3bk0 A 1.6 BS01 CNU A 1 S68 D70 K92 H94 D123 I179 M182 S183 I212 P228 Q241 Y243 G261 R262 S35 D37 K59 H61 D90 I146 M149 S150 I179 P195 Q208 Y210 G228 R229 2.4.2.10,4.1.1.23 0004590,0006207,0044205 P11172 1000 KELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3bk0 A 1.6 BS02 CNU B 1 D128 I129 T132 D95 I96 T99 2.4.2.10,4.1.1.23 0004590,0006207,0044205 P11172 1001 KELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3bk0 B 1.6 BS01 CNU A 1 D128 T132 D95 T99 2.4.2.10,4.1.1.23 0004590,0006207,0044205 P11172 1000 KELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3bk0 B 1.6 BS02 CNU B 1 S68 D70 K92 H94 D123 I179 M182 S183 I212 P228 Q241 Y243 G261 R262 S35 D37 K59 H61 D90 I146 M149 S150 I179 P195 Q208 Y210 G228 R229 2.4.2.10,4.1.1.23 0004590,0006207,0044205 P11172 1001 KELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3ewz A 1.4 BS01 CNU B 1 S257 D259 K281 H283 I368 M371 S372 I401 P417 Q430 Y432 G450 R451 S35 D37 K59 H61 I146 M149 S150 I179 P195 Q208 Y210 G228 R229 2.4.2.10,4.1.1.23 0004590,0006207,0044205 -logKd/Ki=4.10, IC50=79uM P11172 19472232 481 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV 3ewz A 1.4 BS02 CNU B 2 D317 I318 T321 D95 I96 T99 2.4.2.10,4.1.1.23 0004590,0006207,0044205 -logKd/Ki=4.10, IC50=79uM P11172 19472232 482 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV 3ewz B 1.4 BS01 CNU B 1 D317 T321 D95 T99 2.4.2.10,4.1.1.23 0004590,0006207,0044205 ic50=79uM -logKd/Ki=4.10, IC50=79uM P11172 19472232 481 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV 3ewz B 1.4 BS02 CNU B 2 S257 D259 K281 H283 D312 I368 M371 S372 I401 P417 Q430 Y432 G450 R451 S35 D37 K59 H61 D90 I146 M149 S150 I179 P195 Q208 Y210 G228 R229 2.4.2.10,4.1.1.23 0004590,0006207,0044205 ic50=79uM -logKd/Ki=4.10, IC50=79uM P11172 19472232 482 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV 3ewz C 1.4 BS01 CNU B 3 S257 D259 K281 H283 D312 I368 M371 S372 I401 P417 Q430 Y432 G450 R451 S35 D37 K59 H61 D90 I146 M149 S150 I179 P195 Q208 Y210 G228 R229 2.4.2.10,4.1.1.23 0004590,0006207,0044205 P11172 19472232 483 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3ewz C 1.4 BS02 CNU B 4 D317 I318 T321 D95 I96 T99 2.4.2.10,4.1.1.23 0004590,0006207,0044205 P11172 19472232 484 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3ewz D 1.4 BS01 CNU B 3 D317 I318 T321 D95 I96 T99 2.4.2.10,4.1.1.23 0004590,0006207,0044205 P11172 19472232 483 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRL 3ewz D 1.4 BS02 CNU B 4 S257 D259 K281 H283 D312 I368 M371 S372 I401 P417 Q430 Y432 G450 R451 S35 D37 K59 H61 D90 I146 M149 S150 I179 P195 Q208 Y210 G228 R229 2.4.2.10,4.1.1.23 0004590,0006207,0044205 P11172 19472232 484 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRL