3qwi A 2.5 BS02 CUE A 1 F159 G199 M204 Y212 I213 A228 F149 G189 M194 Y202 I203 A218 G29 S153 N154 H164 Y167 K171 Y212 G19 S143 N144 H154 Y157 K161 Y202 1.1.1.62 0000166,0016491,0016614 ic50=2.8uM O93874 21929506 272 YIPGRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKVVSEIKALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSFGHLKDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDFSVPKHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSHHYIPNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVNGKVLTLDGGAA 3qwi B 2.5 BS02 CUE B 1 F159 G199 F205 Y212 I213 M227 A228 F150 G190 F196 Y203 I204 M218 A219 G29 S153 N154 H164 Y167 K171 Y212 G20 S144 N145 H155 Y158 K162 Y203 1.1.1.62 0000166,0016491,0016614 ic50=2.8uM O93874 21929506 272 TYIPGRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKVVSEIKALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSFGHLKDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDFSVPKHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSHHYIPNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVNGKVLTLDGGAA 3qwi D 2.5 BS02 CUE D 1 F159 G199 F205 Y212 A228 F150 G190 F196 Y203 A219 G29 S153 N154 H164 Y167 K171 Y212 G20 S144 N145 H155 Y158 K162 Y203 1.1.1.62 0000166,0016491,0016614 ic50=2.8uM O93874 21929506 272 TYIPGRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKVVSEIKALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSFGHLKDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDFSVPKHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSHHYIPNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVNGKVLTLDGGAA 4fiz A 1.9 BS01 CUE A 1 N154 F159 G199 F205 S209 Y212 I213 A228 N144 F149 G189 F195 S199 Y202 I203 A218 G29 S153 N154 H164 Y167 K171 Y212 G19 S143 N144 H154 Y157 K161 Y202 1.1.1.62 0000166,0016491,0016614 O93874 301 YIPGRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKVVSEIKALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSFGHLKDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDFSVPKHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSHHYIPNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVNGKVLTLDGGAA 5kr9 A 2.25 BS02 CUE A 1 M343 E353 L387 M388 L391 M421 H524 L525 M40 E50 L84 M85 L88 M118 H211 L212 ? IC50=75.7nM P03372 28042045 601 NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL 5kr9 B 2.25 BS02 CUE B 1 E353 L391 M421 H524 L525 E49 L87 M117 H209 L210 ? IC50=75.7nM P03372 28042045 601 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 6hnw A 2.0 BS01 CUE A 1 L45 V53 V66 K68 F113 V116 M163 I174 D175 L43 V51 V64 K66 F111 V114 M161 I172 D173 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 ic50=200nM Ki=7670nM P68400 30840451 401 GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD