6gn1 A 2.6 BS01 F4N A 1 I62 F67 V70 A83 K85 Y134 V135 Q185 L188 C199 D200 I27 F32 V35 A48 K50 Y94 V95 Q145 L148 C159 D160 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0004672,0005524,0006468 IC50=10nM P49841 29873877 502 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 6gn1 B 2.6 BS01 F4N B 1 I62 F67 V70 A83 K85 Y134 V135 Q185 L188 D200 I27 F32 V35 A48 K50 Y94 V95 Q145 L148 D160 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0004672,0005524,0006468 -logKd/Ki=8.00, IC50=10nM IC50=10nM P49841 29873877 502 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR