1s9p A 2.13 BS01 DES A 1 L268 A272 E275 L309 V313 Y326 H434 F435 I438 L36 A40 E43 L77 V81 Y94 H202 F203 I206 ? P62509 15161930 459 PYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMH 1s9p B 2.13 BS01 DES B 1 A272 E275 L309 V313 Y326 H434 F435 I438 A39 E42 L76 V80 Y93 H201 F202 I205 ? P62509 15161930 459 YNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLF 1s9p C 2.13 BS01 DES C 1 L268 C269 A272 E275 L309 V313 Y326 H434 F435 I438 L35 C36 A39 E42 L76 V80 Y93 H201 F202 I205 ? P62509 15161930 500 YNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLE 1s9p D 2.13 BS01 DES D 1 E275 L309 V313 Y326 A431 H434 F435 I438 E42 L76 V80 Y93 A198 H201 F202 I205 ? P62509 15161930 600 YNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV 1tt6 A 1.8 BS01 DES A 1 K15 L17 A109 L110 K6 L8 A100 L101 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 15469931 129 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 1tt6 B 1.8 BS01 DES B 1 L17 A109 L110 S117 L8 A100 L101 S108 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 15469931 128 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 1tz8 A 1.85 BS01 DES B 1 L17 A109 L110 S117 L8 A100 L101 S108 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 15469931 128 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 1tz8 B 1.85 BS01 DES B 1 K15 L17 A109 L110 S117 K6 L8 A100 L101 S108 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 15469931 128 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 1tz8 C 1.85 BS01 DES C 1 L17 A108 L110 S117 L8 A99 L101 S108 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 15469931 129 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNP 1tz8 D 1.85 BS01 DES D 1 K15 L17 A109 L110 S117 K6 L8 A100 L101 S108 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 15469931 128 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 3erd A 2.03 BS02 DES A 1 M343 E353 L387 M421 H524 L525 M39 E49 L83 M117 H220 L221 ? -logKd/Ki=9.90, Ki=0.126nM Ki=0.128000nM, IC50=0.330000nM, EC50=0.110000nM P03372 9875847 600 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL 3erd B 2.03 BS03 DES B 1 M343 E353 M421 H524 L525 M39 E49 M117 H212 L213 ? Ki=0.128000nM, IC50=0.330000nM, EC50=0.110000nM P03372 9875847 800 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL 4zn7 A 1.934 BS02 DES A 1 M343 A350 E353 L387 F404 M421 H524 M39 A46 E49 L83 F100 M117 H210 ? Ki=0.128000nM, IC50=0.330000nM, EC50=0.110000nM P03372 27107013 601 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 4zn7 B 1.934 BS02 DES B 1 M343 A350 E353 L387 F404 M421 H524 L525 M39 A46 E49 L83 F100 M117 H212 L213 ? Ki=0.128000nM, IC50=0.330000nM, EC50=0.110000nM P03372 27107013 600 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR