3caj A 1.8 BS02 EZL A 1 H94 H119 L198 T199 T200 H92 H117 L195 T196 T197 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=8nM -logKd/Ki=8.10, Ki=8nM Ki=8nM, IC50=3nM, Kd=0.71nM P00918 18359629 265 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3dcw A 1.5 BS02 EZL A 1 H94 H119 L198 T199 T200 P202 H91 H116 L194 T195 T196 P198 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki<1nM -logKd/Ki=9.00, Ki=1nM Ki=8nM, IC50=3nM, Kd=0.71nM P00918 19170619 301 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3dd0 A 1.48 BS02 EZL A 1 H94 H119 L198 T199 T200 P201 H92 H117 L195 T196 T197 P198 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki<1nM -logKd/Ki=9.00, Ki=1nM Ki=8nM, IC50=3nM, Kd=0.71nM P00918 19170619 301 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3mdz A 2.32 BS02 EZL A 1 H96 V123 L200 T201 T202 H93 V120 L197 T198 T199 H66 H96 H98 E108 H121 T201 H63 H93 H95 E105 H118 T198 4.2.1.1 0004089,0005737,0005829,0006730,0008270,0016829,0032230,0032849,0046872,0051453,0070050,2001225 -logKd/Ki=9.10, Ki=0.8nM Ki=0.8nM, Kd=0.710000nM P43166 264 MHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASF 5jn9 A 2.1 BS02 EZL A 1 H94 L198 T199 T200 W209 H97 L199 T200 T201 W210 H64 H94 H96 E106 H119 T199 H70 H97 H99 E109 H122 T200 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 -logKd/Ki=7.79, Kd=16.2nM Ki=93nM P22748 28975383 302 AESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jn9 B 2.1 BS02 EZL B 1 H94 L198 T199 T200 P201 H94 L195 T196 T197 P198 H64 H94 H96 E106 H119 T199 H67 H94 H96 E106 H119 T196 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=93nM P22748 28975383 302 HWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jn9 C 2.1 BS02 EZL C 1 H94 H119 V121 L198 T199 T200 H95 H120 V122 L204 T205 T206 H64 H94 H96 E106 H119 T199 H68 H95 H97 E107 H120 T205 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=93nM P22748 28975383 302 SHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jn9 D 2.1 BS02 EZL D 1 H94 H119 L198 T199 T200 H94 H119 L203 T204 T205 H64 H94 H96 E106 H119 T199 H67 H94 H96 E106 H119 T204 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=93nM P22748 28975383 302 HWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5tt3 A 2.2 BS02 EZL A 1 H110 H112 H129 L190 T191 W201 H89 H91 H108 L166 T167 W177 H85 H110 H112 E116 H129 T191 H64 H89 H91 E95 H108 T167 ? 0004089,0008270,0046872 Ki=193nM -logKd/Ki=6.71, Ki=193nM A0A0M3KL20 28002963 303 KWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 5tt3 B 2.2 BS02 EZL B 1 H110 H112 H129 L190 T191 A192 P193 H82 H84 H101 L155 T156 A157 P158 H85 H110 H112 E116 H129 T191 H57 H82 H84 E88 H101 T156 ? 0004089,0008270,0046872 Ki=193nM A0A0M3KL20 28002963 303 KWDYKNHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 5tt3 C 2.2 BS02 EZL C 1 H110 H112 L190 T191 A192 P193 H90 H92 L170 T171 A172 P173 H85 H110 H112 E116 H129 T191 H65 H90 H92 E96 H109 T171 ? 0004089,0008270,0046872 Ki=193nM A0A0M3KL20 28002963 303 TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 5tt3 E 2.2 BS02 EZL E 1 H110 H112 H129 T191 P193 H89 H91 H108 T170 P172 H85 H110 H112 E116 H129 T191 H64 H89 H91 E95 H108 T170 ? 0004089,0008270,0046872 Ki=193nM A0A0M3KL20 28002963 303 KWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 5tt3 F 2.2 BS02 EZL F 1 H110 H112 L190 T191 W201 H88 H90 L163 T164 W174 H85 H110 H112 E116 H129 T191 H63 H88 H90 E94 H107 T164 ? 0004089,0008270,0046872 Ki=193nM A0A0M3KL20 28002963 302 WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 5tt3 G 2.2 BS02 EZL G 1 H110 H112 H129 L190 T191 P193 W201 H87 H89 H106 L161 T162 P164 W172 H85 H110 H112 E116 H129 T191 H62 H87 H89 E93 H106 T162 ? 0004089,0008270,0046872 Ki=193nM A0A0M3KL20 28002963 303 TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQLDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 5tt3 H 2.2 BS02 EZL H 1 H110 H112 L190 T191 H88 H90 L166 T167 H85 H110 H112 E116 H129 T191 H63 H88 H90 E94 H107 T167 ? 0004089,0008270,0046872 Ki=193nM A0A0M3KL20 28002963 303 WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 6bcc A 1.8 BS02 EZL A 1 H94 H119 V121 F131 L198 T199 T200 W209 H91 H116 V118 F127 L194 T195 T196 W205 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=8nM, IC50=3nM, Kd=0.71nM P00918 29429876 302 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 6mwi B 1.75 BS02 EZL B 1 D10 H12 H44 I59 F63 S64 F70 D11 H13 H45 I60 F64 S65 F71 4.6.1.12 0008299,0008685,0016114,0016829,0019288,0046872 Q3JRA0 202 SMDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDPRFKGADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVRE 6ql2 A 1.3 BS02 EZL A 1 H94 H96 H119 Y131 Q135 L198 T199 T200 P201 H91 H93 H116 Y127 Q131 L194 T195 T196 P197 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=1.1nM -logKd/Ki=7.77, Kd=17nM Ki=8nM, IC50=3nM, Kd=0.71nM P00918 31481705 306 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHTFQVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDYGKAQQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLTECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK