1k0u A 3.0 BS02 DEA A 1 H54 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 H53 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 1433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u B 3.0 BS03 DEA B 1 H54 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 F361 H53 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 F360 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 2433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u C 3.0 BS02 DEA C 1 H54 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 M357 F361 H53 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 M356 F360 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 3433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u D 3.0 BS03 DEA D 1 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 M357 F361 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 M356 F360 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 4433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u E 3.0 BS02 DEA E 1 T56 E58 T59 D130 E155 T156 K185 D189 L346 G351 H352 M357 T55 E57 T58 D129 E154 T155 K184 D188 L345 G350 H351 M356 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 5433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u F 3.0 BS03 DEA F 1 T56 E58 D130 E155 T156 K185 D189 L346 G351 H352 M357 T55 E57 D129 E154 T155 K184 D188 L345 G350 H351 M356 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 6433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u G 3.0 BS02 DEA G 1 T56 E58 D130 E155 T156 K185 D189 L346 G351 H352 T55 E57 D129 E154 T155 K184 D188 L345 G350 H351 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 7433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 1k0u H 3.0 BS03 DEA H 1 T56 E58 E155 K185 D189 L346 H352 M357 T55 E57 E154 K184 D188 L345 H351 M356 H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364 H53 S76 S81 D129 E154 N179 K184 D188 N189 C193 H299 H351 S359 Q363 3.13.2.1 0001666,0002439,0004013,0005507,0005634,0005737,0005783,0005829,0006730,0007584,0016787,0019510,0030554,0033353,0042470,0042745,0042802,0051287,0098604 IC50=30nM P10760 11741948 8433 DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY 5jpi A 2.15 BS02 DEA A 1 H53 T55 E57 E211 T212 K241 D245 L404 G409 H410 M415 H54 T56 E58 E212 T213 K242 D246 L405 G410 H411 M416 H53 S76 S81 D137 E211 N236 K241 D245 N246 C250 H356 H410 S418 Q422 H54 S77 S82 D138 E212 N237 K242 D246 N247 C251 H357 H411 S419 Q423 3.13.2.1 0000166,0004013,0005829,0006730,0016787,0033353 Q5CPH1 502 AYKMESRIKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEIRWCSCNIYSTQDHAAAALVKKNIATVFAWKNETIEDYWVCLNDAMTWRNPNDKDKICGPNLIVDDGGDATLILHEGVKAEIEYEKYNKIPEYLETELDENGKQLSMDLKCMYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCKGRLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKSRELVDRSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRY 5jpi B 2.15 BS03 DEA B 1 H53 T55 E57 E211 T212 K241 D245 L404 G409 H410 M415 H50 T52 E54 E207 T208 K237 D241 L400 G405 H406 M411 H53 S76 S81 D137 E211 N236 K241 D245 N246 C250 H356 H410 S418 Q422 H50 S73 S78 D133 E207 N232 K237 D241 N242 C246 H352 H406 S414 Q418 3.13.2.1 0000166,0004013,0005829,0006730,0016787,0033353 Q5CPH1 502 ESRIKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEIRWCSCNIYSTQDHAAAALVKKNIATVFAWKNETIEDYWVCLNDAMTWRNPNKDKICGPNLIVDDGGDATLILHEGVKAEIEYEKYNKIPEYLETELDENGKQLSMDLKCMYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCKGRLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKSRELVDRSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRY 5jpi C 2.15 BS02 DEA C 1 H53 T55 E57 E211 T212 K241 D245 L404 G409 H410 M415 H53 T55 E57 E208 T209 K238 D242 L401 G406 H407 M412 H53 S76 S81 D137 E211 N236 K241 D245 N246 C250 H356 H410 S418 Q422 H53 S76 S81 D134 E208 N233 K238 D242 N243 C247 H353 H407 S415 Q419 3.13.2.1 0000166,0004013,0005829,0006730,0016787,0033353 Q5CPH1 502 YKMESRIKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEIRWCSCNIYSTQDHAAAALVKKNIATVFAWKNETIEDYWVCLNDAMTWRNPDKICGPNLIVDDGGDATLILHEGVKAEIEYEKYNKIPEYLETELDENGKQLSMDLKCMYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCKGRLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKSRELVDRSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRY 5jpi D 2.15 BS03 DEA D 1 H53 T55 E57 E211 T212 K241 D245 L404 G409 H410 M415 H51 T53 E55 E207 T208 K237 D241 L400 G405 H406 M411 H53 S76 S81 D137 E211 N236 K241 D245 N246 C250 H356 H410 S418 Q422 H51 S74 S79 D133 E207 N232 K237 D241 N242 C246 H352 H406 S414 Q418 3.13.2.1 0000166,0004013,0005829,0006730,0016787,0033353 Q5CPH1 502 MESRIKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEIRWCSCNIYSTQDHAAAALVKKNIATVFAWKNETIEDYWVCLNDAMTWRNPKDKICGPNLIVDDGGDATLILHEGVKAEIEYEKYNKIPEYLETELDENGKQLSMDLKCMYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCKGRLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKSRELVDRSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRY