6gu4 A 2.73 BS01 FC8 A 1 I10 A31 F80 L83 S84 M85 D86 Q132 L135 I13 A34 F83 L86 S87 M88 D89 Q135 L138 D128 K130 Q132 N133 D146 V159 T166 D131 K133 Q135 N136 D149 V162 T169 2.7.11.22,2.7.11.23 0000082,0000086,0000226,0000307,0000781,0001618,0003682,0004672,0004674,0004693,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005789,0005813,0005819,0005829,0005856,0005876,0006260,0006281,0006338,0006357,0006468,0006915,0006974,0007077,0007095,0007098,0007344,0008353,0009410,0009636,0010628,0010629,0010971,0014038,0014070,0014075,0014823,0016020,0016301,0016310,0016477,0016579,0018105,0018107,0030261,0030332,0030496,0030544,0030855,0031100,0034501,0035173,0042307,0042542,0042752,0043066,0044772,0045471,0045740,0045931,0045995,0046686,0046688,0046718,0048144,0048511,0048678,0051301,0055015,0060045,0062033,0065003,0070062,0070301,0070371,0071407,0072686,0090166,0097121,0097122,0097125,0097472,0106310,1900182,1902423,1902850,1905448 -logKd/Ki=4.70, Kd>20000nM IC50=31nM P06493 30472117 301 LGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 6guk A 1.3 BS01 FC8 A 1 I10 G11 E12 A31 F80 L83 H84 D86 L134 I10 G11 E12 A31 F70 L73 H74 D76 L124 D127 K129 Q131 N132 D145 T165 D117 K119 Q121 N122 D135 T145 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 Kd=715nM -logKd/Ki=6.15, Kd=715nM IC50=26nM P24941 30472117 301 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL