6qri A 2.4 BS01 CV9 B 1 G146 R147 G131 R132 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 31260301 403 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 6qri A 2.4 BS03 CV9 A 1 D25 Y143 A144 G146 E334 I341 I345 L349 D21 Y128 A129 G131 E319 I326 I330 L334 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 31260301 403 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 6qri B 2.4 BS02 CV9 B 1 D24 D25 Y143 A144 G146 I341 I345 L349 D20 D21 Y128 A129 G131 I326 I330 L334 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 -logKd/Ki=4.82, IC50=15.21uM P68135 31260301 403 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 6qri B 2.4 BS03 CV9 A 1 R147 I330 R132 I315 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 -logKd/Ki=4.82, IC50=15.21uM P68135 31260301 403 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC