1f28 A 1.9 BS02 F89 A 1 F58 G61 E65 H85 I86 W87 D202 G206 F209 S296 F56 G59 E63 H83 I84 W85 D200 G204 F207 S294 E65 W87 Y113 C173 R199 D202 E63 W85 Y111 C171 R197 D200 2.1.1.45 0004799,0005739,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Ki=16nM -logKd/Ki=7.80, Ki=16nM P13100 11358692 401 NAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKFSLRNKTFPLLTTKRVFIRGVIEELLWFIRGETDSLKLREKNIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHFGAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPADLEKMALPPCHMFCQFYVHIPSNNHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCHIYKDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNIQNYHPYETIKMKMSI 1f28 B 1.9 BS03 F89 B 1 F58 E65 I86 W87 D202 G206 F209 Y242 M295 F56 E63 I84 W85 D200 G204 F207 Y240 M293 E65 W87 Y113 C173 R199 D202 E63 W85 Y111 C171 R197 D200 2.1.1.45 0004799,0005739,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Ki=16nM -logKd/Ki=7.80, Ki=16nM P13100 11358692 402 NAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKFSLRNKTFPLLTTKRVFIRGVIEELLWFIRGETDSLKLREKNIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHFGAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPADLEKMALPPCHMFCQFYVHIPSNNHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCHIYKDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNIQNYHPYETIKMKMSI 1f28 C 1.9 BS02 F89 C 1 F58 G61 E65 H85 I86 W87 D202 G206 F209 Y242 S296 F56 G59 E63 H83 I84 W85 D200 G204 F207 Y240 S294 E65 W87 Y113 C173 R199 D202 E63 W85 Y111 C171 R197 D200 2.1.1.45 0004799,0005739,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Ki=16nM P13100 11358692 403 NAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKFSLRNKTFPLLTTKRVFIRGVIEELLWFIRGETDSLKLREKNIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHFGAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPADLEKMALPPCHMFCQFYVHIPSNNHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCHIYKDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNIQNYHPYETIKMKMSI 1f28 D 1.9 BS03 F89 D 1 F58 G61 E65 H85 I86 W87 L170 D202 G206 F209 Y242 M295 F56 G59 E63 H83 I84 W85 L168 D200 G204 F207 Y240 M293 E65 W87 Y113 C173 R199 D202 E63 W85 Y111 C171 R197 D200 2.1.1.45 0004799,0005739,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Ki=16nM P13100 11358692 404 NAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKFSLRNKTFPLLTTKRVFIRGVIEELLWFIRGETDSLKLREKNIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHFGAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPADLEKMALPPCHMFCQFYVHIPSNNHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCHIYKDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNIQNYHPYETIKMKMSI 1sej A 2.87 BS02 F89 A 1 I315 D426 G430 F433 Y466 M519 I313 D424 G428 F431 Y464 M517 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej A 2.87 BS03 F89 A 2 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 605 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej B 2.87 BS03 F89 B 1 E294 I315 W316 G430 F433 M519 E292 I313 W314 G428 F431 M517 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 608 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej B 2.87 BS04 F89 B 2 V9 V10 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 L23 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 609 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej C 2.87 BS02 F89 C 1 E294 I315 W316 D426 G430 F433 Y466 M519 E292 I313 W314 D424 G428 F431 Y464 M517 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 612 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej C 2.87 BS03 F89 C 2 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 613 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej D 2.87 BS03 F89 D 1 E294 I315 D426 G430 F433 Y466 M519 E292 I313 D424 G428 F431 Y464 M517 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 616 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej D 2.87 BS04 F89 D 2 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 617 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej E 2.87 BS02 F89 E 1 E294 I315 G430 F433 M519 E292 I313 G428 F431 M517 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 620 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1sej E 2.87 BS03 F89 E 2 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E292 W314 Y340 C400 R421 D424 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27552 16511011 621 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 1syn A 2.0 BS02 F89 A 1 S54 E58 T78 I79 W80 D169 G173 F176 S54 E58 T78 I79 W80 D169 G173 F176 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 Kd=0.1nM P0A884 8805515 301 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 1syn B 2.0 BS03 F89 B 1 H51 S54 E58 T78 I79 W80 W83 D169 G173 F176 H51 S54 E58 T78 I79 W80 W83 D169 G173 F176 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 Kd=0.1nM P0A884 8805515 301 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 1tlc A 2.1 BS02 F89 A 1 S54 E58 T78 I79 W80 W83 D169 G173 F176 A263 S54 E58 T78 I79 W80 W83 D169 G173 F176 A263 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 7724588 266 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 1tlc B 2.1 BS03 F89 B 1 S54 E58 V77 T78 I79 W80 W83 D169 G173 F176 S54 E58 V77 T78 I79 W80 W83 D169 G173 F176 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 7724588 266 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 1tsd A 1.95 BS02 F89 A 1 S54 E58 T78 I79 W80 W83 L143 D169 G173 F176 Y209 S54 E58 T78 I79 W80 W83 L143 D169 G173 F176 Y209 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 8846221 268 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 1tsd B 1.95 BS03 F89 B 1 S54 E58 I79 W80 W83 D169 G173 F176 Y209 S54 E58 I79 W80 W83 D169 G173 F176 Y209 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 8846221 266 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 2vf0 A 3.0 BS02 F89 A 1 S54 T78 I79 W80 W83 L143 D169 G173 F176 Y209 S54 T78 I79 W80 W83 L143 D169 G173 F176 Y209 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 18403248 1266 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTQRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 2vf0 B 3.0 BS03 F89 B 1 C50 S54 I79 W80 W83 D169 G173 F176 Y209 C50 S54 I79 W80 W83 D169 G173 F176 Y209 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 P0A884 18403248 1266 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTQRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI