2o7o A 1.89 BS01 DXT A 1 H64 S67 N82 F86 H100 R104 P105 V113 Q116 S138 H63 S66 N81 F85 H99 R103 P104 V112 Q115 S137 ? 0000976,0003677,0003700,0006355,0045892,0046677,0046872 P0ACT4 17361981 222 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPAAPDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 2xrl A 1.85 BS01 DXT A 1 H64 S67 N82 F86 H100 P105 V113 Q116 I134 S138 H63 S66 N81 F85 H99 P104 V112 Q115 I133 S137 ? 0000976,0003677,0003700,0006355,0045892,0046677,0046872 P0ACT4 32114262 1211 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGARPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPAAPDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 5om2 A 1.47 BS01 DXT B 1 L273 A274 F277 D278 L251 A252 F255 D256 ? 0003677,0004867,0005515,0005576,0005615,0005634,0006953,0006954,0010466,0019216,0030277,0031093,0034774,0035578,0062023,0070062,0072562 -logKd/Ki=4.06, Kd=86.7uM P01011 29760101 501 DRGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKFEMPFDPQDTHQSRFYLSKKKYVMVPMMSLHHLTIPYFRDEELSCTVVQLNYTGNASALFILPDQDKMEEVEAMLSQETLARFFDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATALEVLFQ 5om2 B 1.47 BS01 DXT B 1 H383 W386 H16 W19 ? -logKd/Ki=4.06, Kd=86.7uM P01011 29760101 501 TIVRFNRPFLMIIVDHFTWSIFFMSKVTNPK 5om3 A 2.0 BS01 DXT B 1 L273 S274 F277 D278 L248 S249 F252 D253 ? 0003677,0004867,0005515,0005576,0005615,0005634,0006953,0006954,0010466,0019216,0030277,0031093,0034774,0035578,0062023,0070062,0072562 -logKd/Ki=4.10, Kd=79.2uM P01011 29760101 501 VDRGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKFEMPFDPQDTHQSRFYLSKKKYVMVPMMSLHHLTIPYFRDEELSCTVVQLNYTGNASALFILPDQDKMEEVEAMLSQETLSRFFDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATALFIPLS 5om3 B 2.0 BS01 DXT B 1 H383 W386 H17 W20 ? -logKd/Ki=4.10, Kd=79.2uM P01011 29760101 501 RTIVRFNRPFLMIIVDHFTWSIFFMSKVTNPKQ 6rbl A 1.9 BS01 DXT A 1 H64 S67 N82 F86 H100 P105 V113 Q116 I134 S138 H63 S66 N81 F85 H99 P104 V112 Q115 I133 S137 ? 0000976,0003677,0003700,0006355,0045892,0046677,0046872 P0ACT4 32114262 301 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLAQQEHTAALTDRDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 6rcr A 2.05 BS01 DXT A 1 H64 S67 N82 F86 P105 Q116 I134 H63 S66 N81 F85 P104 Q115 I133 ? 0000976,0003677,0003700,0006355,0045892,0046677,0046872 P0ACT4 32114262 301 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVALGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTADENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 6rgx B 1.8 BS01 DXT B 1 H64 F86 H100 P105 Q116 H63 F85 H99 P104 Q115 ? 0000976,0003677,0003700,0006355,0045892,0046677,0046872 P0ACT4 32114262 301 SRLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNAAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV 7b8r C 2.1 BS01 DXT C 1 Q176 F178 G179 N274 I277 F615 Q139 F141 G142 N237 I240 F340 ? 0016020,0022857,0055085 P31224 34824229 901 SAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVEATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSY 7b8r C 2.1 BS02 DXT C 2 F136 V139 F178 Y327 M573 F610 F615 F617 F628 F99 V102 F141 Y290 M298 F335 F340 F342 F353 ? 0016020,0022857,0055085 P31224 34824229 902 SAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVEATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSY 7x5p A 3.4 BS01 DXT A 1 D147 W331 D128 W312 ? 0006811,0009279,0015288,0016020,0034220,0046872,0046930 L0RVU0 401 EVYGIIAMQAAYRDYDSGDAKQDDNLGGMQLNNESRIGFRGKKQFANFEPTFIWQIEGGYVDPSFGGEGAGLGERDTFVGFESASWGQVRLGRVLTPMYELVDWPASNPGLGDVYDWGGAIGGAKYQDRQSNTIRWDSPMYADKFSIDAAVGAGDKAGLGAGDDYWGGIAAHYKLGPLQLDAAYEGNRNIEAEGQTWENNTYLVGVQGWFENGISFFAQYKYMEADASNGVNEKQDAMSAGLMYTTGDWQYKLGYAANFDLERDGKTLSNTSDDVVSAQIMYFVDPSAVLYARARMNDFNEGLDGLDDAARWTSGTNGDYNEYSVGVEYYF 7x5p B 3.4 BS01 DXT B 1 Y79 Y118 W136 D147 R148 Y60 Y99 W117 D128 R129 ? 0006811,0009279,0015288,0016020,0034220,0046872,0046930 L0RVU0 401 EVYGIIAMQAAYRDYDSGDAKQDDNLGGMQLNNESRIGFRGKKQFANFEPTFIWQIEGGYVDPSFGGEGAGLGERDTFVGFESASWGQVRLGRVLTPMYELVDWPASNPGLGDVYDWGGAIGGAKYQDRQSNTIRWDSPMYADKFSIDAAVGAGDKAGLGAGDDYWGGIAAHYKLGPLQLDAAYEGNRNIEAEGQTWENNTYLVGVQGWFENGISFFAQYKYMEADASNGVNEKQDAMSAGLMYTTGDWQYKLGYAANFDLERDGKTLSNTSDDVVSAQIMYFVDPSAVLYARARMNDFNEGLDGLDDAARWTSGTNGDYNEYSVGVEYYF 7x5p D 3.4 BS01 DXT D 1 Y118 W136 D147 R148 W331 Y99 W117 D128 R129 W312 ? 0006811,0009279,0015288,0016020,0034220,0046872,0046930 L0RVU0 401 EVYGIIAMQAAYRDYDSGDAKQDDNLGGMQLNNESRIGFRGKKQFANFEPTFIWQIEGGYVDPSFGGEGAGLGERDTFVGFESASWGQVRLGRVLTPMYELVDWPASNPGLGDVYDWGGAIGGAKYQDRQSNTIRWDSPMYADKFSIDAAVGAGDKAGLGAGDDYWGGIAAHYKLGPLQLDAAYEGNRNIEAEGQTWENNTYLVGVQGWFENGISFFAQYKYMEADASNGVNEKQDAMSAGLMYTTGDWQYKLGYAANFDLERDGKTLSNTSDDVVSAQIMYFVDPSAVLYARARMNDFNEGLDGLDDAARWTSGTNGDYNEYSVGVEYYF 7x5p F 3.4 BS01 DXT F 1 W136 D147 W117 D128 ? 0006811,0009279,0015288,0016020,0034220,0046872,0046930 L0RVU0 401 EVYGIIAMQAAYRDYDSGDAKQDDNLGGMQLNNESRIGFRGKKQFANFEPTFIWQIEGGYVDPSFGGEGAGLGERDTFVGFESASWGQVRLGRVLTPMYELVDWPASNPGLGDVYDWGGAIGGAKYQDRQSNTIRWDSPMYADKFSIDAAVGAGDKAGLGAGDDYWGGIAAHYKLGPLQLDAAYEGNRNIEAEGQTWENNTYLVGVQGWFENGISFFAQYKYMEADASNGVNEKQDAMSAGLMYTTGDWQYKLGYAANFDLERDGKTLSNTSDDVVSAQIMYFVDPSAVLYARARMNDFNEGLDGLDDAARWTSGTNGDYNEYSVGVEYYF