1d2s A 1.55 BS02 DHT A 1 S41 S42 D65 F67 N82 L171 S29 S30 D53 F55 N70 L153 ? -logKd/Ki=9.74, Kd=0.182nM IC50=3.8nM, Kd=0.182000nM P04278 10675319 301 PPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSC 1dht A 2.24 BS01 DHT A 1 V143 L149 P187 Y218 H221 S222 E282 V283 V143 L149 P187 Y218 H221 S222 E282 V283 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 10625652 400 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVF 1f5f A 1.7 BS04 DHT A 1 S41 S42 D65 F67 N82 V105 M107 S29 S30 D53 F55 N70 V93 M95 ? IC50=3.8nM, Kd=0.182000nM P04278 10859323 253 PPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSC 1i37 A 2.0 BS01 DHT A 1 L704 N705 L707 Q711 M745 M749 F764 M780 T877 M895 L33 N34 L36 Q40 M74 M78 F93 M109 T206 M224 ? -logKd/Ki=9.57, Ki=0.27nM IC50=3.1nM, EC50=0.97nM, Ki=0.43nM P15207 11320241 201 IFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 1i38 A 2.0 BS01 DHT A 1 L704 N705 L707 Q711 M745 F764 A877 F891 M895 L33 N34 L36 Q40 M74 F93 A206 F220 M224 ? IC50=3.1nM, EC50=0.97nM, Ki=0.43nM P15207 11320241 201 IFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFAFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1kdk A 1.7 BS01 DHT A 1 S41 S42 D65 F67 N82 L171 S30 S31 D54 F56 N71 L160 ? Kd=0.9nM -logKd/Ki=9.05, Kd=0.9nM IC50=3.8nM, Kd=0.182000nM P04278 12054810 301 DPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSC 1kdm A 2.35 BS02 DHT A 1 T40 S41 S42 D65 F67 N82 K134 M139 T29 S30 S31 D54 F56 N71 K123 M128 ? IC50=3.8nM, Kd=0.182000nM P04278 12054810 301 DPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSC 1t5z A 2.3 BS02 DHT A 1 L701 L704 N705 L707 M745 M749 F764 T877 L33 L36 N37 L39 M77 M81 F96 T209 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 15563469 931 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t63 A 2.07 BS02 DHT A 1 L704 N705 Q711 M749 F764 T877 L36 N37 Q43 M81 F96 T209 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 15563469 931 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t65 A 1.66 BS02 DHT A 1 L704 N705 Q711 M749 F764 M780 T877 L36 N37 Q43 M81 F96 M112 T209 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 15563469 931 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 1t73 A 2.2 BS02 DHT A 1 L704 N705 M745 M749 F764 T877 L36 N37 M77 M81 F96 T209 ? O97775 15328534 200 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t74 A 2.0 BS02 DHT A 1 L701 L704 N705 Q711 M745 M749 F764 T877 L32 L35 N36 Q42 M76 M80 F95 T208 ? O97775 15328534 200 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t76 A 2.1 BS02 DHT A 1 L704 N705 Q711 M745 M749 F764 T877 L35 N36 Q42 M76 M80 F95 T208 ? O97775 15328534 200 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t79 A 1.8 BS02 DHT A 1 L704 N705 Q711 M745 M749 F764 T877 L36 N37 Q43 M77 M81 F96 T209 ? O97775 15328534 200 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t7f A 1.6 BS02 DHT A 1 L704 N705 Q711 M749 F764 T877 L36 N37 Q43 M81 F96 T209 ? O97775 15328534 200 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t7m A 1.6 BS02 DHT A 1 L704 N705 Q711 M745 M749 F764 T877 M895 L35 N36 Q42 M76 M80 F95 T208 M226 ? O97775 15328534 200 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t7r A 1.4 BS02 DHT A 1 L704 N705 Q711 M749 F764 T877 L36 N37 Q43 M81 F96 T209 ? O97775 15328534 300 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1t7t A 1.7 BS01 DHT A 1 L701 L704 N705 Q711 M745 M749 F764 T877 M895 L33 L36 N37 Q43 M77 M81 F96 T209 M227 ? O97775 15328534 300 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 1xj7 A 2.7 BS02 DHT A 1 L704 N705 L707 M745 M749 F764 T877 L42 N43 L45 M83 M87 F102 T215 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 15563469 931 HIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2ama A 1.9 BS01 DHT A 1 L704 N705 M745 M749 F764 T877 M895 L34 N35 M75 M79 F94 T201 M219 ? -logKd/Ki=8.00, IC50=10nM IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 16641486 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIATSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 2pio A 2.03 BS01 DHT A 1 L704 N705 M745 M749 F764 T877 L34 N35 M75 M79 F94 T207 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2pip L 1.8 BS01 DHT L 1 L704 N705 M745 F764 T877 L35 N36 M76 F95 T208 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2piq A 2.4 BS01 DHT A 1 L704 N705 M745 M749 F764 T877 L35 N36 M76 M80 F95 T208 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2pir A 2.1 BS01 DHT A 1 L704 N705 M745 T877 L36 N37 M77 T209 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2pit A 1.76 BS01 DHT A 1 L704 N705 M745 M749 F764 T877 L36 N37 M77 M81 F96 T209 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2piu A 2.12 BS01 DHT A 1 L701 L704 N705 Q711 M745 M749 F764 T877 L31 L34 N35 Q41 M75 M79 F94 T207 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2piv A 1.95 BS01 DHT A 1 L704 N705 M745 M749 F764 T877 L35 N36 M76 M80 F95 T208 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2piw A 2.58 BS01 DHT A 1 L704 N705 M745 F764 T877 L34 N35 M75 F94 T207 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2pix A 2.4 BS01 DHT A 1 L701 L704 N705 M745 M749 F764 T877 L31 L34 N35 M75 M79 F94 T207 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2pkl A 2.49 BS02 DHT A 1 L704 N705 L707 Q711 M749 F764 T877 L35 N36 L38 Q42 M80 F95 T208 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 17911242 931 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2qpy A 2.5 BS02 DHT A 1 L704 N705 M745 M749 F764 T877 L34 N35 M75 M79 F94 T207 ? EC50=3.98nM, IC50=1.000000nM P19091 17911242 931 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 2z4j A 2.6 BS02 DHT A 1 L704 N705 Q711 M745 M749 F764 T877 L34 N35 Q41 M75 M79 F94 T207 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 18007036 931 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 3dey X 1.7 BS01 DHT X 1 V143 P187 H221 S222 V225 V143 P187 H214 S215 V218 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 732 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVF 3klm X 1.7 BS01 DHT X 1 V143 P187 H221 S222 V225 V143 P187 H214 S215 V218 1.1.1.51,1.1.1.62 0003824,0004303,0005496,0005515,0005737,0005829,0006629,0006694,0006703,0007040,0007519,0008210,0010467,0016491,0030283,0035410,0036094,0042803,0047035,0047045,0050661,0060348,0060612,0061370,0070401,0071248,0072582,1903924 P14061 20172961 732 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVF 3l3x A 1.55 BS02 DHT A 1 L701 L704 N705 Q711 M745 M749 F764 T877 M895 L33 L36 N37 Q43 M77 M81 F96 T209 M227 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 20086010 1 SQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 3l3z A 2.0 BS02 DHT A 1 L701 L704 N705 Q711 M749 F764 T877 L33 L36 N37 Q43 M81 F96 T208 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 20086010 1 SQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 4k7a A 2.44 BS01 DHT A 1 L704 N705 L707 Q711 M745 T877 L35 N36 L38 Q42 M76 T201 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 1001 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 4oea A 2.12 BS01 DHT A 1 L701 L704 N705 Q711 M745 M749 F764 T877 L32 L35 N36 Q42 M76 M80 F95 T201 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 25091737 1001 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 4oed A 2.79 BS02 DHT A 1 L701 L704 N705 Q711 M742 M749 F764 T877 L32 L35 N36 Q42 M73 M80 F95 T201 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 25091737 1002 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 4oey A 1.83 BS02 DHT A 1 L701 L704 N705 Q711 M745 F764 T877 L31 L34 N35 Q41 M75 F94 T200 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 25091737 1002 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 4oez A 1.8 BS02 DHT A 1 L701 L704 N705 Q711 M745 M749 F764 T877 L32 L35 N36 Q42 M76 M80 F95 T201 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 25091737 1002 QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 4ofr A 2.26 BS02 DHT A 1 L704 N705 Q711 M745 F764 T877 L34 N35 Q41 M75 F94 T202 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 25091737 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIAPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 4ofu A 2.12 BS02 DHT A 1 L704 N705 Q711 F764 T877 L34 N35 Q41 F94 T200 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 25091737 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 5jjm A 2.15 BS03 DHT A 1 L701 L704 N705 Q711 M745 M749 T877 L34 L37 N38 Q44 M78 M82 T210 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 28165461 1001 ECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 5jjm B 2.15 BS03 DHT B 1 L701 L704 N705 Q711 F764 T877 L33 L36 N37 Q43 F96 T209 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 28165461 1001 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 5jjm C 2.15 BS03 DHT C 1 L701 L704 N705 L707 Q711 M745 M749 F764 T877 L34 L37 N38 L40 Q44 M78 M82 F97 T210 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 28165461 1001 ECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 5jjm D 2.15 BS03 DHT D 1 L701 L704 N705 Q711 M745 M749 F764 T877 L33 L36 N37 Q43 M77 M81 F96 T209 ? IC50=>10000nM, EC50=6nM, Ki=0.2nM P10275 28165461 1001 CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 7rae A 2.098 BS02 DHT A 1 L704 N705 Q711 F764 F876 T877 L38 N39 Q45 F98 F210 T211 1001 SNAIPIFLSVLQSIEPEVVYAGYDNTQPDTSASLLTSLNELGERQLVRVVKWAKALPGFRNLHVDDQMTLIQYSWMGVMVFAMGWRSYKNVNSRMLYFAPDLVFNEQRMQKSTMYNLCVRMRHLSQEFVWLQVTQEEFLCMKALLLFSIIPVEGLKNQKYFDELRMNYIKELDRVISFQGKNPTSSSQRFYQLTKLLDSLQPIVRKLHQFTFDLFVQSQSLSVEFPEMMSEIISAQVPKILAGMVKPLLFH 7ztv A 1.94 BS01 DHT A 1 L705 N706 L708 Q712 M746 M750 F765 T878 L34 N35 L37 Q41 M75 M79 F94 T201 ? P15207 36921044 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSLTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 7ztx A 1.89 BS01 DHT A 1 L705 N706 Q712 M746 M750 F765 T878 L34 N35 Q41 M75 M79 F94 T201 ? P10275 36921044 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSVTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT 7ztz A 1.4 BS01 DHT A 1 L702 L705 N706 Q712 M750 F765 T878 M896 L31 L34 N35 Q41 M79 F94 T201 M219 ? P10275 36921044 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLCFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 7zu1 A 1.68 BS01 DHT A 1 L705 N706 M746 M750 F765 T878 L34 N35 M75 M79 F94 T203 ? P10275 36921044 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNANSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 7zu2 A 1.74 BS01 DHT A 1 L702 L705 N706 M746 M750 F765 T878 L31 L34 N35 M75 M79 F94 T200 ? P10275 36921044 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLEITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 8fgy A 2.2 BS01 DHT A 1 L705 N706 Q712 M750 F765 M896 L34 N35 Q41 M79 F94 M219 ? P10275 36995121 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALHSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACSCSRRFYQLTKLLDSVQPIARELYQLAFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 8fgz A 1.61 BS01 DHT A 1 L705 N706 Q712 M750 F765 T878 L34 N35 Q41 M79 F94 T203 ? P10275 36995121 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALHSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACPTSCSRRFYQLTKLLDSVQPIARELYQLTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 8fh0 A 1.59 BS01 DHT A 1 L705 N706 Q712 M750 F765 M896 L34 N35 Q41 M79 F94 M219 ? P10275 36995121 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACSCSRRFYQLTKLLDSVQPIARELYQLAFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 8fh1 A 1.69 BS01 DHT A 1 L705 N706 Q712 M750 F765 M896 L34 N35 Q41 M79 F94 M219 ? P10275 36995121 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACSCSRRFYQLTKLLDSVQPIARELHQLAFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH 8fh2 A 1.59 BS01 DHT A 1 L705 N706 Q712 M750 F765 T878 L34 N35 Q41 M79 F94 T205 ? P10275 36995121 1001 PIFLNVLEAIEPGVVCAGHDNNQPDSFAALHSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRPTSCSRRFYQLTKLLDSVQPIARELYQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH