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BioLiP
Download all results in tab-seperated text for 63 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1hvy:A (1.9) BS01 D16 2.1.1.45 GO:0000900 ... P04818 11329255 PDBbind: -logKd/Ki=6.54, IC50=0.29uM
    BindingDB: IC50=29000nM
    2 1hvy:B (1.9) BS02 D16 2.1.1.45 GO:0000900 ... P04818 11329255 PDBbind: -logKd/Ki=6.54, IC50=0.29uM
    BindingDB: IC50=29000nM
    3 1hvy:C (1.9) BS01 D16 2.1.1.45 GO:0000900 ... P04818 11329255 BindingDB: IC50=29000nM
    4 1hvy:D (1.9) BS02 D16 2.1.1.45 GO:0000900 ... P04818 11329255 BindingDB: IC50=29000nM
    5 1i00:A (2.5) BS02 D16 2.1.1.45 GO:0000900 ... P04818 11316879 MOAD: Ki=0.46uM
    PDBbind: -logKd/Ki=6.34, Ki=0.46uM
    BindingDB: IC50=29000nM
    6 1i00:B (2.5) BS03 D16 2.1.1.45 GO:0000900 ... P04818 11316879 MOAD: Ki=0.46uM
    PDBbind: -logKd/Ki=6.34, Ki=0.46uM
    BindingDB: IC50=29000nM
    7 1rts:A (3.3) BS02 D16 2.1.1.45 GO:0000900 ... P45352 9894005
    8 1rts:B (3.3) BS03 D16 2.1.1.45 GO:0000900 ... P45352 9894005
    9 2kce:A (2.2) BS02 D16 2.1.1.45 GO:0000287 ... P0A884 8939755 MOAD: Ki=0.67uM
    PDBbind: -logKd/Ki=6.17, Ki=0.67uM
    BindingDB: IC50=2300nM
    10 2kce:B (2.2) BS03 D16 2.1.1.45 GO:0000287 ... P0A884 8939755 MOAD: Ki=0.67uM
    PDBbind: -logKd/Ki=6.17, Ki=0.67uM
    BindingDB: IC50=2300nM
    11 2tsr:A (2.6) BS02 D16 2.1.1.45 GO:0000900 ... P45352 9894005 PDBbind: -logKd/Ki=7.54, Ki=29nM
    12 2tsr:B (2.6) BS02 D16 2.1.1.45 GO:0000900 ... P45352 9894005 PDBbind: -logKd/Ki=7.54, Ki=29nM
    13 2tsr:C (2.6) BS02 D16 2.1.1.45 GO:0000900 ... P45352 9894005
    14 2tsr:D (2.6) BS02 D16 2.1.1.45 GO:0000900 ... P45352 9894005
    15 3nrr:A (1.8) BS02 D16 1.5.1.3
    2.1.1.45    		 GO:0000166 ... A7ASX7 21904052
    16 3nrr:A (1.8) BS04 D16 1.5.1.3
    2.1.1.45    		 GO:0000166 ... A7ASX7 21904052
    17 3nrr:B (1.8) BS03 D16 1.5.1.3
    2.1.1.45    		 GO:0000166 ... A7ASX7 21904052
    18 3nrr:B (1.8) BS05 D16 1.5.1.3
    2.1.1.45    		 GO:0000166 ... A7ASX7 21904052
    19 4eb4:A (1.74) BS02 D16 2.1.1.45 GO:0000900 ... P07607 24995339
    20 4eb4:B (1.74) BS03 D16 2.1.1.45 GO:0000900 ... P07607 24995339
    21 4eb4:C (1.74) BS02 D16 2.1.1.45 GO:0000900 ... P07607 24995339
    22 4eb4:D (1.74) BS03 D16 2.1.1.45 GO:0000900 ... P07607 24995339
    23 4fox:A (2.3) BS01 D16 2.1.1.45 GO:0004799 ... P9WFR9 N/A
    24 4fox:B (2.3) BS03 D16 2.1.1.45 GO:0004799 ... P9WFR9 N/A
    25 4fox:C (2.3) BS01 D16 2.1.1.45 GO:0004799 ... P9WFR9 N/A
    26 4fox:D (2.3) BS02 D16 2.1.1.45 GO:0004799 ... P9WFR9 N/A
    27 4fox:E (2.3) BS01 D16 2.1.1.45 GO:0004799 ... P9WFR9 N/A
    28 4fox:F (2.3) BS02 D16 2.1.1.45 GO:0004799 ... P9WFR9 N/A
    29 4fox:G (2.3) BS01 D16 2.1.1.45 GO:0004799 ... P9WFR9 N/A
    30 4fox:H (2.3) BS02 D16 2.1.1.45 GO:0004799 ... P9WFR9 N/A
    31 5h3a:A (2.4) BS01 D16 2.1.1.45 GO:0004799 ... P90463 27936107
    32 5h3a:B (2.4) BS02 D16 2.1.1.45 GO:0004799 ... P90463 27936107
    33 5noo:A (2.9) BS02 D16 2.1.1.45 GO:0004799 ... Q9Y052 28826032
    34 5noo:B (2.9) BS03 D16 2.1.1.45 GO:0004799 ... Q9Y052 28826032
    35 5noo:C (2.9) BS02 D16 2.1.1.45 GO:0004799 ... Q9Y052 28826032
    36 5noo:D (2.9) BS02 D16 2.1.1.45 GO:0004799 ... Q9Y052 28826032
    37 5x5q:A (2.79) BS02 D16 2.1.1.45 GO:0000900 ... P04818 28634233 BindingDB: IC50=29000nM
    38 5x5q:B (2.79) BS02 D16 2.1.1.45 GO:0000900 ... P04818 28634233 BindingDB: IC50=29000nM
    39 5x5q:C (2.79) BS02 D16 2.1.1.45 GO:0000900 ... P04818 28634233 BindingDB: IC50=29000nM
    40 5x5q:D (2.79) BS03 D16 2.1.1.45 GO:0000900 ... P04818 28634233 BindingDB: IC50=29000nM
    41 5x5q:E (2.79) BS03 D16 2.1.1.45 GO:0000900 ... P04818 28634233 BindingDB: IC50=29000nM
    42 5x5q:F (2.79) BS03 D16 2.1.1.45 GO:0000900 ... P04818 28634233 BindingDB: IC50=29000nM
    43 6k7s:A (1.56) BS02 D16 2.1.1.45 GO:0004799 ... A0A423U5Z1 N/A
    44 6k7s:B (1.56) BS03 D16 2.1.1.45 GO:0004799 ... A0A423U5Z1 N/A
    45 6zxo:A (2.6) BS01 D16 2.1.1.45 GO:0000900 ... P04818 33923290 BindingDB: IC50=29000nM
    46 6zxo:B (2.6) BS02 D16 2.1.1.45 GO:0000900 ... P04818 33923290 BindingDB: IC50=29000nM
    47 6zxo:C (2.6) BS01 D16 2.1.1.45 GO:0000900 ... P04818 33923290 BindingDB: IC50=29000nM
    48 6zxo:D (2.6) BS02 D16 2.1.1.45 GO:0000900 ... P04818 33923290 BindingDB: IC50=29000nM
    49 6zxo:E (2.6) BS01 D16 2.1.1.45 GO:0000900 ... P04818 33923290 BindingDB: IC50=29000nM
    50 6zxo:F (2.6) BS02 D16 2.1.1.45 GO:0000900 ... P04818 33923290 BindingDB: IC50=29000nM
    51 7xyk:A (1.433) BS02 D16 2.1.1.45 GO:0004799 ... Q77J90 N/A
    52 7xyk:B (1.433) BS03 D16 2.1.1.45 GO:0004799 ... Q77J90 N/A
    53 7xyk:C (1.433) BS02 D16 2.1.1.45 GO:0004799 ... Q77J90 N/A
    54 7xyk:D (1.433) BS03 D16 2.1.1.45 GO:0004799 ... Q77J90 N/A
    55 8gkf:A (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    56 8gkf:B (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    57 8gkf:C (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    58 8gkf:D (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    59 8gkf:E (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    60 8gkf:F (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    61 8gkf:G (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    62 8gkf:H (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    63 8gkf:I (2.45) BS01 D16 2.7.8.7 GO:0000287 ... O33336 38489355
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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