6gu3 A 2.65 BS01 FB8 A 1 I10 V18 A31 L83 S84 M85 D86 K89 L135 I13 V21 A34 L86 S87 M88 D89 K92 L138 D128 K130 Q132 N133 D146 V159 T166 D131 K133 Q135 N136 D149 V162 T169 2.7.11.22,2.7.11.23 0000082,0000086,0000226,0000307,0000781,0001618,0003682,0004672,0004674,0004693,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005789,0005813,0005819,0005829,0005856,0005876,0006260,0006281,0006338,0006357,0006468,0006915,0006974,0007077,0007095,0007098,0007344,0008353,0009410,0009636,0010628,0010629,0010971,0014038,0014070,0014075,0014823,0016020,0016301,0016310,0016477,0016579,0018105,0018107,0030261,0030332,0030496,0030544,0030855,0031100,0034501,0035173,0042307,0042542,0042752,0043066,0044772,0045471,0045740,0045931,0045995,0046686,0046688,0046718,0048144,0048511,0048678,0051301,0055015,0060045,0062033,0065003,0070062,0070301,0070371,0071407,0072686,0090166,0097121,0097122,0097125,0097472,0106310,1900182,1902423,1902850,1905448 -logKd/Ki=5.36, Kd=4400nM IC50=62nM P06493 30472117 301 LGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 6gu7 A 2.75 BS01 FB8 A 1 I10 A31 K33 E81 L83 S84 D86 K89 L135 D146 I10 A31 K33 E81 L83 S84 D86 K89 L135 D146 D128 K130 Q132 N133 D146 T166 D128 K130 Q132 N133 D146 T157 2.7.11.22,2.7.11.23 0000082,0000086,0000226,0000307,0000781,0001618,0003682,0004672,0004674,0004693,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005789,0005813,0005819,0005829,0005856,0005876,0006260,0006281,0006338,0006357,0006468,0006915,0006974,0007077,0007095,0007098,0007344,0008353,0009410,0009636,0010628,0010629,0010971,0014038,0014070,0014075,0014823,0016020,0016301,0016310,0016477,0016579,0018105,0018107,0030261,0030332,0030496,0030544,0030855,0031100,0034501,0035173,0042307,0042542,0042752,0043066,0044772,0045471,0045740,0045931,0045995,0046686,0046688,0046718,0048144,0048511,0048678,0051301,0055015,0060045,0062033,0065003,0070062,0070301,0070371,0071407,0072686,0090166,0097121,0097122,0097125,0097472,0106310,1900182,1902423,1902850,1905448 -logKd/Ki=5.81, Kd=1560nM IC50=62nM P06493 30472117 301 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 6gue A 1.99 BS01 FB8 A 1 I10 A31 K33 F80 L83 H84 D86 K89 L134 I11 A32 K34 F76 L79 H80 D82 K85 L130 D127 K129 Q131 N132 D145 T158 T165 D123 K125 Q127 N128 D141 T154 T161 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 Kd=4nM -logKd/Ki=8.40, Kd=4nM IC50=6nM P24941 30472117 301 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKITEGVPSTAIREISLLKELNHPNIVKLLDVIHTNNKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 6gue C 1.99 BS01 FB8 C 1 I10 A31 K33 F80 L83 H84 D86 K89 L134 I11 A32 K34 F81 L84 H85 D87 K90 L135 D127 K129 Q131 N132 D145 T158 T165 D128 K130 Q132 N133 D146 T159 T166 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 Kd=4nM IC50=6nM P24941 30472117 301 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVTSMPDYKPSFPRQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 6guh A 1.5 BS01 FB8 A 1 I10 V18 A31 F80 L83 H84 Q85 D86 K89 L134 D145 I12 V20 A33 F74 L77 H78 Q79 D80 K83 L128 D139 D127 K129 Q131 N132 D145 T158 T165 D121 K123 Q125 N126 D139 T144 T151 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 Kd=26nM -logKd/Ki=7.59, Kd=26nM IC50=6nM P24941 30472117 301 EFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 7s6u A 1.74 BS01 FB8 A 1 A47 K49 M100 Y102 V103 R109 L158 C169 A47 K49 M100 Y102 V103 R109 L158 C169 2.7.11.1 0004672,0004674,0005524,0005737,0006338,0006468,0007165,0016310,0044024 A4HXQ3 401 MSLNAADAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIFGNQHYTTSVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHTDLYNSKGIPWSSVFCDHSLKDAKEAYDLLSALLQYLPEDRMKPYEALCHPYFDELHDSATKLPNNKDLPEDLFRFLPSEIEVMSEAQKAKLV