3d4n A 2.5 BS02 D4N A 1 T124 A172 Y177 Y183 G216 A226 M233 T104 A152 Y157 Y163 G196 A206 M212 S170 Y183 K187 S150 Y163 K167 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=0.83nM, Ki=2.7nM P28845 18553955 293 QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYST 3d4n B 2.5 BS02 D4N B 1 A172 Y177 Y183 G216 A226 A153 Y158 Y164 G197 A207 S170 Y183 K187 S151 Y164 K168 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=0.83nM, Ki=2.7nM P28845 18553955 293 QQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSY 3d4n C 2.5 BS02 D4N C 1 L126 L171 A172 Y177 Y183 L217 A223 A226 L107 L152 A153 Y158 Y164 L198 A204 A207 S170 Y183 K187 S151 Y164 K168 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=0.83nM, Ki=2.7nM P28845 18553955 293 QQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3d4n D 2.5 BS02 D4N D 1 T124 L126 A172 Y177 Y183 G216 A223 A226 M233 T105 L107 A153 Y158 Y164 G197 A204 A207 M213 S170 Y183 K187 S151 Y164 K168 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=0.83nM, Ki=2.7nM P28845 18553955 293 QQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS