6gu2 A 2.0 BS01 F9Z A 1 I10 V18 A31 K33 V64 F80 E81 F82 L83 L135 D146 I13 V21 A34 K36 V67 F83 E84 F85 L86 L138 D149 D128 K130 Q132 N133 D146 V159 T166 D131 K133 Q135 N136 D149 V162 T166 2.7.11.22,2.7.11.23 0000082,0000086,0000226,0000307,0000781,0001618,0003682,0004672,0004674,0004693,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005789,0005813,0005819,0005829,0005856,0005876,0006260,0006281,0006338,0006357,0006468,0006915,0006974,0007077,0007095,0007098,0007344,0008353,0009410,0009636,0010628,0010629,0010971,0014038,0014070,0014075,0014823,0016020,0016301,0016310,0016477,0016579,0018105,0018107,0030261,0030332,0030496,0030544,0030855,0031100,0034501,0035173,0042307,0042542,0042752,0043066,0044772,0045471,0045740,0045931,0045995,0046686,0046688,0046718,0048144,0048511,0048678,0051301,0055015,0060045,0062033,0065003,0070062,0070301,0070371,0071407,0072686,0090166,0097121,0097122,0097125,0097472,0106310,1900182,1902423,1902850,1905448 Kd=1600nM -logKd/Ki=5.80, Kd=1600nM P06493 30472117 301 LGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 6gub A 2.52 BS01 F9Z A 1 I10 Y15 V18 A31 K33 V64 F80 E81 L83 L134 D145 I11 Y16 V19 A32 K34 V62 F78 E79 L81 L132 D143 D127 K129 Q131 N132 D145 T158 T165 D125 K127 Q129 N130 D143 T156 T163 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 -logKd/Ki=7.64, Kd=23nM P24941 30472117 301 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLTEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 6gub C 2.52 BS01 F9Z C 1 I10 V18 A31 K33 V64 F80 E81 L83 N132 L134 D145 I11 V19 A32 K34 V65 F81 E82 L84 N133 L135 D146 D127 K129 Q131 N132 D145 T158 T165 D128 K130 Q132 N133 D146 T159 T166 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 P24941 30472117 301 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL