6d8x A 1.9 BS01 EDK A 1 F282 G284 C285 Q286 S289 H323 Y327 L330 I341 F363 M364 H449 Y473 F81 G83 C84 Q85 S88 H122 Y126 L129 I140 F162 M163 H248 Y272 ? 0003677,0004879,0005634,0006355 Ki=1.4nM, EC50=6.2nM P37231 501 GQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6d94 A 1.9 BS02 EDK A 1 F282 G284 C285 Q286 S289 H323 L330 I341 M348 F363 M364 H449 Y473 F76 G78 C79 Q80 S83 H117 L124 I135 M142 F157 M158 H243 Y267 ? 0003677,0004879,0005634,0006355 Ki=1.4nM, EC50=6.2nM P37231 36469765 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6fzf A 1.95 BS02 EDK A 1 I309 F310 G312 C313 Q314 S317 H351 Y355 L358 I369 M376 F391 M392 H477 L497 Y501 I75 F76 G78 C79 Q80 S83 H117 Y121 L124 I135 M142 F157 M158 H243 L263 Y267 ? 0003677,0004879,0005634,0006355 Ki=1.4nM, EC50=6.2nM P37231 30651555 4000 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVMEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6fzf B 1.95 BS02 EDK B 1 F310 G312 C313 Q314 S317 H351 I354 Y355 L358 I369 F391 M392 H477 Y501 F80 G82 C83 Q84 S87 H121 I124 Y125 L128 I139 F161 M162 H247 Y271 ? 0003677,0004879,0005634,0006355 Ki=1.4nM, EC50=6.2nM P37231 30651555 4000 QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVMEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6fzg A 2.1 BS01 EDK A 1 F310 G312 C313 Q314 S317 H351 I369 F388 F391 H477 L493 L497 Y501 F81 G83 C84 Q85 S88 H122 I140 F159 F162 H248 L264 L268 Y272 ? 0003677,0004879,0005634,0006355 -logKd/Ki=6.55, Kd=0.28uM Ki=1.4nM, EC50=6.2nM P37231 30651555 550 MQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKMKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6fzj A 2.011 BS02 EDK A 1 F310 C313 Q314 S317 H351 L358 I369 M376 F391 M392 H477 L497 Y501 F72 C75 Q76 S79 H113 L120 I131 M138 F153 M154 H239 L259 Y263 ? 0003677,0004879,0005634,0006355 Ki=1.4nM, EC50=6.2nM P37231 30651555 550 ADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDINSLMMGEDKIKFKHITPEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6fzj B 2.011 BS02 EDK B 1 F292 F310 C313 Q314 S317 H351 Y355 L358 I369 M376 F391 M392 H477 Y501 F60 F75 C78 Q79 S82 H116 Y120 L123 I134 M141 F156 M157 H242 Y266 ? 0003677,0004879,0005634,0006355 Ki=1.4nM, EC50=6.2nM P37231 30651555 550 NPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDINSLMMGEDKIKFKHITPLQKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6fzp A 2.3 BS02 EDK A 1 F310 G312 C313 Q314 S317 H351 I369 M376 F391 M392 H477 L497 Y501 F63 G65 C66 Q67 S70 H104 I122 M129 F144 M145 H230 L250 Y254 ? 0003677,0004879,0005634,0006355 Ki=1.4nM, EC50=6.2nM P37231 30651555 550 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTSPFVIYDMNSLMMGEDKIKFEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6t1s A 1.65 BS01 EDK A 1 S310 G312 C313 S317 H351 I369 F388 F391 M392 H477 L497 Y501 S79 G81 C82 S86 H120 I138 F157 F160 M161 H246 L266 Y270 ? 0003677,0004879,0005634,0006355 EC50=130nM, Ki=0.049700nM P37231 601 MQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRISQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6t1v A 2.21 BS02 EDK A 1 F310 G312 C313 Q314 S317 H351 I369 F391 M392 H477 Y501 F73 G75 C76 Q77 S80 H114 I132 F154 M155 H240 Y264 ? 0003677,0004879,0005634,0006355 EC50=130nM, Ki=0.049700nM P37231 4000 DLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLYPLLQEIYKDLY 6vzl A 2.07 BS01 EDK A 1 F282 C285 Q286 R288 S289 H323 Y327 L330 I341 S342 F363 M364 H449 Y473 F61 C64 Q65 R67 S68 H102 Y106 L109 I120 S121 F142 M143 H228 Y252 ? 0003677,0004879,0005634,0006355 EC50=130nM, Ki=0.049700nM P37231 33713599 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGTDKSPFVIYDMNSLMMGEDKIEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYK 6vzl B 2.07 BS01 EDK B 1 R280 G284 C285 F287 R288 S289 L330 I341 S342 E343 R56 G60 C61 F63 R64 S65 L106 I117 S118 E119 ? 0003677,0004879,0005634,0006355 EC50=130nM, Ki=0.049700nM P37231 33713599 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTKSPFVIYDMNSLMMGEDKIEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETHPLLQEIYKDL 7jqg A 2.15 BS01 EDK A 1 G284 C285 F287 R288 S289 L330 I341 S342 G60 C61 F63 R64 S65 L106 I117 S118 ? 0003677,0004879,0005634,0006355 EC50=130nM, Ki=0.049700nM P37231 33713599 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTTDKSPFVIYDMNSLMMGEKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIEK 7jqg B 2.15 BS01 EDK B 1 F264 G284 C285 F287 R288 I341 S342 F53 G63 C64 F66 R67 I120 S121 ? 0003677,0004879,0005634,0006355 EC50=130nM, Ki=0.049700nM P37231 33713599 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILDKSPFVIYDMNSLMMGEDKIKFKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETHPLLQEIEK 7rle A 2.5 BS02 EDK A 1 F282 G284 C285 Q286 S289 H323 I341 M348 F363 M364 H449 Y473 F67 G69 C70 Q71 S74 H108 I126 M133 F148 M149 H234 Y258 ? 0003677,0004879,0005634,0006355 P37231 36469765 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 7rle C 2.5 BS02 EDK C 1 F282 C285 Q286 S289 H323 Y327 F363 H449 L465 L469 Y473 F68 C71 Q72 S75 H109 Y113 F149 H235 L251 L255 Y259 ? 0003677,0004879,0005634,0006355 P37231 36469765 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 9ck0 A 2.6 BS02 EDK A 1 F282 G284 C285 S289 H323 L330 I341 F363 H449 Y473 F75 G77 C78 S82 H116 L123 I134 F156 H242 Y266 P37231 501 SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 9cwn A 2.7 BS02 EDK A 1 F310 G312 C313 Q314 S317 H351 L358 I369 M376 F391 M392 H477 L497 Y501 F72 G74 C75 Q76 S79 H113 L120 I131 M138 F153 M154 H239 L259 Y263 P37231 601 SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY