1h83 A 1.9 BS02 DIA A 1 E62 E170 F171 F403 N437 G438 Y439 E58 E166 F167 F399 N433 G434 Y435 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 Ki=300nM Ki=300nM O64411 11258887 590 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMC 1h83 B 1.9 BS02 DIA B 1 E62 F171 Y298 F403 N437 G438 Y439 E58 F167 Y294 F399 N433 G434 Y435 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 Ki=300nM Ki=300nM O64411 11258887 590 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYH 1h83 C 1.9 BS02 DIA C 1 E62 E170 F171 Y298 F403 N437 G438 Y439 E58 E166 F167 Y294 F399 N433 G434 Y435 E62 D195 K300 E58 D191 K296 1.5.3.14,1.5.3.15 0006598,0009505,0016491,0046208,0046592,0048046,0050660,0052893,0052896,0052897,0052900 Ki=300nM Ki=300nM O64411 11258887 590 PRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWVEGVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADSVEEMGEKLSATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILVPRWWSDRFYKGTFSNWPVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILINCAQKKMCKYH 2xmf A 1.5 BS01 DIA A 1 D14 E15 W34 D20 E21 W40 ? E9Q634 1055 GPLGSPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI 3bi5 A 2.5 BS02 DIA A 1 H67 F97 L173 W174 F359 Y450 H63 F93 L169 W170 F350 Y434 H67 H63 1.5.3.17 0003682,0005737,0006338,0015940,0016491,0046208,0046592,0050660,0052897,0052901,0052902,0052903,0052904 P50264 2841 SPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLTNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSMLERETSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVIDGMRANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLKLEHHH 3bi5 B 2.5 BS02 DIA B 1 H67 L173 W174 F359 Y450 G487 H60 L166 W167 F347 Y438 G475 H67 H60 1.5.3.17 0003682,0005737,0006338,0015940,0016491,0046208,0046592,0050660,0052897,0052901,0052902,0052903,0052904 P50264 2842 KKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLTNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSMLERETSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLKLEH 3wwx A 1.49 BS01 DIA A 1 F155 L248 G337 I338 H339 D362 F118 L211 G298 I299 H300 D323 S86 K89 S143 T145 H162 Y191 V197 S260 G340 S49 K52 S106 T108 H125 Y154 V160 S221 G301 ? E2RVJ1 26513520 401 PDHAATQQALEAAVADGVPGAVAQARDGRDRWTGTAGERGGDDRYRVGSITKTFTATVLLQLQAEGRIDLDDPVEKWLPGVVRGNGHDGRKITVRQLLNHTSGIYSYTEDPAFQAKVFGPGFLEHRYDTWTPKQLVAVAMAHEPDFTPGASWNYSNTNFVLAGMVIEKVTGRPYGKAVENRIIKPLKLRATTVPGTRSAMPEPSSPAYSKLSRNAPVHDVSTLNPSIAGAAGEMISDSRDLQTFYRALLQGRLLPKSALNEMTTTVQISPEYPNVGYGLGLMKDKLSCGVEVWGHGGGIHGSSSLAQVTRDGGHSLAGNFNADWAGDSQKVIEAEFCGTA