1cnq A 2.27 BS01 F6P A 1 G26 T27 G28 E29 M30 K112 Y113 V160 M177 G21 T22 G23 E24 M25 K107 Y108 V155 M172 D68 D74 E97 E98 D118 L120 D121 E280 D63 D69 E92 E93 D113 L115 D116 E275 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 9708979 338 FDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1cnq A 2.27 BS02 F6P A 2 D121 G122 N212 Y215 Y244 G246 M248 Y264 K274 R276 D116 G117 N207 Y210 Y239 G241 M243 Y259 K269 R271 D68 D74 E97 E98 D118 L120 D121 E280 D63 D69 E92 E93 D113 L115 D116 E275 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 9708979 339 FDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1eyi A 2.32 BS01 F6P A 1 D121 G122 N212 Y215 Y244 G246 S247 M248 Y264 K274 E280 D115 G116 N206 Y209 Y238 G240 S241 M242 Y258 K268 E274 D68 D74 E97 E98 D118 L120 D121 E280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 10913263 339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1eyj A 2.28 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D113 N204 Y207 Y236 G238 S239 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 10913263 338 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1eyj B 2.28 BS01 F6P B 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 E280 D113 N204 Y207 Y236 G238 S239 M240 Y256 K266 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 10913263 341 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1eyk A 2.23 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D113 N204 Y207 Y236 G238 S239 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 10913263 338 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1eyk B 2.23 BS01 F6P B 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 D113 N204 Y207 Y236 G238 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 10913263 341 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1fbp A 2.5 BS01 F6P A 1 N212 Y215 S247 M248 Y264 K274 L275 N193 Y196 S228 M229 Y245 K255 L256 D68 D74 E97 E98 D118 L120 D121 E280 D49 D55 E78 E79 D99 L101 D102 E261 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 2164670 336 FDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1fbp B 2.5 BS01 F6P B 1 D121 N212 Y244 S247 M248 K274 D102 N193 Y225 S228 M229 K255 D68 D74 E97 E98 D118 L120 D121 E280 D49 D55 E78 E79 D99 L101 D102 E261 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 2164670 336 FDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1fj6 A 2.5 BS01 F6P A 1 D121 G122 N212 Y215 Y244 G246 S247 M248 Y264 K274 D114 G115 N205 Y208 Y237 G239 S240 M241 Y257 K267 D68 D74 E97 E98 D118 L120 D121 E280 D61 D67 E90 E91 D111 L113 D114 E273 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 10998248 401 TNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLWGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1fj9 A 2.5 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 E280 D105 N196 Y199 Y228 G230 S231 M232 Y248 K258 E264 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 10998248 400 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLWGIAGSKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1fj9 B 2.5 BS01 F6P B 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 L275 R276 D105 N196 Y199 Y228 G230 S231 M232 Y248 K258 L259 R260 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 10998248 410 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLWGIAGSKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1fsa A 2.3 BS01 F6P A 1 D121 N212 Y244 M248 Y264 K274 R276 E280 D121 N212 Y244 M248 Y264 K274 R276 E280 D68 D74 E97 E98 D118 L120 D121 E280 D68 D74 E97 E98 D118 L120 D121 E280 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 8931152 338 TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVAAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1fsa B 2.3 BS01 F6P B 1 D121 N212 Y244 M248 Y264 K274 L275 E280 D121 N212 Y244 M248 Y264 K274 L275 E280 D68 D74 E97 E98 D118 L120 D121 E280 D68 D74 E97 E98 D118 L120 D121 E280 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 8931152 338 TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVAAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1hox A 2.1 BS01 F6P A 1 G158 S209 K210 T211 T214 E357 G158 S209 K210 T211 T214 E357 K210 E216 G271 R272 E357 H388 K518 K210 E216 G271 R272 E357 H388 K518 5.3.1.9 0004347,0005125,0005576,0005615,0005737,0005829,0006094,0006096,0007165,0016853,0048029,0051156,0097367,1901135 Q9N1E2 11425306 1001 AALTRNPQFQKLQQWHREHGSELNLRHLFDTDKERFNHFSLTLNTNHGHILLDYSKNLVTEEVMHMLLDLAKSRGVEAARESMFNGEKINSTEDRAVLHVALRNRSNTPIVVDGKDVMPEVNKVLDKMKAFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWFVSNIDGTHIAKTLACLNPESSLFIIASKTFTTQETITNAKTAKDWFLLSAKDPSTVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLAMLGIWYINCFGCETQAVLPYDQYLHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKSTEEARKELQAAGKSPEDLMKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGVVWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDSSTNGLINFIKQQREAK 1hox B 2.1 BS01 F6P B 1 G157 G158 S159 S209 K210 T211 T214 E357 G157 G158 S159 S209 K210 T211 T214 E357 K210 E216 G271 R272 E357 H388 K518 K210 E216 G271 R272 E357 H388 K518 5.3.1.9 0004347,0005125,0005576,0005615,0005737,0005829,0006094,0006096,0007165,0016853,0048029,0051156,0097367,1901135 Q9N1E2 11425306 1002 AALTRNPQFQKLQQWHREHGSELNLRHLFDTDKERFNHFSLTLNTNHGHILLDYSKNLVTEEVMHMLLDLAKSRGVEAARESMFNGEKINSTEDRAVLHVALRNRSNTPIVVDGKDVMPEVNKVLDKMKAFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWFVSNIDGTHIAKTLACLNPESSLFIIASKTFTTQETITNAKTAKDWFLLSAKDPSTVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLAMLGIWYINCFGCETQAVLPYDQYLHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKSTEEARKELQAAGKSPEDLMKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGVVWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDSSTNGLINFIKQQREAK 1kz8 A 2.0 BS01 F6P A 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 E280 D105 N196 Y199 Y228 S231 M232 Y248 K258 E264 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12190310 736 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1kz8 F 2.0 BS01 F6P F 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 E280 D105 N196 Y199 Y228 S231 M232 Y248 K258 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12190310 836 NIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1lby A 2.25 BS01 F6P A 1 D85 Y155 G170 S171 A172 R191 M195 L196 D200 D85 Y155 G170 S171 A172 R191 M195 L196 D200 E67 D82 L84 D85 D200 E67 D82 L84 D85 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 11940584 295 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 1lby A 2.25 BS06 F6P B 1 R165 R167 R165 R167 E67 D82 L84 D85 D200 E67 D82 L84 D85 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 11940584 595 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 1lby B 2.25 BS01 F6P B 1 D385 Y455 Y456 G470 S471 A472 R491 D500 D85 Y155 Y156 G170 S171 A172 R191 D200 E367 D382 L384 D385 T387 D500 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 11940584 595 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 1lev A 2.15 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D97 N188 Y191 Y220 G222 S223 M224 Y240 K250 D74 E97 E98 D118 L120 D121 E280 D50 E73 E74 D94 L96 D97 E256 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12781194 338 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1lev F 2.15 BS01 F6P F 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D97 N188 Y191 Y220 G222 S223 M224 Y240 K250 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12781194 338 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1mto A 3.2 BS01 F6P A 1 D127 M169 R171 E222 H249 R252 D127 M169 R171 E222 H249 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 -logKd/Ki=6.96, Ki=0.11uM P00512 12390023 1002 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto A 3.2 BS02 F6P B 1 R162 R243 R162 R243 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 -logKd/Ki=6.96, Ki=0.11uM P00512 12390023 1001 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto B 3.2 BS01 F6P A 1 R162 R243 R162 R243 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 -logKd/Ki=6.96, Ki=0.11uM P00512 12390023 1002 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto B 3.2 BS02 F6P B 1 D127 M169 R171 E222 H249 R252 D127 M169 R171 E222 H249 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 -logKd/Ki=6.96, Ki=0.11uM P00512 12390023 1001 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto C 3.2 BS01 F6P C 1 D127 M169 E222 H249 R252 D127 M169 E222 H249 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1004 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto C 3.2 BS02 F6P D 1 R162 R243 R162 R243 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1003 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto D 3.2 BS01 F6P C 1 R162 R243 R162 R243 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1004 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto D 3.2 BS02 F6P D 1 D127 M169 R171 E222 H249 R252 D127 M169 R171 E222 H249 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1003 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto E 3.2 BS01 F6P E 1 D127 M169 R171 E222 R252 D127 M169 R171 E222 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1006 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto E 3.2 BS02 F6P F 1 R162 R243 R162 R243 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1005 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto F 3.2 BS01 F6P E 1 R162 R243 R162 R243 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1006 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto F 3.2 BS02 F6P F 1 I126 D127 M169 R171 H249 R252 I126 D127 M169 R171 H249 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1005 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto G 3.2 BS01 F6P G 1 D127 M169 R171 E222 H249 R252 D127 M169 R171 E222 H249 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1008 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto G 3.2 BS02 F6P H 1 R162 R243 R162 R243 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1007 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto H 3.2 BS01 F6P G 1 R162 R243 R162 R243 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1008 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1mto H 3.2 BS02 F6P H 1 D127 M169 R171 E222 H249 R252 D127 M169 R171 E222 H249 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 12390023 1007 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTWVIEVMGRHAGDIALYSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 1nuw A 1.3 BS01 F6P A 1 D1121 G1122 N1212 Y1215 Y1244 G1246 S1247 M1248 Y1264 K1274 R1276 D114 G115 N205 Y208 Y237 G239 S240 M241 Y257 K267 R269 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D61 D67 E90 E91 D111 L113 D114 E273 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595528 2336 TNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nux A 1.6 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 G1246 S1247 M1248 Y1264 K1274 R1276 D114 N205 Y208 Y237 G239 S240 M241 Y257 K267 R269 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D61 D67 E90 E91 D111 L113 D114 E273 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595528 2339 TNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nuy A 1.3 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 G1246 S1247 M1248 Y1264 K1274 R1276 E1280 D114 N205 Y208 Y237 G239 S240 M241 Y257 K267 R269 E273 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D61 D67 E90 E91 D111 L113 D114 E273 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595528 2339 TNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nuz A 1.9 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 G1246 M1248 Y1264 K1274 L1275 E1280 D115 N206 Y209 Y238 G240 M242 Y258 K268 L269 E274 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 2339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nv0 A 1.8 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 G1246 M1248 Y1264 K1274 E1280 D115 N206 Y209 Y238 G240 M242 Y258 K268 E274 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 2339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nv1 A 1.9 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 G1246 M1248 Y1264 K1274 L1275 E1280 D115 N206 Y209 Y238 G240 M242 Y258 K268 L269 E274 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 2339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1nv2 A 2.1 BS01 F6P A 1 D1121 G1122 N1212 Y1215 Y1244 G1246 S1247 M1248 Y1264 K1274 L1275 D115 G116 N206 Y209 Y238 G240 S241 M242 Y258 K268 L269 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 2339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1nv3 A 2.0 BS01 F6P A 1 D1121 G1122 N1212 Y1215 Y1244 G1246 S1247 M1248 Y1264 K1274 D115 G116 N206 Y209 Y238 G240 S241 M242 Y258 K268 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 2339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nv4 A 1.9 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 G1246 M1248 Y1264 K1274 D115 N206 Y209 Y238 G240 M242 Y258 K268 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 2339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nv5 A 1.9 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 G1246 M1248 Y1264 K1274 L1275 E1280 D115 N206 Y209 Y238 G240 M242 Y258 K268 L269 E274 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 2339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1nv6 A 2.15 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 S1247 M1248 Y1264 K1274 D115 N206 Y209 Y238 S241 M242 Y258 K268 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 2339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nv7 A 2.15 BS01 F6P A 1 D1121 N1212 Y1215 Y1244 G1246 S1247 M1248 Y1264 K1274 D113 N204 Y207 Y236 G238 S239 M240 Y256 K266 D1068 D1074 E1097 E1098 D1118 L1120 D1121 E1280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 3336 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1nv7 B 2.15 BS01 F6P B 1 D2121 G2122 N2212 Y2215 Y2244 S2247 M2248 Y2264 K2274 E2280 D113 G114 N204 Y207 Y236 S239 M240 Y256 K266 E272 D2068 D2074 E2097 E2098 D2118 L2120 D2121 E2280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 12595529 4336 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1q9d A 2.35 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 D114 N205 Y208 Y237 G239 M241 Y257 K267 D68 D74 E97 E98 D118 L120 D121 E280 D61 D67 E90 E91 D111 L113 D114 E273 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 14530289 401 TNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1q9d B 2.35 BS02 F6P B 1 D121 G122 Y215 Y244 G246 S247 M248 Y264 K274 D114 G115 Y208 Y237 G239 S240 M241 Y257 K267 D68 D74 E97 E98 D118 L120 D121 E280 D61 D67 E90 E91 D111 L113 D114 E273 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 14530289 411 TNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1rdx A 2.75 BS01 F6P A 1 D121 G122 Y244 Y264 L275 R276 E280 D121 G122 Y244 Y264 L275 R276 E280 D68 D74 E97 E98 D118 L120 D121 E280 D68 D74 E97 E98 D118 L120 D121 E280 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 8844845 338 TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGAAYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1rdx B 2.75 BS01 F6P B 1 N212 G246 S247 M248 K274 N212 G246 S247 M248 K274 D68 D74 E97 E98 D118 L120 D121 E280 D68 D74 E97 E98 D118 L120 D121 E280 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 8844845 338 TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGAAYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1rdy A 2.2 BS01 F6P A 1 G246 S247 M248 Y264 K274 G246 S247 M248 Y264 K274 D68 D74 E97 E98 D118 L120 D121 E280 D68 D74 E97 E98 D118 L120 D121 E280 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 8844845 338 TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGAAYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1rdy B 2.2 BS01 F6P B 1 D121 N212 Y215 M248 Y264 K274 L275 D121 N212 Y215 M248 Y264 K274 L275 D68 D74 E97 E98 D118 L120 D121 E280 D68 D74 E97 E98 D118 L120 D121 E280 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 8844845 338 TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGAAYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1rdz A 2.05 BS01 F6P A 1 D121 Y215 Y244 G246 S247 M248 Y264 K274 R276 D121 Y215 Y244 G246 S247 M248 Y264 K274 R276 D68 D74 E97 E98 D118 L120 D121 E280 D68 D74 E97 E98 D118 L120 D121 E280 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 8844845 338 TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGAAYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1rdz B 2.05 BS01 F6P B 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D68 D74 E97 E98 D118 L120 D121 E280 D68 D74 E97 E98 D118 L120 D121 E280 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 8844845 338 TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGAAYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1t10 A 2.35 BS01 F6P A 1 I204 S207 S257 K258 T259 T262 I156 S159 S209 K210 T211 T214 K258 E264 G324 R325 E410 H441 K569 K210 E216 G276 R277 E362 H393 K521 5.3.1.9 0004347,0005737,0005829,0006094,0006096,0016853,0048029,0051156,0097367,1901135 P42861 15206941 1001 SLLNLPAWKRLQSLYEKYGNDSILSHFEKDHQRFQRYSIEIDLHSDDNFLFLDYSKSHINDEIKDALVALAEERGVRAFAKAMFDGQRVNSTENRAVLHVALRNRSNRPIIVDGKDVMSDVNNVLAQMKDFTERVRSGEWKGQTGKSIYNIVNIGIGGSDLGPVMVTEALKPFSKRDLHCFFVSNVDGTHMAEVLKQVNLEETIFIIASKTFTTQETLTNAMSARNALMSYLKENGISTDGAVAKHFVALSTNTEKVREFGIDTVNMFAFWDWVGGRYSVWSAIGLSVMLSIGYDNFVEFLTGAHVMDNHFASTPTEQNLPMMLALVGIWYNNFFGSETQAVLPYDQYLWRLPAYLQQLDMESNGKGVTKKSGAVAVQTGPIVFGEAGTNGQHAFYQLIHQGTKIIPCDFIGCVQTQNRVGDHHRTLMSNFFAQTEALMVGKNAEEVRQELVKSGMSGDAIENMIPHKTFTGSRPSNSILVNALTPRALGAIIAMYEHKVLVQGAIWGINSYDQWGVELGKVLAKSILPQLKSGNIVSDHDGSTNGLINMFNTRAH 1tip A 2.2 BS01 F6P A 1 I20 Y89 R103 K107 Y118 R148 I20 Y89 R103 K107 Y118 R148 R8 H9 N15 R58 E78 H143 R8 H9 N15 R58 E78 H143 2.7.1.105,3.1.3.46 0003824,0005524,0006003 P07953 9253407 401 MRSIYLCRHGESELNLRGRIGGDSGLSARGKQYAYALANFIRSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCRVESIYLNV 1tip B 2.2 BS01 F6P B 1 Y89 R103 K107 Y118 Q144 R148 Y89 R103 K107 Y118 Q144 R148 R8 H9 N15 R58 E78 H143 R8 H9 N15 R58 E78 H143 2.7.1.105,3.1.3.46 0003824,0005524,0006003 P07953 9253407 402 MRSIYLCRHGESELNLRGRIGGDSGLSARGKQYAYALANFIRSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCRVESIYLNV 1u2t A 2.9 BS02 F6P B 1 D9 L10 D11 T41 G42 D153 D9 L10 D11 T41 G42 D153 3.1.3.24 0000287,0005986,0016787,0016791,0046872,0050307 P74325 15937230 2 MRQLLLISDLDNTWVGDQQALEHLQEYLGDRRGNFYLAYATGRSYHSARELQKQVGLMEPDYWLTAVGSEIYHPEGLDQHWADYLSEHWQRDILQAIADGFEALKPQSPLEQNPWKISYHLDPQACPTVIDQLTEMLKETGIPVQVIFSSGKDVDLLPQRSNKGNATQYLQQHLAMEPSQTLVCGDSGNDIGLFETSARGVIVRNAQPELLHWYDQWGDSRHYRAQSSHAGAILEAIAHFDFLS 1uxr A 2.3 BS02 F6P A 1 R72 R79 I133 R154 R70 R77 I131 R152 N168 K191 E263 C297 E395 E473 N166 K189 E261 C295 E393 E471 1.2.1.90 0000166,0008886,0008911,0016491,0016620,0043878,0050661,0051287 O57693 15288789 1503 AGLLEGVIKEKGGVPVYPSYLAGEWGGSGQEIEVKSPIDLATIAKVISPSREEVERTLDVLFKRGRWSARDMPGTERLAVLRKAADIIERNLDVFAEVLVMNAGKPKSAAVGEVKAAVDRLRLAELDLKKIGGDYIPGDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVVKPSISDPLPAAMAVKALLDAGFPPDAIALLNLPGKEAEKIVADDRVAAVSFTGSTEVGERVVKVGGVKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERPVYGKLVEEVAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLAGGRRLGPTYVQPTFVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAVFGRDVVKIRRAVRLLEVGAIYINDMPRHGIGYYPFGGRKKSGVFREGIGYAVEAVTAYKTIVFNYKGKGVWKYE 1yxi A 2.0 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D115 N206 Y209 Y238 G240 S241 M242 Y258 K268 D68 D74 E97 E98 D118 L120 D121 E280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 339 DTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1yyz A 1.85 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 R276 D112 N203 Y206 Y235 G237 M239 Y255 K265 R267 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 339 IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1yz0 A 2.07 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D113 N204 Y207 Y236 G238 S239 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 1843 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1yz0 B 2.07 BS01 F6P B 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 D113 N204 Y207 Y236 G238 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 1840 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 2axn A 2.1 BS01 F6P A 1 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 T440 I260 G261 E318 Y329 R343 K347 Y358 Q384 R388 T436 R252 H253 N259 S302 E322 H387 R248 H249 N255 S298 E318 H383 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 16316985 736 LELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSNPLMRRNSSS 2bif A 2.4 BS01 F6P A 1 I267 G268 E325 Y336 R350 K354 Y365 Q391 R395 T443 I231 G232 E289 Y300 R314 K318 Y329 Q355 R359 T407 R255 A256 N262 R305 E325 H390 R219 A220 N226 R269 E289 H354 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005524,0005829,0006000,0006003,0016301,0016310,0016787,0046835 P25114 9890980 520 CPTLIVMVGLPARGKTYISKKLTRYLNFIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALAALNDVRKFLSEEGGHVAVFDATNTTRERRAMIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEEQDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRAGESELNLKGRIGGDPGLSPRGREFSKHLAQFISDQNIKDLKVFTSQMKRTIQTAEALSVPYEQFKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEELPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPSEEALVTVPAHQ 2bif B 2.4 BS01 F6P B 1 I267 G268 E325 Y336 R350 K354 Y365 Q391 R395 I231 G232 E289 Y300 R314 K318 Y329 Q355 R359 R255 A256 N262 R305 E325 H390 R219 A220 N226 R269 E289 H354 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005524,0005829,0006000,0006003,0016301,0016310,0016787,0046835 P25114 9890980 550 CPTLIVMVGLPARGKTYISKKLTRYLNFIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALAALNDVRKFLSEEGGHVAVFDATNTTRERRAMIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEEQDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRAGESELNLKGRIGGDPGLSPRGREFSKHLAQFISDQNIKDLKVFTSQMKRTIQTAEALSVPYEQFKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEELPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPSEEALVTVPAHQ 2cxs A 1.5 BS01 F6P A 1 I157 G159 S210 K211 T212 T215 Q354 E358 V515 I157 G159 S210 K211 T212 T215 Q354 E358 V515 K211 E217 G272 R273 E358 H389 K519 K211 E217 G272 R273 E358 H389 K519 5.3.1.9 0001701,0001707,0002639,0004347,0005125,0005515,0005576,0005615,0005737,0005829,0005886,0006002,0006094,0006096,0007165,0007611,0008083,0010595,0016853,0031625,0032355,0032570,0033574,0034101,0035902,0035994,0042593,0043209,0043524,0046686,0048029,0051156,0060170,0061620,0061621,0097367,0141199,1901135 P06745 16375918 1601 MAALTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNLNTNHGHILVDYSKNLVSKEVMQMLVELAKSRGVEAARDNMFSGSKINYTEDRAVLHVALRNRSNTPIKVDGKDVMPEVNRVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLASLSPETSLFIIASKTFTTQETITNAETAKEWFLEAAKDPSAVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFLKTPLEKNAPVLLALLGIWYINCYGCETHALLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKLPEEARKELQAAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIMWDINSFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTNGLISFIKQQRDTKL 2cxs B 1.5 BS01 F6P B 1 G159 S210 K211 T212 T215 Q354 E358 G159 S210 K211 T212 T215 Q354 E358 K211 E217 G272 R273 E358 H389 K519 K211 E217 G272 R273 E358 H389 K519 5.3.1.9 0001701,0001707,0002639,0004347,0005125,0005515,0005576,0005615,0005737,0005829,0005886,0006002,0006094,0006096,0007165,0007611,0008083,0010595,0016853,0031625,0032355,0032570,0033574,0034101,0035902,0035994,0042593,0043209,0043524,0046686,0048029,0051156,0060170,0061620,0061621,0097367,0141199,1901135 P06745 16375918 2601 MAALTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNLNTNHGHILVDYSKNLVSKEVMQMLVELAKSRGVEAARDNMFSGSKINYTEDRAVLHVALRNRSNTPIKVDGKDVMPEVNRVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLASLSPETSLFIIASKTFTTQETITNAETAKEWFLEAAKDPSAVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFLKTPLEKNAPVLLALLGIWYINCYGCETHALLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKLPEEARKELQAAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIMWDINSFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTNGLISFIKQQRDTKL 2cxt A 1.5 BS01 F6P A 1 I157 G159 S210 K211 T212 T215 Q354 E358 V515 I157 G159 S210 K211 T212 T215 Q354 E358 V515 K211 E217 G272 R273 E358 H389 K519 K211 E217 G272 R273 E358 H389 K519 5.3.1.9 0001701,0001707,0002639,0004347,0005125,0005515,0005576,0005615,0005737,0005829,0005886,0006002,0006094,0006096,0007165,0007611,0008083,0010595,0016853,0031625,0032355,0032570,0033574,0034101,0035902,0035994,0042593,0043209,0043524,0046686,0048029,0051156,0060170,0061620,0061621,0097367,0141199,1901135 P06745 16375918 1601 MAALTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNLNTNHGHILVDYSKNLVSKEVMQMLVELAKSRGVEAARDNMFSGSKINYTEDRAVLHVALRNRSNTPIKVDGKDVMPEVNRVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLASLSPETSLFIIASKTFTTQETITNAETAKEWFLEAAKDPSAVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFLKTPLEKNAPVLLALLGIWYINCYGCETHALLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKLPEEARKELQAAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIMWDINSFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTNGLISFIKQQRDTKL 2cxt B 1.5 BS01 F6P B 1 G159 S210 K211 T212 T215 Q354 E358 G159 S210 K211 T212 T215 Q354 E358 K211 E217 G272 R273 E358 H389 K519 K211 E217 G272 R273 E358 H389 K519 5.3.1.9 0001701,0001707,0002639,0004347,0005125,0005515,0005576,0005615,0005737,0005829,0005886,0006002,0006094,0006096,0007165,0007611,0008083,0010595,0016853,0031625,0032355,0032570,0033574,0034101,0035902,0035994,0042593,0043209,0043524,0046686,0048029,0051156,0060170,0061620,0061621,0097367,0141199,1901135 P06745 16375918 2601 MAALTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNLNTNHGHILVDYSKNLVSKEVMQMLVELAKSRGVEAARDNMFSGSKINYTEDRAVLHVALRNRSNTPIKVDGKDVMPEVNRVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLASLSPETSLFIIASKTFTTQETITNAETAKEWFLEAAKDPSAVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFLKTPLEKNAPVLLALLGIWYINCYGCETHALLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKLPEEARKELQAAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIMWDINSFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTNGLISFIKQQRDTKL 2dwo A 2.25 BS01 F6P A 1 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 T440 I260 G261 E318 Y329 R343 K347 Y358 Q384 R388 T436 R252 H253 N259 S302 E322 H387 R248 H249 N255 S298 E318 H383 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 17499765 720 LELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSNPLMRRNS 2dwp A 2.7 BS01 F6P A 1 G71 R74 A125 T126 R132 R189 Y193 G57 R60 A111 T112 R118 R175 Y179 R252 H253 N259 S302 E322 H387 R238 H239 N245 S288 E308 H373 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 17499765 702 ELTQSRVQKIWVPVDHRNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 2dwp A 2.7 BS02 F6P A 2 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 T440 I250 G251 E308 Y319 R333 K337 Y348 Q374 R378 T426 R252 H253 N259 S302 E322 H387 R238 H239 N245 S288 E308 H373 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 17499765 720 ELTQSRVQKIWVPVDHRNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 2f3b A 1.8 BS01 F6P A 1 D121 G122 N212 Y215 Y244 G246 M248 Y264 K274 D112 G113 N203 Y206 Y235 G237 M239 Y255 K265 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 23844654 339 DVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 2f3d A 1.83 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 D112 N203 Y206 Y235 G237 M239 Y255 K265 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 23844654 339 DVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 2i1v B 2.5 BS02 F6P B 1 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 I260 G261 E318 Y329 R343 K347 Y358 Q384 R388 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 17499765 720 LELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSNPLMRRNS 2owz A 2.18 BS01 F6P A 1 D113 N206 Y239 L243 Y257 Y259 K269 E275 D96 N189 Y222 L226 Y240 Y242 K252 E258 D66 E89 E90 D110 L112 D113 E275 D49 E72 E73 D93 L95 D96 E258 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 P0A993 17314096 603 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2ox3 A 2.18 BS01 F6P A 1 D113 N206 Y239 L243 Y257 Y259 K269 E275 D96 N189 Y222 L226 Y240 Y242 K252 E258 D66 E89 E90 D110 L112 D113 E275 D49 E72 E73 D93 L95 D96 E258 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 P0A993 17314096 603 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2r66 A 2.8 BS01 F6P A 1 Q16 G33 G34 Q35 K96 Y128 S152 K157 R180 Q10 G27 G28 Q29 K90 Y122 S146 K151 R174 2.4.1.14 0005985,0016157,0016757,0046524 B8CZ51 18424616 501 IKHVAFLNPQGNFDPADSYWTEHPDFGGQLVYVKEVSLALAEMGVQVDIITRRIKDENWPEFSGEIDYYQETNKVRIVRIPFGGDKFLPKEELWPYLHEYVNKIINFYREEGKFPQVVTTHYGDGGLAGVLLKNIKGLPFTFTGHSLGAQKMEKLNVNTSNFKEMDERFKFHRRIIAERLTMSYADKIIVSTSQERFGQYSHDLYRGAVNVEDDDKFSVIPPGVNTRVFDGEYGDKIKAKITKYLERDLGSERMELPAIIASSRLDQKKNHYGLVEAYVQNKELQDKANLVLTLRGIENPFEDYSRAGQEEKEILGKIIELIDNNDCRGKVSMFPLNSQQELAGCYAYLASKGSVFALTSFYEPFGLAPVEAMASGLPAVVTRNGGPAEILDGGKYGVLVDPEDPEDIARGLLKAFESEETWSAYQEKGKQRVEERYTWQETARGYLEVIQEIADR 2r68 A 2.4 BS02 F6P B 1 Q16 G33 Q35 K96 Y128 S152 K157 R180 Q10 G27 Q29 K90 Y122 S146 K151 R174 2.4.1.14 0005985,0016157,0016757,0046524 B8CZ51 18424616 2 IKHVAFLNPQGNFDPADSYWTEHPDFGGQLVYVKEVSLALAEMGVQVDIITRRIKDENWPEFSGEIDYYQETNKVRIVRIPFGGDKFLPKEELWPYLHEYVNKIINFYREEGKFPQVVTTHYGDGGLAGVLLKNIKGLPFTFTGHSLGAQKMEKLNVNTSNFKEMDERFKFHRRIIAERLTMSYADKIIVSTSQERFGQYSHDLYRGAVNVEDDDKFSVIPPGVNTRVFDGEYGDKIKAKITKYLERDLGSERMELPAIIASSRLDQKKNHYGLVEAYVQNKELQDKANLVLTLRGIENPFEDYSRAGQEEKEILGKIIELIDNNDCRGKVSMFPLNSQQELAGCYAYLASKGSVFALTSFYEPFGLAPVEAMASGLPAVVTRNGGPAEILDGGKYGVLVDPEDPEDIARGLLKAFESEETWSAYQEKGKQRVEERYTWQETARGYLEVIQEIADR 3bxh A 1.85 BS01 F6P A 1 T148 G149 T151 T152 E180 G242 M247 R250 R251 E269 F271 K310 T56 G57 T59 T60 E88 G150 M155 R158 R159 E177 F179 K218 ? 0030246 Kd=94.34uM -logKd/Ki=4.03, Kd=94.34uM O32253 18554327 401 GLTLLEKTLKERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMMTPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSIIEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFNADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAKKLLRDE 3bxh B 1.85 BS01 F6P B 1 T148 G149 G150 T151 T152 E180 G242 M247 R250 R251 E269 F271 K310 T63 G64 G65 T66 T67 E95 G157 M162 R165 R166 E184 F186 K225 ? 0030246 Kd=94.34uM O32253 18554327 401 SNAKDVLGLTLLEKTLKERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMMTPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSIIEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFNADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAKKLLR 3h1y A 2.04 BS01 F6P A 1 H99 P100 H131 K132 P133 E134 M266 A267 D270 N271 H99 P100 H131 K132 P133 E134 M266 A267 D270 N271 5.3.1.8 0004476,0005737,0005829,0005975,0008270,0009298,0016853,0046872 P25081 392 ASMQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRITNGETVSLRDAIEKNKTAMLGEAVANRFGELPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSDIVSLLQPVAGAHSAIAHFLQVPNAERLSQLFASLLNMQGEEKSRALAVLKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVVKLNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPAGELLTAPVKSGAELDFPIPVDDFAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLVLKPGESAFIGADESPVNASGTGRLARVYNKL 3iv8 A 2.53 BS01 F6P A 1 G138 I139 H192 N216 A217 H248 L303 G139 I140 H193 N217 A218 H249 L304 3.5.1.25 0006040,0006044,0006046,0008448,0016787,0016810,0019262,0046872,0047419,0051289 O32445 500 AMYALTNCKIYTGNDVLVKHAVIINGDKIEAVCPIESLPSEMNVVDLNGANLSPGFIDLQLNGCGGVMFNDEITAETIDTMHKANLKSGCTSFLPTLITSSDENMRQAIAAAREYQAKYPNQSLGLHLEGPYLNVMKKGIHSVDFIRPSDDTMIDTICANSDVIAKVTLAPENNKPEHIEKLVKAGIVVSIGHTNATYSEARKSFESGITFATHLFNAMTPMVGREPGVVGAIYDTPEVYAGIIADGFHVDYANIRIAHKIKGEKLVLVTDATAPAGAEMDYFIFVGKKVYYRDGKCVDENGTLGGSALTMIEAVQNTVEHVGIALDEALRMATLYPAKAIGVDEKLGRIKKGMIANLTVFDRDFNVKATVVNGQYEQN 3m5p A 1.65 BS01 F6P A 1 I145 G147 S198 K199 S200 T203 Q342 E346 K505 I147 G149 S200 K201 S202 T205 Q344 E348 K507 K199 E205 G260 R261 E346 H377 K505 K201 E207 G262 R263 E348 H379 K507 5.3.1.9 0004347,0005737,0005829,0006094,0006096,0016853,0048029,0051156,0097367,1901135 Q5NFC4 701 NAMLFCDDSKKYLKEQNINLKNEFDKDDKRVEKFSLKHQNIYFDYSKNLINDYILKSLLESAEKSSLKDKIKQMFNGAKINSTEHRAVLHTALRDLSSTPLIVDGQDIRQEVTKEKQRVKELVEKVVSGRWRGFSGKKITDIVNIGIGGSDLGPKMVVRALQPYHCTDLKVHFVSNVDADSLLQALHVVDPETTLLIIASKSFSTEETLLNSISAREWLLDHYEDEKAVANHFVAISSKLDKVKEFGIDLEHCYKMWDWVGGRYSLWSSIGMSIAFAIGYDNFEKLLAGAYSVDKHFKETEFSKNIPVIMALLASYYSCTYNSQSQALLPYDERLCYFVDYLQQADMESNGKSVNIAGETVNYQTGVVLWGGVGTNGQHAFHQLLHQGNIFIPVDFIAIATSHHNYDNHQQALLANCFAQSQALMFGQSYDMVYNELLKSGLNETQAKELAAHKVIPGNRPSTTILLDELSPYSLGALIALYEHKIFVQGVLWDINSYDQWGVELGKKLGKNILKAMNDDSSDEYQNLDDSTRQLIAKVKNK 3n1c A 2.0 BS01 F6P A 1 D14 G39 N43 R90 G138 S139 D256 D14 G39 N43 R90 G138 S139 D256 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 -logKd/Ki=5.22, Kd=6uM P06999 21147773 400 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 3n1c A 2.0 BS02 F6P D 1 K27 R29 K27 R29 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 -logKd/Ki=5.22, Kd=6uM P06999 21147773 403 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 3n1c B 2.0 BS01 F6P B 1 D14 G38 G39 N43 R90 N92 G138 S139 D256 D14 G38 G39 N43 R90 N92 G138 S139 D254 G253 A254 G255 D256 G251 A252 G253 D254 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 P06999 21147773 402 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLRLCSHDDTQKIYAYLSR 3n1c B 2.0 BS02 F6P C 1 K27 R29 K27 R29 G253 A254 G255 D256 G251 A252 G253 D254 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 P06999 21147773 401 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLRLCSHDDTQKIYAYLSR 3n1c C 2.0 BS01 F6P B 1 K27 R29 K27 R29 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 P06999 21147773 402 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 3n1c C 2.0 BS02 F6P C 1 S12 D14 G39 N43 R90 N92 S139 D256 S12 D14 G39 N43 R90 N92 S139 D256 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 P06999 21147773 401 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 3n1c D 2.0 BS01 F6P A 1 K27 R29 K27 R29 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 -logKd/Ki=5.22, Kd=6uM P06999 21147773 400 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 3n1c D 2.0 BS02 F6P D 1 D14 G38 G39 N43 R90 N92 G138 S139 D256 D14 G38 G39 N43 R90 N92 G138 S139 D256 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 -logKd/Ki=5.22, Kd=6uM P06999 21147773 403 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 3o8o A 2.9 BS01 F6P A 1 D356 M398 G399 R400 E455 H488 D152 M194 G195 R196 E251 H284 G215 R278 D309 S354 D356 D358 R400 G11 R74 D105 S150 D152 D154 R196 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16861 21241708 988 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVA 3o8o A 2.9 BS03 F6P B 1 R391 K482 R187 K278 G215 R278 D309 S354 D356 D358 R400 G11 R74 D105 S150 D152 D154 R196 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16861 21241708 980 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVA 3o8o B 2.9 BS01 F6P A 1 R383 R475 R189 R281 G206 R270 C271 D301 G345 S346 D348 D350 R392 G12 R76 C77 D107 G151 S152 D154 D156 R198 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16862 21241708 988 PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 3o8o B 2.9 BS02 F6P B 1 D348 M390 R392 E447 H481 R484 D154 M196 R198 E253 H287 R290 G206 R270 C271 D301 G345 S346 D348 D350 R392 G12 R76 C77 D107 G151 S152 D154 D156 R198 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16862 21241708 980 PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 3o8o C 2.9 BS01 F6P C 1 D356 R400 E455 R491 D152 R196 E251 R287 G215 R278 D309 S354 D356 D358 R400 G11 R74 D105 S150 D152 D154 R196 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16861 21241708 988 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVA 3o8o D 2.9 BS01 F6P C 1 R383 R475 R189 R281 G206 R270 C271 D301 G345 S346 D348 D350 R392 G12 R76 C77 D107 G151 S152 D154 D156 R198 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16862 21241708 988 PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 3o8o D 2.9 BS02 F6P D 1 D348 M390 R392 E447 H481 R484 D154 M196 R198 E253 H287 R290 G206 R270 C271 D301 G345 S346 D348 D350 R392 G12 R76 C77 D107 G151 S152 D154 D156 R198 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16862 21241708 982 PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 3o8o E 2.9 BS01 F6P E 1 D356 M398 R400 E455 H488 R491 D154 M196 R198 E253 H286 R289 G215 R278 D309 S354 D356 D358 R400 G13 R76 D107 S152 D154 D156 R198 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16861 21241708 988 QKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVA 3o8o E 2.9 BS03 F6P F 1 R391 K482 R189 K280 G215 R278 D309 S354 D356 D358 R400 G13 R76 D107 S152 D154 D156 R198 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16861 21241708 984 QKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVA 3o8o F 2.9 BS01 F6P E 1 R383 R475 R188 R280 G206 R270 C271 D301 G345 S346 D348 D350 R392 G11 R75 C76 D106 G150 S151 D153 D155 R197 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16862 21241708 988 QKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 3o8o F 2.9 BS02 F6P F 1 D348 M390 R392 E447 H481 R484 D153 M195 R197 E252 H286 R289 G206 R270 C271 D301 G345 S346 D348 D350 R392 G11 R75 C76 D106 G150 S151 D153 D155 R197 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16862 21241708 984 QKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 3o8o G 2.9 BS01 F6P G 1 D356 M398 R400 E455 H488 R491 D152 M194 R196 E251 H284 R287 G215 R278 D309 S354 D356 D358 R400 G11 R74 D105 S150 D152 D154 R196 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16861 21241708 988 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLR 3o8o G 2.9 BS03 F6P H 1 R391 K482 R187 K278 G215 R278 D309 S354 D356 D358 R400 G11 R74 D105 S150 D152 D154 R196 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16861 21241708 986 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLR 3o8o H 2.9 BS01 F6P G 1 R383 R475 R189 R281 G206 R270 C271 D301 G345 S346 D348 D350 R392 G12 R76 C77 D107 G151 S152 D154 D156 R198 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16862 21241708 988 PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 3o8o H 2.9 BS02 F6P H 1 I347 D348 M390 G391 R392 E447 H481 R484 I153 D154 M196 G197 R198 E253 H287 R290 G206 R270 C271 D301 G345 S346 D348 D350 R392 G12 R76 C77 D107 G151 S152 D154 D156 R198 2.7.1.11 0003872,0005524,0005737,0006002,0006096 P16862 21241708 986 PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKR 3pr3 A 2.45 BS01 F6P A 1 G158 S231 K232 T233 T236 Q376 E380 G157 S230 K231 T232 T235 Q375 E379 K232 E238 G293 R294 E380 H411 K540 K231 E237 G292 R293 E379 H410 K539 5.3.1.9 0004347,0005829,0006094,0006096,0006098,0016853,0048029,0051156,0097367,1901135 Q8ILA4 580 NMEITNLKSYKELVTLSAEEKTKDLKDYLNDKNRSESLIKKFKNFYMDLSRQRYSEKTLNKLVEYAEEVELKKKVEKTFMGEKVNMTENRSVLHTALRIPIEKINTHKIIIDNKNVLEDVHGVLKKIEKYSDDIRNGVIKTCKNTKFKNVICIGIGGSYLGTEFVYEAMKYYYYNMELNKNEKDQVNNFNNNYDQDNVFNVRFLANVDPNDVNRAIQNLDQYDTLVIIISKTFTTAETMLNARSIKKWLSLKIKDDENLSKHMVAVSTNLKLTDEFGISRDNVFEFWDWVGGRFSVTSSVGILPLSIAFGYKNMRNFLNGCHDMDEHFLHADLKENIPVLLALTSFYNSHFFDYKNVAILPYFQNLLKFSAHIQQLSMESNGKSVDRNNQPIHYNTCQVYFGEPGTNGQHSFYQLIHQGQVIPVELIGFKHSHFPIKFDKEVVSNHDELMTNFFAQADALAIGKTYEQVKEENEKNKMSPELLTHKVFNGNRPSTLLLFDELNFYTCGLLLSLYESRIVAEGFLLNINSFDQWGVELGKVLAKEVRNYFNDTRNQKKSDNTYNFNESTKILLNYYLSK 3pr3 B 2.45 BS01 F6P B 1 I156 G158 S231 K232 T233 T236 Q376 E380 I154 G156 S229 K230 T231 T234 Q374 E378 K232 E238 G293 R294 E380 H411 K540 K230 E236 G291 R292 E378 H409 K538 5.3.1.9 0004347,0005829,0006094,0006096,0006098,0016853,0048029,0051156,0097367,1901135 Q8ILA4 580 MEITNLKSYKELVTLSAEEKTKDLKDYLNDKNRSESLIKKFKNFYMDLSRQRYSEKTLNKLVEYAEEVELKKKVEKTFMGEKVNMTENRSVLHTALRIPIEKINTHKIIIDNKNVLEDVHGVLKKIEKYSDDIRNGVIKTCKNTKFKNVICIGIGGSYLGTEFVYEAMKYYYYNMELNKNEKDQVNNFNNNYDQDNVFNVRFLANVDPNDVNRAIQNLDQYDTLVIIISKTFTTAETMLNARSIKKWLSLKIKDDENLSKHMVAVSTNLKLTDEFGISRDNVFEFWDWVGGRFSVTSSVGILPLSIAFGYKNMRNFLNGCHDMDEHFLHADLKENIPVLLALTSFYNSHFFDYKNVAILPYFQNLLKFSAHIQQLSMESNGKSVDRNNQPIHYNTCQVYFGEPGTNGQHSFYQLIHQGQVIPVELIGFKHSHFPIKFDKEVVSNHDELMTNFFAQADALAIGKTYEQVKEENEKNKMSPELLTHKVFNGNRPSTLLLFDELNFYTCGLLLSLYESRIVAEGFLLNINSFDQWGVELGKVLAKEVRNYFNDTRNQKKSDNTYNFNESTKILLNYYLSK 3pt1 A 1.773 BS01 F6P A 1 R23 E110 D254 G383 D384 L385 R388 K423 R24 E111 D250 G379 D380 L381 R384 K419 3.1.3.- 0005634,0005737,0006974,0008150,0016787,0016791,0046872,0097023,0103026 Q04371 1001 HMTIPGRFMTIDKGTFGEYTASTRWPIIIQNAIDDLSKHQETEKSNGTKFEQGEVIKKELKEFRQEIIDRVPLRPFTEEEIKIANVPLSFNEYLKKHPEVNWGAVEWLFSEVYLYRRVNVLFQRQCEWAKFDIFNRLKQSTFESSFYGVVELALRYENLLPQLREMKQNDDILKVLFKEFIEISLWGNATDLSLLTNATLEDIKSIQGAKARAASESKIVVNDTEKAWEVLTKARADANSREIRVDFVLDNSGFELYADLMLAAFLLQSGLATKCIFHAKDIPYMVSDVMLKDFDILVHDLRDREFFPSGEPSTKESRALDLFAGEMEKFVSSGKIEFREDSFWTTELDYWNLDANETKYHGSILHKDLQKSNLVIFKGDLNYRKLTGDRKWPRTTKWETAIGPLATNGITSLSLRTCKADVQVALPEGLDAKLSQEWEKENPGRGSWWCCSGKWAVICFCSGI 3qpv A 2.5 BS04 F6P A 1 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 I251 G252 E309 Y320 R334 K338 Y349 Q375 R379 R252 H253 N259 S302 E322 H387 R239 H240 N246 S289 E309 H374 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 22275052 720 ELTQSRVQKIWVPVDHRPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSENPLMRRN 3uqd A 2.14 BS02 F6P A 1 D14 G38 G39 N43 R90 S139 D256 D14 G38 G39 N43 R90 S139 D256 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 P06999 30996866 402 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 3uqd B 2.14 BS04 F6P D 1 K27 R29 K27 R29 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 P06999 30996866 402 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 3uqd C 2.14 BS01 F6P A 1 K27 R29 K26 R28 G253 A254 G255 D256 G252 A253 G254 D255 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 P06999 30996866 402 VRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNGTRLCSHDDTQKIYAYLSR 3uqd D 2.14 BS03 F6P D 1 D14 G38 G39 N43 R90 S139 D14 G38 G39 N43 R90 S139 G253 A254 G255 D256 G253 A254 G255 D256 2.7.1.11 0000287,0003872,0005515,0005524,0005829,0005975,0006096,0006974,0009024,0016301,0016310,0016772,0016773,0042802,0042803,0046872,0061615 P06999 30996866 402 MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPVATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQGIRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDDTQKIYAYLSR 4d4j A 3.0 BS02 F6P A 1 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 I261 G262 E319 Y330 R344 K348 Y359 Q385 R389 R252 H253 N259 S302 E322 H387 R249 H250 N256 S299 E319 H384 2.7.1.105,3.1.3.46 0003824,0003873,0005524,0006000,0006003 Q16875 1448 PLELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 4d4k A 3.24 BS02 F6P A 1 E322 Y333 R347 K351 Y362 Q388 R392 E316 Y327 R341 K345 Y356 Q382 R386 R252 H253 N259 S302 E322 H387 R246 H247 N253 S296 E316 H381 2.7.1.105,3.1.3.46 0003824,0003873,0005524,0006000,0006003 Q16875 1448 PLELTQSRVQKIWVPVDHRPSLPRSNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 4d4l A 3.16 BS02 F6P A 1 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 T440 I261 G262 E319 Y330 R344 K348 Y359 Q385 R389 T437 R252 H253 N259 S302 E322 H387 R249 H250 N256 S299 E319 H384 2.7.1.105,3.1.3.46 0003824,0003873,0005524,0006000,0006003 Q16875 1448 PLELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 4d4m A 2.32 BS02 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G260 E317 Y328 R342 K346 Y357 Q383 R387 R252 H253 N259 S302 E322 H387 R247 H248 N254 S297 E317 H382 2.7.1.105,3.1.3.46 0003824,0003873,0005524,0006000,0006003 Q16875 1448 PLELTQSRVQKIWVPVDHRPSLPRSCNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER 4gbv A 2.9 BS01 F6P A 1 D121 N212 Y215 Y244 M248 Y264 K274 D112 N203 Y206 Y235 M239 Y255 K265 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gbw A 2.0 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 R276 D112 N203 Y206 Y235 G237 S238 M239 Y255 K265 R267 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gws A 2.75 BS01 F6P A 1 D121 Y244 G246 M248 Y264 K274 L275 E280 D113 Y236 G238 M240 Y256 K266 L267 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAIHRAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMYDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gws B 2.75 BS01 F6P B 1 D121 G122 N212 Y244 G246 M248 Y264 K274 E280 D113 G114 N204 Y236 G238 M240 Y256 K266 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAIHRAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMYDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gww A 3.2 BS01 F6P A 1 G26 T27 G28 E29 M30 K112 Y113 V160 M177 G19 T20 G21 E22 M23 K91 Y92 V139 M156 D74 E97 E98 D118 L120 D121 E280 D53 E76 E77 D97 L99 D100 E259 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 TNIVTLTRFVKEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gww A 3.2 BS02 F6P A 2 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D100 N191 Y194 Y223 G225 S226 M227 Y243 K253 D74 E97 E98 D118 L120 D121 E280 D53 E76 E77 D97 L99 D100 E259 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 402 TNIVTLTRFVKEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gwx A 2.35 BS01 F6P A 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 D115 N206 Y209 Y238 S241 M242 Y258 K268 D68 D74 E97 E98 D118 L120 D121 E280 D62 D68 E91 E92 D112 L114 D115 E274 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 DTNIVTLTRFVWEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gwy A 3.0 BS01 F6P A 1 D121 Y244 G246 M248 Y264 K274 E280 D112 Y235 G237 M239 Y255 K265 E271 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 IVTLTRFVKEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gwz A 2.6 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 D113 N204 Y207 Y236 G238 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVWEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gwz B 2.6 BS01 F6P B 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D113 N204 Y207 Y236 G238 S239 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVWEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gx3 A 2.25 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 E280 D113 N204 Y207 Y236 G238 M240 Y256 K266 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGMKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gx3 B 2.25 BS01 F6P B 1 D121 G122 N212 Y215 Y244 G246 M248 Y264 K274 E280 D113 G114 N204 Y207 Y236 G238 M240 Y256 K266 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGMKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gx4 A 2.5 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 E280 D113 N204 Y207 Y236 G238 M240 Y256 K266 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGMKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gx4 B 2.5 BS01 F6P B 1 D121 N212 Y215 Y244 M248 Y264 K274 E280 D113 N204 Y207 Y236 M240 Y256 K266 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGMKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gx6 A 2.5 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 E280 D113 N204 Y207 Y236 G238 M240 Y256 K266 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGQFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4gx6 B 2.5 BS01 F6P B 1 D121 G122 N212 Y215 Y244 M248 Y264 K274 E280 D113 G114 N204 Y207 Y236 M240 Y256 K266 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGQFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4h45 A 3.1 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 R276 D112 N203 Y206 Y235 G237 S238 M239 Y255 K265 R267 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGQFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4h46 A 2.5 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 D105 N196 Y199 Y228 G230 M232 Y248 K258 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 401 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4he1 A 2.23 BS01 F6P A 1 D121 N212 Y244 G246 S247 M248 Y264 K274 D95 N186 Y218 G220 S221 M222 Y238 K248 D74 E97 E98 D118 L120 D121 E280 D48 E71 E72 D92 L94 D95 E254 3.1.3.11 0005515,0005634,0005737,0005829,0005886,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030018,0030388,0042132,0042578,0042802,0046872,0070062,0070161 O00757 24086250 401 MLTLTRYVMEKGRQAKGTGELTRLLNSMLTAIKAISSAVRKAGLAKLDVLSNSLVINMLQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQ 4kxp A 2.7 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 R276 D95 N186 Y189 Y218 G220 M222 Y238 K248 R250 D74 E97 E98 D118 L120 D121 E280 D48 E71 E72 D92 L94 D95 E254 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 23844654 401 DVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 4kxp B 2.7 BS01 F6P B 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 D95 N186 Y189 Y218 G220 M222 Y238 K248 D74 E97 E98 D118 L120 D121 E280 D48 E71 E72 D92 L94 D95 E254 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 23844654 401 DVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 4lc9 A 3.4 BS01 F6P A 1 G108 T109 E150 S179 V180 G181 S258 K514 G102 T103 E144 S173 V174 G175 S252 K476 ? 0001678,0004857,0005515,0005634,0005654,0005737,0005739,0005829,0006006,0006606,0009749,0009750,0019210,0019899,0019900,0019904,0030246,0033133,0034504,0042593,0046415,0070095,0070328,0097367,0141089,1901135 Q07071 23957911 701 YQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQCDAEIFQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGGATKILLETLLLAAHKTVVSSQRCLLEILRTFERAHQVTYSQSSKIATLMKQVGISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDIRGFLIGDTSILPSLTETDTVVFIFTLDDNLTEVQALAERVRCQNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESLLQAIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSISEAKARLSAASSVCEVVRSAL 4ma4 A 2.23 BS03 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G256 E313 Y324 R338 K342 Y353 Q379 R383 R252 H253 N259 S302 E322 H387 R243 H244 N250 S293 E313 H378 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 24295899 606 LELTQSRVQKIWVPVDHRPSLPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSNPLMRRNS 4pfk A 2.4 BS01 F6P A 1 D127 M169 E222 H249 R252 D127 M169 E222 H249 R252 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 G11 R72 C73 D103 G104 G124 T125 D127 D129 R171 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P00512 6115424 323 MKRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIQGLVVIGGDGSYQGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHERTYVIEVMGRHAGDIALWSGLAGGAETILIPEADYDMNDVIARLKRGHERGKKHSIIIVAEGVGSGVDFGRQIQEATGFETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVGIQNNQLVDHDIAEALANKHTIDQRMYALSKELSI 4r74 A 1.93 BS01 F6P A 1 T11 S37 G59 Y103 S148 G149 T150 G185 I186 H205 D206 E229 T12 S38 G60 Y104 S149 G150 T151 G186 I187 H206 D207 E230 ? 0015888,0030288,0030975,0030976 Kd=8nM -logKd/Ki=8.10, Kd=8nM A3N294 26295949 401 SKGRLVIYCSATNVMCENAAKTFEQKYDVKTSFIRNGSGSTFAKIEAEKNNPQADVWYGGTLDPQSQAGELGLLEAYRSPNIDQIMPKFQDPAKVKGNLSSAVYIGILGFAVNTERLKKLGIEKIPQCWNDLTDPKLKGEIQIADPQSSGTAYTAIATFAQLWGEDKAFDYFKHLHPNISQYTKSGITPARNAARGETTVGIGFLHDYALEKEQGAPLEMVVPCEGTGYELGGVSILKGARNLDNAKLFVDFALSKEGQETAWKKGQALQTLTNTTAEQSPLAFDLTKLKLIDYDFEKYGASDERKRLINKWVDEIKLA 4r74 B 1.93 BS01 F6P B 1 T11 R34 S37 G59 Y103 S148 G149 T150 G185 I186 H205 D206 E229 T13 R36 S39 G61 Y105 S150 G151 T152 G187 I188 H207 D208 E231 ? 0015888,0030288,0030975,0030976 Kd=8nM A3N294 26295949 401 GSKGRLVIYCSATNVMCENAAKTFEQKYDVKTSFIRNGSGSTFAKIEAEKNNPQADVWYGGTLDPQSQAGELGLLEAYRSPNIDQIMPKFQDPAKVKGNLSSAVYIGILGFAVNTERLKKLGIEKIPQCWNDLTDPKLKGEIQIADPQSSGTAYTAIATFAQLWGEDKAFDYFKHLHPNISQYTKSGITPARNAARGETTVGIGFLHDYALEKEQGAPLEMVVPCEGTGYELGGVSILKGARNLDNAKLFVDFALSKEGQETAWKKGQALQTLTNTTAEQSPLAFDLTKLKLIDYDFEKYGASDERKRLINKWVDEIKLA 4r74 C 1.93 BS01 F6P C 1 T11 S37 G59 Y103 S148 G149 T150 G185 I186 H205 D206 E229 T13 S39 G61 Y105 S150 G151 T152 G187 I188 H207 D208 E231 ? 0015888,0030288,0030975,0030976 Kd=8nM A3N294 26295949 401 GSKGRLVIYCSATNVMCENAAKTFEQKYDVKTSFIRNGSGSTFAKIEAEKNNPQADVWYGGTLDPQSQAGELGLLEAYRSPNIDQIMPKFQDPAKVKGNLSSAVYIGILGFAVNTERLKKLGIEKIPQCWNDLTDPKLKGEIQIADPQSSGTAYTAIATFAQLWGEDKAFDYFKHLHPNISQYTKSGITPARNAARGETTVGIGFLHDYALEKEQGAPLEMVVPCEGTGYELGGVSILKGARNLDNAKLFVDFALSKEGQETAWKKGQALQTLTNTTAEQSPLAFDLTKLKLIDYDFEKYGASDERKRLINKWVDEIKL 4r74 D 1.93 BS01 F6P D 1 T11 S37 G59 Y103 S148 G149 T150 G185 I186 H205 D206 E229 T12 S38 G60 Y104 S149 G150 T151 G186 I187 H206 D207 E230 ? 0015888,0030288,0030975,0030976 Kd=8nM A3N294 26295949 401 SKGRLVIYCSATNVMCENAAKTFEQKYDVKTSFIRNGSGSTFAKIEAEKNNPQADVWYGGTLDPQSQAGELGLLEAYRSPNIDQIMPKFQDPAKVKGNLSSAVYIGILGFAVNTERLKKLGIEKIPQCWNDLTDPKLKGEIQIADPQSSGTAYTAIATFAQLWGEDKAFDYFKHLHPNISQYTKSGITPARNAARGETTVGIGFLHDYALEKEQGAPLEMVVPCEGTGYELGGVSILKGARNLDNAKLFVDFALSKEGQETAWKKGQALQTLTNTTAEQSPLAFDLTKLKLIDYDFEKYGASDERKRLINKWVDEIKLA 4xz2 A 2.67 BS03 F6P B 1 R210 R301 R162 R253 G34 D128 G172 S173 R219 G10 D88 G132 S133 R171 2.7.1.11 0003872,0005515,0005524,0005634,0005737,0005829,0005945,0006002,0006096,0016020,0016208,0016301,0016310,0030388,0042802,0044877,0045296,0046872,0048029,0061621,0070062,0070095,1990830 Q01813 26205495 803 SAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEAFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILA 4xz2 B 2.67 BS03 F6P B 1 D175 M217 R219 E273 H307 R310 D151 M189 R191 E245 H279 R282 G34 R97 C98 D128 G172 S173 D175 D177 R219 G10 R73 C74 D104 G148 S149 D151 D153 R191 2.7.1.11 0003872,0005515,0005524,0005634,0005737,0005829,0005945,0006002,0006096,0016020,0016208,0016301,0016310,0030388,0042802,0044877,0045296,0046872,0048029,0061621,0070062,0070095,1990830 Q01813 26205495 803 SAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEAFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILA 4xz2 C 2.67 BS03 F6P D 1 R210 R301 R160 R251 G34 D128 G172 S173 R219 G9 D87 G131 S132 R169 2.7.1.11 0003872,0005515,0005524,0005634,0005737,0005829,0005945,0006002,0006096,0016020,0016208,0016301,0016310,0030388,0042802,0044877,0045296,0046872,0048029,0061621,0070062,0070095,1990830 Q01813 26205495 803 AIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKETTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILA 4xz2 D 2.67 BS03 F6P D 1 D175 M217 R219 E273 H307 R310 D150 M188 R190 E244 H278 R281 G34 R97 C98 D128 G172 S173 D175 D177 R219 G9 R72 C73 D103 G147 S148 D150 D152 R190 2.7.1.11 0003872,0005515,0005524,0005634,0005737,0005829,0005945,0006002,0006096,0016020,0016208,0016301,0016310,0030388,0042802,0044877,0045296,0046872,0048029,0061621,0070062,0070095,1990830 Q01813 26205495 803 AIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKETTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILA 5ajw A 2.5 BS02 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G259 E316 Y327 R341 K345 Y356 Q382 R386 R252 H253 N259 S302 E322 H387 R246 H247 N253 S296 E316 H381 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1448 PLELTQSRVQKIWVPVDHRPSLPRSNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 5ajx A 2.58 BS02 F6P A 1 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 I261 G262 E319 Y330 R344 K348 Y359 Q385 R389 R252 H253 N259 S302 E322 H387 R249 H250 N256 S299 E319 H384 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1447 PLELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER 5ajy A 2.37 BS02 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G260 E317 Y328 R342 K346 Y357 Q383 R387 R252 H253 N259 S302 E322 H387 R247 H248 N254 S297 E317 H382 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1447 PLELTQSRVQKIWVPVDHRPSLPRSCNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER 5ajz A 2.35 BS02 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G260 E317 Y328 R342 K346 Y357 Q383 R387 R252 H253 N259 S302 E322 H387 R247 H248 N254 S297 E317 H382 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1447 LELTQSRVQKIWVPVDHRPSLPRSCGNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 5ak0 A 2.03 BS02 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G262 E319 Y330 R344 K348 Y359 Q385 R389 R252 H253 N259 S302 E322 H387 R249 H250 N256 S299 E319 H384 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 25849762 1449 PLELTQSRVQKIWVPVDHRPSLPRSCGPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 5et8 A 1.92 BS01 F6P A 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 D86 N165 Y168 Y197 S200 M201 Y217 K227 D74 E97 E98 D118 L120 D121 E280 D39 E62 E63 D83 L85 D86 E233 3.1.3.11 0005515,0005634,0005737,0005829,0005886,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030018,0030388,0042132,0042578,0042802,0046872,0070062,0070161 O00757 401 DMLTLTRYVMGELTQLLNSMLTAIKAISSAVRKAVKKLDVLSNSLVINMLQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGASIGTIFAIYRKPSEKDALQCGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKN 5fbp A 2.1 BS01 F6P A 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 D99 N190 Y193 Y222 S225 M226 Y242 K252 D74 E97 E98 D118 L120 D121 E280 D52 E75 E76 D96 L98 D99 E258 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 1849642 336 FDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 5fbp A 2.1 BS02 F6P A 2 G26 T27 G28 M30 K112 Y113 M177 G21 T22 G23 M25 K90 Y91 M155 D74 E97 E98 D118 L120 D121 E280 D52 E75 E76 D96 L98 D99 E258 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 1849642 338 FDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 5fbp B 2.1 BS01 F6P B 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 D100 N191 Y194 Y223 S226 M227 Y243 K253 D74 E97 E98 D118 L120 D121 E280 D53 E76 E77 D97 L99 D100 E259 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 1849642 336 AFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRNVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 5hr5 A 1.82 BS01 F6P A 1 H258 I269 G270 E327 Y338 R352 K356 Y367 Q393 R397 H231 I242 G243 E300 Y311 R325 K329 Y340 Q366 R370 R257 H258 N264 R307 E327 H392 R230 H231 N237 R280 E300 H365 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005524,0005829,0006000,0006003,0006096,0016301,0016310,0016787,0046835 P26285 27802586 602 KCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRRQAVKSYKSYDFFRHDNEEAMKIRKQCALVALKDVKAYLTEESGQIAVFDATNTTRERRDLILNFAEENSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMDDFLKRIECYKVTYQPLDPDSHDKDLSFIKVINVGQRFLVNKVQDYIQSKIVYYLMNIHVHPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEIADLKVWTSQLKRTIQTAESLGVTYEQWKILNEIDAGVCEEMTYAEIQEQYPDEFALRDEEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPT 5htk A 2.01 BS03 F6P A 1 H257 I268 G269 E326 Y337 R351 K355 Y366 Q392 R396 H227 I238 G239 E296 Y307 R321 K325 Y336 Q362 R366 R256 H257 N263 R306 E326 H391 R226 H227 N233 R276 E296 H361 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006007,0006089,0006090,0006096,0009749,0016301,0016310,0016787,0019900,0019901,0032024,0046835 O60825 27802586 604 ASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPK 5htk B 2.01 BS03 F6P B 1 H257 G269 E326 Y337 R351 K355 Y366 Q392 R396 H227 G239 E296 Y307 R321 K325 Y336 Q362 R366 R256 H257 N263 R306 E326 H391 R226 H227 N233 R276 E296 H361 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006007,0006089,0006090,0006096,0009749,0016301,0016310,0016787,0019900,0019901,0032024,0046835 O60825 27802586 604 ASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPT 5k55 A 1.977 BS01 F6P A 1 D121 N212 Y215 Y244 S247 M248 Y264 K274 E280 D86 N168 Y171 Y200 S203 M204 Y220 K230 E236 D74 E97 E98 D118 L120 D121 E280 D39 E62 E63 D83 L85 D86 E236 3.1.3.11 0005515,0005634,0005737,0005829,0005886,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030018,0030388,0042132,0042578,0042802,0046872,0070062,0070161 O00757 401 DMLTLTRYVMGELTQLLNSMLTAIKAISSAVRKAVKKLDVLSNSLVINMLQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGDCLASIGTIFAIYRKTSEKDALQCGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKN 5l3k B 2.305 BS02 F6P B 1 R18 Y90 D144 R286 R324 R9 Y71 D125 R267 R305 H168 D385 H149 D366 2.4.1.347 0000166,0003824,0005992,0016758 A0A117IMA6 31772052 502 SDFVVVANRLPIDLESWKRSPGGLVTALEPLLRRRRGAWIGWPGIPDSDEDPIVLVLYPVRLSADDVAQYYEGFSNATLWPLYHDVIVKPIYNRQWWERYVEVNRRFAEATSRAAARGATVWVQDYQLQLVPKMLRELRPDLTIGFFLHIPFPPVELFMQLPWRTEITDGLLGADLVGFHLPGGAQNFLFLARRLVGANTSRASVGVRSKFGEVQIGSRTVKVGAFPISIDSADLDRQARQRSIRQRARQIRAELGNPRRILLGVDRLDYTKGIDVRLQAFAELLAEGRVNREDTVFVQLATPSRERVEAYRLLRDDIERQVGHINGEYGEVGHPVVHYLHRPVPREELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELGQAYLVNPHNLDHVKDTMVAALNQTPEEGRRRMRALRRQVLAHDVDLWARSFLDALASTR 5l3k C 2.305 BS02 F6P C 1 R18 L40 Y90 D144 R324 R9 L23 Y65 D119 R293 H168 D385 H143 D354 2.4.1.347 0000166,0003824,0005992,0016758 A0A117IMA6 31772052 502 SDFVVVANRLPIDLSWKRSPGGLVTALEPLLRRRRGAWIGWPGIPDSDEVLYPVRLSADDVAQYYEGFSNATLWPLYHDVIVKPIYNRQWWERYVEVNRRFAEATSRAAARGATVWVQDYQLQLVPKMLRELRPDLTIGFFLHIPFPPVELFMQLPWRTEITDGLLGADLVGFHLPGGAQNFLFLARRLVGANTSRASVGVRSKFGEVVKVGAFPISIDSADLDRQARQRSIRQRARQIRAELGNPRRILLGVDRLDYTKGIDVRLQAFAELLAEGRVNREDTVFVQLATPSRERVEAYRLLRDDIERQVGHINGEYGEVGHPVVHYLHRPVPREELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELGQAYLVNPHNLDHVKDTMVAALNQTPEEGRRRMRALRRQVLAHDVDLWARSFLDALAS 5l3k D 2.305 BS02 F6P D 1 R18 G38 L40 Y90 D144 Y145 R286 R324 R10 G23 L25 Y75 D129 Y130 R271 R309 H168 D385 H153 D370 2.4.1.347 0000166,0003824,0005992,0016758 A0A117IMA6 31772052 502 DSDFVVVANRLPIDLESWKRSPGGLVTALEPLLRRRRGAWIGWPGIPDSDEDPIVDGDLVLYPVRLSADDVAQYYEGFSNATLWPLYHDVIVKPIYNRQWWERYVEVNRRFAEATSRAAARGATVWVQDYQLQLVPKMLRELRPDLTIGFFLHIPFPPVELFMQLPWRTEITDGLLGADLVGFHLPGGAQNFLFLARRLVGANTSRASVGVRSKFGEVQIGSRTVKVGAFPISIDSADLDRQARQRSIRQRARQIRAELGNPRRILLGVDRLDYTKGIDVRLQAFAELLAEGRVNREDTVFVQLATPSRERVEAYRLLRDDIERQVGHINGEYGEVGHPVVHYLHRPVPREELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELGQAYLVNPHNLDHVKDTMVAALNQTPEEGRRRMRALRRQVLAHDVDLWARSFLDALASTR 5l3k E 2.305 BS02 F6P E 1 R18 P37 G38 L40 Y90 D144 R324 R10 P22 G23 L25 Y75 D129 R308 H168 D385 H153 D369 2.4.1.347 0000166,0003824,0005992,0016758 A0A117IMA6 31772052 502 DSDFVVVANRLPIDLESWKRSPGGLVTALEPLLRRRRGAWIGWPGIPDSDEDPIVDGDLVLYPVRLSADDVAQYYEGFSNATLWPLYHDVIVKPIYNRQWWERYVEVNRRFAEATSRAAARGATVWVQDYQLQLVPKMLRELRPDLTIGFFLHIPFPPVELFMQLPWRTEITDGLLGADLVGFHLPGGAQNFLFLARRLVGANTSRASVGVRSKFGEVQGSRTVKVGAFPISIDSADLDRQARQRSIRQRARQIRAELGNPRRILLGVDRLDYTKGIDVRLQAFAELLAEGRVNREDTVFVQLATPSRERVEAYRLLRDDIERQVGHINGEYGEVGHPVVHYLHRPVPREELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELGQAYLVNPHNLDHVKDTMVAALNQTPEEGRRRMRALRRQVLAHDVDLWARSFLDALASTR 5l3k F 2.305 BS02 F6P F 1 R18 G38 Y90 D144 Y145 R324 R10 G23 Y70 D124 Y125 R302 H168 D385 H148 D363 2.4.1.347 0000166,0003824,0005992,0016758 A0A117IMA6 31772052 502 DSDFVVVANRLPIDLESWKRSPGGLVTALEPLLRRRAWIGWPGIPDSDEDPGDLVLYPVRLSADDVAQYYEGFSNATLWPLYHDVIVKPIYNRQWWERYVEVNRRFAEATSRAAARGATVWVQDYQLQLVPKMLRELRPDLTIGFFLHIPFPPVELFMQLPWRTEITDGLLGADLVGFHLPGGAQNFLFLARRLVGANTSRASVGVRSKFGEVQSRTVKVGAFPISIDSADLDRQARQRSIRQRARQIRAELGNPRRILLGVDRLDYTKGIDVRLQAFAELLAEGRVNREDTVFVQLATPSRERVEAYRLLRDDIERQVGHINGEYGEVGHPVVHYLHRPVPREELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELGQAYLVNPHNLDHVKDTMVAALNQTPEEGRRRMRALRRQVLAHDVDLWARSFLDALASTR 5ofu A 2.62 BS02 F6P A 1 D121 G122 Y248 S251 M252 Y268 K278 D105 G106 Y232 S235 M236 Y252 K262 D74 E97 E98 D118 L120 D121 E284 D58 E81 E82 D102 L104 D105 E268 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 402 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN 5ofu B 2.62 BS02 F6P B 1 D121 G122 N218 Y248 G250 S251 M252 Y268 K278 D105 G106 N202 Y232 G234 S235 M236 Y252 K262 D74 E97 E98 D118 L120 D121 E284 D58 E81 E82 D102 L104 D105 E268 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 402 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN 5ofu C 2.62 BS02 F6P C 1 D121 G122 Y248 G250 S251 M252 Y268 K278 D101 G102 Y228 G230 S231 M232 Y248 K258 D74 E97 E98 D118 L120 D121 E284 D55 E78 E79 D98 L100 D101 E264 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 402 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDR 5ofu D 2.62 BS02 F6P D 1 D121 G122 Y248 S251 M252 Y268 K278 D104 G105 Y231 S234 M235 Y251 K261 D74 E97 E98 D118 L120 D121 E284 D57 E80 E81 D101 L103 D104 E267 3.1.3.11 0000166,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0020015,0030388,0042132,0042578,0046872 O97193 28882541 402 PTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRN 5xz7 A 1.6 BS01 F6P A 1 R72 D129 M171 R173 E224 H251 R254 R72 D129 M171 R173 E224 H251 R254 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 P99165 29940104 407 MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDKFDYSLYELANKLSILEHH 5xz8 A 1.95 BS01 F6P A 1 R72 D129 M171 R173 E224 H251 R254 R72 D129 M171 R173 E224 H251 R254 2.7.1.11 0003872,0005524,0005737,0005945,0006002,0006096,0008443,0016208,0016301,0016310,0030388,0042802,0046872,0048029,0061621,0070095 Q2FXM8 29940104 401 MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDKFDYSLYELANKLS 6ayu A 2.2 BS01 F6P A 1 D82 G83 Y114 R159 R161 D181 G182 D183 G205 E208 D83 G84 Y115 R160 R162 D182 G183 D184 G206 E209 3.1.3.11 0005737,0005829,0006071,0006094,0016787,0030388,0042132,0046872 P9WN21 29652259 401 HMELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGSTLMSKGMTNAISVLAVADRGTMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKDLSVRDMTVCILDRPRHAQLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGAIQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPGGCTTHSIVMRSKSGTVRMIEAYHRLSKLNEYSAIDFT 6ayu B 2.2 BS01 F6P B 1 D82 Y114 R159 R161 D181 G182 D183 G205 E208 D83 Y115 R160 R162 D182 G183 D184 G206 E209 3.1.3.11 0005737,0005829,0006071,0006094,0016787,0030388,0042132,0046872 P9WN21 29652259 401 HMELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGSTLMSKGMTNAISVLAVADRGTMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKDLSVRDMTVCILDRPRHAQLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGAIQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPGGCTTHSIVMRSKSGTVRMIEAYHRL 6ayv A 2.3 BS01 F6P A 1 D82 Y114 R159 R161 D181 G182 D183 G205 E208 D83 Y115 R160 R162 D182 G183 D184 G206 E209 3.1.3.11 0005737,0005829,0006071,0006094,0016787,0030388,0042132,0046872 P9WN21 29652259 401 HMELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGATLMSKGMTNAISVLAVADRGTMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKDLSVRDMTVCILDRPRHAQLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGAIQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPGGCTTHSIVMRSKSGTVRMIEAYHRLSKLNEYSAIDFT 6ayv B 2.3 BS01 F6P B 1 D82 Y114 R159 R161 D181 G182 D183 G205 E208 D83 Y115 R160 R162 D182 G183 D184 G206 E209 3.1.3.11 0005737,0005829,0006071,0006094,0016787,0030388,0042132,0046872 P9WN21 29652259 401 HMELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGATLMSKGMTNAISVLAVADRGTMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKDLSVRDMTVCILDRPRHAQLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGAIQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPGGCTTHSIVMRSKSGTVRMIEAYHRLSKLN 6etj A 2.51 BS01 F6P A 1 H253 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 H241 I252 G253 E310 Y321 R335 K339 Y350 Q376 R380 R252 H253 N259 S302 E322 H387 R240 H241 N247 S290 E310 H375 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 30250201 602 ELTQSRVQKIWVPVDHRPSLSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRER 6hvh A 2.36 BS03 F6P A 1 I264 G265 E322 Y333 R347 K351 Y362 Q388 R392 I249 G250 E307 Y318 R332 K336 Y347 Q373 R377 R252 H253 N259 S302 E322 H387 R237 H238 N244 S287 E307 H372 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 30378281 604 ELTQSRVQKIWVPVDHNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSE 6hvi A 1.96 BS03 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G252 E309 Y320 R334 K338 Y349 Q375 R379 R252 H253 N259 S302 E322 H387 R239 H240 N246 S289 E309 H374 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 30378281 603 PLELTQSRVQKIWVPVHRNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSE 6hvj A 2.28 BS02 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G249 E306 Y317 R331 K335 Y346 Q372 R376 R252 H253 N259 S302 E322 H387 R236 H237 N243 S286 E306 H371 2.7.1.105,3.1.3.46 0003824,0003873,0004331,0005515,0005524,0005654,0005829,0006000,0006003,0006096,0006915,0010001,0016301,0016310,0016787,0046835,0061744 Q16875 30378281 602 ELTQSRVQKIWVPVHNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSE 6ibx A 2.11 BS03 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G248 E305 Y316 R330 K334 Y345 Q371 R375 2.7.1.105,3.1.3.46 0003824,0003873,0005524,0006000,0006003 Q16875 30626557 504 ELTQSRVQKIWVPVNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSE 6iby A 2.51 BS03 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G247 E304 Y315 R329 K333 Y344 Q370 R374 2.7.1.105,3.1.3.46 0003824,0003873,0005524,0006000,0006003 Q16875 30626557 504 ELTQSRVQKIWVPNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSE 6ibz A 2.44 BS03 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G250 E307 Y318 R332 K336 Y347 Q373 R377 2.7.1.105,3.1.3.46 0003824,0003873,0005524,0006000,0006003 Q16875 30626557 504 ELTQSRVQKIWVPVDHNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSE 6ic0 A 2.6 BS03 F6P A 1 G265 E322 Y333 R347 K351 Y362 Q388 R392 G248 E305 Y316 R330 K334 Y345 Q371 R375 2.7.1.105,3.1.3.46 0003824,0003873,0005524,0006000,0006003 Q16875 30626557 504 ELTQSRVQKIWVPVNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS 6kih A 3.0 BS02 F6P M 1 A48 Q51 R105 S159 K164 R178 A22 Q25 R79 S133 K138 R152 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAASL 6kih C 3.0 BS02 F6P N 1 G49 Q51 R105 Y135 S159 K164 R249 R253 Y330 G23 Q25 R79 Y109 S133 K138 R223 R227 Y304 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAASL 6kih D 3.0 BS02 F6P O 1 G50 Q51 R105 S159 R178 R249 R253 G24 Q25 R79 S133 R152 R223 R227 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAAS 6kih E 3.0 BS02 F6P P 1 R105 S159 K164 R178 Y330 R79 S133 K138 R152 Y304 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAASL 6kih F 3.0 BS02 F6P Q 1 H36 G49 R105 S159 K164 R249 R253 Y330 H10 G23 R79 S133 K138 R223 R227 Y304 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAAS 6kih H 3.0 BS02 F6P R 1 G49 G50 Q51 R105 Y135 S159 K164 G23 G24 Q25 R79 Y109 S133 K138 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAAS 6kih I 3.0 BS02 F6P S 1 A48 R105 K164 R249 R253 Y330 A22 R79 K138 R223 R227 Y304 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAAS 6kih K 3.0 BS02 F6P T 1 G49 R105 S159 K164 G23 R79 S133 K138 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAAS 6kih L 3.0 BS02 F6P U 1 G49 G50 Q51 R105 Y135 H158 S159 K164 G23 G24 Q25 R79 Y109 H132 S133 K138 ? 0000166,0016757 Q8DIJ5 32528448 2 RQPIALISVHGDPAADVGHESAGGQNIYVRQLGEALAAAGWHVDMFTRKTDPNDPDVIEHSPHCRTIRLQAGPLTYIPREKLFETLPKFVEAFKAYHAKYGYPLIHTNYWLSGWVGWQLRQQFNFQWLHTYHSLGVVKYQVASEQAQRDETRLMVEKAILENADCVIVTSPQEEAYLRRWVSKAGQTRLIPCGTNLKLFYPVADARAQLNLPADEPIVLYVGRFDRRKGIETLVAAMAQIPQGQLLLVGGSDPQRSDGAERRRIEGLVQEYNLGDRVTFVGQIDHEYLAVYYSAANVCVVPSYYEPFGLVAIEAMACGTPVIASAVGGLQFTVIPEETGLLVPPQDANALANAIQRILADPAWARTLGKNGRERVQALFNWEAIALQMGQLYRQLFAASL 6xio A 3.12 BS02 F6P A 1 D36 E90 G114 G115 Q116 K179 S210 M245 D36 E67 G91 G92 Q93 K156 S184 M219 0000287,0005737,0005975,0006000,0006096,0008443,0016773 33839685 502 MDISEWEKRYNEAYSDISKSLKKVKGIFVAYNSNIDAIKHIYPRQIDSPADFVARLIISMRDGKAAEVPTYTTDIHEWLTDNLGFDEARMGGQAGIISNLLANMGIKNVIAYVPWLSKEQAEYFVDSENLLHPVVENGKLELKHPKEAYNPDNKPKVNWIIEFSKGLEVKFAIVVPRDNRLIVSSRPPWIRIDMSEELYEHLPEIGKNIDGAILSGYQMIKEEYEDGKTYKDYVEKAVNVIKRLKEGNPDIRIHVEFTSIQNKLIRKAILKDIVRKHVHSLGLDTVEVANALNVLGYEELAYSVIKKDENAIVALYEGAVILLHELKLERVHVHSLGYYICVVSKDSPVSPEDHRKSLLFASTVAAARALLGNINSLDDIEAGLDVPVSEQGYNQLEKLEKYLVRRGICTLEDFENGCICTPNHDVIIIPTKVVEKPVATVGIGDTISAAAFVSVLAKMKKK 7kmf G 2.91 BS01 F6P G 1 Y130 S131 R132 G196 E198 N208 K209 Y123 S124 R125 G189 E191 N201 K202 ? 0002183,0003743,0005085,0005515,0005737,0005829,0005851,0005886,0006412,0006413,0009408,0009749,0014003,0016020,0042802,0043434,0044237,0050852 Q14232 34103529 401 DKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKALKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL 7kmf H 2.91 BS01 F6P H 1 Y130 S131 R132 G196 E198 N208 K209 K234 Y117 S118 R119 G183 E185 N195 K196 K221 ? 0002183,0003743,0005085,0005515,0005737,0005829,0005851,0005886,0006412,0006413,0009408,0009749,0014003,0016020,0042802,0043434,0044237,0050852 Q14232 34103529 401 DKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRTIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKALKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLY 7lw1 A 2.9 BS03 F6P A 1 I165 D166 M208 R210 E264 H298 R301 I155 D156 M198 R200 E254 H288 R291 2.7.1.11 0003872,0005515,0005524,0005576,0005737,0005829,0005945,0006002,0006096,0009749,0016020,0016208,0016301,0016310,0019900,0030388,0034774,0042802,0046676,0046872,0048029,0061615,0061621,0070061,0070062,0070095,1904813 P17858 34320407 803 ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 7lw1 A 2.9 BS06 F6P D 1 R201 R292 R191 R282 2.7.1.11 0003872,0005515,0005524,0005576,0005737,0005829,0005945,0006002,0006096,0009749,0016020,0016208,0016301,0016310,0019900,0030388,0034774,0042802,0046676,0046872,0048029,0061615,0061621,0070061,0070062,0070095,1904813 P17858 34320407 803 ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 7lw1 D 2.9 BS02 F6P A 1 R201 R292 R191 R282 2.7.1.11 0003872,0005515,0005524,0005576,0005737,0005829,0005945,0006002,0006096,0009749,0016020,0016208,0016301,0016310,0019900,0030388,0034774,0042802,0046676,0046872,0048029,0061615,0061621,0070061,0070062,0070095,1904813 P17858 34320407 803 ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 7lw1 D 2.9 BS05 F6P D 1 I165 D166 M208 R210 E264 H298 R301 I155 D156 M198 R200 E254 H288 R291 2.7.1.11 0003872,0005515,0005524,0005576,0005737,0005829,0005945,0006002,0006096,0009749,0016020,0016208,0016301,0016310,0019900,0030388,0034774,0042802,0046676,0046872,0048029,0061615,0061621,0070061,0070062,0070095,1904813 P17858 34320407 803 ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 7lw1 E 2.9 BS03 F6P E 1 I165 D166 M208 R210 E264 H298 R301 I155 D156 M198 R200 E254 H288 R291 2.7.1.11 0003872,0005515,0005524,0005576,0005737,0005829,0005945,0006002,0006096,0009749,0016020,0016208,0016301,0016310,0019900,0030388,0034774,0042802,0046676,0046872,0048029,0061615,0061621,0070061,0070062,0070095,1904813 P17858 34320407 803 ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 7lw1 E 2.9 BS06 F6P F 1 R201 R292 R191 R282 2.7.1.11 0003872,0005515,0005524,0005576,0005737,0005829,0005945,0006002,0006096,0009749,0016020,0016208,0016301,0016310,0019900,0030388,0034774,0042802,0046676,0046872,0048029,0061615,0061621,0070061,0070062,0070095,1904813 P17858 34320407 803 ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 7lw1 F 2.9 BS02 F6P E 1 R201 R292 R191 R282 2.7.1.11 0003872,0005515,0005524,0005576,0005737,0005829,0005945,0006002,0006096,0009749,0016020,0016208,0016301,0016310,0019900,0030388,0034774,0042802,0046676,0046872,0048029,0061615,0061621,0070061,0070062,0070095,1904813 P17858 34320407 803 ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 7lw1 F 2.9 BS05 F6P F 1 I165 D166 M208 R210 E264 H298 R301 I155 D156 M198 R200 E254 H288 R291 2.7.1.11 0003872,0005515,0005524,0005576,0005737,0005829,0005945,0006002,0006096,0009749,0016020,0016208,0016301,0016310,0019900,0030388,0034774,0042802,0046676,0046872,0048029,0061615,0061621,0070061,0070062,0070095,1904813 P17858 34320407 803 ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 7txa 1 2.4 BS01 F6P 1 1 E57 D84 E87 D116 D187 E214 E57 D84 E87 D116 D187 E214 3.1.3.11 0005829,0006071,0006094,0016787,0030388,0042132,0046872 Q5NEJ8 37352301 401 MNRKVALEAVRVTELAALASWSQMGRGDKIAADQAAVDAMRKALNEVDIDGTVVIGEGELDEAPMLYIGEKVGAGGCEVDIALDPLEGTTITSKGGANALTVLAMADKGGFLNAPDVYMQKIAVGGINAPKGIVDLDDSVTNNLKRIAEFKGVHMSALVVCTMDRPRHEHIIKEARECGARVILINDGDVSGVIATATENSGIDVYIGTGGAPEGVLAAAALKCLGGQMQARLIFNDEEEIKRAHRLGITDLNKKYDIDDLASGDIVFAATGVTDGNMLQGVKRVNSTRRGSYAVTHSVVMRSTTKTVRHITAEHSFDFKEGIEKFMS 7txa C 2.4 BS01 F6P C 1 E57 G58 D116 E214 E57 G58 D116 E214 3.1.3.11 0005829,0006071,0006094,0016787,0030388,0042132,0046872 Q5NEJ8 37352301 401 MNRKVALEAVRVTELAALASWSQMGRGDKIAADQAAVDAMRKALNEVDIDGTVVIGEGELDEAPMLYIGEKVGAGGCEVDIALDPLEGTTITSKGGANALTVLAMADKGGFLNAPDVYMQKIAVGGINAPKGIVDLDDSVTNNLKRIAEFKGVHMSALVVCTMDRPRHEHIIKEARECGARVILINDGDVSGVIATATENSGIDVYIGTGGAPEGVLAAAALKCLGGQMQARLIFNDEEEIKRAHRLGITDLNKKYDIDDLASGDIVFAATGVTDGNMLQGVKRVNSTRRGSYAVTHSVVMRSTTKTVRHITAEHSFDFKEGIEKFMS 8w2g A 3.0 BS01 F6P A 1 I165 D166 M208 E264 H298 R301 I153 D154 M196 E252 H286 R289 P17858 39183237 801 GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ 8w2g A 3.0 BS06 F6P B 1 R201 R292 R189 R280 P17858 39183237 801 GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ 8w2g B 3.0 BS01 F6P A 1 R201 R292 R189 R280 P17858 39183237 801 GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ 8w2g B 3.0 BS03 F6P B 1 I165 D166 M208 E264 H298 R301 I153 D154 M196 E252 H286 R289 P17858 39183237 801 GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ 8w2g C 3.0 BS01 F6P D 1 R201 R292 R189 R280 P17858 39183237 801 GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ 8w2g C 3.0 BS02 F6P C 1 I165 D166 M208 E264 H298 R301 I153 D154 M196 E252 H286 R289 P17858 39183237 801 GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ 8w2g D 3.0 BS01 F6P D 1 I165 D166 M208 E264 H298 R301 I153 D154 M196 E252 H286 R289 P17858 39183237 801 GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ 8w2g D 3.0 BS06 F6P C 1 R201 R292 R189 R280 P17858 39183237 801 GAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQ