1cgp A 3.0 BS04 CMP A 1 V49 S62 G71 E72 R82 S83 A84 T127 V41 S54 G63 E64 R74 S75 A76 T119 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 1653449 206 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1cgp B 3.0 BS04 CMP A 1 L124 S128 L116 S120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 1653449 206 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1cgp B 3.0 BS05 CMP B 1 S62 I70 G71 E72 L73 R82 S83 A84 R123 S54 I62 G63 E64 L65 R74 S75 A76 R115 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 1653449 206 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1cx4 A 2.45 BS01 CMP A 1 I199 Y213 F219 G220 E221 L222 A223 R230 A231 R381 I70 Y84 F90 G91 E92 L93 A94 R101 A102 R244 ? 0001932,0005952,0008603 P12369 11342137 440 RIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVRITMKRNGAVEIARCLRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIV 1cx4 A 2.45 BS02 CMP A 2 I339 F348 G349 E350 L351 A352 R359 A360 A361 Y397 I202 F211 G212 E213 L214 A215 R222 A223 A224 Y260 ? 0001932,0005952,0008603 P12369 11342137 450 RIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVRITMKRNGAVEIARCLRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIV 1g6n A 2.1 BS01 CMP A 1 V49 L61 I70 G71 E72 L73 R82 S83 V43 L55 I64 G65 E66 L67 R76 S77 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11124031 621 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 1g6n B 2.1 BS01 CMP B 1 V349 I370 G371 E372 L373 R382 S383 A384 V43 I64 G65 E66 L67 R76 S77 A78 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11124031 622 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1hw5 A 1.82 BS01 CMP A 1 S62 I70 G71 E72 L73 R82 S83 R123 L127 S62 I70 G71 E72 L73 R82 S83 R123 L127 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 Kb=2.0+-0.3M^-1 (11124966) P0ACJ8 11124966 210 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 1hw5 A 1.82 BS02 CMP A 2 K57 E58 Q170 Q174 G177 C178 S179 R180 K57 E58 Q170 Q174 G177 C178 S179 R180 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 Kb=2.0+-0.3M^-1 (11124966) P0ACJ8 11124966 211 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 1hw5 B 1.82 BS01 CMP A 2 A135 F136 A135 F136 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 Kb=2.0+-0.3M^-1 (11124966) P0ACJ8 11124966 211 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1hw5 B 1.82 BS02 CMP B 1 V49 I70 G71 E72 L73 R82 S83 A84 R123 V49 I70 G71 E72 L73 R82 S83 A84 R123 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 Kb=2.0+-0.3M^-1 (11124966) P0ACJ8 11124966 210 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1i5z A 1.9 BS01 CMP A 1 V49 G71 E72 L73 R82 S83 V86 R123 V44 G66 E67 L68 R77 S78 V81 R118 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 QTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 1i5z A 1.9 BS02 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K52 E53 Q165 G168 Q169 G172 C173 S174 R175 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 302 QTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 1i5z B 1.9 BS01 CMP B 1 I30 V49 I70 G71 E72 L73 R82 S83 R123 I30 V49 I70 G71 E72 L73 R82 S83 R123 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1i6x A 2.2 BS01 CMP A 1 V49 G71 E72 L73 R82 S83 V86 T127 V44 G66 E67 L68 R77 S78 V81 T122 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 QTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKHEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 1i6x A 2.2 BS02 CMP A 2 G56 Q170 G173 G177 C178 S179 R180 G51 Q165 G168 G172 C173 S174 R175 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 302 QTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKHEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 1i6x B 2.2 BS01 CMP B 1 V49 G71 E72 L73 R82 S83 V86 R123 V42 G64 E65 L66 R75 S76 V79 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKHEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1j59 A 2.5 BS03 CMP A 1 I30 V49 L61 G71 L73 R82 S83 I22 V41 L53 G63 L65 R74 S75 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8757802 762 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1j59 B 2.5 BS03 CMP A 1 L124 S128 L116 S120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8757802 762 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1j59 B 2.5 BS04 CMP B 1 G71 L73 R82 S83 A84 G63 L65 R74 S75 A76 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8757802 761 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1lb2 A 3.1 BS03 CMP A 1 V49 L61 I70 G71 E72 L73 R82 S83 A84 T127 V41 L53 I62 G63 E64 L65 R74 S75 A76 T119 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 12202833 679 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 1lpc A 1.7 BS01 CMP A 1 Y73 V74 E119 R180 Q206 V207 W209 S210 Y73 V74 E119 R180 Q206 V207 W209 S210 E177 R180 E177 R180 3.2.2.22 0006952,0016787,0017148,0030598,0035821,0050688,0090729 P24476 15553110 901 ATAYTLNLANPSASQYSSFLDQIRNNVRDTSLIYGGTDVEVIGAPSTTDKFLRLNFQGPRGTVSLGLRRENLYVVAYLAMDNANVNRAYYFKNQITSAELTALFPEVVVANQKQLEYGEDYQAIEKNAKITTGDQSRKELGLGINLLITMIDGVNKKVRVVKDEARFLLIAIQMTAEAARFRYIQNLVTKNFPNKFDSENKVIQFQVSWSKISTAIFGDCKNGVFNKDYDFGFGKVRQAKDLQMGLLKYLGRPK 1nhk L 1.9 BS01 CMP L 1 K11 Y51 H54 F59 L63 I111 N114 H117 K10 Y50 H53 F58 L62 I110 N113 H116 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 P15266 7783219 146 AIERTLSIIKPDGLEKGVIGKIISRFEEKGLKPVAIRLQHLSQAQAEGFYAVHKARPFFKDLVQFMISGPVVLMVLEGENAVLANRDIMGATNPAQAAEGTIRKDFATSIDKNTVHGSDSLENAKIEIAYFFRETEIHSYPYQ 1nhk R 1.9 BS01 CMP R 1 K11 Y51 F59 L63 T93 I111 N114 H117 K10 Y50 F58 L62 T92 I110 N113 H116 2.7.4.6 0004550,0005524,0005737,0006183,0006228,0006241,0009117,0009142,0016301,0016310,0046872 P15266 7783219 1 AIERTLSIIKPDGLEKGVIGKIISRFEEKGLKPVAIRLQHLSQAQAEGFYAVHKARPFFKDLVQFMISGPVVLMVLEGENAVLANRDIMGATNPAQAAEGTIRKDFATSIDKNTVHGSDSLENAKIEIAYFFRETEIHSYPYQK 1o3q A 3.0 BS03 CMP A 1 V49 L61 I70 G71 E72 R82 S83 A84 V42 L54 I63 G64 E65 R75 S76 A77 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724532 1 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1o3q A 3.0 BS04 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 R180 K50 E51 Q163 G166 Q167 G170 C171 R173 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724532 2 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1o3r A 3.0 BS03 CMP A 1 I70 G71 E72 L73 R82 S83 I63 G64 E65 L66 R75 S76 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724532 1 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1o3r A 3.0 BS04 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 R180 K50 E51 Q163 G166 Q167 G170 C171 R173 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724532 2 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1o3s A 3.0 BS03 CMP A 1 V49 I70 G71 E72 L73 R82 S83 R123 V42 I63 G64 E65 L66 R75 S76 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724533 1 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRDTVGRILKMLEDQNLISAHGKTIVVYG 1o3s A 3.0 BS04 CMP A 2 K57 E58 Q170 G173 Q174 C178 S179 R180 K50 E51 Q163 G166 Q167 C171 S172 R173 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724533 2 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRDTVGRILKMLEDQNLISAHGKTIVVYG 1o3t A 2.8 BS03 CMP A 1 V49 I70 G71 E72 L73 R82 S83 T127 V41 I62 G63 E64 L65 R74 S75 T119 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724532 762 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1o3t B 2.8 BS03 CMP A 1 L124 S128 L116 S120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724532 762 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1o3t B 2.8 BS04 CMP B 1 I30 V49 S62 G71 E72 L73 R82 I22 V41 S54 G63 E64 L65 R74 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 11724532 761 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1q43 A 2.0 BS01 CMP A 1 V564 M572 F580 G581 E582 I583 C584 R591 T592 R632 V122 M126 F134 G135 E136 I137 C138 R145 T146 R186 ? O88703 12968185 646 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDR 1q43 B 2.0 BS01 CMP B 1 V564 M572 F580 G581 E582 I583 C584 R591 T592 R632 V120 M124 F132 G133 E134 I135 C136 R143 T144 R184 ? O88703 12968185 646 SRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRI 1q5o A 2.3 BS01 CMP A 1 V564 M572 F580 G581 E582 I583 C584 R591 T592 A593 R632 I636 V122 M130 F138 G139 E140 I141 C142 R149 T150 A151 R190 I194 ? O88703 12968185 201 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSIL 1rgs A 2.8 BS01 CMP A 1 F198 G199 E200 L201 A202 R209 A210 W260 F86 G87 E88 L89 A90 R97 A98 W148 2.7.1.37 0001932,0005952,0008603 P00514 7638597 401 RKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 1rgs A 2.8 BS02 CMP A 2 F322 G323 E324 I325 A326 R333 A334 Y371 F210 G211 E212 I213 A214 R221 A222 Y259 2.7.1.37 0001932,0005952,0008603 P00514 7638597 601 RKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 1run A 2.7 BS03 CMP A 1 S62 G71 E72 R82 S83 A84 S54 G63 E64 R74 S75 A76 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8836098 679 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 1run A 2.7 BS04 CMP B 1 L124 S128 L116 S120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8836098 678 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 1run B 2.7 BS03 CMP A 1 L124 S128 L116 S120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8836098 679 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1run B 2.7 BS04 CMP B 1 V49 S62 G71 E72 L73 R82 S83 T127 V41 S54 G63 E64 L65 R74 S75 T119 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8836098 678 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1ruo A 2.7 BS03 CMP A 1 V49 I70 G71 E72 L73 R82 S83 A84 V41 I62 G63 E64 L65 R74 S75 A76 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8836098 210 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRFTVGRILKMLEDQNLISAHGKTIVVY 1ruo A 2.7 BS04 CMP B 1 L124 S128 L116 S120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8836098 210 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRFTVGRILKMLEDQNLISAHGKTIVVY 1ruo B 2.7 BS03 CMP A 1 L124 S128 L116 S120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8836098 210 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRFTVGRILKMLEDQNLISAHGKTIVVYGTR 1ruo B 2.7 BS04 CMP B 1 V49 L61 S62 G71 E72 L73 R82 S83 A84 V41 L53 S54 G63 E64 L65 R74 S75 A76 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 8836098 210 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRFTVGRILKMLEDQNLISAHGKTIVVYGTR 1sk6 A 3.2 BS04 CMP A 1 K346 H351 G547 T548 H577 G578 T579 N583 K55 H60 G256 T257 H286 G287 T288 N292 4.6.1.1 0005576,0008294 P40136 15131111 289 RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQFKLLYKQLNFTENETDNFEVFQKIID 1sk6 B 3.2 BS03 CMP B 1 H351 G547 T548 G578 N583 H58 G252 T253 G283 N288 4.6.1.1 0005576,0008294 P40136 15131111 290 DVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKLLYKQLNFTENETDNFEVFQKIID 1sk6 C 3.2 BS04 CMP C 1 L348 H351 T548 H577 G578 T579 N583 L57 H60 T257 H286 G287 T288 N292 4.6.1.1 0005576,0008294 P40136 15131111 910 RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQFKLLYKQLNFTENETDNFEVFQKIID 1vp6 A 1.7 BS01 CMP A 1 V282 F296 G297 E298 M299 A300 R307 S308 A309 V311 R348 V65 F79 G80 E81 M82 A83 R90 S91 A92 V94 R131 ? 0005221 Q98GN8 15550244 368 VRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERRG 1vp6 C 1.7 BS01 CMP C 1 V282 F296 G297 E298 M299 A300 R307 S308 A309 V311 R348 V65 F79 G80 E81 M82 A83 R90 S91 A92 V94 R131 ? 0005221 Q98GN8 15550244 360 VRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERRG 1xfw A 3.4 BS02 CMP A 1 L348 G547 T548 G578 T579 E580 N583 L285 G484 T485 G515 T516 E517 N520 Y626 Y627 R630 Y679 D686 Y563 Y564 R567 Y616 D623 4.6.1.1 0003824,0005576,0008237,0008294,0046872 P40136 15719022 901 NNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIID 1xfw B 3.4 BS02 CMP B 1 L348 G547 T548 G578 T579 E580 N583 L285 G484 T485 G515 T516 E517 N520 Y626 Y627 R630 Y679 D686 Y563 Y564 R567 Y616 D623 4.6.1.1 0003824,0005576,0008237,0008294,0046872 P40136 15719022 902 NNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIID 1xfw C 3.4 BS02 CMP C 1 L348 G547 T548 G578 T579 E580 N583 L285 G484 T485 G515 T516 E517 N520 Y626 Y627 R630 Y679 D686 Y563 Y564 R567 Y616 D623 4.6.1.1 0003824,0005576,0008237,0008294,0046872 P40136 15719022 903 NNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIID 1xfw D 3.4 BS02 CMP D 1 L348 G547 T548 G578 T579 E580 N583 L285 G484 T485 G515 T516 E517 N520 Y626 Y627 R630 Y679 D686 Y563 Y564 R567 Y616 D623 4.6.1.1 0003824,0005576,0008237,0008294,0046872 P40136 15719022 904 NNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIID 1xfw E 3.4 BS02 CMP E 1 L348 G547 T548 G578 T579 E580 N583 L285 G484 T485 G515 T516 E517 N520 Y626 Y627 R630 Y679 D686 Y563 Y564 R567 Y616 D623 4.6.1.1 0003824,0005576,0008237,0008294,0046872 P40136 15719022 905 NNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIID 1xfw F 3.4 BS02 CMP F 1 L348 G547 T548 G578 T579 E580 N583 L285 G484 T485 G515 T516 E517 N520 Y626 Y627 R630 Y679 D686 Y563 Y564 R567 Y616 D623 4.6.1.1 0003824,0005576,0008237,0008294,0046872 P40136 15719022 906 NNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIID 1ykd A 1.9 BS01 CMP A 1 R103 T105 A122 I131 G138 I139 A140 Y174 Q196 L198 R46 T48 A65 I74 G81 I82 A83 Y117 Q139 L141 4.6.1.1 P94182 15708973 501 VTEVEQKLQIVHQTLSMLDSHGFENILQEMLQSITLKTGELLGADRTTIFLLDEEKQELWSIVAAGEGDRSLEIRIPADKGIAGEVATFKQVVNIPFDFYHDPRSIFAQKQEKITGYRTYTMLALPLLSEQGRLVAVVQLLNKLKPYSPPDALLAERIDNQGFTSADEQLFQEFAPSIRLILESSRSFYIATQKQRAAAAMMKAVKSLSQSSLDLEDTLKRVMDEAKELMNADRSTLWLIDRDRHELWTKITQDNGSTKELRVPIGKGFAGIVAASGQKLNIPFDLYDHPDSATAKQIDQQNGYRTCSLLCMPVFNGDQELIGVTQLVNKKKTGEFPPYNPETWPIAPECFQASFDRNDEEFMEAFNIQAGVALQNAQLFATV 1ykd A 1.9 BS02 CMP A 2 R291 T293 I308 G325 F326 A327 I355 T363 Q383 R234 T236 I251 G268 F269 A270 I298 T306 Q326 4.6.1.1 P94182 15708973 502 VTEVEQKLQIVHQTLSMLDSHGFENILQEMLQSITLKTGELLGADRTTIFLLDEEKQELWSIVAAGEGDRSLEIRIPADKGIAGEVATFKQVVNIPFDFYHDPRSIFAQKQEKITGYRTYTMLALPLLSEQGRLVAVVQLLNKLKPYSPPDALLAERIDNQGFTSADEQLFQEFAPSIRLILESSRSFYIATQKQRAAAAMMKAVKSLSQSSLDLEDTLKRVMDEAKELMNADRSTLWLIDRDRHELWTKITQDNGSTKELRVPIGKGFAGIVAASGQKLNIPFDLYDHPDSATAKQIDQQNGYRTCSLLCMPVFNGDQELIGVTQLVNKKKTGEFPPYNPETWPIAPECFQASFDRNDEEFMEAFNIQAGVALQNAQLFATV 1ykd B 1.9 BS01 CMP B 1 R103 T105 I131 G138 I139 A140 Y174 Q196 L198 R46 T48 I70 G77 I78 A79 Y113 Q135 L137 4.6.1.1 P94182 15708973 503 VTEVEQKLQIVHQTLSMLDSHGFENILQEMLQSITLKTGELLGADRTTIFLLDEEKQELWSIVAAGSLEIRIPADKGIAGEVATFKQVVNIPFDFYHDPRSIFAQKQEKITGYRTYTMLALPLLSEQGRLVAVVQLLNKLKPYSPPDALLAERIDNQGFTSADEQLFQEFAPSIRLILESSRSFYIATQKQRAAAAMMKAVKSLSQSSLDLEDTLKRVMDEAKELMNADRSTLWLIDRDRHELWTKITQDNGSTKELRVPIGKGFAGIVAASGQKLNIPFDLYDHPDSATAKQIDQQNGYRTCSLLCMPVFNGDQELIGVTQLVNKKKTGEFPPYNPETWPIAPECFQASFDRNDEEFMEAFNIQAGVALQNAQLFATVK 1ykd B 1.9 BS02 CMP B 2 R291 T293 I308 G325 F326 A327 A352 I355 T363 Q383 R230 T232 I247 G264 F265 A266 A291 I294 T302 Q322 4.6.1.1 P94182 15708973 504 VTEVEQKLQIVHQTLSMLDSHGFENILQEMLQSITLKTGELLGADRTTIFLLDEEKQELWSIVAAGSLEIRIPADKGIAGEVATFKQVVNIPFDFYHDPRSIFAQKQEKITGYRTYTMLALPLLSEQGRLVAVVQLLNKLKPYSPPDALLAERIDNQGFTSADEQLFQEFAPSIRLILESSRSFYIATQKQRAAAAMMKAVKSLSQSSLDLEDTLKRVMDEAKELMNADRSTLWLIDRDRHELWTKITQDNGSTKELRVPIGKGFAGIVAASGQKLNIPFDLYDHPDSATAKQIDQQNGYRTCSLLCMPVFNGDQELIGVTQLVNKKKTGEFPPYNPETWPIAPECFQASFDRNDEEFMEAFNIQAGVALQNAQLFATVK 1z5u A 2.3 BS02 CMP A 1 F58 Y72 L73 G115 T194 Y195 F52 Y66 L67 G109 T188 Y189 3.1.3.2 0003993,0016787,0030288,0042597,0046872 Q540U1 502 TLNPGTNVAKLAEQAPVHWVSVAQIENSLTGRPPMAVGFDIDDTVLFSSPGFWRGKKTYSPDSDDYLKNPAFWEKMNNGWDEFSIPKEAARQLIDMHVRRGDSIYFVTGRSQTKTETVSKTLADNFHIPAANMNPVIFAGDKPEQNTKVQWLQEKNMRIFYGDSDNDITAARDCGIRGIRILRAANSTYKPLPQAGAFGEEVIVNSEY 1z5u B 2.3 BS02 CMP B 1 F58 Y72 G115 T194 Y195 F54 Y68 G111 T190 Y191 3.1.3.2 0003993,0016787,0030288,0042597,0046872 Q540U1 504 PSTLNPGTNVAKLAEQAPVHWVSVAQIENSLTGRPPMAVGFDIDDTVLFSSPGFWRGKKTYSPDSDDYLKNPAFWEKMNNGWDEFSIPKEAARQLIDMHVRRGDSIYFVTGRSQTKTETVSKTLADNFHIPAANMNPVIFAGDKPEQNTKVQWLQEKNMRIFYGDSDNDITAARDCGIRGIRILRAANSTYKPLPQAGAFGEEVIVNSEY 1z5u C 2.3 BS02 CMP C 1 F58 Y72 G115 T194 Y195 F52 Y66 G109 T188 Y189 3.1.3.2 0003993,0016787,0030288,0042597,0046872 Q540U1 506 TLNPGTNVAKLAEQAPVHWVSVAQIENSLTGRPPMAVGFDIDDTVLFSSPGFWRGKKTYSPDSDDYLKNPAFWEKMNNGWDEFSIPKEAARQLIDMHVRRGDSIYFVTGRSQTKTETVSKTLADNFHIPAANMNPVIFAGDKPEQNTKVQWLQEKNMRIFYGDSDNDITAARDCGIRGIRILRAANSTYKPLPQAGAFGEEVIVNSEY 1z5u D 2.3 BS02 CMP D 1 F58 Y72 L73 G115 R116 T194 Y195 F54 Y68 L69 G111 R112 T190 Y191 3.1.3.2 0003993,0016787,0030288,0042597,0046872 Q540U1 508 PSTLNPGTNVAKLAEQAPVHWVSVAQIENSLTGRPPMAVGFDIDDTVLFSSPGFWRGKKTYSPDSDDYLKNPAFWEKMNNGWDEFSIPKEAARQLIDMHVRRGDSIYFVTGRSQTKTETVSKTLADNFHIPAANMNPVIFAGDKPEQNTKVQWLQEKNMRIFYGDSDNDITAARDCGIRGIRILRAANSTYKPLPQAGAFGEEVIVNSEY 1zrc A 2.8 BS03 CMP A 1 V49 I70 G71 E72 L73 R82 S83 A84 R123 V42 I63 G64 E65 L66 R75 S76 A77 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 210 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1zrc B 2.8 BS03 CMP B 1 V49 L61 I70 G71 E72 R82 S83 A84 V42 L54 I63 G64 E65 R75 S76 A77 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 210 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1zrd A 2.8 BS03 CMP A 1 V49 I70 G71 E72 L73 R82 S83 A84 V42 I63 G64 E65 L66 R75 S76 A77 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 210 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1zrd B 2.8 BS03 CMP B 1 V49 G71 E72 L73 R82 S83 R123 T127 V42 G64 E65 L66 R75 S76 R116 T120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 210 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1zre A 2.8 BS03 CMP A 1 V49 I70 G71 E72 L73 R82 S83 A84 V42 I63 G64 E65 L66 R75 S76 A77 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 210 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1zre B 2.8 BS03 CMP B 1 V49 G71 E72 L73 R82 S83 A84 T127 V42 G64 E65 L66 R75 S76 A77 T120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 210 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1zrf A 2.1 BS03 CMP A 1 V49 G71 E72 L73 R82 S83 A84 R123 V43 G65 E66 L67 R76 S77 A78 R117 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 622 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 1zrf A 2.1 BS04 CMP A 2 K57 E58 G173 Q174 G177 C178 R180 K51 E52 G167 Q168 G171 C172 R174 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 2622 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 1zrf B 2.1 BS03 CMP B 1 V49 I70 G71 E72 L73 R82 S83 T127 V42 I63 G64 E65 L66 R75 S76 T120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 1622 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 1zrf B 2.1 BS04 CMP B 2 K57 E58 G173 Q174 G177 C178 S179 R180 K50 E51 G166 Q167 G170 C171 S172 R173 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 16427082 3622 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 2cgp A 2.2 BS03 CMP A 1 V49 S62 I70 G71 E72 L73 R82 S83 R123 V42 S55 I63 G64 E65 L66 R75 S76 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 9096308 621 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 2cgp A 2.2 BS04 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 R180 K50 E51 Q163 G166 Q167 G170 C171 R173 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 9096308 622 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 2gzw A 2.21 BS01 CMP A 1 V49 I70 G71 E72 L73 R82 S83 A84 T127 V43 I64 G65 E66 L67 R76 S77 A78 T121 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 1301 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 2gzw A 2.21 BS02 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 K51 E52 Q164 G167 Q168 G171 C172 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 1302 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 2gzw B 2.21 BS01 CMP B 1 V49 I70 G71 E72 L73 R82 S83 A84 R123 V43 I64 G65 E66 L67 R76 S77 A78 R117 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTI 2gzw B 2.21 BS02 CMP B 2 K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K51 E52 Q164 G167 Q168 G171 C172 S173 R174 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 973 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTI 2gzw C 2.21 BS01 CMP C 1 V49 L61 G71 E72 L73 R82 S83 A84 R123 V43 L55 G65 E66 L67 R76 S77 A78 R117 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 2301 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 2gzw C 2.21 BS02 CMP C 2 K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K51 E52 Q164 G167 Q168 G171 C172 S173 R174 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 2302 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 2gzw D 2.21 BS01 CMP D 1 V49 I70 G71 E72 L73 R82 S83 A84 R123 T127 V43 I64 G65 E66 L67 R76 S77 A78 R117 T121 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 2401 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 2gzw D 2.21 BS02 CMP D 2 K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K51 E52 Q164 G167 Q168 G171 C172 S173 R174 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 2973 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 2k0g A -1.00 BS01 CMP A 1 F296 G297 M299 A300 R307 S308 R348 F83 G84 M86 A87 R94 S95 R135 ? 0005221 -logKd/Ki=6.97, Kd=107nM Q98GN8 19465888 370 GSQEVRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA 2our A 1.45 BS01 CMP A 1 H525 L635 L675 I692 F696 M713 Q726 F729 H79 L189 L229 I246 F250 M267 Q280 F283 3.1.4.17 0004114,0007165,0008081 Km=56nM (17389385) Q9Y233 17389385 778 HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACALCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 2ouy A 1.9 BS02 CMP A 1 H525 L635 I692 F696 Q726 F729 H79 L189 I246 F250 Q280 F283 3.1.4.17 0004114,0007165,0008081 Km=56nM (17389385) Q9Y233 17389385 779 HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHNLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWIS 2oz6 A 2.8 BS01 CMP A 1 R59 E60 Q175 G178 R179 G182 C183 S184 R185 R52 E53 Q163 G166 R167 G170 C171 S172 R173 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 Kd=1.0uM (21665969) -logKd/Ki=5.26, Kd=5.5uM P55222 21665969 302 MKLKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGT 2oz6 A 2.8 BS02 CMP A 2 I51 I63 F72 G73 E74 L75 R87 S88 A89 V91 R128 T132 I44 I56 F65 G66 E67 L68 R75 S76 A77 V79 R116 T120 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 Kd=1.0uM (21665969) -logKd/Ki=5.26, Kd=5.5uM P55222 21665969 301 MKLKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGT 2ptm A 1.93 BS01 CMP A 1 I592 T601 F609 G610 E611 I612 C613 R620 V621 R661 I122 T131 F139 G140 E141 I142 C143 R150 V151 R191 ? K1/2=1.1uM (17562314) O76977 17562314 401 DSSSRQYREKLKQVEEYMQYRKLPSHLRNKILDYYEYRYRGKMFDERHIFREVSESIRQDVANYNCRDLVASVPFFVGADSNFVTRVVTLLEFEVFQPADYVIQEGTFGDRMFFIQQGIVDIIMSDGVIATSLSDGSYFGEICLLTRERRVASVKCETYCTLFSLSVQHFNQVLDEFPAMRKTMEEIAVRRL 2pw3 A 1.56 BS02 CMP A 1 H160 M273 L319 I336 Q369 F372 H75 M188 L234 I251 Q284 F287 3.1.4.53 0004114,0007165,0008081 Km=56nM (17562314) Q08499 17582435 1 TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHNVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 2pw3 B 1.56 BS02 CMP B 1 H160 M273 L319 I336 Q369 F372 H73 M186 L232 I249 Q282 F285 3.1.4.53 0004114,0007165,0008081 Km=56nM (17562314) Q08499 17582435 1 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHNVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 2zmf A 2.1 BS01 CMP A 1 R286 F304 D305 F324 G329 I330 A331 F352 N353 V356 T364 Q383 R41 F59 D60 F79 G84 I85 A86 F107 N108 V111 T119 Q138 3.1.4.17 Q9Y233 18477562 2001 QTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIR 2zmf B 2.1 BS01 CMP B 1 R286 C287 F304 D305 F324 G329 I330 A331 F352 N353 V356 Y362 T364 Q383 R39 C40 F57 D58 F77 G82 I83 A84 F105 N106 V109 Y115 T117 Q136 3.1.4.17 Q9Y233 18477562 2001 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 3bpz A 1.65 BS01 CMP A 1 V564 M572 F580 G581 E582 I583 C584 R591 T592 R632 I636 V122 M130 F138 G139 E140 I141 C142 R149 T150 R190 I194 ? O88703 18367452 641 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREKIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRI 3bpz B 1.65 BS01 CMP B 1 V564 F580 G581 E582 I583 C584 R591 T592 R632 I636 V122 F138 G139 E140 I141 C142 R149 T150 R190 I194 ? O88703 18367452 641 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREKIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRI 3bpz C 1.65 BS01 CMP C 1 V564 M572 F580 G581 E582 I583 C584 R591 T592 R632 I636 V122 M129 F137 G138 E139 I140 C141 R148 T149 R189 I193 ? O88703 18367452 641 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREKIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRI 3bpz D 1.65 BS01 CMP D 1 V564 F580 G581 E582 I583 C584 R591 T592 R632 I636 V122 F138 G139 E140 I141 C142 R149 T150 R190 I194 ? O88703 18367452 641 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREKIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRI 3clp A 2.0 BS01 CMP A 1 V282 T284 F296 G297 E298 M299 A300 S308 A309 V311 R348 V65 T67 F79 G80 E81 M82 A83 S91 A92 V94 R131 ? 0005221 -logKd/Ki=3.69, Kd=205.1uM Q98GN8 18619611 1 VRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPESATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERR 3clp C 2.0 BS01 CMP C 1 V282 F296 G297 E298 M299 A300 E307 S308 A309 R348 V65 F79 G80 E81 M82 A83 E90 S91 A92 R131 ? 0005221 Q98GN8 18619611 2 VRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPESATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERRG 3etq A 1.9 BS01 CMP A 1 V564 M572 F580 G581 E582 I583 S584 R591 T592 A593 R632 I636 V122 M130 F138 G139 E140 I141 S142 R149 T150 A151 R190 I194 ? Kd=920+-240nM (19525958) O88703 19525958 1 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNNRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEISLLTRGRRTASVRADTYSRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRI 3etq B 1.9 BS01 CMP B 1 V564 M572 F580 G581 E582 I583 S584 R591 T592 R632 R635 V121 M128 F136 G137 E138 I139 S140 R147 T148 R188 R191 ? Kd=920+-240nM (19525958) O88703 19525958 1 SSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNNRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKNKEMKLSDGSYFGEISLLTRGRRTASVRADTYSRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDR 3gyd A 1.79 BS01 CMP A 1 V74 A87 I95 G96 E97 M98 S99 R106 S107 C110 R151 V84 A97 I105 G106 E107 M108 S109 R116 S117 C120 R161 ? 0000166 Q1GZZ4 300 HHHENLYFQGMYPDLVHLGGADKYFEEILEIVNKIKLFGDFSNEEVRYLCSYMQCYAAPRDCQLLTEGDPGDYLLLILTGEVNVIKDIPNKGIQTIAKVGAGAIIGEMSMIDGMPRSASCVASLPTDFAVLSRDALYQLLANMPKLGNKVLIRLLQLLTARFRESYDRILPKTLGELI 3gyd B 1.79 BS01 CMP B 1 V74 A87 I95 G96 E97 M98 S99 R106 S107 A108 C110 R151 V86 A99 I107 G108 E109 M110 S111 R118 S119 A120 C122 R163 ? 0000166 Q1GZZ4 300 HHHHHENLYFQGMYPDLVHLGGADKYFEEILEIVNKIKLFGDFSNEEVRYLCSYMQCYAAPRDCQLLTEGDPGDYLLLILTGEVNVIKDIPNKGIQTIAKVGAGAIIGEMSMIDGMPRSASCVASLPTDFAVLSRDALYQLLANMPKLGNKVLIRLLQLLTARFRESYDRILPKTLGELI 3h3u B 2.9 BS01 CMP B 1 M1 D2 M1 D2 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 20338852 226 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLIS 3i54 A 2.2 BS01 CMP A 1 F38 M72 F78 G79 E80 L81 S82 R89 T90 S91 R130 T134 F39 M73 F79 G80 E81 L82 S83 R90 T91 S92 R131 T135 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 19740754 301 LYFQSHMDEILARAGIFQGVEPSAIAAQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRA 3i54 B 2.2 BS01 CMP B 1 F38 L69 T70 M72 F78 G79 E80 L81 S82 R89 T90 S91 R130 F40 L65 T66 M68 F74 G75 E76 L77 S78 R85 T86 S87 R126 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 19740754 301 NLYFQSHMDEILARAGIFQEPSAIAALLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRNLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRA 3i54 C 2.2 BS01 CMP C 1 F38 I57 F78 G79 E80 L81 S82 R89 T90 S91 R130 F21 I40 F61 G62 E63 L64 S65 R72 T73 S74 R113 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 19740754 301 AIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRA 3i54 D 2.2 BS01 CMP D 1 F38 L69 F78 G79 E80 L81 S82 R89 T90 S91 R130 F43 L74 F83 G84 E85 L86 S87 R94 T95 S96 R135 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 19740754 301 YFQSHMDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRA 3iyd G 19.8 BS03 CMP G 1 V49 G71 E72 L73 R82 S83 A84 T127 V41 G63 E64 L65 R74 S75 A76 T119 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 19903881 679 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 3iyd H 19.8 BS03 CMP H 1 S62 G71 E72 L73 S83 S54 G63 E64 L65 S75 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 19903881 680 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 3kcc A 1.66 BS01 CMP A 1 V49 S62 I70 G71 E72 L73 R82 S83 R123 V42 S55 I63 G64 E65 L66 R75 S76 R116 V183 V176 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 21255606 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLLVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 3kcc A 1.66 BS02 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K50 E51 Q163 G166 Q167 G170 C171 S172 R173 V183 V176 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 21255606 303 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLLVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 3kcc B 1.66 BS01 CMP B 1 V49 I70 G71 E72 L73 R82 S83 A84 R123 V41 I62 G63 E64 L65 R74 S75 A76 R115 V183 V175 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 21255606 302 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLLVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 3kcc B 1.66 BS02 CMP B 2 K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K49 E50 Q162 G165 Q166 G169 C170 S171 R172 V183 V175 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 21255606 304 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLLVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 3mzh A 2.9 BS03 CMP A 1 F38 L69 G79 E80 L81 S82 R89 S91 R130 F39 L70 G80 E81 L82 S83 R90 S92 R131 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 623 HMDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 3mzh B 2.9 BS03 CMP A 1 L131 N135 L132 N136 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 623 HMDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 3mzh B 2.9 BS04 CMP B 1 N67 L68 L69 N137 D140 L141 R149 K152 Q153 Q156 L183 V184 G185 N68 L69 L70 N138 D141 L142 R150 K153 Q154 Q157 L184 V185 G186 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 621 HMDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 3mzh B 2.9 BS05 CMP B 2 F38 T70 F78 G79 E80 L81 S82 R130 F39 T71 F79 G80 E81 L82 S83 R131 ? 0003677,0003700,0005515,0005829,0005886,0006355,0009274,0030552,0045892,0045893 P9WMH3 622 HMDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 3n10 A 1.6 BS01 CMP A 1 F5 E10 R63 L72 I74 K76 C83 F2 E7 R60 L69 I71 K73 C80 4.6.1.1 0000166,0016829,0046872 A0A2U2H3Y1 21094652 181 HFVGKYEVELKFRVMDLTTLHEQLVAQKATAFTLNNHEKDIYLDANGQDLAKQQISMVLREMNPSGIRLWIVKGPGAERCEASNIEDVSKVQSMLATLGYHPAFTIEKQRSIYFVGKFHITVDHLTGLGDFAEIAIMTDDATELDKLKAECRDFANTFGLQVDQQEPRSYRQLLGF 3n10 B 1.6 BS01 CMP B 1 F5 E10 R63 L72 I74 K76 F2 E7 R60 L69 I71 K73 4.6.1.1 0000166,0016829,0046872 A0A2U2H3Y1 21094652 181 HFVGKYEVELKFRVMDLTTLHEQLVAQKATAFTLNNHEKDIYLDANGQDLAKQQISMVLREMNPSGIRLWIVKGPGAERCEASNIEDVSKVQSMLATLGYHPAFTIEKQRSIYFVGKFHITVDHLTGLGDFAEIAIMTDDATELDKLKAECRDFANTFGLQVDQQEPRSYRQLLGF 3n4m A 2.987 BS03 CMP A 1 V49 L61 G71 E72 L73 R82 S83 A84 T127 V43 L55 G65 E66 L67 R76 S77 A78 T121 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 33205945 210 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 3ocp A 2.49 BS01 CMP A 1 L172 F181 G182 E183 L184 A185 R192 T193 A194 L81 F90 G91 E92 L93 A94 R101 T102 A103 2.7.11.12 Kd=27+-3.6nM (21526164) Kd=27nM -logKd/Ki=7.57, Kd=27nM Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMR 3ocp B 2.49 BS01 CMP B 1 V165 L172 M175 F181 G182 L184 A185 R192 T193 A194 V74 L81 M84 F90 G91 L93 A94 R101 T102 A103 2.7.11.12 Kd=27+-3.6nM (21526164) Kd=27nM Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRT 3of1 A 2.21 BS01 CMP A 1 I212 F231 V233 F247 G248 E249 L250 A251 R258 A259 A260 Y309 I42 F61 V63 F77 G78 E79 L80 A81 R88 A89 A90 Y139 ? P07278 21070946 501 QLQRLEKSIRNNFLFNKLDSDSKRLVINCLEEKSVPKGATIIKQGDQGDYFYVVEKGTVDFYVNDNKVNSSGPGSSFGELALMYNSPRAATVVATSDCLLWALDRLTFRKILLGSSFKKRLMYDDLLKSMPVLKSLTTYDRAKLADALDTKIYQPGETIIREGDQGENFYLIEYGAVDVSKKGQGVINKLKDHDYFGEVALLNDLPRQATVTATKRTKVATLGKSGFQRLLGPAVDVLKLNDPTRH 3of1 A 2.21 BS02 CMP A 2 I330 I357 N358 F366 G367 E368 V369 A370 R377 Q378 P413 I160 I187 N188 F196 G197 E198 V199 A200 R207 Q208 P243 ? P07278 21070946 601 QLQRLEKSIRNNFLFNKLDSDSKRLVINCLEEKSVPKGATIIKQGDQGDYFYVVEKGTVDFYVNDNKVNSSGPGSSFGELALMYNSPRAATVVATSDCLLWALDRLTFRKILLGSSFKKRLMYDDLLKSMPVLKSLTTYDRAKLADALDTKIYQPGETIIREGDQGENFYLIEYGAVDVSKKGQGVINKLKDHDYFGEVALLNDLPRQATVTATKRTKVATLGKSGFQRLLGPAVDVLKLNDPTRH 3ogj A 2.751 BS01 CMP A 1 L172 F181 G182 E183 L184 A185 R192 T193 L81 F90 G91 E92 L93 A94 R101 T102 2.7.11.12 Kd=27+-3.6nM (21526164) Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRT 3ogj B 2.751 BS01 CMP B 1 L172 C173 M175 F181 G182 E183 L184 A185 R192 T193 A194 L81 C82 M84 F90 G91 E92 L93 A94 R101 T102 A103 2.7.11.12 Kd=27+-3.6nM (21526164) Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMR 3otf A 2.4 BS01 CMP A 1 V642 F658 G659 E660 I661 C662 R669 T670 R710 V122 F138 G139 E140 I141 C142 R149 T150 R190 ? Kd=0.83uM -logKd/Ki=6.08, Kd=0.83uM Q9Y3Q4 20829353 725 DSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKK 3pna A 1.503 BS01 CMP A 1 V182 V184 F198 G199 E200 L201 A202 R209 A210 V71 V73 F87 G88 E89 L90 A91 R98 A99 2.7.1.37 P00514 21081668 250 VRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRK 3pna B 1.503 BS01 CMP B 1 F198 G199 E200 L201 A202 R209 A210 F89 G90 E91 L92 A93 R100 A101 2.7.1.37 P00514 21081668 250 SYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILM 3qop A 1.96 BS01 CMP A 1 V49 F62 G71 E72 L73 R82 S83 V86 R123 V42 F55 G64 E65 L66 R75 S76 V79 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3qop B 1.96 BS01 CMP B 1 I30 V49 F62 G71 E72 L73 R82 S83 R123 I23 V42 F55 G64 E65 L66 R75 S76 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3r6s A 2.38 BS01 CMP A 1 F41 L60 L72 F81 G82 E83 L84 S85 R92 T93 R133 T137 F39 L58 L70 F79 G80 E81 L82 S83 R90 T91 R131 T135 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006355,0016301,0016310,0030552,0032993,0045892,0045893,2000874 Q79VI7 301 GVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR 3r6s B 2.38 BS01 CMP B 1 F41 L72 F81 G82 E83 L84 S85 R92 T93 S94 R133 T137 F39 L70 F79 G80 E81 L82 S83 R90 T91 S92 R131 T135 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006355,0016301,0016310,0030552,0032993,0045892,0045893,2000874 Q79VI7 301 GVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR 3r6s C 2.38 BS01 CMP C 1 F41 L60 L72 F81 G82 E83 L84 S85 R92 T93 R133 F39 L58 L70 F79 G80 E81 L82 S83 R90 T91 R131 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006355,0016301,0016310,0030552,0032993,0045892,0045893,2000874 Q79VI7 301 GVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRA 3r6s D 2.38 BS01 CMP D 1 F41 L60 L72 G82 E83 L84 S85 R92 T93 S94 R133 F39 L58 L70 G80 E81 L82 S83 R90 T91 S92 R131 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006355,0016301,0016310,0030552,0032993,0045892,0045893,2000874 Q79VI7 301 GVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRA 3r6s E 2.38 BS01 CMP E 1 F41 M75 G82 E83 L84 S85 R92 T93 F39 M73 G80 E81 L82 S83 R90 T91 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006355,0016301,0016310,0030552,0032993,0045892,0045893,2000874 Q79VI7 301 GVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR 3r6s F 2.38 BS01 CMP F 1 L60 F81 G82 E83 L84 S85 R92 T93 R133 L58 F76 G77 E78 L79 S80 R87 T88 R128 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006355,0016301,0016310,0030552,0032993,0045892,0045893,2000874 Q79VI7 301 GVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHARENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR 3rdi A 2.95 BS01 CMP A 1 V49 F62 I70 G71 E72 L73 R82 S83 V86 V42 F55 I63 G64 E65 L66 R75 S76 V79 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rdi B 2.95 BS01 CMP B 1 V49 F62 I70 G71 E72 L73 R82 S83 V42 F55 I63 G64 E65 L66 R75 S76 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rou A 2.1 BS01 CMP A 1 V49 F62 I70 G71 E72 L73 R82 S83 V86 R123 V45 F58 I66 G67 E68 L69 R78 S79 V82 R119 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 PQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rou A 2.1 BS02 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K53 E54 Q166 G169 Q170 G173 C174 S175 R176 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 302 PQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rou A 2.1 BS03 CMP B 1 L124 S128 L120 S124 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 PQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rou B 2.1 BS01 CMP A 1 L124 S128 L117 S121 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rou B 2.1 BS02 CMP B 1 V49 F62 I70 G71 E72 L73 R82 S83 V86 R123 T127 V42 F55 I63 G64 E65 L66 R75 S76 V79 R116 T120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rpq A 2.61 BS01 CMP A 1 V49 F62 G71 E72 L73 R82 S83 R123 V43 F56 G65 E66 L67 R76 S77 R117 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rpq A 2.61 BS02 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 R180 K51 E52 Q164 G167 Q168 G171 C172 R174 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 302 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3rpq B 2.61 BS01 CMP B 1 V49 F62 G71 E72 L73 R82 S83 R123 T127 V43 F56 G65 E66 L67 R76 S77 R117 T121 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 3rpq B 2.61 BS02 CMP B 2 K57 E58 Q170 G173 Q174 G177 C178 R180 K51 E52 Q164 G167 Q168 G171 C172 R174 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 402 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILFYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 3ryp A 1.6 BS01 CMP A 1 V49 L61 S62 I70 G71 E72 L73 R82 S83 V86 V44 L56 S57 I65 G66 E67 L68 R77 S78 V81 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 QTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3ryp B 1.6 BS01 CMP B 1 V49 I70 G71 E72 L73 R82 S83 R123 V43 I64 G65 E66 L67 R76 S77 R117 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 3ryr A 2.7 BS01 CMP A 1 V49 S62 G71 E72 L73 R82 S83 R123 V42 S55 G64 E65 L66 R75 S76 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3ryr A 2.7 BS02 CMP A 2 K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K50 E51 Q163 G166 Q167 G170 C171 S172 R173 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 302 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 3ryr B 2.7 BS01 CMP B 1 I30 V49 S62 G71 E72 L73 R82 S83 R123 T127 I24 V43 S56 G65 E66 L67 R76 S77 R117 T121 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 401 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 3shr A 2.5 BS01 CMP A 1 K151 L156 F165 G166 E167 L168 A169 R176 T177 K74 L79 F88 G89 E90 L91 A92 R99 T100 2.7.11.12 0001932,0004692,0005524,0005952,0008603 P00516 21893290 401 QAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLK 3shr B 2.5 BS01 CMP B 1 V149 F165 G166 L168 A169 R176 T177 A178 V72 F88 G89 L91 A92 R99 T100 A101 2.7.11.12 0001932,0004692,0005524,0005952,0008603 P00516 21893290 401 QAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLK 3u0z A 2.9 BS01 CMP A 1 L521 F527 G528 E529 I530 C531 R538 T539 R579 R582 L132 F138 G139 E140 I141 C142 R149 T150 R190 R193 ? Kd=39.7nM (22006928) O88704 22006928 646 DSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNS 3u0z B 2.9 BS01 CMP B 1 L521 F527 G528 E529 I530 C531 R538 T539 A540 R579 L132 F138 G139 E140 I141 C142 R149 T150 A151 R190 ? Kd=39.7nM (22006928) O88704 22006928 646 DSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNS 3u10 A 2.3 BS01 CMP A 1 V591 M599 F607 G608 E609 I610 C611 R618 T619 A620 R659 I663 V122 M130 F138 G139 E140 I141 C142 R149 T150 A151 R190 I194 ? Kd=82.0nM (22006928) -logKd/Ki=5.44, Kd=3.6uM Q9UL51 22006928 701 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILL 3u11 A 2.5 BS01 CMP A 1 V642 T650 F658 G659 E660 I661 C662 R669 T670 R710 V122 T130 F138 G139 E140 I141 C142 R149 T150 R190 ? Kd=39.2nM (22006928) Q9Y3Q4 22006928 846 DSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKN 3u11 B 2.5 BS01 CMP B 1 V642 F658 G659 E660 I661 C662 R669 T670 R710 I714 V122 F138 G139 E140 I141 C142 R149 T150 R190 I194 ? Kd=39.2nM (22006928) Q9Y3Q4 22006928 846 DSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILL 4a2u A 2.63 BS01 CMP A 1 F38 I57 L69 F78 G79 E80 L81 S82 R89 T90 S91 R130 T134 F38 I57 L69 F78 G79 E80 L81 S82 R89 T90 S91 R130 T134 0003677,0006355 280 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u A 2.63 BS02 CMP B 1 L131 N135 L131 N135 0003677,0006355 280 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u B 2.63 BS01 CMP B 1 F38 I57 T70 G79 E80 L81 S82 R89 T90 S91 R130 T134 F38 I57 T70 G79 E80 L81 S82 R89 T90 S91 R130 T134 0003677,0006355 280 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u C 2.63 BS01 CMP C 1 F38 I57 T70 F78 G79 E80 L81 S82 R89 T90 S91 F38 I57 T70 F78 G79 E80 L81 S82 R89 T90 S91 0003677,0006355 280 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u D 2.63 BS01 CMP C 1 L131 N135 L115 N119 0003677,0006355 280 SAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u D 2.63 BS02 CMP D 1 F38 I57 F78 G79 E80 L81 S82 R89 T90 S91 T134 F22 I41 F62 G63 E64 L65 S66 R73 T74 S75 T118 0003677,0006355 280 SAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u E 2.63 BS01 CMP E 1 F38 I57 L69 F78 G79 E80 L81 S82 R89 T90 S91 T134 F38 I57 L69 F78 G79 E80 L81 S82 R89 T90 S91 T134 0003677,0006355 280 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u F 2.63 BS01 CMP F 1 F38 L69 F78 G79 E80 L81 S82 R89 T90 S91 R130 T134 F39 L70 F79 G80 E81 L82 S83 R90 T91 S92 R131 T135 0003677,0006355 280 SMDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u G 2.63 BS01 CMP G 1 F38 I57 L69 G79 E80 L81 S82 R89 T90 S91 R130 T134 F38 I57 L69 G79 E80 L81 S82 R89 T90 S91 R130 T134 0003677,0006355 280 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u G 2.63 BS02 CMP H 1 L131 N135 L131 N135 0003677,0006355 280 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4a2u H 2.63 BS01 CMP H 1 F38 I57 F78 G79 E80 L81 S82 R89 T90 S91 R130 T134 F41 I60 F81 G82 E83 L84 S85 R92 T93 S94 R133 T137 0003677,0006355 280 GSHMDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR 4avb A 1.8 BS01 CMP A 1 V67 A79 V87 G88 E89 I90 A91 R98 S99 R138 F142 V59 A71 V79 G80 E81 I82 A83 R90 S91 R130 F134 2.3.1.- 0003700,0005829,0006355,0016407,0016746,0016747,0030552,0046872 O05581 22773105 400 GARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAV 4avb B 1.8 BS01 CMP B 1 V67 A79 V87 G88 E89 I90 A91 R98 S99 A100 R138 F142 V59 A71 V79 G80 E81 I82 A83 R90 S91 A92 R130 F134 2.3.1.- 0003700,0005829,0006355,0016407,0016746,0016747,0030552,0046872 O05581 22773105 400 GARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAV 4avc A 2.806 BS01 CMP A 1 A79 V87 G88 E89 I90 A91 R98 S99 A100 R138 F142 A72 V80 G81 E82 I83 A84 R91 S92 A93 R131 F135 2.3.1.- 0003700,0005829,0006355,0016407,0016746,0016747,0030552,0046872 O05581 22773105 400 TGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG 4avc B 2.806 BS01 CMP B 1 V67 A79 V87 G88 E89 I90 A91 R98 S99 R138 V60 A72 V80 G81 E82 I83 A84 R91 S92 R131 2.3.1.- 0003700,0005829,0006355,0016407,0016746,0016747,0030552,0046872 O05581 22773105 400 TGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG 4clp A 1.9 BS01 CMP A 1 R199 I202 E203 I204 E205 S206 R192 I195 E196 I197 E198 S199 4.6.1.1 0009190,0035556 Kd=54.2mM -logKd/Ki=1.27, Kd=54.2mM Q96PN6 24567411 1473 MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFELDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTE 4clp A 1.9 BS02 CMP A 2 A97 G98 F336 F338 L345 V411 N412 R416 A97 G98 F329 F331 L338 V404 N405 R409 4.6.1.1 0009190,0035556 Kd=54.2mM -logKd/Ki=1.27, Kd=54.2mM Q96PN6 24567411 1474 MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFELDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTE 4clt A 1.95 BS02 CMP A 1 R199 I202 E203 I204 E205 S206 R192 I195 E196 I197 E198 S199 4.6.1.1 0009190,0035556 Ki=54.2uM Q96PN6 24567411 1472 MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKV 4clt A 1.95 BS03 CMP A 2 A97 G98 F336 L345 V406 V411 N412 R416 A97 G98 F329 L338 V399 V404 N405 R409 4.6.1.1 0009190,0035556 Ki=54.2uM Q96PN6 24567411 1473 MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKV 4cyd A 1.82 BS02 CMP A 1 F41 L60 F81 G82 E83 L84 S85 R92 T93 S94 R133 F38 L57 F78 G79 E80 L81 S82 R89 T90 S91 R130 ? 0000166,0003677,0003700,0005829,0006355 Kd=17uM H7C677 25469635 1228 GVQEILSRAGIFQVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR 4cyd B 1.82 BS02 CMP B 1 F41 L60 L72 F81 G82 E83 L84 S85 R92 T93 S94 R133 F39 L58 L70 F79 G80 E81 L82 S83 R90 T91 S92 R131 ? 0000166,0003677,0003700,0005829,0006355 Kd=17uM H7C677 25469635 1228 GVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR 4cyd C 1.82 BS02 CMP C 1 F41 L60 F81 G82 E83 L84 S85 R92 T93 S94 R133 F39 L58 F79 G80 E81 L82 S83 R90 T91 S92 R131 ? 0000166,0003677,0003700,0005829,0006355 Kd=17uM H7C677 25469635 1228 GVQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQEAGALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLEGKSVLIVDTEHLARRAR 4cyd D 1.82 BS02 CMP D 1 F41 F81 G82 E83 L84 S85 R92 T93 S94 R133 T137 F36 F76 G77 E78 L79 S80 R87 T88 S89 R128 T132 ? 0000166,0003677,0003700,0005829,0006355 Kd=17uM H7C677 25469635 1226 VQEILSRAGIGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVADHPAIAEQLLRVLARRLRRTNASLADLIFTDVPGRVAKTLLQLANRFGTQALRVNHDLTQEEIAQLVGASRETVNKALATFAHRGWIRLGKSVLITEHLARR 4d7t A 2.582 BS01 CMP A 1 V348 A358 F366 G367 E368 M369 A370 R377 T378 A379 R418 E421 V123 A133 F141 G142 E143 M144 A145 R152 T153 A154 R192 E195 ? 0005221 E0RR11 25625648 1424 DAAKLLHRERMERVTAFLSYKKISPELQRRILEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEDFIRDIILHLEPVIYGPGEYIIRAGELGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARTFCDLYRLDKETFDRILSRYPEAAQIQELAVRRKEELE 4d7t B 2.582 BS01 CMP B 1 V348 Y357 A358 F366 G367 E368 M369 A370 R377 T378 R418 E421 V102 Y111 A112 F120 G121 E122 M123 A124 R131 T132 R168 E171 ? 0005221 E0RR11 25625648 1424 AAKLLHRERMERVTAFLSYKKISPELQRRILEYFDYLWETRYREVLPPLRLAVAMEDVIEKLFFIDIILHLEPVIYGPGEYIIRAGELGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARTFCDLYRLKETFDRLSYEIAAQIQELAVRRKEELE 4ev0 A 2.402 BS01 CMP A 1 F34 L53 L65 F74 G75 E76 M77 S78 R85 S86 A87 R126 F31 L50 L62 F71 G72 E73 M74 S75 R82 S83 A84 R123 ? 0000166,0000976,0003677,0003700,0005829,0006355,0010628,0030552,0042803,0043565,0045893 Q5SID7 301 SPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQERTLALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHNLAALLARRLREADLELDLLSFEEARNRVAYALLKLLRQGLGPLFQIRHHELAALAGTSRETVSRVLHALAEEGVVRLGPGTVEVREAALLEEIAFGLA 4ev0 D 2.402 BS01 CMP D 1 F34 F74 G75 E76 M77 S78 R85 S86 A87 F32 F72 G73 E74 M75 S76 R83 S84 A85 ? 0000166,0000976,0003677,0003700,0005829,0006355,0010628,0030552,0042803,0043565,0045893 Q5SID7 301 GSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQERTLALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHNLAALLARRLREADLELDLLSFEEARNRVAYALLKLLRQGLGPLFQIRHHELAALAGTSRETVSRVLHALAEEGVVRLGPGTVEVREAALLEEIAFGLA 4ft8 A 1.966 BS01 CMP A 1 V49 L61 I70 G71 E72 L73 R82 S83 A84 R123 T127 V42 L54 I63 G64 E65 L66 R75 S76 A77 R116 T120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24817710 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 4ft8 B 1.966 BS01 CMP B 1 V49 I70 G71 E72 L73 R82 S83 A84 R123 T127 V43 I64 G65 E66 L67 R76 S77 A78 R117 T121 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24817710 301 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 4hbn A 2.6 BS01 CMP A 1 V642 F658 G659 E660 I661 C662 R669 T670 R710 V123 F138 G139 E140 I141 C142 R149 T150 R190 ? -logKd/Ki=6.10, Kd=0.8uM Q9Y3Q4 23103389 801 SDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTGNKETKLADGSYFGEICLLTRGRRTARVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNS 4hzf A 1.48 BS01 CMP A 1 V50 S63 I71 G72 E73 L74 R83 S84 R124 V42 S55 I63 G64 E65 L66 R75 S76 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 4hzf A 1.48 BS02 CMP A 2 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 K50 E51 Q163 G166 Q167 G170 C171 S172 R173 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 302 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 4hzf B 1.48 BS01 CMP B 1 V50 S63 I71 G72 E73 L74 R83 S84 V87 R124 V41 S54 I62 G63 E64 L65 R74 S75 V78 R115 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 4i01 A 2.3 BS01 CMP A 1 S63 G72 E73 L74 R83 S84 A85 V87 R124 T128 S58 G67 E68 L69 R78 S79 A80 V82 R119 T123 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 PQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDLTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 4i01 A 2.3 BS02 CMP A 2 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 K53 E54 Q166 G169 Q170 G173 C174 S175 R176 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 302 PQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDLTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 4i01 B 2.3 BS01 CMP B 1 V50 S63 I71 G72 E73 L74 R83 S84 R124 T128 V42 S55 I63 G64 E65 L66 R75 S76 R116 T120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDLTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 4i02 A 1.75 BS01 CMP A 1 V50 S63 I71 G72 E73 L74 R83 S84 A85 R124 V48 S61 I69 G70 E71 L72 R81 S82 A83 R122 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 LGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISATIVVYGT 4i02 A 1.75 BS02 CMP A 2 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 K56 E57 Q169 G172 Q173 G176 C177 S178 R179 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 302 LGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISATIVVYGT 4i02 A 1.75 BS03 CMP E 1 L125 S129 L123 S127 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 LGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISATIVVYGT 4i02 B 1.75 BS01 CMP B 1 V50 S63 I71 G72 E73 L74 R83 S84 A85 R124 V50 S63 I71 G72 E73 L74 R83 S84 A85 R124 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISATIVVYGT 4i02 B 1.75 BS02 CMP B 2 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 302 MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISATIVVYGT 4i02 C 1.75 BS01 CMP C 1 I31 V50 S63 I71 G72 E73 L74 R83 S84 R124 I23 V42 S55 I63 G64 E65 L66 R75 S76 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 4i02 D 1.75 BS01 CMP D 1 V50 S63 I71 G72 E73 L74 R83 S84 A85 R124 V50 S63 I71 G72 E73 L74 R83 S84 A85 R124 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHTIVVYGT 4i02 D 1.75 BS02 CMP D 2 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 302 MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHTIVVYGT 4i02 E 1.75 BS01 CMP E 1 V50 S63 I71 G72 E73 L74 R83 S84 V87 R124 V42 S55 I63 G64 E65 L66 R75 S76 V79 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 4i02 F 1.75 BS01 CMP F 1 I31 V50 S63 I71 G72 E73 L74 R83 S84 R124 I23 V42 S55 I63 G64 E65 L66 R75 S76 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDATGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 4i09 A 2.05 BS01 CMP A 1 V50 L62 I71 G72 E73 L74 R83 S84 A85 R124 V45 L57 I66 G67 E68 L69 R78 S79 A80 R119 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 PQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKLGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 4i09 B 2.05 BS01 CMP B 1 V50 I71 G72 E73 L74 R83 S84 V87 R124 V42 I63 G64 E65 L66 R75 S76 V79 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKLGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 4i0a A 2.2 BS01 CMP A 1 V50 S63 I71 G72 E73 L74 R83 S84 A85 V87 R124 V43 S56 I64 G65 E66 L67 R76 S77 A78 V80 R117 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKAGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 4i0a A 2.2 BS02 CMP A 2 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 K51 E52 Q164 G167 Q168 G171 C172 S173 R174 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 302 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKAGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 4i0a B 2.2 BS01 CMP A 2 A136 F137 A128 F129 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 302 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKAGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 4i0a B 2.2 BS02 CMP B 1 V50 I71 G72 E73 L74 R83 S84 R124 T128 V42 I63 G64 E65 L66 R75 S76 R116 T120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKAGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 4i0b A 1.5 BS01 CMP A 1 V50 I71 G72 E73 L74 R83 S84 A85 V87 R124 T128 V42 I63 G64 E65 L66 R75 S76 A77 V79 R116 T120 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTLPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 4i0b A 1.5 BS02 CMP A 2 K58 E59 Q171 G174 Q175 G178 C179 S180 R181 K50 E51 Q163 G166 Q167 G170 C171 S172 R173 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 302 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTLPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY 4i0b B 1.5 BS01 CMP B 1 V50 L62 S63 I71 G72 E73 L74 R83 S84 V87 R124 V42 L54 S55 I63 G64 E65 L66 R75 S76 V79 R116 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 24058293 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTLPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 4mgi E 2.8 BS01 CMP E 1 F367 V386 C395 F403 G404 A407 R414 A415 L449 K450 K489 F58 V77 C86 F94 G95 A98 R105 A106 L140 K141 K165 ? 0005085,0007264 Q9EQZ6 1001 MRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNHQDVRSYVRQLNVIDNQRTLSQMSHRLEP 4mgi E 2.8 BS02 CMP E 2 V365 V387 G392 S417 V419 S541 Q542 V56 V78 G83 S108 V110 S217 Q218 ? 0005085,0007264 Q9EQZ6 1002 MRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNHQDVRSYVRQLNVIDNQRTLSQMSHRLEP 4mgk E 2.7 BS01 CMP E 1 F367 F403 G404 Q405 L406 A407 R414 A415 L449 F58 F94 G95 Q96 L97 A98 R105 A106 L140 ? 0005085,0007264 Q9EQZ6 1001 MRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGQLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNHQDVRSYVRQLNVIDNQRTLSQMSHRLEP 4mx3 A 3.88 BS01 CMP A 1 F198 G199 E200 L201 A202 R209 W260 F94 G95 E96 L97 A98 R105 W156 ? 0001707,0001772,0001932,0004862,0005515,0005737,0005771,0005813,0005829,0005886,0005930,0005952,0007189,0007507,0008603,0010629,0019904,0030552,0031588,0031594,0031625,0032024,0032991,0034236,0042802,0044853,0045202,0045214,0046007,0060038,0071377,0098978,0120212,0141162 P00514 24316401 401 EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 4mx3 A 3.88 BS02 CMP A 2 V300 F322 G323 E324 I325 A326 R333 A334 S373 V196 F218 G219 E220 I221 A222 R229 A230 S269 ? 0001707,0001772,0001932,0004862,0005515,0005737,0005771,0005813,0005829,0005886,0005930,0005952,0007189,0007507,0008603,0010629,0019904,0030552,0031588,0031594,0031625,0032024,0032991,0034236,0042802,0044853,0045202,0045214,0046007,0060038,0071377,0098978,0120212,0141162 P00514 24316401 402 EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 4mx3 B 3.88 BS01 CMP B 1 V182 G199 E200 L201 A202 R209 A210 A211 W260 V75 G92 E93 L94 A95 R102 A103 A104 W153 ? 0001707,0001772,0001932,0004862,0005515,0005737,0005771,0005813,0005829,0005886,0005930,0005952,0007189,0007507,0008603,0010629,0019904,0030552,0031588,0031594,0031625,0032024,0032991,0034236,0042802,0044853,0045202,0045214,0046007,0060038,0071377,0098978,0120212,0141162 P00514 24316401 401 AASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 4mx3 B 3.88 BS02 CMP B 2 V300 F322 G323 E324 I325 A326 R333 V337 N372 V193 F215 G216 E217 I218 A219 R226 V230 N265 ? 0001707,0001772,0001932,0004862,0005515,0005737,0005771,0005813,0005829,0005886,0005930,0005952,0007189,0007507,0008603,0010629,0019904,0030552,0031588,0031594,0031625,0032024,0032991,0034236,0042802,0044853,0045202,0045214,0046007,0060038,0071377,0098978,0120212,0141162 P00514 24316401 402 AASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 4qx5 A 1.318 BS01 CMP A 1 V283 L296 R297 F305 G306 E307 K308 A309 R316 T317 A318 Y351 V62 L72 R73 F81 G82 E83 K84 A85 R92 T93 A94 Y127 2.7.11.12 0004692,0005524 Q13976 25271401 401 IKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAY 5ahw A 2.15 BS01 CMP A 1 G10 T11 D12 S16 S17 A40 P95 V113 G114 V116 V129 T146 G9 T10 D11 S15 S16 A39 P73 V91 G92 V94 V107 T124 ? 0000166 Kd=0.000000064M -logKd/Ki=5.17, Kd=6.82uM A0QYW6 25802331 1148 SAYQTVVVGTDGSDSSLRAVDRAGQIAAASNAKLIIATAYFPAPIYAILREANDRAKAAGATDIEERPVVGAPVDALVELADEVKADLLVVGNVGLSTIAGRLLGSVPANVARRSKTDVLIVHTS 5ahw B 2.15 BS01 CMP B 1 G10 T11 D12 S16 S17 A40 V113 G114 V116 V129 T146 G9 T10 D11 S15 S16 A39 V93 G94 V96 V109 T126 ? 0000166 Kd=0.000000064M A0QYW6 25802331 1148 SAYQTVVVGTDGSDSSLRAVDRAGQIAAASNAKLIIATAYFPGNAPIYAILREANDRAKAAGATDIEERPVVGAPVDALVELADEVKADLLVVGNVGLSTIAGRLLGSVPANVARRSKTDVLIVHTS 5ahw C 2.15 BS01 CMP C 1 G10 T11 D12 S16 S17 A40 P95 V113 G114 V116 V129 T146 G9 T10 D11 S15 S16 A39 P94 V112 G113 V115 V128 T145 ? 0000166 Kd=0.000000064M A0QYW6 25802331 1148 SAYQTVVVGTDGSDSSLRAVDRAGQIAAASNAKLIIATAYFPQSEDSRAADVLKDEGYKMAGNAPIYAILREANDRAKAAGATDIEERPVVGAPVDALVELADEVKADLLVVGNVGLSTIAGRLLGSVPANVARRSKTDVLIVHTS 5ahw D 2.15 BS01 CMP D 1 G10 T11 D12 S16 S17 A40 V113 G114 V116 V129 T146 G9 T10 D11 S15 S16 A39 V92 G93 V95 V108 T125 ? 0000166 Kd=0.000000064M A0QYW6 25802331 1148 SAYQTVVVGTDGSDSSLRAVDRAGQIAAASNAKLIIATAYFPQAPIYAILREANDRAKAAGATDIEERPVVGAPVDALVELADEVKADLLVVGNVGLSTIAGRLLGSVPANVARRSKTDVLIVHTS 5ahw E 2.15 BS02 CMP E 1 G10 T11 D12 S16 S17 A40 P95 V113 G114 V116 V129 T146 G9 T10 D11 S15 S16 A39 P73 V91 G92 V94 V107 T124 ? 0000166 Kd=0.000000064M A0QYW6 25802331 1148 SAYQTVVVGTDGSDSSLRAVDRAGQIAAASNAKLIIATAYFPAPIYAILREANDRAKAAGATDIEERPVVGAPVDALVELADEVKADLLVVGNVGLSTIAGRLLGSVPANVARRSKTDVLIVHTS 5ahw F 2.15 BS01 CMP F 1 G10 T11 D12 S16 S17 A40 P95 V113 G114 V116 T146 G9 T10 D11 S15 S16 A39 P73 V91 G92 V94 T124 ? 0000166 Kd=0.000000064M A0QYW6 25802331 1148 SAYQTVVVGTDGSDSSLRAVDRAGQIAAASNAKLIIATAYFPAPIYAILREANDRAKAAGATDIEERPVVGAPVDALVELADEVKADLLVVGNVGLSTIAGRLLGSVPANVARRSKTDVLIVHTS 5btx A 2.1 BS01 CMP A 1 S59 Y61 Y69 N79 H106 T108 S59 Y61 Y69 N79 H106 T108 Kd=280uM -logKd/Ki=3.55, Kd=280uM 26294765 201 MVTKIIWVSNNGKPNLKIEFVSEEEKSNFFKEVKKKASELGLNFPLVQGSGNSLLIEASNYPINPCGCYISPGGKLAINFGKVELSHFILPKVGVKTEHAEIFKDHNTIFFHKHKLPGVNSELTFIPTGTPV 5btx B 2.1 BS01 CMP B 1 S59 P65 Y69 N79 T108 S59 P65 Y69 N79 T108 Kd=280uM 26294765 201 MVTKIIWVSNNGKPNLKIEFVSEEEKSNFFKEVKKKASELGLNFPLVQGSGNSLLIEASNYPINPCGCYISPGGKLAINFGKVELSHFILPKVGVKTEHAEIFKDHNTIFFHKHKLPGVNSELTFIPTGTP 5c6c A 2.05 BS01 CMP A 1 S223 F231 G232 E233 L234 A235 R242 T243 S74 F82 G83 E84 L85 A86 R93 T94 2.7.11.12 Kd=418nM Q13237 26769964 304 RKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRR 5c6c B 2.05 BS01 CMP B 1 S223 F231 G232 E233 L234 A235 R242 T243 S75 F83 G84 E85 L86 A87 R94 T95 2.7.11.12 Kd=418nM Q13237 26769964 304 RVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGELLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMR 5ciz A 5.0098 BS03 CMP A 1 V49 L61 I70 G71 E72 L73 R82 S83 A84 V86 T127 V43 L55 I64 G65 E66 L67 R76 S77 A78 V80 T121 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 5j3u A 1.8 BS01 CMP A 1 K336 Y350 F356 G357 E358 L359 A360 R367 A368 A369 Y405 K192 Y206 F212 G213 E214 L215 A216 R223 A224 A225 Y261 2.7.11.12 0001932,0005952,0008603 A0A0F7V8B2 501 VYEKDEGQKEQLERILRQSFLFNSLDEKDLNTVILAMQEKKIEASTCLIREGDDGECLYIVQSGELNCSKLIDGEERVVKVVGPGDAFGELALLYNAPRAATVTSVSACDLWELGRDTFNAIVKDAATKRRSMYDSFLKSVHILDGMDAYERGKVADALRTEMFTDGAYIVRQGELGDVFYIVEEGSAVATKSFGPGQPPIEVKKYQAGDYFGELALINEEPRAANVIAHGICKVACLERKSFKRLMGSVQDLLSKKASEY 5j3u A 1.8 BS02 CMP A 2 C212 K224 F232 G233 E234 L235 A236 R243 A244 A245 C68 K80 F88 G89 E90 L91 A92 R99 A100 A101 2.7.11.12 0001932,0005952,0008603 A0A0F7V8B2 502 VYEKDEGQKEQLERILRQSFLFNSLDEKDLNTVILAMQEKKIEASTCLIREGDDGECLYIVQSGELNCSKLIDGEERVVKVVGPGDAFGELALLYNAPRAATVTSVSACDLWELGRDTFNAIVKDAATKRRSMYDSFLKSVHILDGMDAYERGKVADALRTEMFTDGAYIVRQGELGDVFYIVEEGSAVATKSFGPGQPPIEVKKYQAGDYFGELALINEEPRAANVIAHGICKVACLERKSFKRLMGSVQDLLSKKASEY 5jrh A 1.644 BS02 CMP A 1 G387 E388 P389 T412 W413 W414 Q415 T416 D500 I512 N521 R526 G383 E384 P385 T408 W409 W410 Q411 T412 D496 I508 N517 R522 T264 T416 E417 N521 R526 K609 T260 T412 E413 N517 R522 K605 6.2.1.1 0003987,0005524,0005829,0006085,0006935,0016208,0016874,0016877,0019427,0046872 Q8ZKF6 27974467 702 HKHAIPANIADRCLINPEQYETKYKQSINDPDTFWGEQGKILDWITPYQKVKNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDTSQSKHISYRELHRDVCRFANTLLDLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSSSRLVITADEGVRAGRSIPLKKNVDDALKNPNVTSVEHVIVLKRTGSDIDWQEGRDLWWRDLIEKASPEHQPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGKEKCPVVDTWWQTETGGFMITPLPGAIELKAGSATRPFFGVQPALVDNEGHPQEGATEGNLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHAIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDLGDTSTLADPGVVEKLLEEKQA 5jrh B 1.644 BS02 CMP B 1 G387 E388 P389 T412 W413 W414 Q415 T416 D500 I512 N521 R526 G382 E383 P384 T407 W408 W409 Q410 T411 D495 I507 N516 R521 T264 T416 E417 N521 R526 K609 T259 T411 E412 N516 R521 K604 6.2.1.1 0003987,0005524,0005829,0006085,0006935,0016208,0016874,0016877,0019427,0046872 Q8ZKF6 27974467 702 KHAIPANIADRCLINPEQYETKYKQSINDPDTFWGEQGKILDWITPYQKVKNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDTSQSKHISYRELHRDVCRFANTLLDLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSSSRLVITADEGVRAGRSIPLKKNVDDALKNPNVTSVEHVIVLKRTGSDIDWQEGRDLWWRDLIEKASPEHQPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGKEKCPVVDTWWQTETGGFMITPLPGAIELKAGSATRPFFGVQPALVDNEGHPQEGATEGNLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHAIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEE 5k8s A 1.15 BS01 CMP A 1 I340 I366 Y369 F375 G376 E377 L378 A379 R386 A387 A388 I390 Y424 L428 I47 I73 Y76 F82 G83 E84 L85 A86 R93 A94 A95 I97 Y131 L135 2.7.11.11 Kd=6nM -logKd/Ki=8.22, Kd=6nM Q7KQK0 27738107 501 GPGAKKRKMYEDILSHVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLNELGLDTTCID 5k8s B 1.15 BS01 CMP B 1 I366 Y369 F375 G376 E377 L378 A379 R386 A387 A388 I390 Y424 L428 I73 Y76 F82 G83 E84 L85 A86 R93 A94 A95 I97 Y131 L135 2.7.11.11 Kd=6nM Q7KQK0 27738107 501 GPGAKKRKMYEDILSHVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLNELGLDTTCIDEN 5kbf A 2.0 BS01 CMP A 1 I236 L248 F257 G258 E259 L260 A261 R268 A269 A270 Y319 I77 L89 F98 G99 E100 L101 A102 R109 A110 A111 Y160 2.7.11.11 0001932,0005952,0008603 Kd=1.2nM -logKd/Ki=8.92, Kd=1.2nM Q7KQK0 27738107 501 SVSANFIPKVYKKDEKEKAKIREALNESFLFNHLNKKEFEIIVNAFFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYKTKENNKKEVLTVLKSKDVFGELALLYNSKRAATATALTKCHLWALDRESFTYIIKDMVAKKRKMYEDILSHVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLNELGLDTTCIDEN 5kbf A 2.0 BS02 CMP A 2 I340 I366 Y369 F375 G376 E377 L378 A379 R386 A387 A388 I390 Y424 L428 I181 I207 Y210 F216 G217 E218 L219 A220 R227 A228 A229 I231 Y265 L269 2.7.11.11 0001932,0005952,0008603 Kd=1.2nM -logKd/Ki=8.92, Kd=1.2nM Q7KQK0 27738107 502 SVSANFIPKVYKKDEKEKAKIREALNESFLFNHLNKKEFEIIVNAFFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYKTKENNKKEVLTVLKSKDVFGELALLYNSKRAATATALTKCHLWALDRESFTYIIKDMVAKKRKMYEDILSHVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLNELGLDTTCIDEN 5kbf B 2.0 BS01 CMP B 1 I366 Y369 F375 G376 E377 L378 A379 R386 A387 A388 I390 Y424 L428 I207 Y210 F216 G217 E218 L219 A220 R227 A228 A229 I231 Y265 L269 2.7.11.11 0001932,0005952,0008603 Kd=1.2nM Q7KQK0 27738107 501 SVSANFIPKVYKKDEKEKAKIREALNESFLFNHLNKKEFEIIVNAFFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYKTKENNKKEVLTVLKSKDVFGELALLYNSKRAATATALTKCHLWALDRESFTYIIKDMVAKKRKMYEDILSHVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLNELGLDTTCIDEN 5kbf B 2.0 BS02 CMP B 2 I236 L248 F257 G258 E259 L260 A261 R268 A269 Y319 I77 L89 F98 G99 E100 L101 A102 R109 A110 Y160 2.7.11.11 0001932,0005952,0008603 Kd=1.2nM Q7KQK0 27738107 502 SVSANFIPKVYKKDEKEKAKIREALNESFLFNHLNKKEFEIIVNAFFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYKTKENNKKEVLTVLKSKDVFGELALLYNSKRAATATALTKCHLWALDRESFTYIIKDMVAKKRKMYEDILSHVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLNELGLDTTCIDEN 5kjx A 1.9 BS01 CMP A 1 V302 F324 G325 E326 I327 A328 R335 A336 Y373 N374 V62 F84 G85 E86 I87 A88 R95 A96 Y133 N134 ? P10644 28583991 401 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV 5kjy A 2.0 BS01 CMP A 1 V302 Q304 R316 F324 G325 E326 I327 A328 R335 T336 Y373 N374 V65 Q67 R77 F85 G86 E87 I88 A89 R96 T97 Y134 N135 ? P10644 28583991 401 STLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEEFVEVRRLGPSDYFGEIALLMNRPRTATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSL 5o3q A 1.75 BS01 CMP A 1 G31 Y32 T33 L65 G30 Y31 T32 L52 ? 0005886,0006808,0009579,0030234,0031676 Kd=2.1uM -logKd/Ki=5.68, Kd=2.1uM P73954 29735650 200 AKPANKLVIVTEKILLKKIAKIIDESGAKGYTVMNTGGKGSDIEANIKFEILTETREMAEEIADRVAVKYFNDYAGIIYICSAEVLYGHTFCGPEGCS 5o3q A 1.75 BS02 CMP B 1 V11 G39 K40 N59 A88 G89 I90 V10 G38 K39 N46 A75 G76 I77 ? 0005886,0006808,0009579,0030234,0031676 Kd=2.1uM -logKd/Ki=5.68, Kd=2.1uM P73954 29735650 201 AKPANKLVIVTEKILLKKIAKIIDESGAKGYTVMNTGGKGSDIEANIKFEILTETREMAEEIADRVAVKYFNDYAGIIYICSAEVLYGHTFCGPEGCS 5o3q B 1.75 BS01 CMP B 1 G31 Y32 T33 L65 G30 Y31 T32 L52 ? 0005886,0006808,0009579,0030234,0031676 Kd=2.1uM P73954 29735650 201 AKPANKLVIVTEKILLKKIAKIIDESGAKGYTVMNTGGKGSDIEANIKFEILTETREMAEEIADRVAVKYFNDYAGIIYICSAEVLYGHTFCGPEGCSAWS 5o3q B 1.75 BS02 CMP B 2 V11 G39 K40 G41 N59 A88 G89 I90 V10 G38 K39 G40 N46 A75 G76 I77 ? 0005886,0006808,0009579,0030234,0031676 Kd=2.1uM P73954 29735650 202 AKPANKLVIVTEKILLKKIAKIIDESGAKGYTVMNTGGKGSDIEANIKFEILTETREMAEEIADRVAVKYFNDYAGIIYICSAEVLYGHTFCGPEGCSAWS 5o3q C 1.75 BS01 CMP A 1 V11 K40 N59 A88 I90 V10 K39 N44 A73 I75 ? 0005886,0006808,0009579,0030234,0031676 -logKd/Ki=5.68, Kd=2.1uM P73954 29735650 200 AKPANKLVIVTEKILLKKIAKIIDESGAKGYTVMNTGGKGIEANIKFEILTETREMAEEIADRVAVKYFNDYAGIIYICSAEVLYGHTFCGPEGCSAWS 5o3q C 1.75 BS02 CMP B 2 G31 Y32 T33 L65 G30 Y31 T32 L50 ? 0005886,0006808,0009579,0030234,0031676 -logKd/Ki=5.68, Kd=2.1uM P73954 29735650 202 AKPANKLVIVTEKILLKKIAKIIDESGAKGYTVMNTGGKGIEANIKFEILTETREMAEEIADRVAVKYFNDYAGIIYICSAEVLYGHTFCGPEGCSAWS 5u6p A 3.51 BS01 CMP A 1 M530 F538 G539 I541 C542 R549 T550 R590 M426 F434 G435 I437 C438 R445 T446 R486 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 28086084 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKD 5u6p B 3.51 BS01 CMP B 1 M530 F538 G539 I541 C542 R549 T550 R590 M426 F434 G435 I437 C438 R445 T446 R486 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 28086084 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKD 5u6p C 3.51 BS01 CMP C 1 M530 F538 G539 I541 C542 R549 T550 R590 M426 F434 G435 I437 C438 R445 T446 R486 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 28086084 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKD 5u6p D 3.51 BS01 CMP D 1 M530 F538 G539 I541 C542 R549 T550 R590 M426 F434 G435 I437 C438 R445 T446 R486 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 28086084 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKD 5w10 A 2.15 BS01 CMP A 1 N46 W47 S48 I67 G82 I83 A84 F105 V109 F115 T117 E136 N44 W45 S46 I65 G80 I81 A82 F103 V107 F113 T115 E134 ? Kd=0.24uM -logKd/Ki=6.62, Kd=0.24uM Q72MQ6 28601495 201 LKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELFFLIAEGIQFNHIRSIRLKSGEGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTIIAVPMIFRGEVHGVIELVNRFDGSSFSPEDLVILQTIADFTAISLAHSDQYEKTK 5w10 B 2.15 BS01 CMP B 1 N46 W47 S48 I67 G82 I83 A84 F105 V109 F115 T117 E136 N43 W44 S45 I64 G79 I80 A81 F102 V106 F112 T114 E133 ? Kd=0.24uM Q72MQ6 28601495 201 KDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELFFLIAEGIQFNHIRSIRLKSGEGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTIIAVPMIFRGEVHGVIELVNRFDGSSFSPEDLVILQTIADFTAISLAHSDQYEKTK 5w10 C 2.15 BS01 CMP C 1 N46 W47 S48 F61 I67 G82 I83 A84 F105 V109 F115 T117 E136 N46 W47 S48 F61 I67 G82 I83 A84 F105 V109 F115 T117 E136 ? Kd=0.24uM Q72MQ6 28601495 201 MTLKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELFFLIAEGIQFNHIRSIRLKSGEGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTIIAVPMIFRGEVHGVIELVNRFSFSPEDLVILQTIADFTAISLAHSDQYEKT 5w10 D 2.15 BS01 CMP D 1 N46 W47 S48 F61 I67 G82 I83 A84 F105 V109 F115 T117 E136 N46 W47 S48 F61 I67 G82 I83 A84 F105 V109 F115 T117 E136 ? Kd=0.24uM Q72MQ6 28601495 201 MTLKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELFFLIAEGIQFNHIRSIRLKSGEGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTIIAVPMIFRGEVHGVIELVNRSFSPEDLVILQTIADFTAISLAHSDQYEKT 6b6h G 3.9 BS03 CMP G 1 V49 L61 G71 L73 R82 S83 A84 V86 R123 V41 L53 G63 L65 R74 S75 A76 V78 R115 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 29146813 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 6b6h H 3.9 BS03 CMP H 1 L61 G71 E72 L73 R82 S83 A84 L53 G63 E64 L65 R74 S75 A76 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 29146813 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 6cju A 3.35 BS01 CMP A 1 G367 E368 M369 R377 T378 A379 G345 E346 M347 R355 T356 A357 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 30028291 500 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ 6cju B 3.35 BS02 CMP B 1 G367 E368 M369 R377 T378 A379 G345 E346 M347 R355 T356 A357 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 30028291 500 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ 6cju C 3.35 BS02 CMP C 1 G367 E368 M369 R377 T378 A379 G345 E346 M347 R355 T356 A357 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 30028291 500 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ 6cju D 3.35 BS02 CMP D 1 G367 E368 M369 R377 T378 A379 G345 E346 M347 R355 T356 A357 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 30028291 500 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ 6dt4 A 1.8 BS01 CMP A 1 V50 L62 I71 G72 E73 L74 R83 S84 R124 V45 L57 I66 G67 E68 L69 R78 S79 R119 ? 0000166,0003677,0003700,0005829,0006355 A0A2U2GZI4 31744922 301 PQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMANRLQITSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 6dt4 B 1.8 BS01 CMP B 1 V50 I71 G72 E73 L74 R83 S84 A85 R124 V42 I63 G64 E65 L66 R75 S76 A77 R116 ? 0000166,0003677,0003700,0005829,0006355 A0A2U2GZI4 31744922 301 DPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMANRLQITSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYG 6ezu A 2.04 BS02 CMP A 1 H417 H421 D458 M530 D575 L576 N578 L593 M614 Q626 F629 H83 H87 D124 M196 D241 L242 N244 L259 M280 Q292 F295 0004114,0007165,0008081 703 LPIHGVETPNDNELEERFSLCLDEWGVDIFEIDRLSNGHALTTVAYRIFQKRDLLKTFCIDPHVFVRYLLRVESTYHADVPYHNSMHAADVLQTAHFLLQAEALDDVFSDLEILAVLFAAAIHDVDHPGVTNQFLINTGHELALQYNDASVLENHHLYMAFKILTEKDCDIFANLGGKKRQTLRRMVIELVLATDMSKHMSLLADLRTMVETKKVSGSGMLNLDNYADRIQILQNMIHCADLSNPAKPLRLYRKWTGRLIEEFFRQGDKERELSLEISPMCDRESVEVEKSQVSFIDFVCHPLWETWCDLVHPCAQLILDTLEDNRDWYECHI 6gpo A 1.48 BS01 CMP A 1 N51 A55 M98 N58 A62 M105 3.6.4.10 0005524,0006457,0016887,0051082,0140662 P07900 30248409 301 LVPRGSHMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAASGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKER 6gpr A 2.35 BS01 CMP A 1 A55 M98 T184 A45 M88 T174 3.6.4.10 0005524,0006457,0016887,0051082,0140662 P07900 30248409 301 PMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEK 6gqu A 1.72 BS01 CMP A 1 N51 A55 M98 N106 T184 N57 A61 M104 N112 T190 3.6.4.10 0005524,0006457,0016887,0051082,0140662 P07900 30248409 301 VPRGSHMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKER 6gyo A 3.4 BS01 CMP A 1 F658 G659 E660 I661 C662 R669 T670 A671 R710 R713 F445 G446 E447 I448 C449 R456 T457 A458 R497 R500 ? 0005216,0005249,0006811,0006813,0016020,0055085 Q9Y3Q4 801 MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRI 6gyo B 3.4 BS01 CMP B 1 F658 G659 E660 I661 C662 R669 T670 A671 R710 R713 F445 G446 E447 I448 C449 R456 T457 A458 R497 R500 ? 0005216,0005249,0006811,0006813,0016020,0055085 Q9Y3Q4 801 MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRI 6gyo C 3.4 BS01 CMP C 1 F658 G659 E660 I661 C662 R669 T670 A671 R710 R713 F445 G446 E447 I448 C449 R456 T457 A458 R497 R500 ? 0005216,0005249,0006811,0006813,0016020,0055085 Q9Y3Q4 801 MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRI 6gyo D 3.4 BS01 CMP D 1 F658 G659 E660 I661 C662 R669 T670 A671 R710 R713 F445 G446 E447 I448 C449 R456 T457 A458 R497 R500 ? 0005216,0005249,0006811,0006813,0016020,0055085 Q9Y3Q4 801 MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRI 6h4g A 2.14352 BS01 CMP A 1 M271 I291 Y299 V307 G308 E309 L310 A311 R318 A319 A320 V322 Y370 M56 I76 Y84 V92 G93 E94 L95 A96 R103 A104 A105 V107 Y155 ? 0001932,0005952,0008603 Q385V6 38517938 501 AKSYVAPYFEKSEDETALILKLLTYNVLFSFLDSRDLMTVAGAMWRVEFKQDDCIMEAGQTTCDKLYIIQDGKADIIKEGQKVYLKVEGTAVGELALMYQTPRAATVKVCTPELIAWALDRDTYRHLVMGSAIRRRETYIQFLTNIPFLSGLDNYEKLQLADALSSDEFEPGDYIIRYGEEGEWLYIILEGSVDVVGRDDDGNEKHVWEFGKGDHVGELEFLNNHANVADVVAKTHVVTAKLNRRHFEMCLGPVIDVLKRTSQQPNYEYYQSKL 6h4g B 2.14352 BS01 CMP B 1 M271 I291 Y299 G308 E309 L310 A311 R318 A319 A320 Y370 M53 I73 Y81 G90 E91 L92 A93 R100 A101 A102 Y152 ? 0001932,0005952,0008603 Q385V6 38517938 501 YVAPYFEKSEDETALILKLLTYNVLFSFLDSRDLMTVAGAMWRVEFKQDDCIMEAGQTTCDKLYIIQDGKADIIKEGQKVYLKVEGTAVGELALMYQTPRAATVKVCTPELIAWALDRDTYRHLVMGSAIRRRETYIQFLTNIPFLSGLDNYEKLQLADALSSDEFEPGDYIIRYGEEGEWLYIILEGSVDVVGRDDDGNEKHVWEFGKGDHVGELEFLNNHANVADVVAKTHVVTAKLNRRHFEMCLGPVIDVLKRTSQQPNYEYYQSKLK 6h7e A 2.3 BS01 CMP A 1 F232 V251 V259 F268 G269 Q270 L271 A272 R279 A280 F174 V193 V201 F210 G211 Q212 L213 A214 R221 A222 ? 0035556 Kd=4500nM O95398 37438343 401 ASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIK 6h7e B 2.3 BS01 CMP B 1 V251 V259 G269 Q270 L271 A272 R279 A280 V195 V203 G213 Q214 L215 A216 R223 A224 ? 0035556 Kd=4500nM O95398 37438343 401 STERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 6hq3 A 2.79 BS01 CMP D 1 R108 R111 R105 R108 ? -logKd/Ki=6.11, Kd=0.775uM Q6MLN6 31355487 901 AAQSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRRKNI 6hq3 B 2.79 BS01 CMP B 1 F17 G57 E58 M59 A60 R67 S68 A69 F13 G53 E54 M55 A56 R63 S64 A65 ? Q6MLN6 31355487 901 AQSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRR 6hq3 C 2.79 BS01 CMP B 1 R108 R111 R103 R106 ? Q6MLN6 31355487 901 QSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRRKNI 6hq3 D 2.79 BS01 CMP D 1 F17 G57 E58 M59 A60 R67 S68 A69 F13 G53 E54 M55 A56 R63 S64 A65 ? -logKd/Ki=6.11, Kd=0.775uM Q6MLN6 31355487 901 AQSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRR 6hq4 A 2.63 BS01 CMP A 1 F56 G57 E58 M59 A60 R67 S68 A69 N113 F51 G52 E53 M54 A55 R62 S63 A64 N108 ? 0000166,0046872 -logKd/Ki=4.65, Kd=22.4uM Q6MLN6 31355487 901 QSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRRKNIGSALDQIKLENQIFQAFQNKEFELFYQPIVNLKNKTITGCEALLRWNSPQHGLVSPNLFIDIIENSSMVIPIGHWIINQALKDLRTIQDQLRLNKKERMADDFMMSINISGRQFTHSDFVNNLEDLREKHDLHTQNIKLEMTERIMMDGAIAIDALNQCRSLGYAISIDDFGTGFSGLQYLTQMPISFLKIDRSFVMKILSDPKSKAVVSSIIHLAHAMDIEVIAEGIEHHEEALVLETLGARFGQGYLFSKPVDLGRFLKLIKL 6hq4 B 2.63 BS01 CMP B 1 F17 F56 G57 E58 M59 A60 R67 S68 A69 F12 F51 G52 E53 M54 A55 R62 S63 A64 ? 0000166,0046872 -logKd/Ki=4.65, Kd=22.4uM Q6MLN6 31355487 901 QSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRSALDQIKLENQIFQAFQNKEFELFYQPIVNLKNKTITGCEALLRWNSPQHGLVSPNLFIDIIENSSMVIPIGHWIINQALKDLRTIQDQLRLNKKERMADDFMMSINISGRQFTHSDFVNNLEDLREKHDLHTQNIKLEMTERIMMDGAIAIDALNQCRSLGYAISIDDFGTGFSGLQYLTQMPISFLKIDRSFVMKILSDPKSKAVVSSIIHLAHAMDIEVIAEGIEHHEEALVLETLGARFGQGYLFSKPVDLGRFLKLIK 6hq5 A 2.83 BS02 CMP A 1 F17 I36 F56 G57 E58 M59 A60 R67 S68 A69 F13 I32 F52 G53 E54 M55 A56 R63 S64 A65 ? 0000166,0046872 Q6MLN6 31355487 802 AQSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRRKNIGQSALDQIKLENQIFQAFQNKEFELFYQPIVNLKNKTITGCEALLRWNSPQHGLVSPNLFIDIIENSSMVIPIGHWIINQALKDLRTIQDQLRLNKKERMADDFMMSINISGRQFTHSDFVNNLEDLREKHDLHTQNIKLEMTERIMMDGAIAIDALNQCRSLGYAISIDDFGTGFSGLQYLTQMPISFLKIDRSFVMKILSDPKSKAVVSSIIHLAHAMDIEVIAEGIEHHEEALVLETLGARFGQGYLFSKPVDLGRFLKLIKL 6hq5 B 2.83 BS01 CMP A 1 R108 K112 R103 K107 ? 0000166,0046872 Q6MLN6 31355487 802 QSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRRKNIGGTQSALDQIKLENQIFQAFQNKEFELFYQPIVNLKNKTITGCEALLRWNSPQHGLVSPNLFIDIIENSSMVIPIGHWIINQALKDLRTIQDQLRLNKKERMADDFMMSINISGRQFTHSDFVNNLEDLREKHDLHTQNIKLEMTERIMMDGAIAIDALNQCRSLGYAISIDDFGTGFSGLQYLTQMPISFLKIDRSFVMKILSDPKSKAVVSSIIHLAHAMDIEVIAEGIEHHEEALVLETLGARFGQGYLFSKPVDLGRFLKLIK 6hq5 B 2.83 BS03 CMP B 1 F17 F56 G57 E58 M59 A60 R67 S68 F12 F51 G52 E53 M54 A55 R62 S63 ? 0000166,0046872 Q6MLN6 31355487 802 QSVDIHKDQIIFSEGDAGDCAYIIEKGRVLIYLTKDKEEIPLTILGEGEIFGEMALIDNQNRSASVRALEDVRLAIVTKQQVLERVSTADKVVQLLMRVLLKRLRRKNIGGTQSALDQIKLENQIFQAFQNKEFELFYQPIVNLKNKTITGCEALLRWNSPQHGLVSPNLFIDIIENSSMVIPIGHWIINQALKDLRTIQDQLRLNKKERMADDFMMSINISGRQFTHSDFVNNLEDLREKHDLHTQNIKLEMTERIMMDGAIAIDALNQCRSLGYAISIDDFGTGFSGLQYLTQMPISFLKIDRSFVMKILSDPKSKAVVSSIIHLAHAMDIEVIAEGIEHHEEALVLETLGARFGQGYLFSKPVDLGRFLKLIK 6loq A 1.331 BS01 CMP A 1 Y93 I94 E108 G132 Y134 I178 R186 Y70 I71 E85 G109 Y111 I155 R163 3.2.2.22 0017148,0030598 P16094 32653369 301 DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLLLPSVSGAGRYLLMHLFNYDGKTITVAVDVTNVYIMGYLADTTSYFFNEPAAELASQYVFRDARRKITLPYSGNYERLQIAAGKPREKIPIGLPALDSAISTLLHYDSTAAAGALLVLIQTTAEAARFKYIEQQIQERAYRDEVPSLATISLENSWSGLSKQIQLAQGNNGIFRTPIVLVDNKGNRVQITNVTSKVVTSNIQLLLNTRNI 6m63 A 2.25 BS01 CMP A 1 V71 F330 G331 E332 M333 A334 R341 V342 A343 R382 V62 F306 G307 E308 M309 A310 R317 V318 A319 R358 ? 0005221,0006091,0008218 P42212,Q98GN8 36097007 400 GDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATNWGNVYITADKQKNGIKANFKIRHNVEGGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLDEYSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTLVTTLVQCFARYPDHMKQHDFFKSAMPEGYIQERTIVFKDDGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNRVNPVELGPGAFFGEMALISGEPRVATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERR 6m63 B 2.25 BS01 CMP B 1 V71 F330 G331 E332 M333 A334 R341 V342 A343 V345 R382 V64 F305 G306 E307 M308 A309 R316 V317 A318 V320 R357 ? 0005221,0006091,0008218 P42212,Q98GN8 36097007 400 RRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATNWGNVYITADKQKNGIKANFKIRHNVEGGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTLVTTLVQCFARYPDHMKQHDFFKSAMPEGYIQERTIVFKDDGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNRVNPVELGPGAFFGEMALISGEPRVATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERR 6mmq A 2.02 BS01 CMP A 1 G31 Y32 T33 L65 G29 Y30 T31 L49 ? 0005524,0006808,0030234,0046872 -logKd/Ki=3.62, Kd=238uM B5II98 201 QQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEA 6mmq A 2.02 BS02 CMP B 1 G39 E40 N59 S88 I90 G37 E38 N43 S72 I74 ? 0005524,0006808,0030234,0046872 -logKd/Ki=3.62, Kd=238uM B5II98 201 QQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEA 6mmq B 2.02 BS01 CMP B 1 G31 Y32 T33 L65 G31 Y32 T33 L51 ? 0005524,0006808,0030234,0046872 B5II98 201 SSQQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEALRAHKF 6mmq B 2.02 BS02 CMP D 1 G39 E40 N59 S88 I90 G39 E40 N45 S74 I76 ? 0005524,0006808,0030234,0046872 B5II98 201 SSQQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEALRAHKF 6mmq C 2.02 BS01 CMP C 1 G31 Y32 T33 L65 G30 Y31 T32 L53 ? 0005524,0006808,0030234,0046872 B5II98 201 SQQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGSSHAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEAL 6mmq C 2.02 BS02 CMP E 1 G39 E40 N59 S88 I90 G38 E39 N47 S76 I78 ? 0005524,0006808,0030234,0046872 B5II98 201 SQQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGSSHAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEAL 6mmq D 2.02 BS01 CMP A 1 G39 E40 N59 S88 I90 G38 E39 N44 S73 I75 ? 0005524,0006808,0030234,0046872 -logKd/Ki=3.62, Kd=238uM B5II98 201 SQQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEAL 6mmq D 2.02 BS02 CMP D 1 G31 Y32 T33 L65 G30 Y31 T32 L50 ? 0005524,0006808,0030234,0046872 -logKd/Ki=3.62, Kd=238uM B5II98 201 SQQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEAL 6mmq E 2.02 BS01 CMP E 1 G31 Y32 T33 L65 G29 Y30 T31 L49 ? 0005524,0006808,0030234,0046872 B5II98 201 QQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEA 6mmq E 2.02 BS02 CMP F 1 G39 E40 G41 N59 S88 I90 G37 E38 G39 N43 S72 I74 ? 0005524,0006808,0030234,0046872 B5II98 201 QQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEA 6mmq F 2.02 BS01 CMP C 1 G39 E40 G41 N59 S88 I90 G38 E39 G40 N45 S74 I76 ? 0005524,0006808,0030234,0046872 B5II98 201 SQQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGSAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEAL 6mmq F 2.02 BS02 CMP F 1 G31 Y32 T33 E63 V64 L65 G30 Y31 T32 E49 V50 L51 ? 0005524,0006808,0030234,0046872 B5II98 201 SQQVWKLVIITEEILLKKVSKIIKEAGASGYTVLAAAGEGSAYSNIKFEVLTASRELADQIQDKVVAKYFDDYSCITYISTVEAL 6pb4 G 4.35 BS03 CMP G 1 V49 S62 G71 E72 L73 S83 R123 V41 S54 G63 E64 L65 S75 R115 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 6pb4 H 4.35 BS02 CMP H 1 L61 S62 E72 L73 S83 R123 L53 S54 E64 L65 S75 R115 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 6pb5 G 4.52 BS03 CMP G 1 V49 L61 S62 G71 S83 R123 T127 V41 L53 S54 G63 S75 R115 T119 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 6pb5 H 4.52 BS03 CMP H 1 V49 L61 S62 G71 E72 R82 S83 A84 V86 V41 L53 S54 G63 E64 R74 S75 A76 V78 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 6pb6 G 4.29 BS02 CMP G 1 V49 S62 L73 S83 R123 V41 S54 L65 S75 R115 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 6pb6 H 4.29 BS02 CMP H 1 G71 E72 L73 S83 G63 E64 L65 S75 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 P0ACJ8 301 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 6rsx A 1.6 BS01 CMP A 1 M180 I199 I201 F221 G222 E223 L224 A225 R232 A233 A234 Y283 M50 I69 I71 F91 G92 E93 L94 A95 R102 A103 A104 Y153 0001932,0005952,0008603 501 VKKQLNPETKARIEKCLRGNILFRSLGEDSLEVVYSSMFEKTAEAGHFIMKQYDEGDNFYVIESGTCNILIQPNPDAEPVHKSTIGPGASFGELALMYGTPRAASVQAVSNVRLWALDRDTFRRILLTQTMRKRRQYEDFLAQVPLFEALTSYERMTMADALQPCTFKDKEIVVKEGEDGGSFYIIIDGKMKVNQTLNGRIHTINILGPKDFFGEMSLMFNQPCVATVVSEGVSHCVSLDRESFTALLGPMEEILQRNMQNYSAPR 6rsx A 1.6 BS02 CMP A 2 V323 I334 N335 F343 G344 E345 M346 S347 C354 V355 Y392 V193 I204 N205 F213 G214 E215 M216 S217 C224 V225 Y262 0001932,0005952,0008603 502 VKKQLNPETKARIEKCLRGNILFRSLGEDSLEVVYSSMFEKTAEAGHFIMKQYDEGDNFYVIESGTCNILIQPNPDAEPVHKSTIGPGASFGELALMYGTPRAASVQAVSNVRLWALDRDTFRRILLTQTMRKRRQYEDFLAQVPLFEALTSYERMTMADALQPCTFKDKEIVVKEGEDGGSFYIIIDGKMKVNQTLNGRIHTINILGPKDFFGEMSLMFNQPCVATVVSEGVSHCVSLDRESFTALLGPMEEILQRNMQNYSAPR 6uqf A 3.04 BS01 CMP A 1 M530 F538 G539 E540 I541 C542 R549 T550 A551 R593 I594 M426 F434 G435 E436 I437 C438 R445 T446 A447 R489 I490 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 31787376 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVERALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 6uqf B 3.04 BS01 CMP B 1 M530 F538 G539 E540 I541 C542 R549 T550 A551 R593 I594 M426 F434 G435 E436 I437 C438 R445 T446 A447 R489 I490 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 31787376 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVERALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 6uqf C 3.04 BS01 CMP C 1 M530 F538 G539 E540 I541 C542 R549 T550 A551 R593 I594 M426 F434 G435 E436 I437 C438 R445 T446 A447 R489 I490 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 31787376 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVERALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 6uqf D 3.04 BS01 CMP D 1 M530 F538 G539 E540 I541 C542 R549 T550 A551 R593 I594 M426 F434 G435 E436 I437 C438 R445 T446 A447 R489 I490 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 31787376 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVERALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 6uqg A 3.54 BS01 CMP A 1 V522 M530 F538 G539 I541 C542 R549 T550 R590 V633 V417 M425 F433 G434 I436 C437 R444 T445 R485 V528 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 31787376 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTDDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 6uqg B 3.54 BS01 CMP B 1 V522 M530 F538 G539 I541 C542 R549 T550 R590 V633 V417 M425 F433 G434 I436 C437 R444 T445 R485 V528 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 31787376 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTDDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 6uqg C 3.54 BS01 CMP C 1 V522 M530 F538 G539 I541 C542 R549 T550 R590 V633 V417 M425 F433 G434 I436 C437 R444 T445 R485 V528 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 31787376 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTDDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 6uqg D 3.54 BS01 CMP D 1 V522 M530 F538 G539 I541 C542 R549 T550 R590 V633 V417 M425 F433 G434 I436 C437 R444 T445 R485 V528 ? 0005216,0005249,0006811,0006813,0016020,0055085 O60741 31787376 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTDDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 6vxz A 3.42 BS01 CMP A 1 Y357 G367 E368 M369 R377 Y334 G344 E345 M346 R354 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 33328472 501 PTYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVALFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ 6vxz B 3.42 BS01 CMP B 1 Y357 G367 E368 M369 R377 Y334 G344 E345 M346 R354 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 33328472 501 PTYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVALFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ 6vxz C 3.42 BS01 CMP C 1 Y357 G367 E368 M369 R377 Y334 G344 E345 M346 R354 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 33328472 501 PTYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVALFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ 6vxz D 3.42 BS01 CMP D 1 Y357 G367 E368 M369 R377 Y334 G344 E345 M346 R354 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 33328472 501 PTYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVALFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQ 7e3w A 1.55 BS01 CMP A 1 F51 F199 L201 F60 F208 L210 ? 0016787 Q2FXM0 33950015 301 GLVPRGSHMMKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF 7e3w B 1.55 BS01 CMP B 1 F51 F171 F199 L201 F61 F181 F209 L211 ? 0016787 Q2FXM0 33950015 301 SGLVPRGSHMMKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF 7e3w C 1.55 BS01 CMP C 1 F51 F171 F199 L201 F52 F172 F200 L202 ? 0016787 Q2FXM0 33950015 301 MMKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF 7e3w D 1.55 BS01 CMP D 1 F51 F171 F199 F54 F174 F202 ? 0016787 Q2FXM0 33950015 301 SHMMKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF 7e3w E 1.55 BS01 CMP E 1 F51 F171 F199 L201 F53 F173 F201 L203 ? 0016787 Q2FXM0 33950015 301 HMMKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF 7e3w F 1.55 BS01 CMP F 1 F51 F199 L201 F53 F201 L203 ? 0016787 Q2FXM0 33950015 301 HMMKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF 7few A 1.75 BS01 CMP A 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 R128 I42 I54 F63 G64 E65 L66 R78 S79 A80 R119 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 37007650 301 LKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEGSEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGTR 7few B 1.75 BS01 CMP B 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 V91 R128 T132 I41 I53 F62 G63 E64 L65 R76 S77 A78 V80 R117 T121 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 37007650 301 KHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKESEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRNEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGT 7ff0 A 2.6 BS01 CMP A 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 R128 I43 I55 F64 G65 E66 L67 R79 S80 A81 R120 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 37007650 301 KLKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEGSEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGTR 7ff0 B 2.6 BS01 CMP B 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 V91 I40 I52 F61 G62 E63 L64 R73 S74 A75 V77 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 37007650 301 HLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGTR 7ff8 A 2.8 BS01 CMP A 1 I51 F72 G73 E74 L75 R87 S88 A89 R128 I43 F64 G65 E66 L67 R73 S74 A75 R114 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 KLKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVF 7ff8 B 2.8 BS01 CMP B 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 R128 T132 I34 I46 F55 G56 E57 L58 R65 S66 A67 R104 T108 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 302 AHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEEERSAWVRAKVECEVAEISYAKFRELSQSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFG 7ff9 A 2.4 BS01 CMP A 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 T132 I39 I51 F60 G61 E62 L63 R72 S73 A74 T117 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 LDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFESEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFG 7ff9 B 2.4 BS01 CMP B 1 I51 I63 F72 G73 E74 L75 R87 S88 V91 R128 T132 I39 I51 F60 G61 E62 L63 R72 S73 V76 R113 T117 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 LDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKTMVVFG 7ff9 C 2.4 BS01 CMP C 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 V91 R128 T132 I39 I51 F60 G61 E62 L63 R72 S73 A74 V76 R113 T117 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 LDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFESEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFG 7ff9 D 2.4 BS01 CMP D 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 V91 R128 T132 I38 I50 F59 G60 E61 L62 R74 S75 A76 V78 R115 T119 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 DKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEGSEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVF 7ff9 E 2.4 BS01 CMP E 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 R128 T132 I37 I49 F58 G59 E60 L61 R70 S71 A72 R111 T115 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 KLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVF 7ff9 F 2.4 BS01 CMP F 1 I51 I63 F72 G73 E74 L75 R87 S88 A89 V91 R128 I30 I42 F51 G52 E53 L54 R63 S64 A65 V67 R104 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 RRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFG 7ff9 G 2.4 BS01 CMP G 1 I51 I63 F72 G73 L75 R87 S88 A89 V91 R128 I39 I51 F60 G61 L63 R72 S73 A74 V76 R113 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 LDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFESEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFG 7ff9 H 2.4 BS01 CMP H 1 I51 I63 F72 G73 E74 R87 S88 A89 V91 R128 T132 I30 I42 F51 G52 E53 R62 S63 A64 V66 R103 T107 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 P55222 301 RRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVF 7jme A 1.55 BS01 CMP A 1 A242 K248 G250 G251 G252 V253 A254 S332 G334 I335 F336 A35 K41 G43 G44 G45 V46 A47 S125 G127 I128 F129 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 32981460 401 NSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFL 7lz4 A 4.155 BS01 CMP A 1 F198 G199 E200 L201 A202 R209 D211 W260 F90 G91 E92 L93 A94 R101 D103 W152 ? 0001932,0005952,0008603 P00514 34006641 401 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 A 4.155 BS02 CMP A 2 V300 Q302 V313 F322 G323 E324 I325 R333 A334 A335 Y371 N372 S373 V192 Q194 V205 F214 G215 E216 I217 R225 A226 A227 Y263 N264 S265 ? 0001932,0005952,0008603 P00514 34006641 402 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 B 4.155 BS01 CMP B 1 F198 G199 E200 L201 A202 R209 D211 W260 F90 G91 E92 L93 A94 R101 D103 W152 ? 0001932,0005952,0008603 P00514 34006641 401 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 B 4.155 BS02 CMP B 2 V300 Q302 V313 G323 E324 I325 A326 R333 A334 A335 Y371 V192 Q194 V205 G215 E216 I217 A218 R225 A226 A227 Y263 ? 0001932,0005952,0008603 P00514 34006641 402 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 C 4.155 BS01 CMP C 1 F198 G199 L201 R209 D211 W260 F90 G91 L93 R101 D103 W152 ? 0001932,0005952,0008603 P00514 34006641 401 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 C 4.155 BS02 CMP C 2 V281 V300 V313 F322 G323 E324 I325 R333 A334 A335 Y371 V173 V192 V205 F214 G215 E216 I217 R225 A226 A227 Y263 ? 0001932,0005952,0008603 P00514 34006641 402 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 D 4.155 BS01 CMP D 1 F198 G199 E200 L201 A202 R209 D211 W260 F91 G92 E93 L94 A95 R102 D104 W153 ? 0001932,0005952,0008603 P00514 34006641 401 AASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNS 7lz4 D 4.155 BS02 CMP D 2 Q302 V313 F322 G323 E324 I325 R333 A334 A335 Y371 N372 Q195 V206 F215 G216 E217 I218 R226 A227 A228 Y264 N265 ? 0001932,0005952,0008603 P00514 34006641 402 AASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNS 7lz4 E 4.155 BS01 CMP E 1 G199 E200 L201 A202 R209 D211 W260 G91 E92 L93 A94 R101 D103 W152 ? 0001932,0005952,0008603 P00514 34006641 401 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 E 4.155 BS02 CMP E 2 V300 F322 G323 E324 I325 A326 R333 A335 Y371 V192 F214 G215 E216 I217 A218 R225 A227 Y263 ? 0001932,0005952,0008603 P00514 34006641 402 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 F 4.155 BS01 CMP F 1 F198 G199 E200 L201 A202 R209 D211 W260 F90 G91 E92 L93 A94 R101 D103 W152 ? 0001932,0005952,0008603 P00514 34006641 401 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 F 4.155 BS02 CMP F 2 V300 Q302 F322 G323 E324 I325 A326 R333 A335 V337 Y371 V192 Q194 F214 G215 E216 I217 A218 R225 A227 V229 Y263 ? 0001932,0005952,0008603 P00514 34006641 402 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 G 4.155 BS01 CMP G 1 F198 G199 E200 L201 A202 R209 D211 W260 F90 G91 E92 L93 A94 R101 D103 W152 ? 0001932,0005952,0008603 P00514 34006641 401 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 G 4.155 BS02 CMP G 2 F322 G323 E324 A326 R333 A334 A335 Y371 F214 G215 E216 A218 R225 A226 A227 Y263 ? 0001932,0005952,0008603 P00514 34006641 402 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 H 4.155 BS01 CMP H 1 F198 G199 L201 R209 D211 W260 F90 G91 L93 R101 D103 W152 ? 0001932,0005952,0008603 P00514 34006641 401 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7lz4 H 4.155 BS02 CMP H 2 V281 V300 V313 F322 G323 E324 I325 R333 A335 V337 Y371 V173 V192 V205 F214 G215 E216 I217 R225 A227 V229 Y263 ? 0001932,0005952,0008603 P00514 34006641 402 ASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRADTVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 7np4 A 3.3 BS01 CMP A 1 F659 G660 E661 I662 C663 R670 R711 R714 I715 F445 G446 E447 I448 C449 R456 R497 R500 I501 ? 0005216,0005249,0006811,0006813,0016020,0055085 Q9TV66 34166608 1001 MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTDIILDPRRIKMKYLKSWFVVDFVSSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSLNNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPMGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRI 7np4 B 3.3 BS01 CMP B 1 F659 G660 E661 I662 C663 R670 R711 R714 I715 F445 G446 E447 I448 C449 R456 R497 R500 I501 ? 0005216,0005249,0006811,0006813,0016020,0055085 Q9TV66 34166608 1001 MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTDIILDPRRIKMKYLKSWFVVDFVSSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSLNNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPMGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRI 7np4 C 3.3 BS01 CMP C 1 F659 G660 E661 I662 C663 R670 R711 R714 I715 F445 G446 E447 I448 C449 R456 R497 R500 I501 ? 0005216,0005249,0006811,0006813,0016020,0055085 Q9TV66 34166608 1001 MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTDIILDPRRIKMKYLKSWFVVDFVSSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSLNNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPMGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRI 7np4 D 3.3 BS01 CMP D 1 F659 G660 E661 I662 C663 R670 R711 R714 I715 F445 G446 E447 I448 C449 R456 R497 R500 I501 ? 0005216,0005249,0006811,0006813,0016020,0055085 Q9TV66 34166608 1001 MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTDIILDPRRIKMKYLKSWFVVDFVSSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSLNNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPMGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRI 7pza A 2.72 BS03 CMP A 1 L63 R76 F84 G85 E86 M87 A88 R95 S96 A97 T140 L56 R69 F77 G78 E79 M80 A81 R88 S89 A90 T133 ? 0000166,0003677,0003700,0005829,0006355,0046872 Q92SD2 37017526 301 SAFWRSFPIFEEFDSETLCELSGIASYRKWSAGTVIFQRGDQGDYMIVVVSGRIKLSLFTPQGRELMLRQHEAGALFGEMALLDGQPRSADATAVTAAEGYVIGKKDFLALITQRPKTAEAVIRFLCAQLRDTTDRLETIALYDLNARVARFFLATLRQIHGSEMPQSANLRLTLSQTDIASILGASRPKVNRAILSLEESGAIKRADGIICCNVGRLLSIADPE 7pza B 2.72 BS03 CMP B 1 F44 L63 F84 G85 E86 M87 A88 R95 S96 T140 F39 L58 F79 G80 E81 M82 A83 R90 S91 T135 ? 0000166,0003677,0003700,0005829,0006355,0046872 Q92SD2 37017526 301 RSSAFWRSFPIFEEFDSETLCELSGIASYRKWSAGTVIFQRGDQGDYMIVVVSGRIKLSLFTPQGRELMLRQHEAGALFGEMALLDGQPRSADATAVTAAEGYVIGKKDFLALITQRPKTAEAVIRFLCAQLRDTTDRLETIALYDLNARVARFFLATLRQIHGSEMPQSANLRLTLSQTDIASILGASRPKVNRAILSLEESGAIKRADGIICCNVGRLLSIADP 7rhg A 2.88 BS01 CMP A 1 V536 F544 G545 R561 T562 V381 F389 G390 R406 T407 ? 0005216,0005221,0006811,0016020,0055085 P29973 34699778 701 VVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLL 7rhg B 2.88 BS01 CMP B 1 V1009 V1020 R1042 V357 V368 R390 ? 0005221 Q14028 34699778 1301 PQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRML 7rhg C 2.88 BS01 CMP C 1 F535 G545 R561 T562 A563 F380 G390 R406 T407 A408 ? 0005216,0005221,0006811,0016020,0055085 P29973 34699778 701 VVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMK 7rhg D 2.88 BS01 CMP D 1 V526 V536 F544 R561 T562 A563 V371 V381 F389 R406 T407 A408 ? 0005216,0005221,0006811,0016020,0055085 P29973 34699778 701 VVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLL 7rsh A 3.0 BS01 CMP A 1 F366 G367 E368 R377 F349 G350 E351 R360 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFEPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRR 7rsh B 3.0 BS01 CMP B 1 F366 G367 E368 R377 F349 G350 E351 R360 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFEPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRR 7rsh C 3.0 BS01 CMP C 1 F366 G367 E368 R377 F349 G350 E351 R360 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFEPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRR 7rsh D 3.0 BS01 CMP D 1 F366 G367 E368 R377 F349 G350 E351 R360 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 502 TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFEPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRR 7rtf A 2.9 BS01 CMP A 1 G367 R377 T378 A379 G347 R357 T358 A359 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 7rtf B 2.9 BS01 CMP B 1 G367 R377 T378 A379 G347 R357 T358 A359 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 7rtf C 2.9 BS01 CMP C 1 G367 R377 T378 A379 G347 R357 T358 A359 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 7rtf D 2.9 BS01 CMP D 1 G367 R377 T378 A379 G347 R357 T358 A359 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 7rtj A 3.8 BS01 CMP A 1 Y357 F366 G367 E368 R377 R418 Y335 F344 G345 E346 R355 R396 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7rtj B 3.8 BS02 CMP B 1 Y357 F366 G367 E368 R377 R418 Y335 F344 G345 E346 R355 R396 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 503 TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7rtj C 3.8 BS02 CMP C 1 Y357 F366 G367 E368 R377 R418 Y335 F344 G345 E346 R355 R396 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 503 TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7rtj D 3.8 BS02 CMP D 1 Y357 F366 G367 E368 R377 R418 Y335 F344 G345 E346 R355 R396 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 503 TYTLVWKVWILAVTLYFAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7ru0 A 4.3 BS01 CMP A 1 F366 G367 M369 R377 F333 G334 M336 R344 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVR 7ru0 B 4.3 BS01 CMP B 1 F366 G367 M369 R377 F333 G334 M336 R344 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVR 7ru0 C 4.3 BS01 CMP C 1 F366 G367 M369 R377 F333 G334 M336 R344 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVR 7ru0 D 4.3 BS01 CMP D 1 F366 G367 M369 R377 F333 G334 M336 R344 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVR 7ryr A 3.6 BS01 CMP A 1 Y357 F366 G367 E368 M369 A370 R418 Y326 F335 G336 E337 M338 A339 R387 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7ryr B 3.6 BS01 CMP B 1 Y357 F366 G367 E368 M369 A370 R418 Y326 F335 G336 E337 M338 A339 R387 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7ryr C 3.6 BS01 CMP C 1 Y357 F366 G367 E368 M369 A370 R418 Y326 F335 G336 E337 M338 A339 R387 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7ryr D 3.6 BS02 CMP D 1 Y357 F366 G367 E368 M369 A370 R418 Y326 F335 G336 E337 M338 A339 R387 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7rys A 3.7 BS01 CMP A 1 G367 E368 M369 T378 R418 G336 E337 M338 T347 R387 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7rys B 3.7 BS01 CMP B 1 G367 E368 M369 T378 R418 G336 E337 M338 T347 R387 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7rys C 3.7 BS01 CMP C 1 G367 E368 M369 T378 R418 G336 E337 M338 T347 R387 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7rys D 3.7 BS03 CMP D 1 G367 E368 M369 T378 R418 G336 E337 M338 T347 R387 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36376326 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRIINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKE 7tj5 A 2.41 BS01 CMP A 1 F366 G367 M369 R377 T378 A379 F343 G344 M346 R354 T355 A356 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 7tj5 B 2.41 BS01 CMP B 1 F366 G367 M369 R377 T378 A379 F343 G344 M346 R354 T355 A356 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 603 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 7tj5 C 2.41 BS02 CMP C 1 F366 G367 M369 R377 T378 A379 F343 G344 M346 R354 T355 A356 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 603 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 7tj5 D 2.41 BS01 CMP D 1 F366 G367 M369 R377 T378 A379 F343 G344 M346 R354 T355 A356 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 603 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 7tj6 A 2.9 BS01 CMP A 1 F366 G367 T378 R418 F339 G340 T351 R391 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRR 7tj6 B 2.9 BS01 CMP B 1 F366 G367 T378 R418 F339 G340 T351 R391 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 502 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRR 7tj6 C 2.9 BS02 CMP C 1 F366 G367 T378 R418 F339 G340 T351 R391 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 502 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRR 7tj6 D 2.9 BS01 CMP D 1 F366 G367 T378 R418 F339 G340 T351 R391 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 502 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRR 7tkt A 3.6 BS01 CMP A 1 F366 G367 E368 M369 R377 T378 A379 F340 G341 E342 M343 R351 T352 A353 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAV 7tkt B 3.6 BS02 CMP B 1 F366 G367 E368 M369 R377 T378 A379 F340 G341 E342 M343 R351 T352 A353 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAV 7tkt C 3.6 BS02 CMP C 1 F366 G367 E368 M369 R377 T378 A379 F340 G341 E342 M343 R351 T352 A353 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAV 7tkt D 3.6 BS03 CMP D 1 F366 G367 E368 M369 R377 T378 A379 F340 G341 E342 M343 R351 T352 A353 ? 0005221,0016020,0034220,0044877,0098655 G0GA88 36352139 507 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAV 8pd8 A 3.3 BS01 CMP A 1 L1008 F1032 G1043 M1045 G1046 R1053 N1054 A1055 L853 F859 G870 M872 G873 R880 N881 A882 ? 0006812,0015297,0015385,0016020,0055085,1902600 A3RL54 37880361 1401 AHAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVPLVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILALFGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLGASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQVAVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEVSGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVVVTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRNAVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINATTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADADWDIATAACEISDPYSSPREFADMMEEARLRMLKAEKISYWKQFEHGMLAREALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISHHMAFEVTINIAIVLNIVPIIMEFVVQDKMLQKIEDALRISNYVFFVIYAIEAIVKILGLGRHYIVSHWNKFDAFILVVALVDIIIAETSSIKVVKLFRLLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKIIDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIRTILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPPENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVSGLVKLYGKSVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAEDMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHLERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTVHKLTFQYTATEEPRLFVVRN 8pd8 B 3.3 BS01 CMP B 1 L1008 F1032 G1043 M1045 G1046 R1053 N1054 A1055 L853 F859 G870 M872 G873 R880 N881 A882 ? 0006812,0015297,0015385,0016020,0055085,1902600 A3RL54 37880361 1401 AHAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVPLVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILALFGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLGASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQVAVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEVSGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVVVTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRNAVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINATTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADADWDIATAACEISDPYSSPREFADMMEEARLRMLKAEKISYWKQFEHGMLAREALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISHHMAFEVTINIAIVLNIVPIIMEFVVQDKMLQKIEDALRISNYVFFVIYAIEAIVKILGLGRHYIVSHWNKFDAFILVVALVDIIIAETSSIKVVKLFRLLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKIIDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIRTILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPPENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVSGLVKLYGKSVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAEDMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHLERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTVHKLTFQYTATEEPRLFVVRN 8pd9 A 3.6 BS01 CMP A 1 L1008 F1032 G1043 G1046 R1053 N1054 R1097 L855 F861 G872 G875 R882 N883 R926 ? 0006812,0015297,0015385,0016020,0055085,1902600 A3RL54 37880361 1401 AHAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVPLVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILALFGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLGASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQVAVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEVSGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVVVTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRNAVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINATTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADADWDIATAACEISDPYSPSPREFADMMEEARLRMLKAEKISYWKQFEHGMLAREALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISHHMAFEVTINIAIVLNIVPIIMEFVVQDKMALQKIEDALRISNYVFFVIYAIEAIVKILGLGRHYIVSHWNKFDAFILVVALVDIIIAETSSIKVVKLFRLLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKIIDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIRTILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPPENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVSGLVKLYGKSVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAEDMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHLERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTVHKLTFQYTATEEPRLFVVRNAEYN 8qvz A 1.774 BS01 CMP A 1 K29 Y69 F77 L81 T111 V129 N132 H135 K11 Y51 F59 L63 T93 V111 N114 H117 Q13232 201 GAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE 8qvz B 1.774 BS01 CMP B 1 K29 Y69 F77 L81 T111 V129 N132 H135 K11 Y51 F59 L63 T93 V111 N114 H117 Q13232 201 GAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE 8qvz C 1.774 BS01 CMP C 1 K29 Y69 F77 L81 T111 V129 N132 H135 K15 Y55 F63 L67 T97 V115 N118 H121 Q13232 201 GHMTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE 8qvz D 1.774 BS01 CMP D 1 K29 Y69 F77 L81 V129 N132 H135 K11 Y51 F59 L63 V111 N114 H117 Q13232 201 GAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE 8qvz E 1.774 BS01 CMP E 1 K29 Y69 F77 V129 N132 H135 K15 Y55 F63 V115 N118 H121 Q13232 201 GHMTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE 8qvz F 1.774 BS01 CMP F 1 K29 Y69 F77 L81 T111 V129 N132 H135 K12 Y52 F60 L64 T94 V112 N115 H118 Q13232 201 TGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE 8set A 3.42 BS01 CMP A 1 M4954 C4958 F4959 T4979 H4983 N4984 L4985 M4295 C4299 F4300 T4320 H4324 N4325 L4326 ? 0003151,0005216,0005219,0005245,0005262,0005509,0005515,0005516,0005524,0005790,0006811,0006816,0006874,0006936,0006941,0008144,0014802,0014808,0015278,0015643,0016020,0016529,0019722,0030018,0031090,0033017,0034704,0035381,0042383,0042802,0043588,0043931,0044325,0046872,0048741,0051209,0051289,0055085,0070588,0071277,0071313,0097718,1990425 P11716 37192614 5101 VQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFTLEQSLSVRALQEMLANHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSCCEEGYVTGGHVLRLFHGHMDECLTISAADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLVVVDACKAHTKATSFCFRVSKEKLPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAILHQEGHMDDALFLTRCQQEESQAARMIHSTAGLYNQFIKGLDSFSGKPRGSGPPAGPALPIEAVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEYAGEEAAESWKEIVNLLYELLASLIRGNRANCALFSTNLDWVVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVNFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPPEHPHYEVARMDGTVDTPPCLRLAHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTDNRDDPEIILNTTTYYYSVRVFAGQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRAGERLGWAVQCQDPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRKGGNARRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGVAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEELEEGLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYALLMRAFTMSAAETARRTREFRSPPQEQINMLLHFKDEADEEDCPLPEDIRQDLQDFHQDLLAHCGIQLEKKPQSLQELVSHMVVRWAQEDYVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGETKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRMAMPCLCAIAGALPPDYVDASYSSKAEKNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENVDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRLDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLDRLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMKRLAVFAQPIVSRARPELLHSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNANAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMARRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIMLAKTRYALKDTDEEVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYHLEQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEVEVSFEEKEMEKQRLLYQQSRLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINFEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 8set B 3.42 BS01 CMP B 1 M4954 C4958 F4959 T4979 H4983 N4984 L4985 M4295 C4299 F4300 T4320 H4324 N4325 L4326 ? 0003151,0005216,0005219,0005245,0005262,0005509,0005515,0005516,0005524,0005790,0006811,0006816,0006874,0006936,0006941,0008144,0014802,0014808,0015278,0015643,0016020,0016529,0019722,0030018,0031090,0033017,0034704,0035381,0042383,0042802,0043588,0043931,0044325,0046872,0048741,0051209,0051289,0055085,0070588,0071277,0071313,0097718,1990425 P11716 37192614 5101 VQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFTLEQSLSVRALQEMLANHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSCCEEGYVTGGHVLRLFHGHMDECLTISAADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLVVVDACKAHTKATSFCFRVSKEKLPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAILHQEGHMDDALFLTRCQQEESQAARMIHSTAGLYNQFIKGLDSFSGKPRGSGPPAGPALPIEAVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEYAGEEAAESWKEIVNLLYELLASLIRGNRANCALFSTNLDWVVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVNFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPPEHPHYEVARMDGTVDTPPCLRLAHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTDNRDDPEIILNTTTYYYSVRVFAGQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRAGERLGWAVQCQDPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRKGGNARRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGVAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEELEEGLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYALLMRAFTMSAAETARRTREFRSPPQEQINMLLHFKDEADEEDCPLPEDIRQDLQDFHQDLLAHCGIQLEKKPQSLQELVSHMVVRWAQEDYVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGETKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRMAMPCLCAIAGALPPDYVDASYSSKAEKNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENVDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRLDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLDRLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMKRLAVFAQPIVSRARPELLHSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNANAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMARRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIMLAKTRYALKDTDEEVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYHLEQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEVEVSFEEKEMEKQRLLYQQSRLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINFEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 8set C 3.42 BS01 CMP C 1 M4954 C4958 F4959 T4979 H4983 N4984 L4985 M4295 C4299 F4300 T4320 H4324 N4325 L4326 ? 0003151,0005216,0005219,0005245,0005262,0005509,0005515,0005516,0005524,0005790,0006811,0006816,0006874,0006936,0006941,0008144,0014802,0014808,0015278,0015643,0016020,0016529,0019722,0030018,0031090,0033017,0034704,0035381,0042383,0042802,0043588,0043931,0044325,0046872,0048741,0051209,0051289,0055085,0070588,0071277,0071313,0097718,1990425 P11716 37192614 5101 VQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFTLEQSLSVRALQEMLANHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSCCEEGYVTGGHVLRLFHGHMDECLTISAADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLVVVDACKAHTKATSFCFRVSKEKLPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAILHQEGHMDDALFLTRCQQEESQAARMIHSTAGLYNQFIKGLDSFSGKPRGSGPPAGPALPIEAVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEYAGEEAAESWKEIVNLLYELLASLIRGNRANCALFSTNLDWVVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVNFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPPEHPHYEVARMDGTVDTPPCLRLAHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTDNRDDPEIILNTTTYYYSVRVFAGQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRAGERLGWAVQCQDPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRKGGNARRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGVAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEELEEGLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYALLMRAFTMSAAETARRTREFRSPPQEQINMLLHFKDEADEEDCPLPEDIRQDLQDFHQDLLAHCGIQLEKKPQSLQELVSHMVVRWAQEDYVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGETKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRMAMPCLCAIAGALPPDYVDASYSSKAEKNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENVDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRLDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLDRLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMKRLAVFAQPIVSRARPELLHSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNANAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMARRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIMLAKTRYALKDTDEEVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYHLEQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEVEVSFEEKEMEKQRLLYQQSRLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINFEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 8set D 3.42 BS01 CMP D 1 M4954 C4958 F4959 T4979 H4983 N4984 L4985 M4295 C4299 F4300 T4320 H4324 N4325 L4326 ? 0003151,0005216,0005219,0005245,0005262,0005509,0005515,0005516,0005524,0005790,0006811,0006816,0006874,0006936,0006941,0008144,0014802,0014808,0015278,0015643,0016020,0016529,0019722,0030018,0031090,0033017,0034704,0035381,0042383,0042802,0043588,0043931,0044325,0046872,0048741,0051209,0051289,0055085,0070588,0071277,0071313,0097718,1990425 P11716 37192614 5101 VQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFTLEQSLSVRALQEMLANHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSCCEEGYVTGGHVLRLFHGHMDECLTISAADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLVVVDACKAHTKATSFCFRVSKEKLPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAILHQEGHMDDALFLTRCQQEESQAARMIHSTAGLYNQFIKGLDSFSGKPRGSGPPAGPALPIEAVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEYAGEEAAESWKEIVNLLYELLASLIRGNRANCALFSTNLDWVVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVNFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPPEHPHYEVARMDGTVDTPPCLRLAHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTDNRDDPEIILNTTTYYYSVRVFAGQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRAGERLGWAVQCQDPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRKGGNARRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGVAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEELEEGLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYALLMRAFTMSAAETARRTREFRSPPQEQINMLLHFKDEADEEDCPLPEDIRQDLQDFHQDLLAHCGIQLEKKPQSLQELVSHMVVRWAQEDYVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGETKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRMAMPCLCAIAGALPPDYVDASYSSKAEKNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENVDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRLDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLDRLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMKRLAVFAQPIVSRARPELLHSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNANAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMARRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIMLAKTRYALKDTDEEVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYHLEQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEVEVSFEEKEMEKQRLLYQQSRLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINFEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 8sf0 A 2.9 BS01 CMP A 1 M4954 C4958 F4959 T4979 H4983 N4984 M545 C549 F550 T570 H574 N575 ? 0003151,0005216,0005219,0005245,0005262,0005509,0005515,0005516,0005524,0005790,0006811,0006816,0006874,0006936,0006941,0008144,0014802,0014808,0015278,0015643,0016020,0016529,0019722,0030018,0031090,0033017,0034704,0035381,0042383,0042802,0043588,0043931,0044325,0046872,0048741,0051209,0051289,0055085,0070588,0071277,0071313,0097718,1990425 P11716 37192614 5101 NFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 8sf0 B 2.9 BS01 CMP B 1 M4954 C4958 F4959 T4979 H4983 N4984 M545 C549 F550 T570 H574 N575 ? 0003151,0005216,0005219,0005245,0005262,0005509,0005515,0005516,0005524,0005790,0006811,0006816,0006874,0006936,0006941,0008144,0014802,0014808,0015278,0015643,0016020,0016529,0019722,0030018,0031090,0033017,0034704,0035381,0042383,0042802,0043588,0043931,0044325,0046872,0048741,0051209,0051289,0055085,0070588,0071277,0071313,0097718,1990425 P11716 37192614 5101 NFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 8sf0 C 2.9 BS01 CMP C 1 M4954 C4958 F4959 T4979 H4983 N4984 M545 C549 F550 T570 H574 N575 ? 0003151,0005216,0005219,0005245,0005262,0005509,0005515,0005516,0005524,0005790,0006811,0006816,0006874,0006936,0006941,0008144,0014802,0014808,0015278,0015643,0016020,0016529,0019722,0030018,0031090,0033017,0034704,0035381,0042383,0042802,0043588,0043931,0044325,0046872,0048741,0051209,0051289,0055085,0070588,0071277,0071313,0097718,1990425 P11716 37192614 5101 NFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 8sf0 D 2.9 BS01 CMP D 1 M4954 C4958 F4959 T4979 H4983 N4984 M545 C549 F550 T570 H574 N575 ? 0003151,0005216,0005219,0005245,0005262,0005509,0005515,0005516,0005524,0005790,0006811,0006816,0006874,0006936,0006941,0008144,0014802,0014808,0015278,0015643,0016020,0016529,0019722,0030018,0031090,0033017,0034704,0035381,0042383,0042802,0043588,0043931,0044325,0046872,0048741,0051209,0051289,0055085,0070588,0071277,0071313,0097718,1990425 P11716 37192614 5101 NFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGYMEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 8t4m A 3.16 BS01 CMP A 1 M530 F538 G539 I541 R549 T550 A551 R590 I594 V633 M428 F436 G437 I439 R447 T448 A449 R488 I492 V531 ? 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 8t4m B 3.16 BS01 CMP B 1 M530 F538 G539 I541 R549 T550 A551 R590 I594 V633 M428 F436 G437 I439 R447 T448 A449 R488 I492 V531 ? 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 8t4m C 3.16 BS01 CMP C 1 M530 F538 G539 I541 R549 T550 A551 R590 I594 V633 M428 F436 G437 I439 R447 T448 A449 R488 I492 V531 ? 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 8t4m D 3.16 BS01 CMP D 1 M530 F538 G539 I541 R549 T550 A551 R590 I594 V633 M428 F436 G437 I439 R447 T448 A449 R488 I492 V531 ? 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 8t4y A 3.58 BS01 CMP A 1 V522 M530 E540 I541 R549 T550 R590 I594 V388 M396 E406 I407 R415 T416 R456 I460 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 KFSLRMFGSQKAVEKEQERVKTIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLAHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 8t4y B 3.58 BS01 CMP B 1 V522 M530 E540 I541 R549 T550 R590 I594 V388 M396 E406 I407 R415 T416 R456 I460 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 KFSLRMFGSQKAVEKEQERVKTIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLAHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 8t4y C 3.58 BS01 CMP C 1 V522 M530 E540 I541 R549 T550 R590 I594 V388 M396 E406 I407 R415 T416 R456 I460 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 KFSLRMFGSQKAVEKEQERVKTIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLAHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 8t4y D 3.58 BS01 CMP D 1 V522 M530 E540 I541 R549 T550 R590 I594 V388 M396 E406 I407 R415 T416 R456 I460 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 KFSLRMFGSQKAVEKEQERVKTIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLAHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA 8t50 A 3.6 BS01 CMP A 1 M530 F538 G539 E540 I541 C542 R549 T550 A551 R590 I594 M378 F386 G387 E388 I389 C390 R397 T398 A399 R438 I442 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 NKFSLRMFGSQKAVEKEQERVKTADFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQNQENEILKQIVKHDREMVQA 8t50 B 3.6 BS01 CMP B 1 M530 F538 G539 E540 I541 C542 R549 T550 R590 I594 M378 F386 G387 E388 I389 C390 R397 T398 R438 I442 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 NKFSLRMFGSQKAVEKEQERVKTADFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQNQENEILKQIVKHDREMVQA 8t50 C 3.6 BS01 CMP C 1 M530 G539 E540 I541 C542 R549 T550 A551 R590 I594 M378 G387 E388 I389 C390 R397 T398 A399 R438 I442 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 NKFSLRMFGSQKAVEKEQERVKTADFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQNQENEILKQIVKHDREMVQA 8t50 D 3.6 BS01 CMP D 1 M530 G539 E540 I541 C542 R549 T550 R590 I594 M378 G387 E388 I389 C390 R397 T398 R438 I442 0003254,0005222,0005248,0005249,0005267,0005272,0005515,0005886,0006814,0019228,0022843,0030424,0030425,0030552,0034702,0035725,0042391,0042802,0045176,0045211,0046549,0048787,0051289,0051867,0060078,0071320,0071805,0098855,0098978,0140232 O60741 38890331 901 NKFSLRMFGSQKAVEKEQERVKTADFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQNQENEILKQIVKHDREMVQA 8t5y A 1.44 BS01 CMP A 1 W177 Y178 R179 I181 Q184 L192 W170 Y171 R172 I174 Q177 L185 0003677 37945601 501 EPESDVKGRILDAAADAFMLRGFANTTIDDIADDVGATAGLIYYHFRSKFDIFLAVYEDGMRRVRERVEPYVGAPGTGRQRLVAMSVAHVENLMIDLGYHHVVHQRDQASTALKVRQRDALAALNELRRDYERMFHHVITEGIADGSLRNVDDALATRTLLSNLNAVDVWYRKIEGQTEKEVHDLASQVVDLLIGGIGAT 8vt9 A 2.9 BS01 CMP A 1 V348 A358 G367 M369 R377 T378 A379 V339 A349 G358 M360 R368 T369 A370 G0GA88 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRRTSGRKPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 8vt9 B 2.9 BS01 CMP B 1 V348 A358 G367 M369 R377 T378 A379 V339 A349 G358 M360 R368 T369 A370 G0GA88 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRRTSGRKPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 8vt9 C 2.9 BS01 CMP C 1 V348 A358 G367 M369 R377 T378 A379 V339 A349 G358 M360 R368 T369 A370 G0GA88 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRRTSGRKPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 8vt9 D 2.9 BS02 CMP D 1 V348 A358 G367 M369 R377 T378 A379 V339 A349 G358 M360 R368 T369 A370 G0GA88 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRRTSGRKPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 8vta A 3.0 BS01 CMP A 1 V348 F366 G367 E368 M369 R377 T378 V339 F357 G358 E359 M360 R368 T369 G0GA88 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRRTSGRKPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQE 8vta B 3.0 BS01 CMP B 1 V348 F366 G367 E368 M369 R377 T378 V339 F357 G358 E359 M360 R368 T369 G0GA88 503 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRRTSGRKPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQE 8vta C 3.0 BS01 CMP C 1 V348 F366 G367 E368 M369 R377 T378 V339 F357 G358 E359 M360 R368 T369 G0GA88 503 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRRTSGRKPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQE 8vta D 3.0 BS01 CMP D 1 V348 F366 G367 E368 M369 R377 T378 V339 F357 G358 E359 M360 R368 T369 G0GA88 503 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRRTSGRKPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQE 8vtb A 2.5 BS01 CMP A 1 A358 F366 G367 E368 M369 R377 T378 A343 F351 G352 E353 M354 R362 T363 G0GA88 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATAILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 8vtb B 2.5 BS01 CMP B 1 A358 F366 G367 E368 M369 R377 T378 A343 F351 G352 E353 M354 R362 T363 G0GA88 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATAILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 8vtb C 2.5 BS01 CMP C 1 A358 F366 G367 E368 M369 R377 T378 A343 F351 G352 E353 M354 R362 T363 G0GA88 501 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATAILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 8vtb D 2.5 BS01 CMP D 1 A358 F366 G367 E368 M369 R377 T378 A343 F351 G352 E353 M354 R362 T363 G0GA88 504 TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIPLDLAFESRPTLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQASATAILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA 8xq7 A 3.15 BS01 CMP A 1 V989 L1008 F1032 G1043 M1045 G1046 R1053 N1054 R1097 V829 L848 F853 G864 M866 G867 R874 N875 R918 0005886,0006814,0007338,0015297,0015385,0015386,0019933,0030552,0030553,0031514,0036126,0042803,0051453,0061827,0071805,0098719 A3RL54 38957574 2001 APKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVPLVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILALFGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLGASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQVAVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEVSGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVVVTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRNAVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINATTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADADWDIATAACEISDPYSADELTLGERKSVCPGCKAMVPNEPSPREFADMMEEARLRMLKAEKISYWKQFEHGMLAREALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISAFEVTINIAIVLNIVPIIMEFQKIEDALRISNYVFFVIYAIEAIVKILGSHWNKFDAFILVVALVDVVKLFRLLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKIIDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIRTILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPPENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVSGLVKLYGKVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAEDMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHLERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTVHKLTFQYTATEEPRLFVVRNAEPILDGRLDVDSKRSLISITEISSNMCL 8xq7 B 3.15 BS01 CMP B 1 L1008 F1032 G1043 M1045 G1046 R1053 N1054 A1055 R1097 L848 F853 G864 M866 G867 R874 N875 A876 R918 0005886,0006814,0007338,0015297,0015385,0015386,0019933,0030552,0030553,0031514,0036126,0042803,0051453,0061827,0071805,0098719 A3RL54 38957574 2001 APKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVPLVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILALFGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLGASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQVAVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEVSGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVVVTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRNAVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINATTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADADWDIATAACEISDPYSADELTLGERKSVCPGCKAMVPNEPSPREFADMMEEARLRMLKAEKISYWKQFEHGMLAREALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISAFEVTINIAIVLNIVPIIMEFQKIEDALRISNYVFFVIYAIEAIVKILGSHWNKFDAFILVVALVDVVKLFRLLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKIIDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIRTILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPPENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVSGLVKLYGKVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAEDMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHLERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTVHKLTFQYTATEEPRLFVVRNAEPILDGRLDVDSKRSLISITEISSNMCL 8xq8 A 3.35 BS01 CMP A 1 F1032 G1043 M1045 G1046 R1053 N1054 F889 G900 M902 G903 R910 N911 0005886,0006814,0007338,0015297,0015385,0015386,0019933,0030552,0030553,0031514,0036126,0042803,0051453,0061827,0071805,0098719 A3RL54 38957574 2001 HAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVPLVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILALFGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLGASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQVAVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEVSGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVVVTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRNAVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINATTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADADWDIATAACEISDPYSADELTLGERKSVCPGCKAMVPNEPSPREFADMMEEARLRMLKAEKISYWKQFEHGMLAREALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISEKLMYKICHHMAFEVTINIAIVLNIVPIIMEFVVQDKMQKIEDALRISNYVFFVIYAIEAIVKILGLGRHYIVSHWNKFDAFILVVALVDIIIAETLSSIKVVKLFRLLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKIIDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIRTILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPPENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVSGLVKLYGKVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAEDMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHLERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTVHKLTFQYTATEEPRLFVVRNAEY 9bc7 A 3.3 BS01 CMP A 1 G539 I541 C542 R549 T550 G437 I439 C440 R447 T448 O60741 39085604 704 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMLLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKD 9bc7 B 3.3 BS01 CMP B 1 G539 I541 C542 R549 T550 G437 I439 C440 R447 T448 O60741 39085604 704 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMLLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKD 9bc7 C 3.3 BS01 CMP C 1 G539 I541 C542 R549 T550 G437 I439 C440 R447 T448 O60741 39085604 704 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMLLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKD 9bc7 D 3.3 BS01 CMP D 1 G539 I541 C542 R549 T550 G437 I439 C440 R447 T448 O60741 39085604 704 MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGRALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMLLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKD