1lke A 1.9 BS01 DOG A 1 Q28 Y39 Y47 R58 H86 F114 W129 L131 Q24 Y35 Y43 R54 H82 F110 W120 L122 ? 0000302,0005576,0005737,0006629,0006950,0031409 Kd=30.2nM -logKd/Ki=7.52, Kd=30.2nM P09464 12823976 500 DGACPEVKPVDNFDWSQYHGKWWQVAAYPDHITKYGKCGWAEYTPEGKSVKVSRYSVIHGKEYFSEGTAYPVGDSKIGKIYHSYTIGGVTQEGVFNVLSTDNKNYIIGYFCSYGHMDLVWVLSRSMVLTGEAKTAVENYLIGSPVVDSQKLVYSDFS 3ra7 H 2.798 BS01 DOG L 1 W47 Y57 Y110 M112 W47 Y57 Y110 M112 21536919 3123 EVQLVESGGGLVKPGGSLKLSCAVSGFTFSDYAMSWIRQTPENRLEWVASINIGATYAYYPDSVKGRFTISRDNAKNTLFLQMSSLGSEDTAMYYCARPGSPYEYDKAYYSMAYWGPGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPR 3ra7 I 2.798 BS01 DOG M 1 Y57 Y110 Y57 Y110 21536919 3123 EVQLVESGGGLVKPGGSLKLSCAVSGFTFSDYAMSWIRQTPENRLEWVASINIGATYAYYPDSVKGRFTISRDNAKNTLFLQMSSLGSEDTAMYYCARPGSPYEYDKAYYSMAYWGPGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPR 3ra7 M 2.798 BS01 DOG M 1 Q89 S91 Q89 S91 21536919 3123 DVQMTQSTSSLSASLGDRVTISCRASQDIKNYLNWYQQKPGGTVKLLIYYSSTLLSGVPSRFSGRGSGTDFSLTITNLEREDIATYFCQQSITLPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR 4j8t A 2.05 BS01 DOG A 1 L14 Y34 H54 F58 Y101 Y115 L117 V124 L14 Y34 H54 F58 Y101 Y115 L117 V124 ? Kd=168nM -logKd/Ki=6.77, Kd=168nM Kd=474nM Q9HYR3 24005320 201 MNAKEIVVHALRLLENGDARGWCDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVHTVSGGKLAADYISVLRTRDGQILLYRLFFNPLRVLEPL 4j8t B 2.05 BS01 DOG B 1 L14 Y34 F58 Y101 Y115 L117 L13 Y33 F57 Y97 Y111 L113 ? Kd=168nM Kd=474nM Q9HYR3 24005320 201 NAKEIVVHALRLLENGDARGWCDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVHTVKLAADYISVLRTRDGQILLYRLFFNPLRVL 4j8t C 2.05 BS01 DOG C 1 L14 Y34 F58 Y101 Y115 L117 L14 Y34 F58 Y96 Y110 L112 ? Kd=168nM Kd=474nM Q9HYR3 24005320 201 MNAKEIVVHALRLLENGDARGWCDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVHKLAADYISVLRTRDGQILLYRLFFNPLRVL 4j8t D 2.05 BS01 DOG D 1 L14 Y34 H54 F58 Y101 Y115 L117 L14 Y34 H54 F58 Y99 Y113 L115 ? Kd=168nM Kd=474nM Q9HYR3 24005320 201 MNAKEIVVHALRLLENGDARGWCDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVHSGGKLAADYISVLRTRDGQILLYRLFFNPLRVLEPL 4j9a A 3.2 BS01 DOG A 1 L14 Y34 Y41 M55 Y61 Y99 Y101 Y115 L117 L13 Y33 Y40 M54 Y60 Y98 Y100 Y114 L116 ? -logKd/Ki=8.22, Kd<6nM Kd=474nM Q9HYR3 24005320 201 NAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVLTASGGKLAYDYIAVWRTRDGQILLYRLFFNPLR 4j9a B 3.2 BS01 DOG B 1 Y34 Y41 M55 Y61 Y99 Y101 Y115 L117 Y33 Y40 M54 Y60 Y98 Y100 Y112 L114 ? Kd=474nM Q9HYR3 24005320 201 NAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVLTASGGKLAYDYIAVWRTRQILLYRLFFNPLRV 4j9a C 3.2 BS01 DOG C 1 Y34 Y41 H54 M55 F66 Y99 Y101 Y115 L117 F119 Y33 Y40 H53 M54 F65 Y98 Y100 Y114 L116 F118 ? Kd=474nM Q9HYR3 24005320 201 NAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVLTASGGKLAYDYIAVWRTRDGQILLYRLFFNPLR 4j9a D 3.2 BS01 DOG D 1 Y34 H54 M55 Y61 F66 Y99 Y101 Y34 H54 M55 Y61 F66 Y98 Y100 ? Kd=474nM Q9HYR3 24005320 201 MNAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVLTAGGKLAYDYIAVWRTRDGQILLYRLFFNPLRVL 4j9a E 3.2 BS01 DOG E 1 Y34 Y41 M55 Y99 Y101 L117 Y33 Y40 M54 Y89 Y91 L104 ? Kd=474nM Q9HYR3 24005320 201 NAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYDLAIGEFHGDGVLGKLAYDYIAVWRTQILLYRLFFNPLRV 4j9a F 3.2 BS01 DOG F 1 Y34 Y41 M55 Y99 Y101 L117 Y33 Y40 M54 Y96 Y98 L114 ? Kd=474nM Q9HYR3 24005320 201 NAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDGVLTASKLAYDYIAVWRTRDGQILLYRLFFNPLRVLE 4j9a G 3.2 BS01 DOG G 1 Y34 F84 Y101 Y33 F78 Y83 ? Kd=474nM Q9HYR3 24005320 201 NAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTVQFYETADPDLAIGEFHGDDYIAVWRTRDGQILLYRLFFNPLR 4j9a H 3.2 BS01 DOG H 1 Y34 Y41 Y61 Y99 Y101 Y115 L117 F119 Y33 Y40 Y60 Y89 Y91 Y105 L107 F109 ? Kd=474nM Q9HYR3 24005320 201 NAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTRFTDVQFYETADPDLAIGEFHGDGVAYDYIAVWRTRDGQILLYRLFFNPLR 4j9a I 3.2 BS01 DOG I 1 Y34 Y41 H54 Y101 Y115 L117 Y34 Y41 H54 Y89 Y103 L105 ? Kd=474nM Q9HYR3 24005320 201 MNAKEIVVHALRLLENGDARGWSDLFHPEGVLEYPYPPPGYKTRFEGRETIWAHMRLFPEYMTIRFTDVQFYETADPDLAIGEFHGDDYIAVWRTRDGQILLYRLFFNPLR 5bvb A 2.06 BS01 DOG A 1 L14 Y34 W41 M55 H58 W64 Y84 Y101 W119 L15 Y35 W42 M56 H59 W65 Y85 Y102 W120 Kd=0.498uM 26419257 201 SMNAKEILVHSLRLLENGDARGWCDLFHPEGVLEYPYAPPGWKTRFEGRETIWAHMRLHPEHVTWRFTDVQFYETADPDLAIGEYHGDGVVTVSGGKYAADYITVLRTRDGQILLLRVFWNPLRILEAAG 5bvb A 2.06 BS02 DOG C 1 A128 G129 A129 G130 Kd=0.498uM 26419257 201 SMNAKEILVHSLRLLENGDARGWCDLFHPEGVLEYPYAPPGWKTRFEGRETIWAHMRLHPEHVTWRFTDVQFYETADPDLAIGEYHGDGVVTVSGGKYAADYITVLRTRDGQILLLRVFWNPLRILEAAG 5bvb B 2.06 BS01 DOG B 1 L14 Y34 M55 W64 Y84 Y101 L15 Y35 M56 W65 Y85 Y102 Kd=0.498uM 26419257 201 SMNAKEILVHSLRLLENGDARGWCDLFHPEGVLEYPYAPPGWKTRFEGRETIWAHMRLHPEHVTWRFTDVQFYETADPDLAIGEYHGDGVVTVSGGKYAADYITVLRTRDGQILLLRVFWNPLRIL 5bvb C 2.06 BS01 DOG C 1 L14 Y34 W64 Y84 Y101 W119 L15 Y35 W65 Y85 Y102 W120 Kd=0.498uM 26419257 201 SMNAKEILVHSLRLLENGDARGWCDLFHPEGVLEYPYAPPGWKTRFEGRETIWAHMRLHPEHVTWRFTDVQFYETADPDLAIGEYHGDGVVTVSGGKYAADYITVLRTRDGQILLLRVFWNPLRILEAAG 5bvb D 2.06 BS01 DOG D 1 W64 Y84 Y101 W119 W67 Y87 Y104 W122 Kd=0.498uM 26419257 201 GSSMNAKEILVHSLRLLENGDARGWCDLFHPEGVLEYPYAPPGWKTRFEGRETIWAHMRLHPEHVTWRFTDVQFYETADPDLAIGEYHGDGVVTVSGGKYAADYITVLRTRDGQILLLRVFWNPLRI