4de3 A 1.44 BS01 DN8 A 1 N104 Y105 S130 N132 P167 N170 T235 G236 S237 G238 D240 N76 Y77 S102 N104 P139 N142 T207 G208 S209 G210 D211 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM -logKd/Ki=5.52, Ki=3.0uM Q9L5C8 22296601 301 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 A 1.44 BS02 DN8 A 2 N104 Y105 S237 N76 Y77 S209 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM -logKd/Ki=5.52, Ki=3.0uM Q9L5C8 22296601 302 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 A 1.44 BS03 DN8 A 3 A79 A150 F151 A154 A51 A122 F123 A126 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM -logKd/Ki=5.52, Ki=3.0uM Q9L5C8 22296601 303 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 A 1.44 BS04 DN8 A 4 I173 D176 I145 D148 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM -logKd/Ki=5.52, Ki=3.0uM Q9L5C8 22296601 304 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 A 1.44 BS05 DN8 A 5 R191 Q192 R163 Q164 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM -logKd/Ki=5.52, Ki=3.0uM Q9L5C8 22296601 305 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 A 1.44 BS06 DN8 A 6 S274 R276 S244 R246 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM -logKd/Ki=5.52, Ki=3.0uM Q9L5C8 22296601 306 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 B 1.44 BS01 DN8 B 1 N104 Y105 S130 N132 P167 N170 T235 G236 S237 D240 N77 Y78 S103 N105 P140 N143 T208 G209 S210 D212 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM Q9L5C8 22296601 301 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 B 1.44 BS02 DN8 B 2 N104 Y105 N77 Y78 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM Q9L5C8 22296601 302 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 B 1.44 BS03 DN8 B 3 K82 L142 G143 A150 F151 K55 L115 G116 A123 F124 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM Q9L5C8 22296601 303 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 B 1.44 BS04 DN8 B 4 G147 A150 R153 E158 G120 A123 R126 E131 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM Q9L5C8 22296601 304 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4de3 B 1.44 BS05 DN8 B 5 K111 H112 A125 K84 H85 A98 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=3uM Q9L5C8 22296601 305 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL