1i1e A 2.5 BS01 DM2 A 1 E1188 E1189 G1238 I1239 H1240 R1241 C1257 S1259 W1261 Y1262 E1185 E1186 G1235 I1236 H1237 R1238 C1254 S1256 W1258 Y1259 H229 E230 H233 E267 R369 H229 E230 H233 E267 R369 3.4.24.69 0004222,0005515,0005576,0006508,0008237,0008270,0008289,0008320,0016020,0020002,0030430,0035821,0044161,0044164,0044221,0044231,0046872,0071806,0090729 Kd=9.4uM -logKd/Ki=5.03, Kd=9.4uM P10844 11679763 3001 PVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQENKGASIFNRRGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCKSVGICIDVDNEDLFFIADKNSFSDDLSKNERIEYNTQSNYIENDFPINELILDTDLISKIELPSENTESLTDFNVDVPVYEKQPAIKKIFTDENTIFQYLYSQTFPLDIRDISLTSSFDDALLFSNKVYSFFSMDYIKTANKVVEAGLFAGWVKQIVNDFVIEANKSNTMDKIADISLIVPYIGLALNVGNETAKGNFENAFEIAGASILLEFIPELLIPVVGAFLLESYIDNKNKIIKTIDNALTKRNEKWSDMYGLIVAQWLSTVNTQFYTIKEGMYKALNYQAQALEEIIKYRYNIYSEKEKSNINIDFNDINSKLNEGINQAIDNINNFINGCSVSYLMKKMIPLAVEKLLDFDNTLKKNLLNYIDENKLYLIGSAEYEKSKVNKYLKTIMPFDLSIYTNDTILIEMFNKYNSEILNNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLTSSANSKIRVTQNQNIIFNSVFLDFSVSFWIRIPKYKNDGIQNYIHNEYTIINCMKNNSGWKISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRWFFVTITNNLNNAKIYINGKLESNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYFSIFNTELSQSNIEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSYIKLKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRRKSNSQSINDDIVRKEDYIYLDFFNLNQEWRVYTYKYFKKEEEKLFLAPISDSDEFYNTIQIKEYDEQPTYSCQLLFKKDEESTDEIGLIGIHRFYESGIVFEEYKDYFCISKWYLKEVKRKPYNLKLGCNWQFIPKDEGWTE 2dr6 A 3.3 BS01 DM2 A 1 S134 Q176 L177 F178 G179 F615 F617 S134 Q176 L177 F178 G179 F601 F603 ? 0005515,0005886,0009410,0009636,0015125,0015562,0015567,0015721,0015895,0015908,0016020,0022857,0042802,0042908,0042910,0042930,0042931,0046677,0055085,0098567,0140330,1990281 P31224 16915237 2002 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRK 4dx7 A 2.253 BS01 DM2 A 1 M575 F617 T676 R717 N719 E826 M862 M575 F617 T676 R717 N719 E826 M862 ? 0005515,0005886,0009410,0009636,0015125,0015562,0015567,0015721,0015895,0015908,0016020,0022857,0042802,0042908,0042910,0042930,0042931,0046677,0055085,0098567,0140330,1990281 P31224 22451937 1105 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEH 4dx7 A 2.253 BS02 DM2 A 2 F617 F664 F666 T676 F617 F664 F666 T676 ? 0005515,0005886,0009410,0009636,0015125,0015562,0015567,0015721,0015895,0015908,0016020,0022857,0042802,0042908,0042910,0042930,0042931,0046677,0055085,0098567,0140330,1990281 P31224 22451937 1106 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEH 4dx7 B 2.253 BS01 DM2 B 1 Q89 E130 Q176 F178 V612 F615 Q89 E130 Q176 F178 V612 F615 ? 0005515,0005886,0009410,0009636,0015125,0015562,0015567,0015721,0015895,0015908,0016020,0022857,0042802,0042908,0042910,0042930,0042931,0046677,0055085,0098567,0140330,1990281 P31224 22451937 1104 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRF 4zvm A 1.973 BS03 DM2 A 1 W105 G149 G150 M154 I194 W105 G149 G150 M154 I194 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=274nM P16083 26636353 303 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvm A 1.973 BS04 DM2 B 1 F126 F178 F126 F178 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=274nM P16083 26636353 303 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvm B 1.973 BS01 DM2 A 1 Q122 F126 F178 Q122 F126 F178 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=274nM P16083 26636353 303 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4zvm B 1.973 BS04 DM2 B 1 W105 G149 G150 I194 W105 G149 G150 I194 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=274nM P16083 26636353 303 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 5mra B 3.74 BS02 DM2 B 1 F134 R174 Q181 G182 F103 R143 Q150 G151 F95 G118 V120 F64 G87 V89 ? 0005509 -logKd/Ki=8.00, Kd=10nM P30626 28726784 204 MDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 5om7 A 1.727 BS01 DM2 A 1 Q242 L273 F277 E278 Q220 L251 F255 E256 ? 0003677,0004867,0005515,0005576,0005615,0005634,0006953,0006954,0010466,0019216,0030277,0031093,0034774,0035578,0062023,0070062,0072562 -logKd/Ki=5.74, Kd=1.8uM P01011 29760101 501 DRGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKFEMPFDPQDTHQSRFYLSKKKYVMVPMMSLHHLTIPYFRDEELSCTVVQLNYTGNASALFILPDQDKMEEVEAMLSQETLSRFFESLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATALEVLFQ 5om7 B 1.727 BS01 DM2 A 1 V381 N383 W386 V15 N17 W20 ? -logKd/Ki=5.74, Kd=1.8uM P01011 29760101 501 RTIVRFNRPFLMIIVDNFTWSIFFMSKVTNPKQ 6ftp A 1.8 BS01 DM2 B 1 L273 S274 F277 E278 L280 L248 S249 F252 E253 L255 ? 0003677,0004867,0005515,0005576,0005615,0005634,0006953,0006954,0010466,0019216,0030277,0031093,0034774,0035578,0062023,0070062,0072562 -logKd/Ki=5.82, Kd=1.5uM P01011 29760101 501 LASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKFEMPFDPQDTHQSRFYLSKKKYVMVPMMSLHHLTIPYFRDEELSCTVVQLNYTGNASALFILPDQDKMEEVEAMLSQETLSRFFESLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTERSAATALEVLFQ 6ftp B 1.8 BS01 DM2 B 1 V381 N383 W386 V15 N17 W20 ? -logKd/Ki=5.82, Kd=1.5uM P01011 29760101 501 RTIVRFNRPFLMIIVDNFTWSIFFMSKVTNPKQA 8r2j A 2.4 BS01 DM2 A 1 F106 E128 N132 F227 N231 F106 E128 N132 F227 N231 301 STILVTGATGNVGRNVVRQLAERGHDVRALTRRARPGAAPEGVRVQEGDLTHPKTLKDALEGVDALFLFPVAATAEEVVGMAKSAGVRRIVVLSSGAVTAGYDTDFHLPVERAVEASGLEWTHVRPGEFAMNKLALWGPPIRAERVVREPAPDAGWFPVHEQDIADVAVLALTEEGHAGQAYTLNGPELLTHRRQVELIADAMGEEIRLEVVTPQQAREIYLAQGGFAAENVDFLLGFEDYGSLGPMPTAEAVTGRPARTFAQWARDHADEFRA 8r2j A 2.4 BS02 DM2 A 2 A97 Y102 D103 W156 N231 F234 Y241 A97 Y102 D103 W156 N231 F234 Y241 302 STILVTGATGNVGRNVVRQLAERGHDVRALTRRARPGAAPEGVRVQEGDLTHPKTLKDALEGVDALFLFPVAATAEEVVGMAKSAGVRRIVVLSSGAVTAGYDTDFHLPVERAVEASGLEWTHVRPGEFAMNKLALWGPPIRAERVVREPAPDAGWFPVHEQDIADVAVLALTEEGHAGQAYTLNGPELLTHRRQVELIADAMGEEIRLEVVTPQQAREIYLAQGGFAAENVDFLLGFEDYGSLGPMPTAEAVTGRPARTFAQWARDHADEFRA 8r2j B 2.4 BS01 DM2 B 1 S95 E128 N132 F227 N231 S95 E128 N132 F227 N231 301 STILVTGATGNVGRNVVRQLAERGHDVRALTRRARPGAAPEGVRVQEGDLTHPKTLKDALEGVDALFLFPVAATAEEVVGMAKSAGVRRIVVLSSGAVTAGYDTDFHLPVERAVEASGLEWTHVRPGEFAMNKLALWGPPIRAERVVREPAPDAGWFPVHEQDIADVAVLALTEEGHAGQAYTLNGPELLTHRRQVELIADAMGEEIRLEVVTPQQAREIYLAQGGFAAENVDFLLGFEDYGGSLGPMPTAEAVTGRPARTFAQWARDHADEFRA 8r2j B 2.4 BS02 DM2 B 2 A97 Y102 D103 W156 N231 F234 Y241 A97 Y102 D103 W156 N231 F234 Y241 302 STILVTGATGNVGRNVVRQLAERGHDVRALTRRARPGAAPEGVRVQEGDLTHPKTLKDALEGVDALFLFPVAATAEEVVGMAKSAGVRRIVVLSSGAVTAGYDTDFHLPVERAVEASGLEWTHVRPGEFAMNKLALWGPPIRAERVVREPAPDAGWFPVHEQDIADVAVLALTEEGHAGQAYTLNGPELLTHRRQVELIADAMGEEIRLEVVTPQQAREIYLAQGGFAAENVDFLLGFEDYGGSLGPMPTAEAVTGRPARTFAQWARDHADEFRA