1jtx A 2.85 BS01 CVI A 1 W61 E90 Y93 Y103 E120 Y123 I124 N157 T161 W60 E89 Y92 Y102 E119 Y122 I123 N156 T160 ? 0003677,0003700,0045892 P0A0N4 11739955 200 NLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESKWQEQWKKEQIKAKTNREKFYLYNELSLTTEYYYPLQNAIIEFYTEYYKTNSINEKMNKLENKYIDAYHVIFKEGNLNGEWSINDVNAVSKIAANAVNGIVTFTHEQNINERIKLMNKFSQIFLNGLS 3vw1 B 2.21 BS01 CVI B 1 Y59 L66 M70 I88 S91 Y92 I106 L130 F155 Y52 L59 M63 I81 S84 Y85 I99 L123 F148 ? 0000976,0003677,0003700,0006355 -logKd/Ki=4.67, Kd=21.2uM A0A0F6AY66 23800819 301 DKKQALLEAATQAIAQSGIAASTAVIARNAGVAEGTLFRYFATKDELINTLYLHLKQDLCQSMIMELDRSITDAKMMTRFIWNSYISWGLNHPARHRAIRQLAVSEKLTKETEQRADDMFPELRDLCHRSVLMVFMSDEYRAFGDGLFLALAETTMDFAARDPARAGEYIALGFEAMWRALTRE 3vw1 D 2.21 BS01 CVI D 1 Y59 C67 M70 I88 I106 F127 L130 C134 V138 F155 Y52 C60 M63 I81 I99 F120 L123 C127 V131 F148 ? 0000976,0003677,0003700,0006355 A0A0F6AY66 23800819 301 DKKQALLEAATQAIAQSGIAASTAVIARNAGVAEGTLFRYFATKDELINTLYLHLKQDLCQSMIMELDRSITDAKMMTRFIWNSYISWGLNHPARHRAIRQLAVSEKLTKETEQRADDMFPELRDLCHRSVLMVFMSDEYRAFGDGLFLALAETTMDFAARDPARAGEYIALGFEAMWRALTR 5ov9 A 2.4 BS01 CVI A 1 D74 L76 Y341 D74 L76 Y334 G121 G122 G154 S203 A204 G242 F297 F299 E334 H447 G121 G122 G154 S203 A204 G242 F290 F292 E327 H440 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 ic50=2.2uM -logKd/Ki=5.66, IC50=2.2uM P21836 28867801 608 EGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLS 5ov9 A 2.4 BS02 CVI A 2 Y72 D283 W286 H287 Y341 Y72 D276 W279 H280 Y334 G121 G122 G154 S203 A204 G242 F297 F299 E334 H447 G121 G122 G154 S203 A204 G242 F290 F292 E327 H440 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 ic50=2.2uM -logKd/Ki=5.66, IC50=2.2uM P21836 28867801 609 EGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLS 5ov9 B 2.4 BS01 CVI B 1 D74 L76 Y341 D71 L73 Y331 G121 G122 G154 S203 A204 G242 F297 F299 E334 H447 G118 G119 G151 S200 A201 G239 F287 F289 E324 H437 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 ic50=2.2uM P21836 28867801 602 EDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLS 5ov9 B 2.4 BS02 CVI B 2 Y72 D283 W286 H287 Y341 Y69 D273 W276 H277 Y331 G121 G122 G154 S203 A204 G242 F297 F299 E334 H447 G118 G119 G151 S200 A201 G239 F287 F289 E324 H437 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 ic50=2.2uM P21836 28867801 603 EDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLS 5vlm A 3.403 BS01 CVI A 1 M67 Q71 A86 L87 G88 I98 W101 W125 D163 Y166 F178 M63 Q67 A82 L83 G84 I94 W97 W121 D159 Y162 F174 ? 0003677,0009889,0080090 E3G817 30190458 301 NREERRETIMQAAMRVALDQGFTGMTVRNIATAAGVAAGQVHHHFTSSGELKSQAFIRVIREMMDLQRLSRTAGWREQLFSALGSEDGRLEPYIRLWRQAQLLADSDPEIKSAYLLTMNLWHDEAVRIIRAGHAAGEFTLRDSAENIAWRLISLVCGLDGIYVLGMPEVDDAAFTRHLQHVIQLELFS 5vlm B 3.403 BS01 CVI B 1 M67 Q71 A86 L87 G88 I98 W101 Q105 W125 V159 D163 Y166 D175 F178 M64 Q68 A83 L84 G85 I95 W98 Q102 W122 V156 D160 Y163 D172 F175 ? 0003677,0009889,0080090 E3G817 30190458 301 LNREERRETIMQAAMRVALDQGFTGMTVRNIATAAGVAAGQVHHHFTSSGELKSQAFIRVIREMMDLQRLSRTAGWREQLFSALGSEDGRLEPYIRLWRQAQLLADSDPEIKSAYLLTMNLWHDEAVRIIRAGHAAGEFTLRDSAENIAWRLISLVCGLDGIYVLGMPEVDDAAFTRHLQHVIQLELFS 5vlm C 3.403 BS01 CVI C 1 M67 Q71 A86 L87 I98 W101 W125 D163 Y166 F178 M62 Q66 A81 L82 I93 W96 W120 D158 Y161 F173 ? 0003677,0009889,0080090 E3G817 30190458 301 REERRETIMQAAMRVALDQGFTGMTVRNIATAAGVAAGQVHHHFTSSGELKSQAFIRVIREMMDLQRLSRTAGWREQLFSALGSEDGRLEPYIRLWRQAQLLADSDPEIKSAYLLTMNLWHDEAVRIIRAGHAAGEFTLRDSAENIAWRLISLVCGLDGIYVLGMPEVDDAAFTRHLQHVIQLELFS 5vlm D 3.403 BS01 CVI D 1 M67 Q71 A86 S89 I98 Q105 W125 V159 D163 F178 M66 Q70 A85 S88 I97 Q104 W124 V158 D162 F177 ? 0003677,0009889,0080090 E3G817 30190458 301 GYLNREERRETIMQAAMRVALDQGFTGMTVRNIATAAGVAAGQVHHHFTSSGELKSQAFIRVIREMMDLQRLSRTAGWREQLFSALGSEDGRLEPYIRLWRQAQLLADSDPEIKSAYLLTMNLWHDEAVRIIRAGHAAGEFTLRDSAENIAWRLISLVCGLDGIYVLGMPEVDDAAFTRHLQHVIQLELFS 5vlm E 3.403 BS01 CVI E 1 M67 Q71 A86 W101 Y118 W125 D163 Y166 F178 M63 Q67 A82 W97 Y114 W121 D159 Y162 F174 ? 0003677,0009889,0080090 E3G817 30190458 301 NREERRETIMQAAMRVALDQGFTGMTVRNIATAAGVAAGQVHHHFTSSGELKSQAFIRVIREMMDLQRLSRTAGWREQLFSALGSEDGRLEPYIRLWRQAQLLADSDPEIKSAYLLTMNLWHDEAVRIIRAGHAAGEFTLRDSAENIAWRLISLVCGLDGIYVLGMPEVDDAAFTRHLQHVIQLELFS 5vlm F 3.403 BS01 CVI F 1 M67 Q71 A86 L87 I98 W101 Q105 W125 D163 Y166 M66 Q70 A85 L86 I97 W100 Q104 W124 D162 Y165 ? 0003677,0009889,0080090 E3G817 30190458 301 GYLNREERRETIMQAAMRVALDQGFTGMTVRNIATAAGVAAGQVHHHFTSSGELKSQAFIRVIREMMDLQRLSRTAGWREQLFSALGSEDGRLEPYIRLWRQAQLLADSDPEIKSAYLLTMNLWHDEAVRIIRAGHAAGEFTLRDSAENIAWRLISLVCGLDGIYVLGMPEVDDAAFTRHLQHVIQLELFS 5vlm G 3.403 BS01 CVI G 1 M67 Q71 A86 L87 I98 W101 W125 C160 D163 Y166 M63 Q67 A82 L83 I94 W97 W121 C156 D159 Y162 ? 0003677,0009889,0080090 E3G817 30190458 301 NREERRETIMQAAMRVALDQGFTGMTVRNIATAAGVAAGQVHHHFTSSGELKSQAFIRVIREMMDLQRLSRTAGWREQLFSALGSEDGRLEPYIRLWRQAQLLADSDPEIKSAYLLTMNLWHDEAVRIIRAGHAAGEFTLRDSAENIAWRLISLVCGLDGIYVLGMPEVDDAAFTRHLQHVIQLELFS 5vlm H 3.403 BS01 CVI H 1 M67 Q71 A86 L87 G88 I98 W101 Q105 W125 D163 Y166 F178 M66 Q70 A85 L86 G87 I97 W100 Q104 W124 D162 Y165 F177 ? 0003677,0009889,0080090 E3G817 30190458 301 GYLNREERRETIMQAAMRVALDQGFTGMTVRNIATAAGVAAGQVHHHFTSSGELKSQAFIRVIREMMDLQRLSRTAGWREQLFSALGSEDGRLEPYIRLWRQAQLLADSDPEIKSAYLLTMNLWHDEAVRIIRAGHAAGEFTLRDSAENIAWRLISLVCGLDGIYVLGMPEVDDAAFTRHLQHVIQLELFS 6pub A 2.43 BS01 CVI A 1 M1 F4 S6 P7 F8 Y33 Y34 M4 F7 S9 P10 F11 Y36 Y37 2.3.1.28 0016740,0016746,0046677 Q9KMN1 301 SNAMNFFTSPFSGIPLDQQVTNPNIIVGKHSYYSGYYHGHSFDDCVRYLHPERDDVDKLVIGSFCSIGSGAVFMMAGNQGHRSDWISTFPFFYQDNDNFADARDGFTRSGDTIIGHDVWIGTEAMIMPGVKIGHGAIIASRSVVTKDVAPYEVVGSNPAKHIKFRFSDVEIAMLLEMAWWNWPESWLKESMQSLCSSDIEGLYLNWQSKA