1n3i A 1.9 BS02 DIH A 1 Y92 A120 A121 G122 Y188 E189 V205 M207 N231 H243 Y86 A114 A115 G116 Y182 E183 V199 M201 N225 H237 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 6.3.2.1 0003824,0004731,0006139,0009116,0016763 Kd=1.3nM -logKd/Ki=8.89, Ki=1.3nM P9WIL5 12755607 401 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1n3i B 1.9 BS02 DIH B 1 Y92 A120 A121 G122 Y188 E189 V205 M207 N231 H243 Y86 A114 A115 G116 Y182 E183 V199 M201 N225 H237 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 6.3.2.1 0003824,0004731,0006139,0009116,0016763 Kd=1.3nM -logKd/Ki=8.89, Ki=1.3nM P9WIL5 12755607 402 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1n3i C 1.9 BS02 DIH C 1 H90 Y92 A120 A121 G122 Y188 E189 V205 M207 N231 H243 H84 Y86 A114 A115 G116 Y182 E183 V199 M201 N225 H237 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 6.3.2.1 0003824,0004731,0006139,0009116,0016763 Kd=1.3nM P9WIL5 12755607 403 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1rsz A 2.2 BS01 DIH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 V260 Y86 A114 A115 G116 F198 E199 V215 M217 N241 H255 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 2a0w A 2.28 BS01 DIH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 V260 Y86 A114 A115 G116 F198 E199 V215 M217 N241 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 G257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 G255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=270pM P00491 17407325 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANGEEVLAAGKQAAQKLEQFVSILMASIPL 2a0x A 2.28 BS01 DIH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 V260 Y86 A114 A115 G116 F198 E199 V215 M217 N241 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 F257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 F255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=950pM P00491 17407325 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANFEEVLAAGKQAAQKLEQFVSILMASIPL 2a0y A 2.28 BS01 DIH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 D257 V260 Y86 A114 A115 G116 F198 E199 V215 M217 N241 D255 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 D257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 D255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=900pM P00491 17407325 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANDEEVLAAGKQAAQKLEQFVSILMASIPL 2p4s A 2.2 BS02 DIH A 1 Y173 A201 A202 G203 F285 E286 I302 G303 M304 N328 H342 Y84 A112 A113 G114 F196 E197 I213 G214 M215 N239 H253 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 Ki=0.31nM -logKd/Ki=9.51, Ki=0.31nM A4Q998 17918964 401 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 2p4s B 2.2 BS02 DIH B 1 H171 Y173 A201 A202 G203 F285 E286 I302 M304 N328 H342 H82 Y84 A112 A113 G114 F196 E197 I213 M215 N239 H253 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 Ki=0.31nM A4Q998 17918964 403 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 2p4s C 2.2 BS02 DIH C 1 Y173 A201 A202 G203 F285 E286 I302 M304 N328 H342 Y84 A112 A113 G114 F196 E197 I213 M215 N239 H253 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 Ki=0.31nM -logKd/Ki=9.51, Ki=0.31nM A4Q998 17918964 402 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 3bgs A 2.099 BS01 DIH A 1 A116 A117 G118 F200 E201 V217 M219 N243 A116 A117 G118 F200 E201 V217 M219 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=380pM -logKd/Ki=9.42, Ki=380pM P00491 18154341 301 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 3occ A 1.7 BS01 DIH A 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 M63 S89 C90 G91 F158 V177 E178 M179 E180 D203 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H3 G19 R23 R42 E74 R86 S89 S202 D203 I205 R216 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 TPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ B 1.7 BS01 DIH B 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 M63 S89 C90 G91 F158 V177 E178 M179 E180 D203 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H3 G19 R23 R42 E74 R86 S89 S202 D203 I205 R216 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 TPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ C 1.7 BS01 DIH C 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 I207 M62 S88 C89 G90 F157 V176 E177 M178 E179 D202 I204 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H2 G18 R22 R41 E73 R85 S88 S201 D202 I204 R215 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 PHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ D 1.7 BS01 DIH D 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 ATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ E 1.7 BS01 DIH E 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 ATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ F 1.7 BS01 DIH A 1 H5 R44 H4 R43 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 ATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ F 1.7 BS02 DIH F 1 M65 S91 C92 F160 V179 E180 M181 E182 D205 I207 M64 S90 C91 F159 V178 E179 M180 E181 D204 I206 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 ATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3of3 A 1.83 BS01 DIH A 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 B 1.83 BS01 DIH B 1 M78 S104 C105 G106 F173 V192 E193 M194 E195 D218 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 B 1.83 BS02 DIH E 1 H18 R57 H4 R43 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 C 1.83 BS01 DIH C 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 D 1.83 BS01 DIH D 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQA 3of3 E 1.83 BS01 DIH E 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 F 1.83 BS01 DIH F 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 I220 M64 S90 C91 F159 V178 E179 M180 E181 D204 I206 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 G 1.83 BS01 DIH G 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 H 1.83 BS01 DIH H 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 I 1.83 BS01 DIH I 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 J 1.83 BS01 DIH J 1 M78 S104 C105 F173 V192 E193 M194 E195 M64 S90 C91 F159 V178 E179 M180 E181 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 K 1.83 BS01 DIH K 1 M78 S104 C105 F173 V192 E193 M194 E195 S217 D218 M64 S90 C91 F159 V178 E179 M180 E181 S203 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 L 1.83 BS01 DIH L 1 M78 S104 C105 F173 V192 E193 M194 E195 S217 D218 M64 S90 C91 F159 V178 E179 M180 E181 S203 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 8pqr A 1.586 BS01 DIH A 1 A9 S10 F14 P40 F41 V58 D62 D82 G84 V85 E88 A8 S9 F13 P39 F40 V57 D61 D81 G83 V84 E87 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQADLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLTGM 8pqr A 1.586 BS02 DIH C 1 D111 L119 M120 D110 L118 M119 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQADLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLTGM 8pqr B 1.586 BS01 DIH B 1 A9 S10 F14 P40 F41 V58 D62 D82 G84 V85 E88 A8 S9 F13 P39 F40 V57 D61 D81 G83 V84 E87 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQADLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLTGM 8pqr B 1.586 BS02 DIH D 1 D111 L119 M120 D110 L118 M119 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQADLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLTGM 8pqr C 1.586 BS01 DIH A 1 D111 N118 L119 M120 D110 N117 L118 M119 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQADLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLTGM 8pqr C 1.586 BS02 DIH C 1 A9 S10 F14 P40 F41 V58 D62 D82 G84 V85 E88 A8 S9 F13 P39 F40 V57 D61 D81 G83 V84 E87 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQADLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLTGM 8pqr D 1.586 BS01 DIH B 1 D111 L119 M120 D110 L118 M119 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQADLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLT 8pqr D 1.586 BS02 DIH D 1 S10 F14 P40 F41 N44 V58 D62 D82 G84 V85 E88 S9 F13 P39 F40 N43 V57 D61 D81 G83 V84 E87 ? 0009159,0016740,0046872,0070694 K9TVX3 38449528 201 KRKIIYLASPYGFSQQQKTLLLPPIVRALEALGIEVWEPFARNNQIDFSQADWAYRVAQADLQDVKNCDGIFAVVNGTPPDEGVMVELGMAIALNKAIFLFRDDFRRCSDNERYPLNLMLFAGLPEIGWENYYYTSVDEIQSHDKALYKWLT 8swq A 1.979 BS01 DIH A 1 A129 A130 G131 F213 E214 M232 N256 H281 V284 A125 A126 G127 F209 E210 M228 N252 H277 V280 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVSTVPGHSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swq B 1.979 BS01 DIH B 1 Y100 A129 A130 G131 F213 E214 M232 N256 H281 V284 Y88 A117 A118 G119 F185 E186 M204 N228 H253 V256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swq D 1.979 BS01 DIH D 1 Y100 A129 A130 G131 F213 E214 M232 N256 H281 V284 Y88 A117 A118 G119 F201 E202 M220 N244 H269 V272 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swq E 1.979 BS01 DIH E 1 Y100 A129 A130 G131 F213 E214 M232 N256 H281 V284 Y85 A114 A115 G116 F182 E183 M201 N225 H250 V253 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 EQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI