1a4q A 1.9 BS02 DPC A 1 R115 E116 D148 W176 I220 R222 A244 E274 E275 R291 N293 R373 Y408 R40 E41 D73 W101 I145 R147 A169 E199 E200 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=3.6uM -logKd/Ki=5.44, IC50=3.6uM P27907 9526556 466 EPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL 1a4q B 1.9 BS02 DPC B 1 R115 E116 D148 R149 I220 R222 A244 E274 E275 R291 N293 R373 Y408 R40 E41 D73 R74 I145 R147 A169 E199 E200 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=3.6uM P27907 9526556 466 EPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL 1bji A 2.0 BS02 DPC A 1 R118 E119 D151 I222 R224 A246 E276 E277 R292 N294 R371 Y406 R37 E38 D70 I142 R144 A166 E196 E197 R212 N214 R290 Y324 D151 E277 R292 R371 Y406 D70 E197 R212 R290 Y324 3.2.1.18 0004308,0005975,0016020,0033644,0046761,0055036 ic50=0.002uM -logKd/Ki=8.70, IC50=2nM P03472 9526556 479G RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSCYGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPNALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL