1nfz A 1.97 BS03 EIP A 1 K21 R51 K55 C67 G68 H69 R83 Y104 E114 E116 K18 R48 K52 C64 G65 H66 R80 Y101 E111 E113 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 12540835 301 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFT 1nfz B 1.97 BS03 EIP B 1 K21 R51 K55 C67 G68 H69 R83 Y104 E114 E116 W161 K18 R48 K52 C64 G65 H66 R80 Y101 E111 E113 W158 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 12540835 302 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFTQLKL 1ow2 A 2.0 BS03 EIP A 1 K21 R51 A67 G68 H69 R83 E114 E116 W161 K18 R48 A64 G65 H66 R80 E111 E113 W158 H25 H32 A67 H69 E87 Y104 E114 E116 W161 H22 H29 A64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 14696183 301 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVAGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFT 1ow2 B 2.0 BS03 EIP B 1 K21 R51 A67 G68 H69 R83 E114 E116 K18 R48 A64 G65 H66 R80 E111 E113 H25 H32 A67 H69 E87 Y104 E114 E116 W161 H22 H29 A64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 14696183 301 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVAGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFTQLKL 1ppw A 2.21 BS03 EIP A 1 K21 R51 K55 C67 G68 H69 Y104 E114 E116 W161 K18 R48 K52 C64 G65 H66 Y101 E111 E113 W158 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 ic50~50uM -logKd/Ki=4.30, IC50=50uM Q46822 15643873 301 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFT 1ppw B 2.21 BS03 EIP B 1 K21 R51 C67 G68 H69 R83 Y104 E116 W161 K18 R48 C64 G65 H66 R80 Y101 E113 W158 H25 H32 C67 H69 E87 Y104 E114 E116 W161 H22 H29 C64 H66 E84 Y101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 ic50~50uM Q46822 15643873 301 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFTQLKL 2b2k A 1.97 BS03 EIP A 1 K21 R51 C67 G68 H69 R83 E114 E116 K18 R48 C64 G65 H66 R80 E111 E113 H25 H32 C67 H69 E87 F104 E114 E116 W161 H22 H29 C64 H66 E84 F101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 16617181 401 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRFRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFT 2b2k B 1.97 BS03 EIP B 1 K21 R51 C67 H69 R83 E114 E116 W161 K18 R48 C64 H66 R80 E111 E113 W158 H25 H32 C67 H69 E87 F104 E114 E116 W161 H22 H29 C64 H66 E84 F101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 16617181 401 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRFRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFTQLKL 2g73 A 1.97 BS03 EIP A 1 K21 A34 R51 C67 G68 H69 E114 E116 W161 K18 A31 R48 C64 G65 H66 E111 E113 W158 H25 H32 C67 H69 E87 F104 E114 E116 W161 H22 H29 C64 H66 E84 F101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 16617181 186 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRFRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFT 2g73 B 1.97 BS03 EIP B 1 K21 R51 C67 G68 H69 R83 F104 E114 E116 W161 K18 R48 C64 G65 H66 R80 F101 E111 E113 W158 H25 H32 C67 H69 E87 F104 E114 E116 W161 H22 H29 C64 H66 E84 F101 E111 E113 W158 5.3.3.2 0000287,0003824,0004452,0005737,0006974,0008270,0008299,0016853,0046872,0050992 Q46822 16617181 186 EHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRFRATDPSGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLHGIDATPWAFSPWMVMQATNREARKRLSAFTQLKL 3ke8 A 1.7 BS02 EIP A 1 V40 H41 A73 H74 H124 E126 T167 T168 S225 S226 N227 S269 V40 H41 A73 H74 H124 E126 T167 T168 S225 S226 N227 S269 1.17.7.4 0005829,0008299,0016114,0016491,0019288,0042380,0046872,0050992,0051538,0051539,0051745 P62623 20080550 998 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELR 3ke8 B 1.7 BS02 EIP B 1 V40 H41 A73 H74 H124 E126 T167 S225 S226 N227 S269 V40 H41 A73 H74 H124 E126 T167 S225 S226 N227 S269 1.17.7.4 0005829,0008299,0016114,0016491,0019288,0042380,0046872,0050992,0051538,0051539,0051745 P62623 20080550 998 MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEVPKELRV