2aou A 2.3 BS01 CQA A 1 Y15 F19 Q94 Q143 Y146 V173 W179 W183 F243 E246 Y11 F15 Q90 Q139 Y142 V169 W175 W179 F239 E242 2.1.1.8 0001692,0001695,0005654,0005737,0005813,0005829,0006548,0007585,0008168,0008170,0032259,0046539,0070062 Ki=18.6nM -logKd/Ki=7.73, Ki=18.6nM Ki=19nM P50135 16168438 402 MRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA 2aou A 2.3 BS02 CQA A 2 D180 W183 G187 F190 P191 D193 Y198 T245 T247 D176 W179 G183 F186 P187 D189 Y194 T241 T243 2.1.1.8 0001692,0001695,0005654,0005737,0005813,0005829,0006548,0007585,0008168,0008170,0032259,0046539,0070062 Ki=18.6nM -logKd/Ki=7.73, Ki=18.6nM Ki=19nM P50135 16168438 403 MRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA 2aou B 2.3 BS01 CQA B 1 Y15 F19 Q94 Q143 Y146 V173 W179 W183 Y12 F16 Q91 Q140 Y143 V170 W176 W180 2.1.1.8 0001692,0001695,0005654,0005737,0005813,0005829,0006548,0007585,0008168,0008170,0032259,0046539,0070062 Ki=18.6nM Ki=19nM P50135 16168438 400 SMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA 2aou B 2.3 BS02 CQA B 2 R6 S7 W183 G187 F190 P191 D193 Y198 T245 R3 S4 W180 G184 F187 P188 D190 Y195 T242 2.1.1.8 0001692,0001695,0005654,0005737,0005813,0005829,0006548,0007585,0008168,0008170,0032259,0046539,0070062 Ki=18.6nM Ki=19nM P50135 16168438 401 SMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA 4fgz A 1.994 BS01 CQA A 1 I30 F31 G32 G39 E42 L213 V216 E217 Y220 I22 F23 G24 G31 E34 L205 V208 E209 Y212 2.1.1.103 0000139,0000234,0005737,0005794,0006656,0008168,0008654,0009058,0016020,0032259 ic50=1350uM -logKd/Ki=2.87, IC50=1350uM IC50=1350000nM Q8IDQ9 22771008 301 SDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGYFKATKN 4fgz A 1.994 BS02 CQA A 2 E171 Y175 G243 R246 K247 E163 Y167 G235 R238 K239 2.1.1.103 0000139,0000234,0005737,0005794,0006656,0008168,0008654,0009058,0016020,0032259 ic50=1350uM -logKd/Ki=2.87, IC50=1350uM IC50=1350000nM Q8IDQ9 22771008 302 SDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGYFKATKN 4fgz B 1.994 BS01 CQA B 1 I30 F31 G32 G39 E42 L213 V216 E217 Y220 I22 F23 G24 G31 E34 L205 V208 E209 Y212 2.1.1.103 0000139,0000234,0005737,0005794,0006656,0008168,0008654,0009058,0016020,0032259 ic50=1350uM IC50=1350000nM Q8IDQ9 22771008 301 SDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGYFKATKN 4fgz B 1.994 BS02 CQA B 2 E171 E174 Y175 G243 R246 K247 E163 E166 Y167 G235 R238 K239 2.1.1.103 0000139,0000234,0005737,0005794,0006656,0008168,0008654,0009058,0016020,0032259 ic50=1350uM IC50=1350000nM Q8IDQ9 22771008 302 SDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGYFKATKN 4mwz B 1.5 BS02 CQA B 1 F28 G29 G36 I39 E209 L210 L213 E214 K217 F29 G30 G37 I40 E210 L211 L214 E215 K218 2.1.1.103 0009058,0016740 A5K867 303 HMISEPVDIKYLENNQYSDEGIKAYEFIFGEDYISSGGIIATTKILSDIQLDANSKVLDIGSGLGGGCKYINEKYGAHVHGVDICEKMVTIAKLRNQDKAKIEFEAKDILKKDFPESTFDMIYSRDSILHLSYADKKMLFEKCYKWLKPNGILLITDYCADKIENWDEEFKAYIKKRKYTLMPIQEYGDLIKSCKFQNVEAKDISDYWLELLQLELSKLEEKKEEFLKVYSIKEYNSLKDGWTRKIKDTKRDLQKWGYFKAQKMI