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BioLiP
Download all results in tab-seperated text for 58 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1d2s:A (1.55) BS02 DHT ? N/A P04278 10675319 PDBbind: -logKd/Ki=9.74, Kd=0.182nM
    BindingDB: IC50=3.8nM, Kd=0.182000nM
    2 1dht:A (2.24) BS01 DHT 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 10625652
    3 1f5f:A (1.7) BS04 DHT ? N/A P04278 10859323 BindingDB: IC50=3.8nM, Kd=0.182000nM
    4 1i37:A (2.0) BS01 DHT ? N/A P15207 11320241 PDBbind: -logKd/Ki=9.57, Ki=0.27nM
    BindingDB: IC50=3.1nM, EC50=0.97nM, Ki=0.43nM
    5 1i38:A (2.0) BS01 DHT ? N/A P15207 11320241 BindingDB: IC50=3.1nM, EC50=0.97nM, Ki=0.43nM
    6 1kdk:A (1.7) BS01 DHT ? N/A P04278 12054810 MOAD: Kd=0.9nM
    PDBbind: -logKd/Ki=9.05, Kd=0.9nM
    BindingDB: IC50=3.8nM, Kd=0.182000nM
    7 1kdm:A (2.35) BS02 DHT ? N/A P04278 12054810 BindingDB: IC50=3.8nM, Kd=0.182000nM
    8 1t5z:A (2.3) BS02 DHT ? N/A P10275 15563469 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    9 1t63:A (2.07) BS02 DHT ? N/A P10275 15563469 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    10 1t65:A (1.66) BS02 DHT ? N/A P10275 15563469 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    11 1t73:A (2.2) BS02 DHT ? N/A O97775 15328534
    12 1t74:A (2.0) BS02 DHT ? N/A O97775 15328534
    13 1t76:A (2.1) BS02 DHT ? N/A O97775 15328534
    14 1t79:A (1.8) BS02 DHT ? N/A O97775 15328534
    15 1t7f:A (1.6) BS02 DHT ? N/A O97775 15328534
    16 1t7m:A (1.6) BS02 DHT ? N/A O97775 15328534
    17 1t7r:A (1.4) BS02 DHT ? N/A O97775 15328534
    18 1t7t:A (1.7) BS01 DHT ? N/A O97775 15328534
    19 1xj7:A (2.7) BS02 DHT ? N/A P10275 15563469 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    20 2ama:A (1.9) BS01 DHT ? N/A P10275 16641486 PDBbind: -logKd/Ki=8.00, IC50=10nM
    BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    21 2pio:A (2.03) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    22 2pip:L (1.8) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    23 2piq:A (2.4) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    24 2pir:A (2.1) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    25 2pit:A (1.76) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    26 2piu:A (2.12) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    27 2piv:A (1.95) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    28 2piw:A (2.58) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    29 2pix:A (2.4) BS01 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    30 2pkl:A (2.49) BS02 DHT ? N/A P10275 17911242 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    31 2qpy:A (2.5) BS02 DHT ? N/A P19091 17911242 BindingDB: EC50=3.98nM, IC50=1.000000nM
    32 2z4j:A (2.6) BS02 DHT ? N/A P10275 18007036 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    33 3dey:X (1.7) BS01 DHT 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 N/A
    34 3klm:X (1.7) BS01 DHT 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 20172961
    35 3l3x:A (1.55) BS02 DHT ? N/A P10275 20086010 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    36 3l3z:A (2.0) BS02 DHT ? N/A P10275 20086010 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    37 4k7a:A (2.44) BS01 DHT ? N/A P10275 N/A BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    38 4oea:A (2.12) BS01 DHT ? N/A P10275 25091737 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    39 4oed:A (2.79) BS02 DHT ? N/A P10275 25091737 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    40 4oey:A (1.83) BS02 DHT ? N/A P10275 25091737 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    41 4oez:A (1.8) BS02 DHT ? N/A P10275 25091737 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    42 4ofr:A (2.26) BS02 DHT ? N/A P10275 25091737 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    43 4ofu:A (2.12) BS02 DHT ? N/A P10275 25091737 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    44 5jjm:A (2.15) BS03 DHT ? N/A P10275 28165461 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    45 5jjm:B (2.15) BS03 DHT ? N/A P10275 28165461 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    46 5jjm:C (2.15) BS03 DHT ? N/A P10275 28165461 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    47 5jjm:D (2.15) BS03 DHT ? N/A P10275 28165461 BindingDB: IC50=>10000nM, EC50=6nM, Ki=0.2nM
    48 7rae:A (2.098) BS02 DHT N/A N/A N/A N/A
    49 7ztv:A (1.94) BS01 DHT ? N/A P15207 36921044
    50 7ztx:A (1.89) BS01 DHT ? N/A P10275 36921044
    51 7ztz:A (1.4) BS01 DHT ? N/A P10275 36921044
    52 7zu1:A (1.68) BS01 DHT ? N/A P10275 36921044
    53 7zu2:A (1.74) BS01 DHT ? N/A P10275 36921044
    54 8fgy:A (2.2) BS01 DHT ? N/A P10275 36995121
    55 8fgz:A (1.61) BS01 DHT ? N/A P10275 36995121
    56 8fh0:A (1.59) BS01 DHT ? N/A P10275 36995121
    57 8fh1:A (1.69) BS01 DHT ? N/A P10275 36995121
    58 8fh2:A (1.59) BS01 DHT ? N/A P10275 36995121
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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