1a27 A 1.9 BS01 EST A 1 S142 V143 G144 M147 L149 Y155 V225 F259 M279 S142 V143 G144 M147 L149 Y155 V225 F259 M279 1.1.1.51,1.1.1.62 0004303,0005737,0006703,0016491 P14061 350 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFG 1a52 A 2.8 BS01 EST A 1 E353 L387 M388 L391 F404 H524 L525 E48 L82 M83 L86 F99 H219 L220 ? -logKd/Ki=9.86, Ki=0.138nM IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 9600906 1 LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHERLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEML 1a52 B 2.8 BS01 EST B 1 E353 L387 H524 L525 E49 L83 H220 L221 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 9600906 2 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHERLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEML 1aqu A 1.6 BS02 EST A 1 R23 Y81 K106 H108 F142 M247 R17 Y68 K93 H95 F129 M234 K48 H108 S138 K42 H95 S125 2.8.2.4 0004304,0005496,0005737,0005829,0006629,0007565,0008146,0008210,0016740,0050294,0051923 P49891 9360604 304 EYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIATYPKSGTTWISEVVYMIYKEGDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKFRME 1aqu B 1.6 BS02 EST B 1 R23 Y81 K106 F142 M247 R17 Y68 K93 F129 M234 K48 H108 S138 K42 H95 S125 2.8.2.4 0004304,0005496,0005737,0005829,0006629,0007565,0008146,0008210,0016740,0050294,0051923 P49891 9360604 303 EYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIATYPKSGTTWISEVVYMIYKEEDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKFRM 1e6w C 1.7 BS02 EST C 1 Q165 Y168 L206 Q159 Y162 L200 G21 N121 T153 S155 Y168 K172 F201 G15 N115 T147 S149 Y162 K166 F195 1.1.1.159,1.1.1.178,1.1.1.239,1.1.1.35,1.1.1.53,1.1.1.62 0000049,0001540,0003857,0004303,0005496,0005739,0005783,0006550,0006631,0006635,0006699,0007005,0008033,0008202,0008207,0008209,0008210,0008584,0008709,0016491,0018454,0030283,0030331,0030678,0033327,0042645,0042802,0043527,0044594,0047015,0047035,0047044,0051287,0051289,0062173,0070901,0097745,0106281,0106282,0106283,1990180 O70351 11023795 302 SVKGLVAVITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFNVIRLVAGVMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVVTIAPGLFATPLLTNFLASQVPFPSRLGDPAEYAHLVQMVIENPFLNGEVIRLDGAIRMQP 1ere A 3.1 BS01 EST A 1 E353 L387 F404 H524 L525 E43 L77 F94 H211 L212 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 9338790 600 SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR 1ere B 3.1 BS01 EST B 1 E353 F404 H524 L525 E43 F94 H211 L212 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 9338790 600 SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR 1ere C 3.1 BS01 EST C 1 E353 F404 H524 L525 E43 F94 H211 L212 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 9338790 600 SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR 1ere D 3.1 BS01 EST D 1 E353 F404 H524 L525 E43 F94 H211 L212 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 9338790 600 SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR 1ere E 3.1 BS01 EST E 1 E353 F404 H524 L525 E43 F94 H211 L212 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 9338790 600 SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR 1ere F 3.1 BS01 EST F 1 E353 L387 F404 H524 L525 E43 L77 F94 H211 L212 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 9338790 600 SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR 1fds A 1.7 BS01 EST A 1 S142 V143 G186 P187 H221 F226 F259 M279 S142 V143 G186 P187 H216 F221 F254 M274 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 8805577 350 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDV 1fdt A 2.2 BS01 EST A 1 S142 V143 Y155 H221 F226 F259 M279 S142 V143 Y155 H221 F226 F259 M279 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 8805577 350 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFG 1fdu A 2.7 BS01 EST A 1 S142 V143 G144 Y155 P187 F192 Y218 S142 V143 G144 Y155 P187 F192 Y214 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 9525918 351 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGVLDRTDIHTFHRFYQYLALSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFG 1fdu B 2.7 BS01 EST B 1 V143 L149 F226 M279 V143 L149 F221 M274 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 9525918 354 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLVLDRTDIHTFHRFYQYLALSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFG 1fdu C 2.7 BS01 EST C 1 S142 V143 G144 L149 Y155 G186 P187 F259 M279 S142 V143 G144 L149 Y155 G186 P187 F259 M279 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 9525918 353 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLALSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFG 1fdu D 2.7 BS01 EST D 1 S142 V143 G144 L149 Y155 F259 S142 V143 G144 L149 Y155 F255 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 9525918 352 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLEVLDRTDIHTFHRFYQYLALSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFG 1fdw A 2.7 BS01 EST A 1 V143 Q221 S222 F259 V143 Q215 S216 F253 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 9525918 350 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAGSPEEVLDRTDIHTFHRFYQYLAQSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFG 1g50 A 2.9 BS01 EST A 1 E353 L387 R394 F404 H524 L525 E50 L84 R91 F101 H221 L222 ? -logKd/Ki=6.28, Kd=0.53uM IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11437591 600 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLH 1g50 B 2.9 BS01 EST B 1 E1353 L1387 M1388 L1391 F1404 G1521 H1524 L1525 E50 L84 M85 L88 F101 G218 H221 L222 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11437591 1600 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL 1g50 C 2.9 BS01 EST C 1 E2353 L2387 M2388 L2391 F2404 G2521 H2524 L2525 E50 L84 M85 L88 F101 G218 H221 L222 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11437591 2600 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAH 1gwr A 2.4 BS02 EST A 1 L346 A350 E353 F404 H524 L38 A42 E45 F96 H213 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11937504 600 LALSLTADQMVSALLDAEPPILYSEYRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL 1gwr B 2.4 BS02 EST B 1 E353 F404 L525 E47 F98 L216 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11937504 600 SLALSLTADQMVSALLDAEPPILYSEYDPPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR 1iol A 2.3 BS01 EST A 1 S142 V143 G186 H221 F259 S142 V143 G186 H221 F259 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 8756321 400 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLEVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVF 1jgl H 2.15 BS01 EST L 1 Q35 W95 G97 Q33 W94 G96 -logKd/Ki=8.70, Kd=2nM 11451948 911 QIQLVQSGPELKKPGETVRISCKASDYMTSGMQWVQQMPGKGLKWIGWLNTQSGVPEYAEDFKGRFAFSLETTAYLQINNLKNEDTATYFCATWGGNSAYWGQGTTLTVSSAKTTPPSVYPLAPGNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR 1jgl L 2.15 BS01 EST L 1 Y36 Y49 H89 F91 W96 Y36 Y49 H89 F91 W96 ? Kd=2nM -logKd/Ki=8.70, Kd=2nM Q7TS98 11451948 911 DIQMTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYNAKTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGTYYCHHFWSTPWTFGGGTKLEVKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 1jnn H 3.2 BS01 EST H 1 F35 E99 K100 D101 F35 E99 K100 D101 ? Q99LC4 11812141 350 EVQLQQSGAELVKPGASVRLSCSASGFNIKDTYMFWVKQRPEQGLDWIGRINPANGISKYDPRFQGKATLTADTSSNTAYLQLDNLTSEDTAVYYCAIEKDLPWGQGTLVTVSVAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR 1jnn L 3.2 BS01 EST H 1 Y36 L46 H89 F91 Y36 L46 H89 F91 ? Q7TS98 11812141 350 QIVMTQTPASLSASVGETVTITCRASGNIYNYLAWYQQKQGKSPQLLVYNAKTLVDGVPLRFSGSGSGTQYSLKINSLQPEDFGNYYCHHFWNTPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR 1lhu A 1.8 BS02 EST A 1 S42 G58 D65 F67 V105 M107 K134 I141 S29 G45 D52 F54 V92 M94 K121 I128 ? -logKd/Ki=8.83, Kd=1.48nM IC50=50nM, Kd=1.5nM P04278 12065592 301 PAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSC 1pcg A 2.7 BS02 EST A 1 E353 L387 F404 H524 L525 E49 L83 F100 H209 L210 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 13679575 1 NSLALSLTADQMVSALLDAEPPILYSEYDPTPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKSKNVVPLYDLLLEMLDAH 1pcg B 2.7 BS02 EST B 1 E353 L387 F404 H524 L525 E50 L84 F101 H220 L221 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 13679575 2 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKSKNVVPLYDLLLEMLDAH 1qkt A 2.2 BS01 EST A 1 L346 E353 L387 F404 M421 L43 E50 L84 F101 M118 ? Kd=0.92nM -logKd/Ki=9.04, Kd=0.92nM IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11278577 600 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKSKNVVPLYDLLLEMLDAHRLHA 1qku A 3.2 BS01 EST A 1 E353 L387 F404 H524 L525 E53 L87 F104 H224 L225 ? -logKd/Ki=9.59, Kd=0.26nM IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11278577 600 SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLH 1qku B 3.2 BS01 EST B 1 E353 L387 F404 H524 L525 E50 L84 F101 H221 L222 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11278577 600 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLH 1qku C 3.2 BS01 EST C 1 E353 L387 F404 H524 L525 E50 L84 F101 H221 L222 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11278577 600 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLH 2d06 A 2.3 BS02 EST A 1 P47 K106 H108 F142 V148 F247 P40 K99 H101 F135 V141 F240 K48 H108 S138 K41 H101 S131 2.8.2.1 0004062,0005515,0005737,0005829,0006068,0006584,0006805,0008146,0008202,0008210,0009308,0009812,0016740,0047894,0050294,0050427,0050656,0051923 Ki=83.2uM -logKd/Ki=4.08, Ki=83.2uM Kd=1200nM P50225 16221673 304 SRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGHSLPEETVDFMVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL 2d06 B 2.3 BS02 EST B 1 F24 P47 K106 H108 F142 Y240 F247 F17 P40 K99 H101 F135 Y233 F240 K48 H108 S138 K41 H101 S131 2.8.2.1 0004062,0005515,0005737,0005829,0006068,0006584,0006805,0008146,0008202,0008210,0009308,0009812,0016740,0047894,0050294,0050427,0050656,0051923 Ki=83.2uM Kd=1200nM P50225 16221673 305 SRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGHSLPEETVDFMVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL 2j7x A 2.1 BS02 EST A 1 E260 L294 F311 H430 L431 E41 L75 F92 H205 L206 ? -logKd/Ki=8.77, IC50=1.7nM EC50=0.14nM, IC50=1.7nM Q62986 1454 TLSPEQLVLTLLEAEPPNVLVSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAH 2ocf A 2.95 BS01 EST A 1 L346 E353 M421 H524 L525 L42 E49 M117 H209 L210 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 11818562 596 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 2yja B 1.82 BS02 EST B 1 E353 L387 F404 M421 H524 L525 E49 L83 F100 M117 H220 L221 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 21612236 1550 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL 3oll A 1.5 BS02 EST A 1 E305 M336 F356 H475 L476 E44 M75 F95 H212 L213 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 20922740 600 ALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 3oll B 1.5 BS02 EST B 1 E305 M336 F356 H475 L476 E44 M75 F95 H211 L212 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 20922740 600 ALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 3ols A 2.2 BS02 EST A 1 L298 E305 M336 F356 H475 L476 L35 E42 M73 F93 H207 L208 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 20922740 600 SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNA 3ols B 2.2 BS02 EST B 1 L298 E305 M336 L339 L343 F356 I373 H475 L476 L35 E42 M73 L76 L80 F93 I110 H204 L205 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 20922740 600 SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTAKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEML 3uud A 1.6 BS02 EST A 1 L346 E353 F404 H524 L525 L42 E49 F100 H217 L218 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 22927406 600 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL 3uud B 1.6 BS02 EST B 1 E353 F404 H524 L525 E50 F101 H211 L212 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 22927406 600 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLH 4j24 A 2.1 BS02 EST A 1 E305 F356 H475 L476 E44 F95 H202 L203 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 ALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 B 2.1 BS02 EST B 1 E305 L339 F356 I376 H475 L476 E45 L79 F96 I116 H205 L206 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 DALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 C 2.1 BS02 EST C 1 L298 E305 F356 H475 L476 L37 E44 F95 H202 L203 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 ALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 D 2.1 BS02 EST D 1 E305 M336 F356 H475 L476 E42 M73 F93 H199 L200 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNA 4j26 A 2.3 BS02 EST A 1 L298 E305 M336 L339 F356 H475 L476 L38 E45 M76 L79 F96 H205 L206 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 DALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j26 B 2.3 BS02 EST B 1 L298 E305 M336 L339 F356 H475 L476 L38 E45 M76 L79 F96 H206 L207 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 DALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4jvl A 1.943 BS02 EST A 1 Y20 F80 K105 H107 F141 A146 Y19 F79 K104 H106 F140 A145 K47 H107 S137 K46 H106 S136 2.8.2.4 0004062,0004304,0005496,0005515,0005737,0005829,0006068,0006629,0006711,0008146,0008202,0008210,0016740,0031965,0045600,0047894,0050294,0050427,0051923 P49888 23959441 702 NSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTEALNEKFDKHYEQQMKESTLKFRTE 4jvl B 1.943 BS02 EST B 1 Y20 F80 K105 H107 F141 A146 Y19 F79 K104 H106 F140 A145 K47 H107 S137 K46 H106 S136 2.8.2.4 0004062,0004304,0005496,0005515,0005737,0005829,0006068,0006629,0006711,0008146,0008202,0008210,0016740,0031965,0045600,0047894,0050294,0050427,0051923 P49888 23959441 302 NSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTEALNEKFDKHYEQQMKESTLKFRT 4pxm A 1.9 BS02 EST A 1 E353 L387 F404 G521 H524 L525 E47 L81 F98 G202 H205 L206 ? -logKd/Ki=8.89, Kd=1.3nM IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26836308 2000 ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYGLLLEMLDAHRL 4pxm B 1.9 BS02 EST B 1 E353 H524 L525 E42 H202 L203 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26836308 2000 SLALSLTADQMVSALLDAEPPILYSESEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYGLLLEMLDAHR 5dx3 A 2.0903 BS02 EST A 1 E353 H524 L525 E47 H208 L209 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 601 ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH 5dx3 B 2.0903 BS02 EST B 1 E353 L387 F404 M421 H524 E40 L74 F91 M108 H200 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 1000 LSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKMVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 5dxb A 2.08 BS02 EST A 1 E353 F404 G521 H524 L525 E47 F98 G205 H208 L209 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 1000 ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 5dxb B 2.08 BS02 EST B 1 E353 L387 G521 H524 E42 L76 G198 H201 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 601 ALSLTADQMVSALLDAEPPILYSEYFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVPLSDLLLEMLDAHR 5dxe A 1.5 BS02 EST A 1 E353 F404 H524 L525 E47 F98 H208 L209 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 1000 ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH 5dxe B 1.5 BS02 EST B 1 E353 L387 F404 H524 L525 E41 L75 F92 H201 L202 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 1000 LSLTADQMVSALLDAEPPILYSEYFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 5dxg A 1.86 BS02 EST A 1 E353 F404 H524 L525 E47 F98 H207 L208 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 1000 ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 5dxg B 1.86 BS02 EST B 1 E353 F404 H524 E40 F91 H198 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 601 LSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 5gs4 A 2.4 BS02 EST A 1 M343 L346 E353 L387 F404 H524 L525 M32 L35 E42 L76 F93 H213 L214 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 29045135 603 SLALSLTADQMVSALLDAEPPILYSESEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAH 5gtr A 2.804 BS02 EST A 1 L346 A350 E353 L387 L391 R394 M421 I424 H524 L525 L35 A39 E42 L76 L80 R83 M110 I113 H213 L214 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 29045135 601 SLALSLTADQMVSALLDAEPPILYSESEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAH 5hyr A 2.271 BS02 EST A 1 A350 E353 F404 H524 L525 A44 E47 F98 H207 L208 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 601 ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHL 5hyr B 2.271 BS02 EST B 1 E353 L387 H524 L525 E41 L75 H200 L201 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 26928945 601 ALSLTADQMVSALLDAEPPILYSEYSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH 5toa A 2.5 BS01 EST A 1 L298 E305 M336 F356 G472 H475 L476 L36 E43 M74 F94 G201 H204 L205 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 28615710 601 ALSPEQLVLTLLEAEPPHVLISRPAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLR 5toa B 2.5 BS01 EST B 1 E305 M336 F356 G472 H475 L476 E45 M76 F96 G203 H206 L207 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 28615710 601 MALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLR 5wgd A 1.8 BS02 EST A 1 E353 H524 L525 E46 H205 L206 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 29725689 601 LSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH 5wgd B 1.8 BS02 EST B 1 E353 F404 H524 L525 E39 F90 H198 L199 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 29725689 601 ALSLTADQMVSALLDAEPPILYSSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 5wgq A 2.3 BS02 EST A 1 L346 E353 H524 L525 L36 E43 H208 L209 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 29725689 601 LSLTADQMVSALLDAEPPILYSEYDPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH 5wgq B 2.3 BS02 EST B 1 M343 E353 L387 H524 L525 M35 E45 L79 H205 L206 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 29725689 601 LALSLTADQMVSALLDAEPPILYSEYDPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 6cbz A 1.65 BS02 EST A 1 E353 F404 H524 L525 E45 F96 H204 L205 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 29739819 601 SLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL 6cbz B 1.65 BS02 EST B 1 E353 F404 H524 L525 E40 F91 H200 L201 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 29739819 602 AASLTADQMVSALLDAEPPILYSFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKMVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 6keo AA 1.7 BS01 EST AA 1 P15 F39 D113 S114 L208 P12 F36 D110 S111 L205 2.5.1.18 0003824,0004364,0004769,0005737,0006694,0006749,0009636,0016740,0042632,0045456 Q7JYX0 32241910 301 PKPILYYDERSPPVRSCLMLIKLLDIDVELRFVNLFKGEQFQKDFLALNPQHSVPTLVHGDLVLTDSHAILIHLAEKFDEGGSLWPQEHAERMKVLNLLLFECSFLFRRDSDFMSAIVRQGFANVDVAHHERKLTEAYIIMERYLENSDFMAGPQLTLADLSIVTTLSTVNLMFPLSQFPRLRRWFTAMQQLDAYEANCSGLEKLRQTMESVGSFQFPSSSAVVT 6keo BA 1.7 BS01 EST BA 1 P15 F39 D113 M117 V121 L208 P12 F36 D110 M114 V118 L205 2.5.1.18 0003824,0004364,0004769,0005737,0006694,0006749,0009636,0016740,0042632,0045456 Q7JYX0 32241910 301 PKPILYYDERSPPVRSCLMLIKLLDIDVELRFVNLFKGEQFQKDFLALNPQHSVPTLVHGDLVLTDSHAILIHLAEKFDEGGSLWPQEHAERMKVLNLLLFECSFLFRRDSDFMSAIVRQGFANVDVAHHERKLTEAYIIMERYLENSDFMAGPQLTLADLSIVTTLSTVNLMFPLSQFPRLRRWFTAMQQLDAYEANCSGLEKLRQTMESVGSFQFPS 6kep AA 1.55 BS02 EST AA 1 P15 L38 F39 D113 S114 M117 V121 R122 L208 P12 L35 F36 D110 S111 M114 V118 R119 L205 2.5.1.18 0003824,0004364,0004769,0005737,0006694,0006749,0009636,0016740,0042632,0045456 Q7JYX0 32241910 302 PKPILYYDERSPPVRSCLMLIKLLDIDVELRFVNLFKGEQFQKDFLALNPQHSVPTLVHGDLVLTDSHAILIHLAEKFDEGGSLWPQEHAERMKVLNLLLFECSFLFRRDSDFMSAIVRQGFANVDVAHHERKLTEAYIIMERYLENSDFMAGPQLTLADLSIVTTLSTVNLMFPLSQFPRLRRWFTAMQQLDAYEANCSGLEKLRQTMESVGSFQFPSSSAVVT 6kep BA 1.55 BS02 EST BA 1 P15 F39 D113 S114 M117 V121 L208 P12 F36 D110 S111 M114 V118 L205 2.5.1.18 0003824,0004364,0004769,0005737,0006694,0006749,0009636,0016740,0042632,0045456 Q7JYX0 32241910 302 PKPILYYDERSPPVRSCLMLIKLLDIDVELRFVNLFKGEQFQKDFLALNPQHSVPTLVHGDLVLTDSHAILIHLAEKFDEGGSLWPQEHAERMKVLNLLLFECSFLFRRDSDFMSAIVRQGFANVDVAHHERKLTEAYIIMERYLENSDFMAGPQLTLADLSIVTTLSTVNLMFPLSQFPRLRRWFTAMQQLDAYEANCSGLEKLRQTMESVGSFQFPS 6oyv A 3.101 BS01 EST A 1 A133 F231 D326 G329 A330 L509 A71 F169 D252 G255 A256 L435 0004497,0005506,0016705,0020037 32156703 601 PPGPFPWPHLSFARLARRYGDVFQIRLGSCPVVVLNGERAIRQALVQQGAAFAGRPPFPSFQVVSGGRSLAFGRYSERWKVQRRVAHSTVRAFSTGQPRSRRVLEQHVLGEARELVRLLVRGSAGGAFLDPAPLTVVAVANVMSAVCFGCRYSHDDAEFRGLLSHNEKFGRTVGAGSLVDVLPWLQRFPNPVRTAFRDFQQLNRDFYSFVLDKFLRHRSSLRPGAAPRDMMDAFIHTVPRLDLEYVPATVTDIFGASQDTLSTALQWLLILFTRYPEVQARVQEELDRVVGRDRLPCMDDQPHLPYVMAFLYEAMRFSSFVPVTIPHATTADTSIMGYHIPKDTVVFVNQWSVNHDPVKWPNPEDFNPARFLDKNGFINKDLASSVMIFSVGKRRCIGEELSKMQLFLFISILAHQCNFRANPDEDSKMDFSYGLTIKPKSFTINVTLRST 6oyv B 3.101 BS01 EST B 1 F134 G329 A330 L509 F73 G256 A257 L430 0004497,0005506,0016705,0020037 32156703 601 PPGPFPWPPHLSFARLARRYGDVFQIRLGSCPVVVLNGERAIRQALVQQGAAFAGRPPFPSFQVVSGGRSLAFGRYSERWKVQRRVAHSTVRAFSTGQPRSRRVLEQHVLGEARELVRLLVRGSAGGAFLDPAPLTVVAVANVMSAVCFGCRYSHDDAEFRGLLSHNEKFGRTVGAGSLVDVLPWLQRFPNPVRTAFRDFQQLNRDFYSFVLDKFLRHRSSLRPGAAPRDMMDAFIHTVPRLDLEYVPATVTDIFGASQDTLSTALQWLLILFTRYPEVQARVQEELDRVVGRDRLPCMDDQPHLPYVMAFLYEAMRFSSFVPVTIPHATTADTSIMGYHIPKDTVVFVNQWSVNHDPVKWPNPEDFNPARFLNKDLASSVMIFSVGKRRCIGEELSKMQLFLFISILAHQCNFRANPDEDSKMDFSYGLTIKPKSFTINVTLRST 6pit A 2.25 BS01 EST A 1 L346 E353 L387 G521 H524 L525 L30 E37 L71 G199 H202 L203 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 31523967 601 ALSLTADQMVSALLDAEPPILYSASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKVPLSDLLLEMLDAH 6pit B 2.25 BS02 EST B 1 L346 E353 L387 M421 H524 L525 L29 E36 L70 M104 H195 L196 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 31523967 601 LSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH 6pyf A 1.73 BS02 EST A 1 S42 G58 D65 F67 N82 K134 I141 S29 G45 D52 F54 N69 K121 I128 ? IC50=50nM, Kd=1.5nM P04278 31852737 302 PAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAKISASAPTSLRSC 7axi A 2.15 BS01 EST A 1 D205 S247 F251 H407 R410 L411 M425 D47 S89 F93 H245 R248 L249 M263 ? 0003677,0004879,0006355 O75469 33361153 501 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS 7axj A 2.3 BS02 EST A 1 D205 L206 S247 F251 H407 R410 L411 D50 L51 S92 F96 H248 R251 L252 ? 0003677,0004879,0006355 O75469 33361153 502 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGSL 7axk A 2.0 BS01 EST A 1 D205 S247 F251 H407 R410 L411 D47 S89 F93 H245 R248 L249 ? 0003677,0004879,0006355 O75469 33361153 501 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS 7axl A 2.5 BS01 EST A 1 D205 M243 S247 F251 H407 R410 L411 D48 M86 S90 F94 H250 R253 L254 ? 0003677,0004879,0006355 O75469 33361153 501 VQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS 7nel A 1.45 BS02 EST A 1 E353 F404 H524 L525 E49 F100 H218 L219 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 34006920 601 SLALSLTADQIISALLEAEPPILYSEYDPSRPFSEAYMMGLLTNLADRELVHMINWAKKVPGFVDLSLHDQVHLLESAWLEILMIGLVWRSMDHPGKLLFAPDLLLDREQGKSVEGMVEIFDMLLATSERFREMKLQREEFVCLKAIILLNSGVYTFSTLKSLENKEKIHRMLDKITDALIWYMAKSGLSLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKSKNVVPLSDLLLEMLDAHR 7nel B 1.45 BS02 EST B 1 E353 L387 F404 H524 L525 E50 L84 F101 H221 L222 ? IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM P03372 34006920 601 NSLALSLTADQIISALLEAEPPILYSEYDPSRPFSEAYMMGLLTNLADRELVHMINWAKKVPGFVDLSLHDQVHLLESAWLEILMIGLVWRSMDHPGKLLFAPDLLLDREQGKSVEGMVEIFDMLLATSERFREMKLQREEFVCLKAIILLNSGVYTFLSSTLKSLENKEKIHRMLDKITDALIWYMAKSGLSLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKSKNVVPLSDLLLEMLDAHR 8fw0 A 2.37 BS01 EST A 1 F88 T91 F95 W136 L170 F74 T77 F81 W122 L156 ? 0003677 P39897 38326294 301 LKTKEHLMLAALETFYRKGIARTSLNEIAQAAGVTRGALYWHFKNKEDLFDALFQRICDDIENCIAQGGSWTVFRHTLLHFFERLQSNDIHYKFHNILFLKCEHTEQNAAVIAIARKHQAIWREKITAVLTEAVENQDLADDLDKETAVIFIKSTLDGLIWRWFSSGESFDLGKTAPRIIGIMMDNLENHPCLRR 8fw0 B 2.37 BS01 EST B 1 F88 T91 F95 K139 I140 F75 T78 F82 K126 I127 ? 0003677 P39897 38326294 301 KTKEHLMLAALETFYRKGIARTSLNEIAQAAGVTRGALYWHFKNKEDLFDALFQRICDDIENCIAQDAGGSWTVFRHTLLHFFERLQSNDIHYKFHNILFLKCEHTEQNAAVIAIARKHQAIWREKITAVLTEAVENQDLADDLDKETAVIFIKSTLDGLIWRWFSSGESFDLGKTAPRIIGIMMDNLENHPCLRR 8fw0 C 2.37 BS01 EST C 1 T91 F95 W136 I140 L170 D171 T76 F80 W121 I125 L155 D156 ? 0003677 P39897 38326294 302 LKTKEHLMLAALETFYRKGIARTSLNEIAQAAGVTRGALYWHFKNKEDLFDALFQRICDDIENCIAGGSWTVFRHTLLHFFERLQSNDIHYKFHNILFLKCEHTEQNAAVIAIARKHQAIWREKITAVLTEAVENQDLADDLDKETAVIFIKSTLDGLIWRWFSSGESFDLGKTAPRIIGIMMDNLENHPCLRRK 8fw0 D 2.37 BS01 EST D 1 T91 L92 F95 W136 I140 L170 T74 L75 F78 W119 I123 L153 ? 0003677 P39897 38326294 301 KTKEHLMLAALETFYRKGIARTSLNEIAQAAGVTRGALYWHFKNKEDLFDALFQRICDDIENCIGGSWTVFRHTLLHFFERLQSNDIHYKFHNILFLKCEHTEQNAAVIAIARKHQAIWREKITAVLTEAVENQDLADDLDKETAVIFIKSTLDGLIWRWFSSGESFDLGKTAPRIIGIMMDNLENHPCLRRK 8rh4 A 2.52 BS01 EST A 1 S334 P336 S260 P262 P24046 511 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 A 2.52 BS02 EST A 2 N332 R337 N258 R263 P24046 514 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 B 2.52 BS01 EST A 2 S334 P336 S260 P262 P24046 514 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 B 2.52 BS02 EST B 1 N332 R337 S339 N258 R263 S265 P24046 511 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 C 2.52 BS01 EST B 1 S334 P336 S260 P262 P24046 511 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 C 2.52 BS02 EST C 1 N332 R337 S339 N258 R263 S265 P24046 512 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 D 2.52 BS01 EST C 1 S334 P336 S260 P262 P24046 512 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 D 2.52 BS02 EST D 1 N332 R337 S339 N258 R263 S265 P24046 502 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 E 2.52 BS01 EST A 1 N332 R337 S339 N258 R263 S265 P24046 511 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh4 E 2.52 BS02 EST D 1 S334 P336 S260 P262 P24046 502 SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh7 A 2.78 BS01 EST B 1 N332 S339 N248 S255 P24046 609 DFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh7 B 2.78 BS01 EST C 1 N332 S339 N248 S255 P24046 609 DFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh7 C 2.78 BS01 EST D 1 N332 S339 N248 S255 P24046 712 DFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh7 D 2.78 BS01 EST E 1 N332 S339 N248 S255 P24046 711 DFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS 8rh7 E 2.78 BS01 EST A 1 N332 S339 N248 S255 P24046 508 DFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS