPDTAPPIAHGFADIWRRTCEGMTPAWCARSARHWRNYFDGYVDEAESRFAQYLAMRRHTIGVQPTVDLAERAGRFEVPHRVFDSAVMSAMLQIAVDVNLLLNDIASLEKNMVMSHMQNEVRARLEQYLLLESCLPKVGEIYQLDTAEREALERYRTDAVRTVIRGSYDWH 6wkh A 2.55 BS01 FDF A 1 W76 F77 D80 R173 N219 W69 F70 D73 R158 N204 W76 F77 D80 D84 R157 R173 I177 N219 W308 H309 W69 F70 D73 D77 R150 R158 I162 N204 W265 H266 4.2.3.7 0016829,0017000,0046872,0050467 Q55012 32786410 401 HIPLPGRQSPDHARAEAEQLAWPRSLGLIRSDAAAERHLRGGYADLASRFYPHATGADLDLGVDLMSWWFLFDDLFDGPRGENPEDTKQLTDQVAAALDGPLPDTAPPIAHGFADIWRRTCEGMTPAWCARSARHWRNYFDGYVDEAESRAAQYLAMRRHTIGVQPTVDLAERAGRFEVPHRVFDSAVMSAMLQIAVDVNLLLNDIASVSHMQNEVRARLEQYLLLESCLPKVGEIYQLDTAEREALERYRTDAVRTVIRGSYDWHR 6wkj A 2.3 BS01 FDF A 1 L72 M73 H76 F77 D80 Y146 G178 V179 T182 N219 L64 M65 H68 F69 D72 Y136 G151 V152 T155 N192 H76 F77 D80 D84 R173 I177 N219 W308 H309 H68 F69 D72 D76 R146 I150 N192 W250 H251 4.2.3.7 0016829,0017000,0046872,0050467 Q55012 32786410 401 IPLPGRQSPDHARAEAEQLAWPRSLGLIRSDAAAERHLRGGYADLASRFYPHATGADLDLGVDLMSWHFLFDDLFDPRGEPEDTKQLTDQVAAALDGPLPDTAPPIAHGFADIWRRTCEGMTPAWCARSARHWRNYFDGYVDEAERRHTIGVQPTVDLAERAGRFEVPHRVFDSAVMSAMLQIAVDVNLLLNDIAHMQNEVRARLEQYLLLESCLPKVGEIYQLDTAEREALERYRTDAVRTVIRGSYDWH