1di8 A 2.2 BS01 DTQ A 1 I10 A31 K33 F80 F82 L83 H84 L134 D145 I10 A31 K33 F74 F76 L77 H78 L128 D139 D127 K129 Q131 N132 D145 T165 D121 K123 Q125 N126 D139 T150 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 ic50=1uM -logKd/Ki=6.00, IC50=1uM IC50=1000nM P24941 10633045 500 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 3nyv A 1.88 BS01 DTQ A 1 G58 A78 K80 M112 Y131 L181 D195 G17 A37 K39 M71 Y90 L140 D154 D174 K176 E178 N179 D195 T214 D133 K135 E137 N138 D154 T173 2.7.11.17 0004672,0004674,0004683,0005509,0005516,0005524,0005634,0005737,0006468,0009931,0016020,0016310,0018105,0035556,0046777,0046872 Q9BJF5 701 HSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLKLCGN 4btk A 2.0 BS01 DTQ A 1 I72 K87 E101 C115 M131 L133 Q134 D200 I24 K39 E53 C67 M83 L85 Q86 D152 2.7.11.1 0004672,0005524,0006468 Kd=0.24uM -logKd/Ki=6.62, Kd=0.24uM Kd=240nM Q5TCY1 24039150 1337 DILPANYVVKDRWKVLKKIGGGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWE 5amn A 2.57 BS01 DTQ A 1 L730 V738 A756 K758 E775 V804 A807 G810 L881 D892 L29 V37 A55 K57 E74 V103 A106 G109 L160 D171 D874 A876 R878 N879 D892 D153 A155 R157 N158 D171 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=8.35, IC50=4.5nM IC50=380nM P07949 26874741 2018 GPLSLSVDAFKIDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMV 6u0k A 1.744 BS01 DTQ A 1 F32 I35 K50 E64 M94 L96 Q97 D163 F24 I27 K42 E56 M86 L88 Q89 D155 2.7.11.1 0004672,0004674,0005524,0006468 Q6IQ55 302 LDILSVGILVKERWKVLRKIGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWE 6u0k B 1.744 BS01 DTQ B 1 I27 F32 I35 K50 E64 M94 L96 Q97 D163 I20 F25 I28 K43 E57 M87 L89 Q90 D156 2.7.11.1 0004672,0004674,0005524,0006468 Q6IQ55 303 LDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEK