3ike A 2.3 BS02 CYT A 1 A102 P105 K106 L107 A108 K134 T135 A102 P105 K106 L107 A108 K134 T135 4.6.1.12 0008299,0008685,0016114,0016829,0019288,0046872 Q63T71 21359640 901 MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDPRFKGADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVR 3ike B 2.3 BS01 CYT B 1 A102 P105 K106 L107 A108 K134 T135 A97 P100 K101 L102 A103 K129 T130 4.6.1.12 0008299,0008685,0016114,0016829,0019288,0046872 Q63T71 21359640 901 MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLDADVLLHAITDALFGAAALGDIGRHFSDTDPRFADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVR 3ike C 2.3 BS01 CYT C 1 A102 P105 K106 L107 A108 K134 A92 P95 K96 L97 A98 K124 4.6.1.12 0008299,0008685,0016114,0016829,0019288,0046872 Q63T71 21359640 901 MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFDSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVR 3mbm A 1.8 BS02 CYT A 1 A102 L107 A108 K134 T135 A102 L107 A108 K134 T135 4.6.1.12 0008299,0008685,0016114,0016829,0019288,0046872 Q3JRA0 21359640 164 MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDPRFKGADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVR 3mbm B 1.8 BS03 CYT B 1 A102 K106 L107 A108 A133 K134 T135 A98 K102 L103 A104 A129 K130 T131 4.6.1.12 0008299,0008685,0016114,0016829,0019288,0046872 Q3JRA0 21359640 164 MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGSDADVLLHAITDALFGAAALGDIGRHFSDTDKGADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVR 3mbm C 1.8 BS04 CYT C 1 A102 K106 L107 A108 A133 K134 T135 A95 K99 L100 A101 A126 K127 T128 4.6.1.12 0008299,0008685,0016114,0016829,0019288,0046872 Q3JRA0 21359640 165 MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVR 3oah A 3.0 BS01 CYT A 1 G627 H628 F629 G410 H411 F412 ? 0005198,0019028 O56137 20861247 737 ADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISSASTGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTTNDGVTTIANNLTSTVQVFSDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQNQSGSAQNKDLLFSRGSPAGMSVQPKNWLPGPCYRQQRVSKTKTDNNNSNFTWTGASKYNLNGRESIINPGTAMASHKDDKDKFFPMSGVMIFGKESAGASNTALDNVMITDEEEIKATNPVATERFGTVAVNLQSSSTDPATGDVHVMGALPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPPAEFSATKFASFITQYSTGQVSVEIEWELQKENSKRWNPEVQYTSNYAKSANVDFTVDNNGLYTEPRPIGTRYLTRPL 3slb A 2.0 BS02 CYT A 1 W80 S81 R82 P83 R108 W83 S84 R85 P86 R111 2.3.1.81 0008080,0016746,0046353,0046677 A0A3P1UCA6 267 SNAMNDIVASTQLPNTIKTITNDLRKLGLKKGMTVIVHSSLSSIGWISGGAVAVVEALMEVITEEGTIIMPTQSSDLSDPKHWSRPPVPEEWWQIIRDNVPAFEPHITPTRAMGKVVECFRTYPNVVRSNHPLGSFAAWGRHAEEITVNQSLSMSLGEESPLRKIYDLDGYILLIGVGYDSNTSVGLSEVRSGACELIKVGAPIIENGERVWKEFVDMDYDSDKFVEIGVEFEQKGTVTMGKIGNAKCRLMKQRDIVDFGTEWFRK 3slb B 2.0 BS02 CYT B 1 W80 S81 R82 R108 W83 S84 R85 R111 2.3.1.81 0008080,0016746,0046353,0046677 A0A3P1UCA6 267 SNAMNDIVASTQLPNTIKTITNDLRKLGLKKGMTVIVHSSLSSIGWISGGAVAVVEALMEVITEEGTIIMPTQSSDLSDPKHWSRPPVPEEWWQIIRDNVPAFEPHITPTRAMGKVVECFRTYPNVVRSNHPLGSFAAWGRHAEEITVNQSLSMSLGEESPLRKIYDLDGYILLIGVGYDSNTSVGLSEVRSGACELIKVGAPIIENGERVWKEFVDMDYDSDKFVEIGVEFEQKGTVTMGKIGNAKCRLMKQRDIVDFGTEWFRK 3slb C 2.0 BS02 CYT C 1 W80 S81 R82 P83 R108 W81 S82 R83 P84 R109 2.3.1.81 0008080,0016746,0046353,0046677 A0A3P1UCA6 267 AMNDIVASTQLPNTIKTITNDLRKLGLKKGMTVIVHSSLSSIGWISGGAVAVVEALMEVITEEGTIIMPTQSSDLSDPKHWSRPPVPEEWWQIIRDNVPAFEPHITPTRAMGKVVECFRTYPNVVRSNHPLGSFAAWGRHAEEITVNQSLSMSLGEESPLRKIYDLDGYILLIGVGYDSNTSVGLSEVRSGACELIKVGAPIIENGERVWKEFVDMDYDSDKFVEIGVEFEQKGTVTMGKIGNAKCRLMKQRDIVDFGTEWFRK 3slb D 2.0 BS02 CYT D 1 W80 S81 R82 P83 R108 W83 S84 R85 P86 R111 2.3.1.81 0008080,0016746,0046353,0046677 A0A3P1UCA6 267 SNAMNDIVASTQLPNTIKTITNDLRKLGLKKGMTVIVHSSLSSIGWISGGAVAVVEALMEVITEEGTIIMPTQSSDLSDPKHWSRPPVPEEWWQIIRDNVPAFEPHITPTRAMGKVVECFRTYPNVVRSNHPLGSFAAWGRHAEEITVNQSLSMSLGEESPLRKIYDLDGYILLIGVGYDSNTSVGLSEVRSGACELIKVGAPIIENGERVWKEFVDMDYDSDKFVEIGVEFEQKGTVTMGKIGNAKCRLMKQRDIVDFGTEWFRK 4iqi A 1.5 BS01 CYT A 1 I93 S95 E234 I267 I65 S67 E206 I239 C194 T197 D201 H233 E234 C166 T169 D173 H205 E206 1.7.1.13 0003674,0005575,0005737,0006400,0008150,0008616,0016491,0033739,0046857 Q9KTK0 301 NQYDPSLLQPVPRSLNRNDLHLSATLPFQGCDIWTLYELSWLNQKGLPQVAIGEVSIPATSANLIESKSFKLYLNSYNQTRFASWDEVQTRLVHDLSACAGETVTVNVKSLNEYTAEPIVTMQGECIDDQDIEIANYEFDDALLQGAAQGEEVSEVLHSHLLKSNCLITNQPDWGSVEIAYHGAKMNREALLRYLVSFREHNEFHEQCVERIFTDIMRYCQPQSLTVYARYTRRGGLDINPFRSSHQSAPNHNQRMARQ 4iqi B 1.5 BS01 CYT B 1 W62 S95 F232 H233 E234 W34 S67 F204 H205 E206 C194 T197 D201 H233 E234 C166 T169 D173 H205 E206 1.7.1.13 0003674,0005575,0005737,0006400,0008150,0008616,0016491,0033739,0046857 Q9KTK0 301 NQYDPSLLQPVPRSLNRNDLHLSATLPFQGCDIWTLYELSWLNQKGLPQVAIGEVSIPATSANLIESKSFKLYLNSYNQTRFASWDEVQTRLVHDLSACAGETVTVNVKSLNEYTAEPIVTMQGECIDDQDIEIANYEFDDALLQGAAQGEEVSEVLHSHLLKSNCLITNQPDWGSVEIAYHGAKMNREALLRYLVSFREHNEFHEQCVERIFTDIMRYCQPQSLTVYARYTRRGGLDINPFRSSHQSAPNHNQRMARQ 4ld4 B 3.0 BS02 CYT B 1 F48 N66 H77 F50 N68 H79 3.5.-.- 0003824,0006152,0008270,0016787,0046872,0047974 Q82Y41 24083949 202 GHMNDALHIGLPPFLVQANNEPRVLAAPEARMGYVLELVRANIAADGGPFAAAVFERDSGLLIAAGTNRVVPGRCSAAHAEILALSLAQAKLDTHDLSADGLPACELVTSAEPCVMCFGAVIWSGVRSLVCAARSDDVEAIGFDEGPRPENWMGGLEARGITVTTGLLRDAACALLREYNAC 4zt8 A 1.98 BS01 CYT A 1 Y70 G109 I155 R163 Y70 G109 I155 R163 I71 E160 R163 I71 E160 R163 3.2.2.22 0000166,0016787,0017148,0030598,0035821,0090729 -logKd/Ki=4.39, Kd=41uM D9J2T9 29124196 304 DVSFRLSGADPSSYGMFIKDLRNALPHTEKVYNIPLLLPSVSGAGRYLLMHLFNYDGNTITVAVDVTNVYIMGYLALTTSYFFNEPAADLASQYVFRSARRKITLPYSGNYERLQIAAGKPREKIPIGLPALDTAISTLLHYDSTAAAGALLVLIQTTAEAARFKYIEQQIQERAYRDEVPSSATISLENSWSGLSKQIQLAQGNNGVFRTPTVLVDSKGNRVQITNVTSNVVTSNIQLLLNTKNI 5buv A 1.75 BS01 CYT A 1 E48 H139 E49 H140 H63 K73 C133 D167 H64 K74 C134 D168 5.1.3.13 0005829,0008830,0019305,0045226 A1JNA0 26174084 203 ASIINITELNISGCYLIESPIFSDERGEFVKTHHQEIFKNFGLEIPSAEEYYSRSKNNVIRGMHFQQYPDDHNKLVFCPEGEVLDVFLDIRKDSNTYGQFMSFILNPHNRRSIFLAKGIAHGFLSMKDNTLIVCKTSTVHSPSRDSGIHWNSFGFKWPVENPIISDKDRNLDCF 5buv B 1.75 BS01 CYT B 1 E48 H139 E48 H139 H63 K73 C133 D167 H63 K73 C133 D167 5.1.3.13 0005829,0008830,0019305,0045226 A1JNA0 26174084 203 SIINITELNISGCYLIESPIFSDERGEFVKTHHQEIFKNFGLEIPSAEEYYSRSKNNVIRGMHFQQYPDDHNKLVFCPEGEVLDVFLDIRKDSNTYGQFMSFILNPHNRRSIFLAKGIAHGFLSMKDNTLIVCKTSTVHSPSRDSGIHWNSFGFKWPVENPIISDKDRNLDCF 5efo A 1.63 BS01 CYT A 1 F161 Q165 R167 F159 Q163 R165 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L228 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 302 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQPDHATLKETEARSIKVVVEAARKMLK 5efo B 1.63 BS01 CYT B 1 T94 G95 F161 Q165 T94 G95 F161 Q165 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 302 MTKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5efo C 1.63 BS01 CYT C 1 F161 Q165 F159 Q163 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 303 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5efo C 1.63 BS02 CYT C 2 R178 F179 W186 R176 F177 W184 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 304 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5efo D 1.63 BS01 CYT D 1 G95 F161 Q165 I220 G93 F159 Q163 I218 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 302 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5efo D 1.63 BS02 CYT D 2 R178 F179 E185 R176 F177 E183 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 303 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5epu A 1.06 BS01 CYT A 1 T94 G95 F161 Q165 T93 G94 F160 Q164 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H6 G24 R28 R46 E78 R89 T92 R166 I218 I219 R221 L232 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 301 TKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5epu B 1.06 BS01 CYT B 1 T93 T94 G95 F161 Q165 R167 T92 T93 G94 F160 Q164 R166 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H6 G24 R28 R46 E78 R89 T92 R166 I218 I219 R221 L232 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 304 TKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5epu C 1.06 BS01 CYT C 1 T94 G95 F161 Q165 R167 T92 G93 F159 Q163 R165 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 302 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5epu D 1.06 BS01 CYT D 1 T94 G95 F161 Q165 T93 G94 F160 Q164 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H6 G24 R28 R46 E78 R89 T92 R166 I218 I219 R221 L232 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 302 TKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5epu E 1.06 BS01 CYT E 1 T94 G95 F161 Q165 T92 G93 F159 Q163 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 304 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5epu F 1.06 BS01 CYT F 1 T94 G95 F161 Q165 T92 G93 F159 Q163 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 304 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5ere A 2.0 BS02 CYT A 1 V413 I437 Q440 M460 V461 E462 D468 V382 I406 Q409 M429 V430 E431 D437 ? 0046872 C8WZ86 602 KPVVGVILPFSSAFEDIAVEQQRAVELALAESGSAFEIVFKDGGADVDTAVQAFQDLVRSQENLAAVVSCSSWASSAIHPLAAEKDIFHVAIGSAALKRTEPGHTIRLTVGVQQEQEQLAAYLTDFERIAVLAMDNNLGSSWIRMLEDRFPKQVVAAQEYNPQQMDIAAQLATIKARDSEALVLISAGEAATIAKQARQAGIKAQLVGTRPIQRAEVLAASAFTNGLVYTYPSYNQDHPFMSAFTDRYGLEPGFFGVEAYDLCTTLSRALEQGRQTPKALFEWYAGNTFTGALGKVTFANDGDASYPYIFKKVTESGFRVAEFQFPMLLTQTAQELNAIFKDMDRSVAAAAEQLSTTGLRGDRASAILETLFNENQYAYNCVTVDATGTIVNVAPKQYSSVIGEDISGQEQIIRLHETHQPVLSQAIKMVEGFVGIDLEHPVFDQDGGFIGSVSVLTQPDFFGSIISRKVHNFPVEIFVLQRDGTTIYDVNAEEIGKNAFAIARKMVSQAEGEGTYRAKQLLWTSIGLHGTNYRLALTYG 5ko5 A 1.36 BS01 CYT A 1 L118 A119 G120 Y202 E203 M221 L114 A115 G116 Y198 E199 M217 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 S243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 -logKd/Ki=4.57, Kd=27uM A0A0U3AGT1 30192840 301 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 5ko6 A 1.42 BS01 CYT A 1 L118 A119 G120 Y202 E203 M221 N245 L116 A117 G118 Y200 E201 M219 N243 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 L116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 30192840 301 TPVVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 5lok A 1.109 BS02 CYT A 1 T93 T94 G95 F161 Q165 R167 T91 T92 G93 F159 Q163 R165 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 304 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5lok B 1.109 BS02 CYT B 1 T94 G95 F161 Q165 I220 T93 G94 F160 Q164 I219 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H6 G24 R28 R46 E78 R89 T92 R166 I218 I219 R221 L232 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 305 TKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5lok C 1.109 BS02 CYT C 1 T94 G95 F161 Q165 I220 T93 G94 F160 Q164 I219 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H6 G24 R28 R46 E78 R89 T92 R166 I218 I219 R221 L232 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 304 TKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5lok D 1.109 BS02 CYT D 1 T93 T94 G95 F161 Q165 R167 T91 T92 G93 F159 Q163 R165 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 303 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5lok E 1.109 BS02 CYT E 1 T94 G95 F161 Q165 T93 G94 F160 Q164 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H6 G24 R28 R46 E78 R89 T92 R166 I218 I219 R221 L232 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 306 TKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 5lok F 1.109 BS02 CYT F 1 T94 G95 F161 Q165 R167 I220 T92 G93 F159 Q163 R165 I218 H7 G25 R29 R47 E79 R90 T93 R167 I219 I220 R222 L233 H5 G23 R27 R45 E77 R88 T91 R165 I217 I218 R220 L231 2.4.2.3 0003824,0004850,0005737,0005829,0009116,0009164,0009166,0016757,0016763,0044206,0046872,0047847 Q9K4U1 303 KTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVEAARKMLK 7qoa A 2.4 BS01 CYT A 1 F33 Q105 W108 F204 A207 F30 Q102 W105 F201 A204 0015209,0016020,0022857,0055085 35775318 501 DNNYSQGPVPISARKGGLALTFVMLGLTFFSASMWTGGALGTGLSFNDFFLAVLIGNLLLGIYTAFLGFIGSKTGLTTHLLARYSFGIKGSWLPSFLLGGTQVGWFGVGVAMFAIPVGKATGIDINLLIAVSGILMTITVFFGISALTVLSIIAVPAIAILGSYSVYLAIHDMGGLSTLMNVKPTQPLDFNLALAMVVGSFISAGTLTADFVRFGRNPKVAVVVAIIAFFLGNTLMFVFGAAGAASLGMADISDVMIAQGLLLPAIVVLGLNIWTTNDNALYASGLGFANITGLSSKKLSVINGIVGTVCALWLYNNFVGWLTFLSAAIPPVGGVIIADYLMNKARYNTFNIATMQSVNWVALLAVAIGIVAGHWLPGIVPVNAVLGGAISYAVLNPILNR 7qoa B 2.4 BS01 CYT B 1 F33 W108 F204 A207 F30 W105 F201 A204 0015209,0016020,0022857,0055085 35775318 501 DNNYSQGPVPISARKGGLALTFVMLGLTFFSASMWTGGALGTGLSFNDFFLAVLIGNLLLGIYTAFLGFIGSKTGLTTHLLARYSFGIKGSWLPSFLLGGTQVGWFGVGVAMFAIPVGKATGIDINLLIAVSGILMTITVFFGISALTVLSIIAVPAIAILGSYSVYLAIHDMGGLSTLMNVKPTQPLDFNLALAMVVGSFISAGTLTADFVRFGRNPKVAVVVAIIAFFLGNTLMFVFGAAGAASLGMADISDVMIAQGLLLPAIVVLGLNIWTTNDNALYASGLGFANITGLSSKKLSVINGIVGTVCALWLYNNFVGWLTFLSAAIPPVGGVIIADYLMNKARYNTFNIATMQSVNWVALLAVAIGIVAGHWLPGIVPVNAVLGGAISYAVLNPILN