1u4d A 2.1 BS01 DBQ A 1 D134 A156 K158 E206 L207 A208 L259 D270 D18 A40 K42 E82 L83 A84 L135 D146 D252 A254 R256 N257 D270 V292 D128 A130 R132 N133 D146 V161 2.7.10.2,2.7.11.1 0004672,0004713,0005524,0006468 Q07912 15308621 398 LTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQDHYVMVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQ 1u4d B 2.1 BS01 DBQ B 1 L132 A156 K158 L207 A208 L259 D270 L16 A40 K42 L82 A83 L131 D142 D252 A254 R256 N257 D270 V292 D124 A126 R128 N129 D142 V164 2.7.10.2,2.7.11.1 0004672,0004713,0005524,0006468 Q07912 15308621 401 LTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQP 1z57 A 1.7 BS01 DBQ A 1 V175 A189 K191 F241 L244 L295 V324 D325 V30 A44 K46 F96 L99 L150 V175 D176 D288 K290 N293 D325 T342 D143 K145 N148 D176 T193 2.7.12.1 0004672,0005524,0006468 P49759 19278650 1 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 2c3j A 2.1 BS01 DBQ A 1 V23 A36 K38 E85 Y86 C87 L137 S147 D148 V15 A28 K30 E72 Y73 C74 L124 S134 D135 D130 K132 E134 N135 D148 T170 D117 K119 E121 N122 D135 T157 2.7.11.1 0000077,0004672,0004674,0005524,0006468 Ki=0.659uM -logKd/Ki=6.18, Ki=0.659uM IC50=725nM O14757 16289938 1271 VEDWDLVQTLGEGEVQLAVNRVTEEAVAVKIVDMKRENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK 2cn8 A 2.7 BS02 DBQ A 1 L226 V234 A247 L301 L303 M304 E308 L354 T367 L15 V19 A32 L71 L73 M74 E78 L124 T137 D347 K349 N352 D368 D117 K119 N122 D138 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=5.46, IC50=3.5uM IC50=183nM O96017 16794575 1506 YPKALRDEYIMSKTLGSEVKLAFERKTCKKVAIKIISKNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILTSLMRTLCPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEEN