Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only
Online Services

I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
Download all results in tab-seperated text for 49284 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
  • Sort results by
    << < 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 > >>
    Go to page

    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    47401 8wm6:l (2.7) BS14 CLA N/A N/A N/A 38734819
    47402 8wm6:m (2.7) BS01 CLA N/A N/A N/A 38734819
    47403 8wm6:m (2.7) BS02 CLA N/A N/A N/A 38734819
    47404 8wm6:m (2.7) BS03 CLA N/A N/A N/A 38734819
    47405 8wm6:m (2.7) BS04 CLA N/A N/A N/A 38734819
    47406 8wm6:m (2.7) BS05 CLA N/A N/A N/A 38734819
    47407 8wm6:m (2.7) BS06 CLA N/A N/A N/A 38734819
    47408 8wm6:m (2.7) BS07 CLA N/A N/A N/A 38734819
    47409 8wm6:m (2.7) BS08 CLA N/A N/A N/A 38734819
    47410 8wm6:m (2.7) BS09 CLA N/A N/A N/A 38734819
    47411 8wm6:m (2.7) BS10 CLA N/A N/A N/A 38734819
    47412 8wm6:m (2.7) BS12 CLA N/A N/A N/A 38734819
    47413 8wm6:m (2.7) BS13 CLA N/A N/A N/A 38734819
    47414 8wm6:m (2.7) BS19 CLA N/A N/A N/A 38734819
    47415 8wm6:n (2.7) BS01 CLA N/A N/A N/A 38734819
    47416 8wm6:n (2.7) BS04 CLA N/A N/A N/A 38734819
    47417 8wm6:n (2.7) BS05 CLA N/A N/A N/A 38734819
    47418 8wm6:n (2.7) BS06 CLA N/A N/A N/A 38734819
    47419 8wm6:n (2.7) BS07 CLA N/A N/A N/A 38734819
    47420 8wm6:n (2.7) BS08 CLA N/A N/A N/A 38734819
    47421 8wm6:n (2.7) BS09 CLA N/A N/A N/A 38734819
    47422 8wm6:n (2.7) BS10 CLA N/A N/A N/A 38734819
    47423 8wm6:n (2.7) BS11 CLA N/A N/A N/A 38734819
    47424 8wm6:n (2.7) BS12 CLA N/A N/A N/A 38734819
    47425 8wm6:n (2.7) BS13 CLA N/A N/A N/A 38734819
    47426 8wm6:n (2.7) BS16 CLA N/A N/A N/A 38734819
    47427 8wm6:s (2.7) BS02 CLA N/A N/A N/A 38734819
    47428 8wm6:s (2.7) BS03 CLA N/A N/A N/A 38734819
    47429 8wm6:s (2.7) BS06 CLA N/A N/A N/A 38734819
    47430 8wm6:s (2.7) BS07 CLA N/A N/A N/A 38734819
    47431 8wm6:s (2.7) BS08 CLA N/A N/A N/A 38734819
    47432 8wm6:s (2.7) BS09 CLA N/A N/A N/A 38734819
    47433 8wm6:s (2.7) BS10 CLA N/A N/A N/A 38734819
    47434 8wm6:s (2.7) BS11 CLA N/A N/A N/A 38734819
    47435 8wmj:A (3.0) BS01 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47436 8wmj:A (3.0) BS02 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47437 8wmj:A (3.0) BS03 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47438 8wmj:A (3.0) BS04 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47439 8wmj:A (3.0) BS05 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47440 8wmj:A (3.0) BS06 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47441 8wmj:A (3.0) BS07 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47442 8wmj:A (3.0) BS08 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47443 8wmj:A (3.0) BS09 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47444 8wmj:A (3.0) BS10 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47445 8wmj:A (3.0) BS11 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47446 8wmj:A (3.0) BS12 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47447 8wmj:A (3.0) BS13 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47448 8wmj:A (3.0) BS14 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47449 8wmj:A (3.0) BS15 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47450 8wmj:A (3.0) BS16 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47451 8wmj:A (3.0) BS17 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47452 8wmj:A (3.0) BS18 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47453 8wmj:A (3.0) BS19 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47454 8wmj:A (3.0) BS20 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47455 8wmj:A (3.0) BS21 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47456 8wmj:A (3.0) BS22 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47457 8wmj:A (3.0) BS23 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47458 8wmj:A (3.0) BS24 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47459 8wmj:A (3.0) BS25 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47460 8wmj:A (3.0) BS26 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47461 8wmj:A (3.0) BS27 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47462 8wmj:A (3.0) BS28 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47463 8wmj:A (3.0) BS29 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47464 8wmj:A (3.0) BS30 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47465 8wmj:A (3.0) BS31 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47466 8wmj:A (3.0) BS32 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47467 8wmj:A (3.0) BS33 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47468 8wmj:A (3.0) BS34 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47469 8wmj:A (3.0) BS35 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47470 8wmj:A (3.0) BS36 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47471 8wmj:A (3.0) BS37 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47472 8wmj:A (3.0) BS38 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47473 8wmj:A (3.0) BS39 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47474 8wmj:A (3.0) BS40 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47475 8wmj:A (3.0) BS41 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47476 8wmj:A (3.0) BS42 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47477 8wmj:A (3.0) BS43 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47478 8wmj:A (3.0) BS50 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47479 8wmj:A (3.0) BS51 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47480 8wmj:A (3.0) BS52 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47481 8wmj:A (3.0) BS53 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47482 8wmj:A (3.0) BS55 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47483 8wmj:A (3.0) BS56 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47484 8wmj:A (3.0) BS57 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47485 8wmj:A (3.0) BS59 CLA 1.97.1.12 GO:0000287 ... A6MVZ7 38734819
    47486 8wmj:B (3.0) BS01 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47487 8wmj:B (3.0) BS02 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47488 8wmj:B (3.0) BS03 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47489 8wmj:B (3.0) BS04 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47490 8wmj:B (3.0) BS05 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47491 8wmj:B (3.0) BS06 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47492 8wmj:B (3.0) BS07 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47493 8wmj:B (3.0) BS09 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47494 8wmj:B (3.0) BS10 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47495 8wmj:B (3.0) BS11 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47496 8wmj:B (3.0) BS12 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47497 8wmj:B (3.0) BS13 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47498 8wmj:B (3.0) BS14 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47499 8wmj:B (3.0) BS15 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47500 8wmj:B (3.0) BS16 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47501 8wmj:B (3.0) BS17 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47502 8wmj:B (3.0) BS18 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47503 8wmj:B (3.0) BS19 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47504 8wmj:B (3.0) BS20 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47505 8wmj:B (3.0) BS21 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47506 8wmj:B (3.0) BS22 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47507 8wmj:B (3.0) BS23 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47508 8wmj:B (3.0) BS24 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47509 8wmj:B (3.0) BS25 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47510 8wmj:B (3.0) BS26 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47511 8wmj:B (3.0) BS27 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47512 8wmj:B (3.0) BS28 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47513 8wmj:B (3.0) BS29 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47514 8wmj:B (3.0) BS30 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47515 8wmj:B (3.0) BS31 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47516 8wmj:B (3.0) BS32 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47517 8wmj:B (3.0) BS33 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47518 8wmj:B (3.0) BS34 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47519 8wmj:B (3.0) BS35 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47520 8wmj:B (3.0) BS36 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47521 8wmj:B (3.0) BS37 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47522 8wmj:B (3.0) BS38 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47523 8wmj:B (3.0) BS39 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47524 8wmj:B (3.0) BS40 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47525 8wmj:B (3.0) BS41 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47526 8wmj:B (3.0) BS42 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47527 8wmj:B (3.0) BS43 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47528 8wmj:B (3.0) BS44 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47529 8wmj:B (3.0) BS45 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47530 8wmj:B (3.0) BS46 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47531 8wmj:B (3.0) BS47 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47532 8wmj:B (3.0) BS53 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47533 8wmj:B (3.0) BS54 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47534 8wmj:B (3.0) BS56 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47535 8wmj:B (3.0) BS58 CLA 1.97.1.12 GO:0000287 ... A6MVZ6 38734819
    47536 8wmj:F (3.0) BS01 CLA ? N/A A6MVU7 38734819
    47537 8wmj:F (3.0) BS02 CLA ? N/A A6MVU7 38734819
    47538 8wmj:F (3.0) BS03 CLA ? N/A A6MVU7 38734819
    47539 8wmj:F (3.0) BS04 CLA ? N/A A6MVU7 38734819
    47540 8wmj:F (3.0) BS05 CLA ? N/A A6MVU7 38734819
    47541 8wmj:F (3.0) BS06 CLA ? N/A A6MVU7 38734819
    47542 8wmj:F (3.0) BS07 CLA ? N/A A6MVU7 38734819
    47543 8wmj:F (3.0) BS09 CLA ? N/A A6MVU7 38734819
    47544 8wmj:I (3.0) BS01 CLA ? GO:0009507 ... A6MVV1 38734819
    47545 8wmj:I (3.0) BS02 CLA ? GO:0009507 ... A6MVV1 38734819
    47546 8wmj:I (3.0) BS03 CLA ? GO:0009507 ... A6MVV1 38734819
    47547 8wmj:I (3.0) BS06 CLA ? GO:0009507 ... A6MVV1 38734819
    47548 8wmj:J (3.0) BS01 CLA ? GO:0009507 ... A6MVU6 38734819
    47549 8wmj:J (3.0) BS02 CLA ? GO:0009507 ... A6MVU6 38734819
    47550 8wmj:J (3.0) BS03 CLA ? GO:0009507 ... A6MVU6 38734819
    47551 8wmj:J (3.0) BS04 CLA ? GO:0009507 ... A6MVU6 38734819
    47552 8wmj:J (3.0) BS05 CLA ? GO:0009507 ... A6MVU6 38734819
    47553 8wmj:J (3.0) BS08 CLA ? GO:0009507 ... A6MVU6 38734819
    47554 8wmj:J (3.0) BS10 CLA ? GO:0009507 ... A6MVU6 38734819
    47555 8wmj:J (3.0) BS11 CLA ? GO:0009507 ... A6MVU6 38734819
    47556 8wmj:K (3.0) BS01 CLA ? GO:0009507 ... A6MVS9 38734819
    47557 8wmj:K (3.0) BS02 CLA ? GO:0009507 ... A6MVS9 38734819
    47558 8wmj:K (3.0) BS03 CLA ? GO:0009507 ... A6MVS9 38734819
    47559 8wmj:K (3.0) BS05 CLA ? GO:0009507 ... A6MVS9 38734819
    47560 8wmj:K (3.0) BS06 CLA ? GO:0009507 ... A6MVS9 38734819
    47561 8wmj:L (3.0) BS01 CLA ? GO:0009507 ... A6MVV8 38734819
    47562 8wmj:L (3.0) BS02 CLA ? GO:0009507 ... A6MVV8 38734819
    47563 8wmj:L (3.0) BS03 CLA ? GO:0009507 ... A6MVV8 38734819
    47564 8wmj:L (3.0) BS04 CLA ? GO:0009507 ... A6MVV8 38734819
    47565 8wmj:L (3.0) BS05 CLA ? GO:0009507 ... A6MVV8 38734819
    47566 8wmj:L (3.0) BS07 CLA ? GO:0009507 ... A6MVV8 38734819
    47567 8wmj:L (3.0) BS08 CLA ? GO:0009507 ... A6MVV8 38734819
    47568 8wmj:L (3.0) BS09 CLA ? GO:0009507 ... A6MVV8 38734819
    47569 8wmj:L (3.0) BS11 CLA ? GO:0009507 ... A6MVV8 38734819
    47570 8wmj:M (3.0) BS01 CLA ? GO:0009507 ... A6MVT4 38734819
    47571 8wmj:Q (3.0) BS01 CLA N/A N/A N/A 38734819
    47572 8wmj:Q (3.0) BS02 CLA N/A N/A N/A 38734819
    47573 8wmj:Q (3.0) BS03 CLA N/A N/A N/A 38734819
    47574 8wmj:Q (3.0) BS04 CLA N/A N/A N/A 38734819
    47575 8wmj:R (3.0) BS01 CLA N/A N/A N/A 38734819
    47576 8wmj:R (3.0) BS02 CLA N/A N/A N/A 38734819
    47577 8wmj:R (3.0) BS03 CLA N/A N/A N/A 38734819
    47578 8wmj:R (3.0) BS05 CLA N/A N/A N/A 38734819
    47579 8wmj:a (3.0) BS01 CLA N/A N/A N/A 38734819
    47580 8wmj:a (3.0) BS02 CLA N/A N/A N/A 38734819
    47581 8wmj:a (3.0) BS03 CLA N/A N/A N/A 38734819
    47582 8wmj:a (3.0) BS04 CLA N/A N/A N/A 38734819
    47583 8wmj:a (3.0) BS05 CLA N/A N/A N/A 38734819
    47584 8wmj:a (3.0) BS06 CLA N/A N/A N/A 38734819
    47585 8wmj:a (3.0) BS07 CLA N/A N/A N/A 38734819
    47586 8wmj:a (3.0) BS08 CLA N/A N/A N/A 38734819
    47587 8wmj:a (3.0) BS09 CLA N/A N/A N/A 38734819
    47588 8wmj:a (3.0) BS10 CLA N/A N/A N/A 38734819
    47589 8wmj:a (3.0) BS11 CLA N/A N/A N/A 38734819
    47590 8wmj:a (3.0) BS12 CLA N/A N/A N/A 38734819
    47591 8wmj:a (3.0) BS18 CLA N/A N/A N/A 38734819
    47592 8wmj:b (3.0) BS01 CLA N/A N/A N/A 38734819
    47593 8wmj:b (3.0) BS02 CLA N/A N/A N/A 38734819
    47594 8wmj:b (3.0) BS04 CLA N/A N/A N/A 38734819
    47595 8wmj:b (3.0) BS05 CLA N/A N/A N/A 38734819
    47596 8wmj:b (3.0) BS06 CLA N/A N/A N/A 38734819
    47597 8wmj:b (3.0) BS07 CLA N/A N/A N/A 38734819
    47598 8wmj:b (3.0) BS08 CLA N/A N/A N/A 38734819
    47599 8wmj:b (3.0) BS09 CLA N/A N/A N/A 38734819
    47600 8wmj:b (3.0) BS10 CLA N/A N/A N/A 38734819

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417