1i7z A 2.3 BS01 COC A 1 Y32 H34 S91 R92 E93 Y36 H38 S95 R96 E97 ? 0002250,0003823,0005576,0005615,0005886,0006955,0016064,0019814,0050853,0070062,0071735,0071738,0071742,0071745,0071753,0072562 Kd=0.4uM -logKd/Ki=6.40, Kd=0.4uM P01834 11469854 301 DLVLTQSPASLAVSLGQRATISCRASKSVSTSGYNYMHWYQQKPGQPPKLLIYLASNLASGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCLYSREFPPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1i7z B 2.3 BS01 COC A 1 Y95 S97 P98 D101 Y99 S101 P102 D105 ? -logKd/Ki=6.40, Kd=0.4uM P01857 11469854 301 QVQLQQSGPELKKPGETVKISCKTSGYSFTNYGMNWVKQAPGKGLKWMGWINTYTGEPTYADDFRGRFAFSLATSASTAYLQIINLKNEDTATYFCETYDSPLGDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 1i7z C 2.3 BS01 COC C 1 Y30 H34 L50 S91 R92 E93 Y34 H38 L54 S95 R96 E97 ? 0002250,0003823,0005576,0005615,0005886,0006955,0016064,0019814,0050853,0070062,0071735,0071738,0071742,0071745,0071753,0072562 Kd=0.4uM P01834 11469854 302 DLVLTQSPASLAVSLGQRATISCRASKSVSTSGYNYMHWYQQKPGQPPKLLIYLASNLASGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCLYSREFPPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1i7z D 2.3 BS01 COC C 1 Y95 S97 P98 D101 Y99 S101 P102 D105 ? P01857 11469854 302 QVQLQQSGPELKKPGETVKISCKTSGYSFTNYGMNWVKQAPGKGLKWMGWINTYTGEPTYADDFRGRFAFSLATSASTAYLQIINLKNEDTATYFCETYDSPLGDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 1q72 H 1.7 BS01 COC H 1 D31 W33 V95 Q97 D31 W33 V101 Q103 Kd=0.0000123M -logKd/Ki=6.85, Kd=0.14uM 15885702 401 EVTLQESGGGLVQPGGSMKLSCAASGFTFSDAWVDWVRQSPGKGLEWVAEIRNKANNHATKYTESVKGRFTISRDDSKSSVYLQMNSLRAEDTGIYYCTSVPQLGRGFAYWGQGTLVTVSAASTTPPSVYPLAPGSGGAGSMVTLGCLVKGYFPEPVTVTWNSGALSSGVHTFPAVLNGDLYTLSSSVTVPSSTWPSQTVTCNVAHPASSTQVDKKIVPK 1q72 L 1.7 BS01 COC H 1 Y32 H91 F96 Y37 H96 F101 -logKd/Ki=6.85, Kd=0.14uM 15885702 401 DIVMTQAAPSVPVTPGESVSISCRSSKSLLHSNGYTYLHWFLQRPGQSPQLLIYRVSNLASGVPDRFSGSGSGTAFTLRFSRVEAEDVGVYYCMQHLEYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPQDITVSWKIDGAERSSGVLNSWTDQDSSDSTYSMSSTLTLTKDEYERHSSYTCEATHKTSTSPITKSFNRGE 2ajv H 1.5 BS01 COC L 1 A34 Y50 Y97 A34 Y51 Y101 ? A2NUE8 16472740 501 EVKLSESGPGLVKPSQSLSLTCTVTGYSITTNYAWTWIRQFPGNKLEWMGYIRSSVITRYNPSLKSRISITQDTSKNQFFLQLNSVTTEDTATYYCARYDYYGNTGDYWGQGTSVTVSSAKTTPPSVYPLAPGTAALKSSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLTSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPR 2ajv L 1.5 BS01 COC L 1 Y27D Y32 F91 V92 F96 Y31 Y37 F96 V97 F101 ? 0005576,0005886,0030183 P01837 16472740 501 DIVITQDELSNPVTSGESVSISCRSSRSLLYKDGRTYLNWFLQRPGQSPQLLIYLMSTRASGVSDRFSGSGSGTDFTLEISRVKAEDVGVYYCQQFVEYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR 2pgz A 1.76 BS01 COC A 1 Y93 W147 Y188 C190 C191 Y195 Y97 W151 Y192 C194 C195 Y199 ? 0004888,0005216,0005230,0006811,0016020,0034220 Kd=1.8uM -logKd/Ki=5.74, Kd=1.8uM Q8WSF8 17481657 401 DDDDKLHSQANLMRLKSDLFNRSYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 2pgz B 1.76 BS01 COC A 1 Y55 Q57 I118 Y57 Q59 I120 ? 0004888,0005216,0005230,0006811,0016020,0034220 -logKd/Ki=5.74, Kd=1.8uM Q8WSF8 17481657 401 DDDDKLHSQANLMRLKSDLFNYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRF 2pgz E 1.76 BS01 COC D 1 Q57 I118 Q59 I120 ? 0004888,0005216,0005230,0006811,0016020,0034220 Q8WSF8 17481657 401 DDDDKLHSQANLMRLKSDLFNYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER 4xp4 A 2.8 BS02 COC A 1 F43 D46 V120 D121 Y124 F319 S320 F325 S421 G425 F19 D22 V96 D97 Y100 F254 S255 F260 S356 G360 ? 0016020 Q7K4Y6 25970245 706 DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLAVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFEGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLATLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD 4xpb A 3.05 BS03 COC A 1 F43 A44 D46 V120 Y124 F319 S320 G322 F325 S421 G425 F19 A20 D22 V96 Y100 F252 S253 G255 F258 S354 G358 ? 0016020 Q7K4Y6 25970245 702 DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLAVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVGFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLATLGLDSSFGGMEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD 8de3 A 3.3 BS01 COC A 1 Y132 D135 A206 F372 F378 S475 G479 T534 Y17 D20 A91 F257 F263 S360 G364 T419 ? 0016020 F1RN70 1004 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGFAICVIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNVTWMLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIILSILLVRGATLPGAWRGVLFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHFWSKRREWLALGVVITCFLGSLITLTFGGAYVVKLLEEFATGPAVLTVALIEAVAVFWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLVFIICSFLMSPPQLWLFQYNYPQWSIILGYCIGTSSFICIPTYITYRLIITPGTLKERIVKGITPETP 9eo4 B 2.66 BS06 COC B 1 F76 A77 D79 N82 V152 G153 Y156 G323 F326 G426 F20 A21 D23 N26 V96 G97 Y100 G249 F252 G352 0001504,0002020,0005102,0005326,0005330,0005334,0005515,0005737,0005886,0006836,0006865,0007595,0007608,0007626,0008504,0009410,0009986,0010039,0014070,0015293,0015844,0015872,0015874,0016020,0016600,0021984,0022857,0030424,0032809,0035094,0035240,0035725,0040018,0042053,0042220,0042416,0042420,0042734,0042995,0043005,0043025,0043176,0043679,0044877,0045121,0045211,0045471,0046872,0050890,0051583,0051591,0051620,0051721,0060134,0090494,0098691,1901363,1990384 Q01959 39112703 707 AQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV