3k83 A 2.251 BS01 F27 A 1 M191 F192 S193 S217 D237 I238 G239 S241 G268 C269 V270 L278 T488 M159 F160 S161 S185 D205 I206 G207 S209 G236 C237 V238 L246 T456 K142 S217 S218 T236 I238 G239 G240 S241 F244 K110 S185 S186 T204 I206 G207 G208 S209 F212 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 Ki=22nM -logKd/Ki=7.66, Ki=0.022uM Ki=22nM, IC50=6nM P97612 19924997 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQP 3k83 B 2.251 BS01 F27 B 1 M191 F192 S193 S217 D237 I238 G239 S241 G268 C269 V270 T488 M159 F160 S161 S185 D205 I206 G207 S209 G236 C237 V238 T456 K142 S217 S218 T236 I238 G239 G240 S241 F244 K110 S185 S186 T204 I206 G207 G208 S209 F212 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 Ki=22nM Ki=22nM, IC50=6nM P97612 19924997 1 GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQ