1b5d A 2.2 BS01 DCM A 1 K28 C148 R168 S169 N170 D171 D179 H216 Y218 K28 C148 R168 S169 N170 D171 D179 H216 Y218 E60 C148 D179 E60 C148 D179 2.1.2.8 0016740,0047153 P08773 10064578 300 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGKYA 1b5d A 2.2 BS02 DCM B 1 R123 R124 R123 R124 E60 C148 D179 E60 C148 D179 2.1.2.8 0016740,0047153 P08773 10064578 400 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGKYA 1b5d B 2.2 BS01 DCM A 1 R123 R124 R123 R124 E60 C148 D179 E60 C148 D179 2.1.2.8 0016740,0047153 P08773 10064578 300 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGKYA 1b5d B 2.2 BS02 DCM B 1 K28 Y96 C148 R168 S169 N170 D171 D179 H216 Y218 K28 Y96 C148 R168 S169 N170 D171 D179 H216 Y218 E60 C148 D179 E60 C148 D179 2.1.2.8 0016740,0047153 P08773 10064578 400 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGKYA 1b5e A 1.6 BS01 DCM A 1 K28 Y96 C148 R168 S169 N170 D171 D179 H216 Y218 K28 Y96 C148 R168 S169 N170 D171 D179 H216 Y218 E60 C148 D179 E60 C148 D179 2.1.2.8 0016740,0047153 P08773 10064578 300 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDY 1b5e A 1.6 BS02 DCM B 1 R123 R124 R123 R124 E60 C148 D179 E60 C148 D179 2.1.2.8 0016740,0047153 P08773 10064578 400 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDY 1b5e B 1.6 BS01 DCM A 1 R123 R124 R123 R124 E60 C148 D179 E60 C148 D179 2.1.2.8 0016740,0047153 P08773 10064578 300 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDY 1b5e B 1.6 BS02 DCM B 1 K28 Y96 C148 R168 S169 N170 D171 D179 H216 Y218 K28 Y96 C148 R168 S169 N170 D171 D179 H216 Y218 E60 C148 D179 E60 C148 D179 2.1.2.8 0016740,0047153 P08773 10064578 400 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDY 1nja A 2.5 BS01 DCM A 1 R23 L195 C198 H199 R218 S219 A220 D221 H259 Y261 R23 L195 C198 H199 R218 S219 A220 D221 H259 Y261 E60 W82 Y146 C198 R218 D221 E60 W82 Y146 C198 R218 D221 2.1.1.45 0004799,0005737,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Kd=0.49uM -logKd/Ki=6.31, Kd=0.49uM P00469 8611496 317 MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEEMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFCIASYALLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIKLLNYDPYPAIKAPVAV 1njc A 2.5 BS01 DCM A 1 R23 Q217 R218 S219 A220 D221 D229 H259 R23 Q217 R218 S219 A220 D221 D229 H259 E60 W82 Y146 C198 R218 D221 E60 W82 Y146 C198 R218 D221 2.1.1.45 0004799,0005737,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Kd=2.8uM -logKd/Ki=5.55, Kd=2.8uM P00469 8611496 317 MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEEMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFDIASYALLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIKLLNYDPYPAIKAPVAV 1nje A 2.3 BS01 DCM A 1 R23 R218 S219 A220 D221 N229 H259 Y261 R23 R218 S219 A220 D221 N229 H259 Y261 E60 W82 Y146 C198 R218 D221 E60 W82 Y146 C198 R218 D221 2.1.1.45 0004799,0005737,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Kd=160uM -logKd/Ki=3.80, Kd=160uM P00469 8611496 317 MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEEMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIKLLNYDPYPAIKAPVAV 2jat A 2.6 BS02 DCM A 1 V9 K13 Y42 Y43 Q54 R78 D83 F86 E150 V9 K13 Y42 Y43 Q54 R75 D80 F83 E138 2.7.1.113 0004138,0005524,0005737,0006139,0009157,0016301,0016310,0019136 Q93IG4 17229440 1205 MKIAIFGTVGAGKSTISAEISKKLGYEIFKEPVEENPYFEQYYKDLKKTVFKMQIYMLTARSKQLKQLENIIFDRTLLEDPIFMKVNYDLNNVDQTDYNTYIDFYNNVVLLSFDIVIYLRVSTKTAISRIKKRGRSEELLIGEEYWETLNKNYEEFYKQNVYDFPFFVVDAELDVKTQIELIMNKLNSIK 2jat B 2.6 BS02 DCM B 1 V9 K13 Y42 Y43 Q54 R78 D83 F86 E150 V9 K13 Y42 Y43 Q54 R78 D83 F86 E141 2.7.1.113 0004138,0005524,0005737,0006139,0009157,0016301,0016310,0019136 Q93IG4 17229440 1204 MKIAIFGTVGAGKSTISAEISKKLGYEIFKEPVEENPYFEQYYKDLKKTVFKMQIYMLTARSKQLKQAKNLENIIFDRTLLEDPIFMKVNYDLNNVDQTDYNTYIDFYNNVVLLSFDIVIYLRVSTKTAISRIKKRGRSEELLIGEEYWETLNKNYEEFYKQNVYDFPFFVVDAELDVKTQIELIMNKLNSI 2qrn A 3.4 BS03 DCM A 1 I30 E53 W58 Y86 F96 R128 F137 E197 I11 E34 W39 Y54 F64 R96 F105 E165 E53 R128 E34 R96 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 18084067 403 RIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 2qrn B 3.4 BS03 DCM B 1 I30 E53 W58 Y86 R128 F137 E197 I11 E34 W39 Y54 R96 F105 E165 E53 R128 E34 R96 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 18084067 403 RIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 2qrn C 3.4 BS03 DCM C 1 I30 E53 Y86 F96 Q97 R128 F137 E197 I11 E34 Y54 F64 Q65 R96 F105 E165 E53 R128 E34 R96 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 18084067 403 RIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 2qrn D 3.4 BS03 DCM D 1 I30 E53 W58 Y86 F96 Q97 R128 D133 F137 E197 I11 E34 W39 Y54 F64 Q65 R96 D101 F105 E165 E53 R128 E34 R96 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 18084067 403 RIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4p9c A 2.6 BS02 DCM A 1 H40 W42 G44 T45 S47 N71 K75 H41 W43 G45 T46 S48 N72 K76 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c B 2.6 BS02 DCM B 1 H40 W42 G44 T45 S47 N71 K75 H41 W43 G45 T46 S48 N72 K76 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c C 2.6 BS02 DCM C 1 H40 W42 G44 T45 N71 H41 W43 G45 T46 N72 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c D 2.6 BS02 DCM D 1 H40 W42 G44 T45 S47 N71 H41 W43 G45 T46 S48 N72 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c E 2.6 BS02 DCM E 1 H40 G41 W42 G44 T45 S47 N71 H41 G42 W43 G45 T46 S48 N72 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c F 2.6 BS02 DCM F 1 H40 W42 G44 T45 S47 N71 H41 W43 G45 T46 S48 N72 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c G 2.6 BS02 DCM G 1 H40 W42 G44 T45 S47 N71 H41 W43 G45 T46 S48 N72 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c H 2.6 BS02 DCM H 1 H40 W42 G44 T45 S47 N71 H40 W42 G44 T45 S47 N71 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 MKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c I 2.6 BS02 DCM I 1 H40 G41 W42 G44 T45 S47 N71 H40 G41 W42 G44 T45 S47 N71 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 MKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c J 2.6 BS02 DCM J 1 H40 W42 G44 T45 S47 N71 H41 W43 G45 T46 S48 N72 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c K 2.6 BS02 DCM K 1 H40 W42 G44 T45 S47 N71 H41 W43 G45 T46 S48 N72 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 HMKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 4p9c L 2.6 BS02 DCM L 1 H40 W42 G44 T45 S47 N71 H40 W42 G44 T45 S47 N71 ? 0000166,0003824,0004132,0006220,0008270,0016787,0046872 H6WFU3 25404739 202 MKPEIKEAYMKTAELFSQVSNCKRMKVGAIVVKNGSILAHGWNGTPSGFHTNCCELEDGSTNPFVLHAEQNALVKMAKSSESIDGSELFCTHSPCPDCSKMIAQAGVKKVYYRNEYRITDGIDVLQQLGVEVEKM 5arl A 2.61 BS01 DCM A 1 H12 K40 F42 N43 T44 H116 F117 H14 K42 F44 N45 T46 H118 F119 H12 K40 H116 F117 D118 H14 K42 H118 F119 D120 3.1.27.- 0003676 P15468 26748441 1120 KMQDRMYQRFLRQHVDPDATGGNDAYCNLMMQRRKMTSHYCKRFNTFIHEDIWNIRSICSTSNIQCKNGQMNCHEGVVKVTACRETGSSRAPNCRYRAMASTRRVVIACEGNPEVPVHFDK 5arl B 2.61 BS01 DCM B 1 H12 K40 N43 T44 H116 H14 K42 N45 T46 H118 H12 K40 H116 F117 D118 H14 K42 H118 F119 D120 3.1.27.- 0003676 P15468 26748441 1120 KMQDRMYQRFLRQHVDPDATGGNDAYCNLMMQRRKMTSHYCKRFNTFIHEDIWNIRSICSTSNIQCKNGQMNCHEGVVKVTACRETGSSRAPNCRYRAMASTRRVVIACEGNPEVPVHFDK 5arl C 2.61 BS01 DCM C 1 H12 F42 N43 T44 F117 H13 F43 N44 T45 F118 H12 K40 H116 F117 D118 H13 K41 H117 F118 D119 3.1.27.- 0003676 P15468 26748441 1120 MQDRMYQRFLRQHVDPDATGGNDAYCNLMMQRRKMTSHYCKRFNTFIHEDIWNIRSICSTSNIQCKNGQMNCHEGVVKVTACRETGSSRAPNCRYRAMASTRRVVIACEGNPEVPVHFDK 5arl D 2.61 BS01 DCM D 1 H12 K40 F42 N43 T44 H116 F117 K119 H13 K41 F43 N44 T45 H117 F118 K120 H12 K40 H116 F117 D118 H13 K41 H117 F118 D119 3.1.27.- 0003676 P15468 26748441 1120 MQDRMYQRFLRQHVDPDATGGNDAYCNLMMQRRKMTSHYCKRFNTFIHEDIWNIRSICSTSNIQCKNGQMNCHEGVVKVTACRETGSSRAPNCRYRAMASTRRVVIACEGNPEVPVHFDK 5fbf A 1.04 BS04 DCM A 1 K68 Y69 F81 D83 H145 A151 N154 H168 K48 Y49 F61 D63 H125 A131 N134 H148 W21 H26 D65 K68 H80 H135 D139 H145 H168 D172 W1 H6 D45 K48 H60 H115 D119 H125 H148 D152 3.1.30.1 0003676,0004518,0004519,0005575,0006308,0016788,0046872 P24021 28036383 601 WGNLGHETVAYIAQSFVASSTESFCQNILGDDSTSYLANVATWADTYKYTDAGEFSKPYHFIDAQDNPPQSCGVDYDRDCGSAGCSISAIQNYTNILLESPNGSEALNALKFVVHIIGDIHQPLHDENLEAGGNGIDVTYDGETTNLHHIWDTNMPEEAAGGYSLSVAKTYADLLTERIKTGTYSSKKDSWTDGIDIKDPVSTSMIWAADANTYVCSTVLDDGLAYINSTDLSGEYYDKSQPVFEELIAKAGYRLAAWLDLIASQPS 5fbf A 1.04 BS05 DCM A 2 W21 D65 K68 Y69 H80 D139 H145 D172 W1 D45 K48 Y49 H60 D119 H125 D152 W21 H26 D65 K68 H80 H135 D139 H145 H168 D172 W1 H6 D45 K48 H60 H115 D119 H125 H148 D152 3.1.30.1 0003676,0004518,0004519,0005575,0006308,0016788,0046872 P24021 28036383 602 WGNLGHETVAYIAQSFVASSTESFCQNILGDDSTSYLANVATWADTYKYTDAGEFSKPYHFIDAQDNPPQSCGVDYDRDCGSAGCSISAIQNYTNILLESPNGSEALNALKFVVHIIGDIHQPLHDENLEAGGNGIDVTYDGETTNLHHIWDTNMPEEAAGGYSLSVAKTYADLLTERIKTGTYSSKKDSWTDGIDIKDPVSTSMIWAADANTYVCSTVLDDGLAYINSTDLSGEYYDKSQPVFEELIAKAGYRLAAWLDLIASQPS 5jp9 A 2.101 BS01 DCM A 1 R31 C155 R175 N177 D178 D186 H216 Y218 R27 C151 R171 N173 D174 D182 H212 Y214 E68 E64 ? 0004799,0005829,0006231,0008168,0016741,0032259 B4Y380 28000775 401 TFGTFQDAYLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHISVPARRANVVFNFAEALWYLSGSDRLDFIQYYAPGIAAYSADGRTLRGTAYGPRIFRHPAGGVNQWENVVKTLTDDPDSKRAVIQIFDPRELAVADNIDVACTLALQFLIRDGLLCGIGYMRANDAFRGAVSDVFSFTFLQEFTARYLGLGIGTYHHVVGSVHIYDSDARWAERVLDAPGFPAMPDGDNWPHVRRVLEWEERLRTNAARLSADALDALDLPAYWKHVVALFEAHRQVRHEDTPDRALLAALPEVYRQSLAVKWPGHFG 5jp9 A 2.101 BS02 DCM B 1 K133 R134 K129 R130 E68 E64 ? 0004799,0005829,0006231,0008168,0016741,0032259 B4Y380 28000775 401 TFGTFQDAYLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHISVPARRANVVFNFAEALWYLSGSDRLDFIQYYAPGIAAYSADGRTLRGTAYGPRIFRHPAGGVNQWENVVKTLTDDPDSKRAVIQIFDPRELAVADNIDVACTLALQFLIRDGLLCGIGYMRANDAFRGAVSDVFSFTFLQEFTARYLGLGIGTYHHVVGSVHIYDSDARWAERVLDAPGFPAMPDGDNWPHVRRVLEWEERLRTNAARLSADALDALDLPAYWKHVVALFEAHRQVRHEDTPDRALLAALPEVYRQSLAVKWPGHFG 5jp9 B 2.101 BS01 DCM A 1 K133 R134 K129 R130 E68 E64 ? 0004799,0005829,0006231,0008168,0016741,0032259 B4Y380 28000775 401 TFGTFQDAYLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHISVPARRANVVFNFAEALWYLSGSDRLDFIQYYAPGIAAYSADGRTLRGTAYGPRIFRHPAGGVNQWENVVKTLTDDPDSKRAVIQIFDPRELAVADNIDVACTLALQFLIRDGLLCGIGYMRANDAFRGAVSDVFSFTFLQEFTARYLGLGIGTYHHVVGSVHIYDSDARWAERVLDARPGFPAMPDGDNWPHVRRVLEWEERLRTNAARLSADALDALDLPAYWKHVVALFEAHRQVRHEDTPDRALLAALPEVYRQSLAVKWPGHFG 5jp9 B 2.101 BS02 DCM B 1 R31 Y104 C155 R175 N177 D178 D186 H216 R27 Y100 C151 R171 N173 D174 D182 H212 E68 E64 ? 0004799,0005829,0006231,0008168,0016741,0032259 B4Y380 28000775 401 TFGTFQDAYLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHISVPARRANVVFNFAEALWYLSGSDRLDFIQYYAPGIAAYSADGRTLRGTAYGPRIFRHPAGGVNQWENVVKTLTDDPDSKRAVIQIFDPRELAVADNIDVACTLALQFLIRDGLLCGIGYMRANDAFRGAVSDVFSFTFLQEFTARYLGLGIGTYHHVVGSVHIYDSDARWAERVLDARPGFPAMPDGDNWPHVRRVLEWEERLRTNAARLSADALDALDLPAYWKHVVALFEAHRQVRHEDTPDRALLAALPEVYRQSLAVKWPGHFG 5mql B 3.25 BS02 DCM B 1 I30 E53 Y86 F96 Q97 R128 D133 F137 R192 R194 I10 E33 Y53 F63 Q64 R95 D100 F104 R159 R161 E53 R128 E33 R95 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 29127277 302 IKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNVQSTGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 5mql C 3.25 BS02 DCM C 1 E53 W58 Y86 F96 Q97 R128 D133 F137 R192 E197 E35 W40 Y54 F64 Q65 R96 D101 F105 R160 E165 E53 R128 E35 R96 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 29127277 303 TRIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNVQSTGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 5mqt B 3.2 BS02 DCM B 1 I30 K34 E53 W58 L82 Y86 F96 Q97 R128 F137 R192 I11 K15 E34 W39 L51 Y55 F65 Q66 R97 F106 R161 E53 R128 E34 R97 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 29127277 303 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNVQSTNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 5mqt D 3.2 BS02 DCM D 1 I30 E53 V55 A56 F96 Q97 E127 R128 F137 I11 E34 V36 A37 F62 Q63 E93 R94 F103 E53 R128 E34 R94 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 29127277 302 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 5w0u A 2.9 BS02 DCM A 1 R1025 T1027 N1051 S1085 P1086 C1087 Y1114 R391 T393 N412 S446 P447 C448 Y475 3.5.4.38 0003824,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,Q9GZX7 28757211 2002 IEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAAEFMDPATFTYQFKNVRWAKGRRETYLCYVVKRSESLDFGYLRNKNGCHVALLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRKAEPEGLRRLAEAGVQIAIMTYKDYEYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRILQ 5w0u B 2.9 BS04 DCM B 1 R1025 T1027 S1085 P1086 C1087 Y1114 R391 T393 S446 P447 C448 Y475 3.5.4.38 0003824,0005515,0006974,0008643,0015144,0015768,0016020,0030288,0034219,0034289,0042597,0042956,0043190,0055052,0055085,0060326,1901982,1990060 P0AEX9,Q9GZX7 28757211 2002 IEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAAEFMDPATFTYQFKNVRWAKGRRETYLCYVVKRSESLDFGYLRNKNGCHVALLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRKAEPEGLRRLAEAGVQIAIMTYKDYEYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRILQ 5xpd A 2.788 BS01 DCM A 1 S20 L23 F24 I75 P195 N196 S15 L18 F19 I70 P190 N191 ? 0005506,0016020,0046872,0051119 Q9FGQ2 28878024 301 NLWAFVFGILGNIISFVLFLAPVPTFVRICKKKSTEGFQSLPYVSALFNAMLWIYYAMQKDGTAFLLITINAFGCVIETIYIVLFVSYANKKTRISTLKVLGLLNFLGFAAIVLVCELLTKGSTREKVLGGICVGFSVSMFAAPLSIMRVVVRTRSVEFMPFSLSLFLTINAVTWLFYGLAIKDFYVALPNVLGAFLGAVQMILYIIFKYYKTPVAQMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQFEEV 5zrg A 1.3 BS01 DCM A 1 R22 E33 L79 D116 R20 E31 L77 D114 3.6.1.55 0000166,0006260,0006281,0008413,0016787,0035539,0044715,0044716,0046872 A0R2K6 30312643 201 KQIVVAGALISRGTLLVAQRDRPAELAGLWELPGGKVTPGESDADALARELREELGVDVAVGERLGADVALNDAMTLRAYRVTLRSGSPHPHDHRALRWVGADEIDGLAWVPADRAWVPDLVAALS 6a46 A 2.0 BS02 DCM A 1 E16 A17 L20 K73 I77 Y122 H188 D193 E14 A15 L18 K71 I75 Y120 H179 D184 3.1.11.2 0000287,0003676,0004527,0005634,0006259,0006281,0008296,0008311,0008408,0042803,0046872 Q9R1A9 30357414 303 EPPRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSGSLVLPRVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQGFLSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGLDRAHSRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELLAWADEQARSWAHIEPMYVPPDGP 6a46 B 2.0 BS01 DCM B 1 D14 E16 A17 G19 L20 K73 Y122 D12 E14 A15 G17 L18 K69 Y118 3.1.11.2 0000287,0003676,0004527,0005634,0006259,0006281,0008296,0008311,0008408,0042803,0046872 Q9R1A9 30357414 301 EPPRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSLVLPRVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQGFLSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGLDRAHRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELLAWADEQARSWAHIEPM 6a9a A 1.9 BS01 DCM A 1 K28 Y96 S148 R168 S169 N170 D171 N179 H216 Y218 K28 Y96 S148 R168 S169 N170 D171 N179 H216 Y218 2.1.2.8 0016740,0047153 P08773 30867918 302 MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMSTNTVQYLIRDKKINAVVNMRSNDVVFGFRNNYAWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGKYA 6sqy A 1.9 BS02 DCM A 1 H38 W47 H51 D98 Y102 H18 W27 H31 D78 Y82 3.6.1.12 0000166,0000287,0005634,0005737,0005739,0005829,0006253,0009143,0016462,0016787,0032556,0042262,0042802,0046872,0047429,0047840 Q9QY93 31954130 202 MPFRFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKSDTEPGPQAWPPKERAALQEELSDVLIYLVALAARCHVDLPQAVISKMDTNRQRYPVHLS 6sqy D 1.9 BS02 DCM D 1 H38 W47 H51 D98 Y102 H18 W27 H31 D78 Y82 3.6.1.12 0000166,0000287,0005634,0005737,0005739,0005829,0006253,0009143,0016462,0016787,0032556,0042262,0042802,0046872,0047429,0047840 Q9QY93 31954130 202 MPFRFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKSDTEPGPQAWPPKERAALQEELSDVLIYLVALAARCHVDLPQAVISKMDTNRQRYPVHL 7fh4 A 1.996 BS01 DCM A 1 D21 T24 V26 N43 K58 K61 Y62 H67 Q69 L92 P94 C95 D19 T22 V24 N41 K56 K59 Y60 H65 Q67 L90 P92 C93 ? 0000166,0003824,0004132,0006220,0008270,0046872 O41078 35764100 201 KAEKFYSLACYHAQLFSKDPNTKVAALVIDNNNNIASVGYNGLPRGFEETSDRWEKPMKYNYVVHAQANAIATAARNGVRLDGCSIITTLFPCKECSKLIIQSGIRKVITSKPCKDSSWLESFSFSNEMFDECGIEVEYL 7fh4 B 1.996 BS01 DCM B 1 D21 T24 V26 N43 K58 K61 Y62 H67 Q69 P94 W121 D19 T22 V24 N41 K56 K59 Y60 H65 Q67 P92 W119 ? 0000166,0003824,0004132,0006220,0008270,0046872 O41078 35764100 201 KAEKFYSLACYHAQLFSKDPNTKVAALVIDNNNNIASVGYNGLPRGFEETSDRWEKPMKYNYVVHAQANAIATAARNGVRLDGCSIITTLFPCKECSKLIIQSGIRKVITSKPCKDSSWLESFSFSNEMFDECGIEVEYL 7p9t A 1.79 BS04 DCM A 1 R354 G392 R395 F417 F500 D506 R329 G367 R370 F392 F475 D481 3.1.3.35,3.1.3.5,3.1.3.89,3.1.3.91,3.1.3.99 0000166,0002953,0005515,0005654,0005829,0005886,0006196,0006259,0007159,0008252,0008253,0008270,0009166,0009897,0009986,0010035,0016020,0016787,0016788,0033198,0042802,0046032,0046034,0046086,0046872,0050340,0050483,0050484,0050728,0055074,0070062,0098552,0106411,0110148,0140928 P21589 34403084 604 PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANISASGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTSCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS 8hcd B 2.0 BS02 DCM B 1 E20 A21 G23 L24 I84 Y129 H195 E13 A14 G16 L17 I77 Y122 H181 3.1.11.2 0003676,0008408 Q91XB0 37870446 302 HGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAALKALEQASSKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQWVDEHARPFSTVKPMYG 8hcd D 2.0 BS01 DCM D 1 E20 A21 G23 L24 I84 Y129 H195 E17 A18 G20 L21 I81 Y126 H184 3.1.11.2 0003676,0008408 Q91XB0 37870446 301 QTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAALKALEQASKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQWVDEHARPFSTVKPMYG 8hcd E 2.0 BS01 DCM E 1 L19 E20 A21 G23 L24 I84 Y129 H195 L11 E12 A13 G15 L16 I76 Y121 H187 3.1.11.2 0003676,0008408 Q91XB0 37870446 301 GHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAALKALEQASSPSGNGSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQWVDEHARPFSTVKPMYGT