6bku A 2.0 BS01 DXV A 1 I171 G174 V179 A192 K194 F267 L269 V270 P274 L319 D330 I13 G16 V21 A34 K36 F86 L88 V89 P93 L138 D149 D312 K314 N317 D330 T350 D131 K133 N136 D149 T169 2.7.11.17 0004672,0005524,0006468 IC50=7.9nM Q96RR4 501 SMQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 6cd6 A 2.2 BS01 DXV A 1 I134 G137 V142 A155 K157 F230 L232 L233 G236 P237 L282 D293 I10 G13 V18 A31 K33 F85 L87 L88 G91 P92 L137 D148 D275 K277 N280 D293 T313 D130 K132 N135 D148 T168 2.7.11.17 0004672,0005524,0006468 Q8N5S9 501 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 6cd6 B 2.2 BS01 DXV B 1 I134 G137 V142 A155 K157 F230 L232 L233 G236 P237 L282 D293 I12 G15 V20 A33 K35 F86 L88 L89 G92 P93 L138 D149 D275 K277 N280 D293 T313 D131 K133 N136 D149 T169 2.7.11.17 0004672,0005524,0006468 Q8N5S9 501 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 6cd6 C 2.2 BS01 DXV C 1 I134 G137 V142 A155 K157 F230 L232 L233 G236 P237 L282 D293 I11 G14 V19 A32 K34 F85 L87 L88 G91 P92 L137 D148 D275 K277 N280 D293 T313 D130 K132 N135 D148 T168 2.7.11.17 0004672,0005524,0006468 Q8N5S9 501 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 6cd6 D 2.2 BS01 DXV D 1 I134 G137 V142 A155 K157 F230 L232 L233 G236 P237 L282 D293 I12 G15 V20 A33 K35 F86 L88 L89 G92 P93 L138 D149 D275 K277 N280 D293 T313 D131 K133 N136 D149 T169 2.7.11.17 0004672,0005524,0006468 Q8N5S9 501 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK