1ro7 A 1.8 BS01 CSF C 1 G8 G10 C30 N31 Q32 N51 L54 T131 S132 G133 I153 D154 F155 Y156 S161 Y162 F178 H188 G8 G10 C30 N31 Q32 N51 L54 T131 S132 G133 I153 D154 F155 Y156 S161 Y162 F178 H188 R129 Y156 Y162 H188 R129 Y156 Y162 H188 2.4.99.- -logKd/Ki=3.18, Ki=657uM Q9LAK3 14730352 1001 MKKVIIAGNGPSLKEIDYSRLPNDFDVFRCNQFYFEDKYYLGKKCKAVFYNPSLFFEQYYTLKHLIQNQEYETELIMCSNYNQAHLENENFVKTFYDYFPDAHLGYDFFKQLKDFNAYFKFHEIYFNQRITSGVYMCAVAIALGYKEIYLSGIDFYQNGSSYAFDTKQKNLLKLAPNFKNDNSHYIGHSKNTDIKALEFLEKTYKIKLYCLCPNSLLANFIELAPNLNSNFIIQEKNNYTKDILIPSSEAYGKFSKNI 1ro7 B 1.8 BS01 CSF C 2 G8 N9 G10 C30 N31 Q32 N51 L54 T131 S132 I153 D154 F155 F178 H188 G8 N9 G10 C30 N31 Q32 N51 L54 T131 S132 I153 D154 F155 F166 H167 R129 H188 R129 H167 2.4.99.- Q9LAK3 14730352 2001 MKKVIIAGNGPSLKEIDYSRLPNDFDVFRCNQFYFEDKYYLGKKCKAVFYNPSLFFEQYYTLKHLIQNQEYETELIMCSNYNQAHLENENFVKTFYDYFPDAHLGYDFFKQLKDFNAYFKFHEIYFNQRITSGVYMCAVAIALGYKEIYLSGIDFQKNLLKLAPNFHSKNTDIKALEFLEKTYKIKLYCLCPNSLLANFIELAPNLNSNFIIQEKNNYTKDILIPSSEAYGKFSKNI 1ro7 C 1.8 BS01 CSF C 3 G8 G10 C30 N31 Q32 N51 L54 T131 S132 G133 I153 D154 F155 Y156 S161 Y162 H188 G8 G10 C30 N31 Q32 N51 L54 T131 S132 G133 I153 D154 F155 Y156 S157 Y158 H174 R129 Y156 Y162 H188 R129 Y156 Y158 H174 2.4.99.- Ki=657uM Q9LAK3 14730352 3001 MKKVIIAGNGPSLKEIDYSRLPNDFDVFRCNQFYFEDKYYLGKKCKAVFYNPSLFFEQYYTLKHLIQNQEYETELIMCSNYNQAHLENENFVKTFYDYFPDAHLGYDFFKQLKDFNAYFKFHEIYFNQRITSGVYMCAVAIALGYKEIYLSGIDFYSYAFDTKQKNLLKLAPGHSKNTDIKALEFLEKTYKIKLYCLCPNSLLANFIELAPNLNSNFIIQEKNNYTKDILIPSSEAYGKFSKN 1ro7 D 1.8 BS01 CSF C 4 G8 N9 G10 N31 Q32 N51 L54 T131 S132 G152 D154 Y156 H188 G8 N9 G10 N31 Q32 N51 L54 T131 S132 G152 D154 Y156 H168 R129 Y156 H188 R129 Y156 H168 2.4.99.- Q9LAK3 14730352 4001 MKKVIIAGNGPSLKEIDYSRLPNDFDVFRCNQFYFEDKYYLGKKCKAVFYNPSLFFEQYYTLKHLIQNQEYETELIMCSNYNQAHLENENFVKTFYDYFPDAHLGYDFFKQLKDFNAYFKFHEIYFNQRITSGVYMCAVAIALGYKEIYLSGIDFYQKNLLKLAPIGHSKNTDIKALEFLEKTYKIKLYCLCPNSLLANFIELAPNLNSNFIIQEKNNYTKDILIPSSEAYGKFSKNI 2drj A 2.25 BS01 CSF A 1 G8 N9 G10 N31 Q32 N51 T131 S132 G152 D154 Y156 G7 N8 G9 N30 Q31 N50 T130 S131 G151 D153 Y155 R129 Y156 R128 Y155 2.4.99.- Q9LAK3 16862130 1001 KKVIIAGNGPSLKEIDYSRLPNDFDVFRCNQFYFEDKYYLGKKCKAVFYNPSLFFEQYYTLKHLIQNQEYETELIMCSNYNQAHLENENYVKTFYDYFPDAHLGYDFFKQLKDFNAYFKFHEIYFNQRITSGVYMCAVAIALGYKEIYLSGIDFYTKQKNLLKLAPNKNTDIKALEFLEKTYKIKLYCLCPNSLLANFIGLAPNLNSNFIIQEKNNYTKDILIPSSEAYGKFS 2ihj A 2.0 BS01 CSF A 1 R63 D141 G142 S143 M144 G266 W270 K309 H311 S336 E338 S356 R39 D117 G118 S119 M120 G242 W246 K285 H287 S312 E314 S332 2.4.99.4 0016757 Ki=25.7uM -logKd/Ki=4.59, Ki=25.7uM Q15KI8 17487984 1741 MKTITLYLDPASLPALNQLMDFTQNNEDKTHPRIFGLSRFKIPDNIITQYQNIHFVELKDNRPTEALFTILDQYPGNIELNIHLNIAHSVQLIRPILAYRFKHLDRVSIQQLNLYDDGSMEYVDLEKEENKDISAEIKQAEKQLSHYLLTGKIKFDNPTIARYVWQSAFPVKYHFLSTDYFEKAEFLQPLKEYLAENYQKMDWTAYQQLTPEQQAFYLTLVGFNDEVKQSLEVQQAKFIFTGTTTWEGNTDVREYYAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRGGEINDYILNNAKNITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLPKEKISHIIFTSNNPYVKVMRRLGIIDESQVIFWDSLKQLG 2ihk A 1.9 BS01 CSF A 1 L37 R63 D141 G142 S143 M144 G266 W270 K309 G310 H311 P312 S336 E338 S355 S356 L13 R39 D117 G118 S119 M120 G242 W246 K285 G286 H287 P288 S312 E314 S331 S332 2.4.99.4 0016757 Ki=10.2uM Q15KI8 17487984 1741 MKTITLYLDPASLPALNQLMDFTQNNEDKTHPRIFGLSRFKIPDNIITQYQNIHFVELKDNRPTEALFTILDQYPGNIELNIHLNIAHSVQLIRPILAYRFKHLDRVSIQQLNLYDDGSMEYVDLEKEENKDISAEIKQAEKQLSHYLLTGKIKFDNPTIARYVWQSAFPVKYHFLSTDYFEKAEFLQPLKEYLAENYQKMDWTAYQQLTPEQQAFYLTLVGFNDEVKQSLEVQQAKFIFTGTTTWEGNTDVREYYAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRGGEINDYILNNAKNITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLPKEKISHIIFTNNPYVKVMRRLGIIDESQVIFWDSLKQL 2ihz A 2.0 BS03 CSF A 1 S36 L37 R63 D141 G142 S143 M144 G266 T268 W270 K309 G310 H311 P312 S336 F337 E338 S355 S356 S12 L13 R39 D117 G118 S119 M120 G242 T244 W246 K285 G286 H287 P288 S312 F313 E314 S331 S332 2.4.99.4 0016757 Ki=27.5uM Q15KI8 17487984 1741 MKTITLYLDPASLPALNQLMDFTQNNEDKTHPRIFGLSRFKIPDNIITQYQNIHFVELKDNRPTEALFTILDQYPGNIELNIHLNIAHSVQLIRPILAYRFKHLDRVSIQQLNLYDDGSMEYVDLEKEENKDISAEIKQAEKQLSHYLLTGKIKFDNPTIARYVWQSAFPVKYHFLSTDYFEKAEFLQPLKEYLAENYQKMDWTAYQQLTPEQQAFYLTLVGFNDEVKQSLEVQQAKFIFTGTTTWEGNTDVREYYAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRGGEINDYILNNAKNITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLPKEKISHIIFTSALNNPYVKVMRRLGIIDESQVIFWDSLKQL 2iy7 A 1.85 BS01 CSF A 1 L37 R63 D141 S143 M144 G266 W270 K309 G310 H311 P312 S336 F337 E338 S355 S356 L13 R39 D117 S119 M120 G242 W246 K285 G286 H287 P288 S312 F313 E314 S331 S332 ? 0016757 Q15KI8 18304450 1414 SKTITLYLDPASLPALNQLMDFTQNNEDKTHPRIFGLSRFKIPDNIITQYQNIHFVELKDNRPTEALFTILDQYPGNIELNIHLNIAHSVQLIRPILAYRFKHLDRVSIQQLNLYDDGSMEYVDLEKEENKDISAEIKQAEKQLSHYLLTGKIKFDNPTIARYVWQSAFPVKYHFLSTDYFEKAEFLQPLKEYLAENYQKMDWTAYQQLTPEQQAFYLTLVGFNDEVKQSLEVQQAKFIFTGTTTWEGNTEVREYYAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRGGEINDYILNNAKNITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLPKEKISHIIFTNNPYVKVMRRLGIIDESQVIFWDSLKELG 2iy8 A 2.5 BS03 CSF A 1 S36 L37 R63 D141 G142 S143 M144 G266 K309 G310 H311 P312 S336 E338 S355 S356 L357 S12 L13 R39 D117 G118 S119 M120 G242 K285 G286 H287 P288 S312 E314 S331 S332 L333 ? Q9CP67 18304450 1415 SKTITLYLDPASLPALNQLMDFTQNNEDKTHPRIFGLSRFKIPDNIITQYQNIHFVELKDNRPTEALFTILDQYPGNIELNIHLNIAHSVQLIRPILAYRFKHLDRVSIQQLNLYDDGSMEYVDLEKEENKDISAEIKQAEKQLSHYLLTGKIKFDNPTIARYVWQSAFPVKYHFLSTDYFEKAEFLQPLKEYLAENYQKMDWTAYQQLTPEQQAFYLTLVGFNDEVKQSLEVQQAKFIFTGTTTWEGNTEVREYYAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRGGEINDYILNNAKNITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLPKEKISHIIFTNNPYVKVMRRLGIIDESQVIFWDSLKELG 2p2v A 1.85 BS01 CSF A 1 G23 N24 G25 C45 N46 Q47 N66 T146 S147 G148 I168 D169 F170 Y171 I176 Y177 F196 P198 H202 G19 N20 G21 C41 N42 Q43 N62 T142 S143 G144 I164 D165 F166 Y167 I172 Y173 F190 P192 H196 R144 Y171 Y177 H202 R140 Y167 Y173 H196 2.4.99.- Q9RGF1 17518445 1001 RMENELIVSKNMQNIIIAGNGPSLKNINYKRLPREYDVFRCNQFYFEDKYYLGKKIKAVFFNPGVFLQQYHTAKQLILKNEYEIKNIFCSTFNLPFIESNDFLHQFYNFFPDAKLGYEVIENLKEFYAYIKYNEIYFNKRITSGVYMCAIAIALGYKTIYLCGIDFYEGDVIYPFEAMSTNIKTIFPGDFKPSNCHSKEYDIEALKLLKSIYKVNIYALCDDSILANHFPLSININNNFTLENKHNNSINDILLTDNTPGVSFYKNQLKADNKIM 2wqq A 2.25 BS01 CSF A 1 G8 N9 G10 C30 N31 Q32 N51 T131 S132 G133 G152 D154 Y156 Y162 F178 H188 G7 N8 G9 C29 N30 Q31 N50 T130 S131 G132 G151 D153 Y155 Y156 F172 H175 R129 Y156 Y162 H188 R128 Y155 Y156 H175 2.4.99.- 0016757 Q9LAK3 19824695 1259 KKVIIAGNGPSLKEIDYSRLPNDFDVFRCNQFYFEDKYYLGKKCKAVFYNPSLFFEQYYTLKHLIQNQEYETELIMCSNYNQAHLENENFVKTFYDYFPDAHLGYDFFKQLKDFNAYFKFHEIQFNQRITSGVYMCAVAIALGYKEIYLSGIDFYYAFDTKQKNLLKLAPNFKGHSKNTDIKALEFLEKTYKIKLYCLCPNSLLANFIGLAPNLNSNFIIQEKNNYTKDILIPSSEAYGKFSKNI 2yk7 A 2.18 BS01 CSF A 1 L254 G255 H280 P281 R282 V298 I299 E300 S322 L206 G207 H232 P233 R234 V250 I251 E252 S274 2.4.3.6 P72097 21880735 1371 PVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENNNEKYDYYFNQIKDKAEWAYFFHLPYGLNKSFNFIPTMAELKVKAMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTINLIQSSSYLGDEFSVNGTIKRNFARMMIGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKAGDETGGTVRILLGSPDKEMKEISEKAAKNFNIQYVAPHPRQTYGLSGVTTLNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFTQSGIPILTFDDK 4r84 A 1.7 BS01 CSF A 1 G357 K399 G400 H401 P402 F427 E428 A444 S445 S446 L447 G334 K376 G377 H378 P379 F404 E405 A421 S422 S423 L424 2.4.99.1 O66375 25451227 501 KETVSSNSADVVETETYQLTPIDAPSSFLSHSWEQTCGTPILNESDKQAISFDFVAPELKQDEKYCFTFKGITGDHRYITNTTLTVVAPTLEVYIDHASLPSLQQLIHIIQAKDEYPSNQRFVSWKRVTVDADNANKLNIHTYPLKGNNTSPEMVAAIDEYAQSKNRLNIEFYTNTAHVFNNLPPIIQPLYNNEKVKISHISLYDDGSSEYVSLYQWKDTPNKIETLEGEVSLLANYLAGTSPDAPKGMGNRYNWHKLYDTDYYFLREDYLDVEANLHDLRDYLGSSAKQMPWDEFAKLSDSQQTLFLDIVGFDKEQLQQQYSQSPLPNFIFTGTTTWAGGETKEYYAQQQVNVINNAINETSPYYLGKDYDLFFKGHPAGGVINDIILGSFPDMINIPAKISFEVLMMTDMLPDTVAGIASSLYFTIPADKVNFIVFTSSDTITDREEALKSPLVQVMLTLGIVKEKDVLFWA 4r84 B 1.7 BS01 CSF B 1 G357 K399 G400 H401 P402 F427 E428 A444 S445 L447 G334 K376 G377 H378 P379 F404 E405 A421 S422 L424 2.4.99.1 O66375 25451227 501 KETVSSNSADVVETETYQLTPIDAPSSFLSHSWEQTCGTPILNESDKQAISFDFVAPELKQDEKYCFTFKGITGDHRYITNTTLTVVAPTLEVYIDHASLPSLQQLIHIIQAKDEYPSNQRFVSWKRVTVDADNANKLNIHTYPLKGNNTSPEMVAAIDEYAQSKNRLNIEFYTNTAHVFNNLPPIIQPLYNNEKVKISHISLYDDGSSEYVSLYQWKDTPNKIETLEGEVSLLANYLAGTSPDAPKGMGNRYNWHKLYDTDYYFLREDYLDVEANLHDLRDYLGSSAKQMPWDEFAKLSDSQQTLFLDIVGFDKEQLQQQYSQSPLPNFIFTGTTTWAGGETKEYYAQQQVNVINNAINETSPYYLGKDYDLFFKGHPAGGVINDIILGSFPDMINIPAKISFEVLMMTDMLPDTVAGIASSLYFTIPADKVNFIVFTSSDTITDREEALKSPLVQVMLTLGIVKEKDVLFWA 4r84 C 1.7 BS01 CSF C 1 G357 K399 H401 F427 E428 A444 S445 S446 L447 G334 K376 H378 F404 E405 A421 S422 S423 L424 2.4.99.1 O66375 25451227 501 KETVSSNSADVVETETYQLTPIDAPSSFLSHSWEQTCGTPILNESDKQAISFDFVAPELKQDEKYCFTFKGITGDHRYITNTTLTVVAPTLEVYIDHASLPSLQQLIHIIQAKDEYPSNQRFVSWKRVTVDADNANKLNIHTYPLKGNNTSPEMVAAIDEYAQSKNRLNIEFYTNTAHVFNNLPPIIQPLYNNEKVKISHISLYDDGSSEYVSLYQWKDTPNKIETLEGEVSLLANYLAGTSPDAPKGMGNRYNWHKLYDTDYYFLREDYLDVEANLHDLRDYLGSSAKQMPWDEFAKLSDSQQTLFLDIVGFDKEQLQQQYSQSPLPNFIFTGTTTWAGGETKEYYAQQQVNVINNAINETSPYYLGKDYDLFFKGHPAGGVINDIILGSFPDMINIPAKISFEVLMMTDMLPDTVAGIASSLYFTIPADKVNFIVFTSSDTITDREEALKSPLVQVMLTLGIVKEKDVLFWA 4r84 D 1.7 BS01 CSF D 1 G357 K399 G400 H401 P402 F427 E428 A444 S445 L447 G334 K376 G377 H378 P379 F404 E405 A421 S422 L424 2.4.99.1 O66375 25451227 501 KETVSSNSADVVETETYQLTPIDAPSSFLSHSWEQTCGTPILNESDKQAISFDFVAPELKQDEKYCFTFKGITGDHRYITNTTLTVVAPTLEVYIDHASLPSLQQLIHIIQAKDEYPSNQRFVSWKRVTVDADNANKLNIHTYPLKGNNTSPEMVAAIDEYAQSKNRLNIEFYTNTAHVFNNLPPIIQPLYNNEKVKISHISLYDDGSSEYVSLYQWKDTPNKIETLEGEVSLLANYLAGTSPDAPKGMGNRYNWHKLYDTDYYFLREDYLDVEANLHDLRDYLGSSAKQMPWDEFAKLSDSQQTLFLDIVGFDKEQLQQQYSQSPLPNFIFTGTTTWAGGETKEYYAQQQVNVINNAINETSPYYLGKDYDLFFKGHPAGGVINDIILGSFPDMINIPAKISFEVLMMTDMLPDTVAGIASSLYFTIPADKVNFIVFTSSDTITDREEALKSPLVQVMLTLGIVKEKDVLFWA 5bo9 A 2.3 BS04 CSF A 1 G166 N167 S168 C189 N190 N211 I214 S300 T301 G302 F321 W322 P323 Y336 H337 H354 G77 N78 S79 C100 N101 N122 I125 S211 T212 G213 F232 W233 P234 Y247 H248 H260 R298 H354 R209 H260 2.4.3.-,2.4.3.8 0006486,0008373 O43173 26192331 412 WKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFESHQLPAEFQLLYRMHGEGLTKLTLSHCA 5bo9 B 2.3 BS03 CSF B 1 N167 S168 C189 N190 N211 I214 S300 T301 G302 F321 W322 P323 Y336 H337 N78 S79 C100 N101 N122 I125 S211 T212 G213 F232 W233 P234 Y247 H248 R298 R209 2.4.3.-,2.4.3.8 0006486,0008373 O43173 26192331 410 WKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDQLPAEFQLLYRMHGEGLTKLTLSHCA