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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

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BioLiP
Download all results in tab-seperated text for 49284 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    37001 7y7a:Bo (4.3) BS42 CLA 1.97.1.12 GO:0000287 ... W0RYU6 36922595
    37002 7y7a:Bo (4.3) BS43 CLA 1.97.1.12 GO:0000287 ... W0RYU6 36922595
    37003 7y7a:Bo (4.3) BS44 CLA 1.97.1.12 GO:0000287 ... W0RYU6 36922595
    37004 7y7a:Bo (4.3) BS45 CLA 1.97.1.12 GO:0000287 ... W0RYU6 36922595
    37005 7y7a:Bo (4.3) BS47 CLA 1.97.1.12 GO:0000287 ... W0RYU6 36922595
    37006 7y7a:Bo (4.3) BS48 CLA 1.97.1.12 GO:0000287 ... W0RYU6 36922595
    37007 7y7a:Bo (4.3) BS49 CLA 1.97.1.12 GO:0000287 ... W0RYU6 36922595
    37008 7y7a:Bo (4.3) BS50 CLA 1.97.1.12 GO:0000287 ... W0RYU6 36922595
    37009 7y7a:C9 (4.3) BS02 CLA ? GO:0005737 ... W0RYK4 36922595
    37010 7y7a:C9 (4.3) BS03 CLA ? GO:0005737 ... W0RYK4 36922595
    37011 7y7a:C9 (4.3) BS04 CLA ? GO:0005737 ... W0RYK4 36922595
    37012 7y7a:C9 (4.3) BS05 CLA ? GO:0005737 ... W0RYK4 36922595
    37013 7y7a:C9 (4.3) BS06 CLA ? GO:0005737 ... W0RYK4 36922595
    37014 7y7a:C9 (4.3) BS07 CLA ? GO:0005737 ... W0RYK4 36922595
    37015 7y7a:C9 (4.3) BS08 CLA ? GO:0005737 ... W0RYK4 36922595
    37016 7y7a:C9 (4.3) BS09 CLA ? GO:0005737 ... W0RYK4 36922595
    37017 7y7a:C9 (4.3) BS10 CLA ? GO:0005737 ... W0RYK4 36922595
    37018 7y7a:C9 (4.3) BS11 CLA ? GO:0005737 ... W0RYK4 36922595
    37019 7y7a:C9 (4.3) BS12 CLA ? GO:0005737 ... W0RYK4 36922595
    37020 7y7a:C9 (4.3) BS13 CLA ? GO:0005737 ... W0RYK4 36922595
    37021 7y7a:C9 (4.3) BS14 CLA ? GO:0005737 ... W0RYK4 36922595
    37022 7y7a:CE (4.3) BS02 CLA ? GO:0005737 ... W0RYK4 36922595
    37023 7y7a:CE (4.3) BS03 CLA ? GO:0005737 ... W0RYK4 36922595
    37024 7y7a:CE (4.3) BS04 CLA ? GO:0005737 ... W0RYK4 36922595
    37025 7y7a:CE (4.3) BS05 CLA ? GO:0005737 ... W0RYK4 36922595
    37026 7y7a:CE (4.3) BS06 CLA ? GO:0005737 ... W0RYK4 36922595
    37027 7y7a:CE (4.3) BS07 CLA ? GO:0005737 ... W0RYK4 36922595
    37028 7y7a:CE (4.3) BS08 CLA ? GO:0005737 ... W0RYK4 36922595
    37029 7y7a:CE (4.3) BS09 CLA ? GO:0005737 ... W0RYK4 36922595
    37030 7y7a:CE (4.3) BS10 CLA ? GO:0005737 ... W0RYK4 36922595
    37031 7y7a:CE (4.3) BS11 CLA ? GO:0005737 ... W0RYK4 36922595
    37032 7y7a:CE (4.3) BS12 CLA ? GO:0005737 ... W0RYK4 36922595
    37033 7y7a:CE (4.3) BS13 CLA ? GO:0005737 ... W0RYK4 36922595
    37034 7y7a:CE (4.3) BS14 CLA ? GO:0005737 ... W0RYK4 36922595
    37035 7y7a:CO (4.3) BS02 CLA ? GO:0005737 ... W0RYK4 36922595
    37036 7y7a:CO (4.3) BS03 CLA ? GO:0005737 ... W0RYK4 36922595
    37037 7y7a:CO (4.3) BS04 CLA ? GO:0005737 ... W0RYK4 36922595
    37038 7y7a:CO (4.3) BS05 CLA ? GO:0005737 ... W0RYK4 36922595
    37039 7y7a:CO (4.3) BS06 CLA ? GO:0005737 ... W0RYK4 36922595
    37040 7y7a:CO (4.3) BS07 CLA ? GO:0005737 ... W0RYK4 36922595
    37041 7y7a:CO (4.3) BS08 CLA ? GO:0005737 ... W0RYK4 36922595
    37042 7y7a:CO (4.3) BS09 CLA ? GO:0005737 ... W0RYK4 36922595
    37043 7y7a:CO (4.3) BS10 CLA ? GO:0005737 ... W0RYK4 36922595
    37044 7y7a:CO (4.3) BS11 CLA ? GO:0005737 ... W0RYK4 36922595
    37045 7y7a:CO (4.3) BS12 CLA ? GO:0005737 ... W0RYK4 36922595
    37046 7y7a:CO (4.3) BS13 CLA ? GO:0005737 ... W0RYK4 36922595
    37047 7y7a:CO (4.3) BS14 CLA ? GO:0005737 ... W0RYK4 36922595
    37048 7y7a:CZ (4.3) BS02 CLA ? GO:0005737 ... W0RYK4 36922595
    37049 7y7a:CZ (4.3) BS03 CLA ? GO:0005737 ... W0RYK4 36922595
    37050 7y7a:CZ (4.3) BS04 CLA ? GO:0005737 ... W0RYK4 36922595
    37051 7y7a:CZ (4.3) BS05 CLA ? GO:0005737 ... W0RYK4 36922595
    37052 7y7a:CZ (4.3) BS06 CLA ? GO:0005737 ... W0RYK4 36922595
    37053 7y7a:CZ (4.3) BS07 CLA ? GO:0005737 ... W0RYK4 36922595
    37054 7y7a:CZ (4.3) BS08 CLA ? GO:0005737 ... W0RYK4 36922595
    37055 7y7a:CZ (4.3) BS09 CLA ? GO:0005737 ... W0RYK4 36922595
    37056 7y7a:CZ (4.3) BS10 CLA ? GO:0005737 ... W0RYK4 36922595
    37057 7y7a:CZ (4.3) BS11 CLA ? GO:0005737 ... W0RYK4 36922595
    37058 7y7a:CZ (4.3) BS12 CLA ? GO:0005737 ... W0RYK4 36922595
    37059 7y7a:CZ (4.3) BS13 CLA ? GO:0005737 ... W0RYK4 36922595
    37060 7y7a:CZ (4.3) BS14 CLA ? GO:0005737 ... W0RYK4 36922595
    37061 7y7a:Cm (4.3) BS02 CLA ? GO:0005737 ... W0RYK4 36922595
    37062 7y7a:Cm (4.3) BS03 CLA ? GO:0005737 ... W0RYK4 36922595
    37063 7y7a:Cm (4.3) BS04 CLA ? GO:0005737 ... W0RYK4 36922595
    37064 7y7a:Cm (4.3) BS05 CLA ? GO:0005737 ... W0RYK4 36922595
    37065 7y7a:Cm (4.3) BS06 CLA ? GO:0005737 ... W0RYK4 36922595
    37066 7y7a:Cm (4.3) BS07 CLA ? GO:0005737 ... W0RYK4 36922595
    37067 7y7a:Cm (4.3) BS08 CLA ? GO:0005737 ... W0RYK4 36922595
    37068 7y7a:Cm (4.3) BS09 CLA ? GO:0005737 ... W0RYK4 36922595
    37069 7y7a:Cm (4.3) BS10 CLA ? GO:0005737 ... W0RYK4 36922595
    37070 7y7a:Cm (4.3) BS11 CLA ? GO:0005737 ... W0RYK4 36922595
    37071 7y7a:Cm (4.3) BS12 CLA ? GO:0005737 ... W0RYK4 36922595
    37072 7y7a:Cm (4.3) BS13 CLA ? GO:0005737 ... W0RYK4 36922595
    37073 7y7a:Cm (4.3) BS14 CLA ? GO:0005737 ... W0RYK4 36922595
    37074 7y7a:D9 (4.3) BS01 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37075 7y7a:D9 (4.3) BS02 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37076 7y7a:D9 (4.3) BS05 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37077 7y7a:D9 (4.3) BS06 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37078 7y7a:D9 (4.3) BS08 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37079 7y7a:D9 (4.3) BS09 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37080 7y7a:DE (4.3) BS01 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37081 7y7a:DE (4.3) BS02 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37082 7y7a:DE (4.3) BS05 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37083 7y7a:DE (4.3) BS06 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37084 7y7a:DE (4.3) BS08 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37085 7y7a:DE (4.3) BS09 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37086 7y7a:DO (4.3) BS01 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37087 7y7a:DO (4.3) BS04 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37088 7y7a:DO (4.3) BS05 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37089 7y7a:DO (4.3) BS07 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37090 7y7a:DO (4.3) BS08 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37091 7y7a:DZ (4.3) BS01 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37092 7y7a:DZ (4.3) BS04 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37093 7y7a:DZ (4.3) BS05 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37094 7y7a:DZ (4.3) BS07 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37095 7y7a:DZ (4.3) BS08 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37096 7y7a:Dm (4.3) BS01 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37097 7y7a:Dm (4.3) BS02 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37098 7y7a:Dm (4.3) BS05 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37099 7y7a:Dm (4.3) BS06 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37100 7y7a:Dm (4.3) BS08 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37101 7y7a:Dm (4.3) BS09 CLA 1.10.3.9 GO:0005506 ... W0RYZ0 36922595
    37102 7y7a:F7 (4.3) BS01 CLA ? GO:0009507 ... W0RZ71 36922595
    37103 7y7a:F7 (4.3) BS02 CLA ? GO:0009507 ... W0RZ71 36922595
    37104 7y7a:F7 (4.3) BS03 CLA ? GO:0009507 ... W0RZ71 36922595
    37105 7y7a:F7 (4.3) BS04 CLA ? GO:0009507 ... W0RZ71 36922595
    37106 7y7a:F7 (4.3) BS05 CLA ? GO:0009507 ... W0RZ71 36922595
    37107 7y7a:F7 (4.3) BS06 CLA ? GO:0009507 ... W0RZ71 36922595
    37108 7y7a:F7 (4.3) BS07 CLA ? GO:0009507 ... W0RZ71 36922595
    37109 7y7a:Fo (4.3) BS01 CLA ? GO:0009507 ... W0RZ71 36922595
    37110 7y7a:Fo (4.3) BS02 CLA ? GO:0009507 ... W0RZ71 36922595
    37111 7y7a:Fo (4.3) BS03 CLA ? GO:0009507 ... W0RZ71 36922595
    37112 7y7a:Fo (4.3) BS04 CLA ? GO:0009507 ... W0RZ71 36922595
    37113 7y7a:Fo (4.3) BS05 CLA ? GO:0009507 ... W0RZ71 36922595
    37114 7y7a:Fo (4.3) BS06 CLA ? GO:0009507 ... W0RZ71 36922595
    37115 7y7a:Fo (4.3) BS07 CLA ? GO:0009507 ... W0RZ71 36922595
    37116 7y7a:H9 (4.3) BS01 CLA ? GO:0009507 ... W0RYU5 36922595
    37117 7y7a:H9 (4.3) BS02 CLA ? GO:0009507 ... W0RYU5 36922595
    37118 7y7a:H9 (4.3) BS03 CLA ? GO:0009507 ... W0RYU5 36922595
    37119 7y7a:H9 (4.3) BS04 CLA ? GO:0009507 ... W0RYU5 36922595
    37120 7y7a:H9 (4.3) BS05 CLA ? GO:0009507 ... W0RYU5 36922595
    37121 7y7a:HE (4.3) BS01 CLA ? GO:0009507 ... W0RYU5 36922595
    37122 7y7a:HE (4.3) BS02 CLA ? GO:0009507 ... W0RYU5 36922595
    37123 7y7a:HE (4.3) BS03 CLA ? GO:0009507 ... W0RYU5 36922595
    37124 7y7a:HE (4.3) BS04 CLA ? GO:0009507 ... W0RYU5 36922595
    37125 7y7a:HE (4.3) BS05 CLA ? GO:0009507 ... W0RYU5 36922595
    37126 7y7a:HO (4.3) BS01 CLA ? GO:0009507 ... W0RYU5 36922595
    37127 7y7a:HO (4.3) BS02 CLA ? GO:0009507 ... W0RYU5 36922595
    37128 7y7a:HO (4.3) BS03 CLA ? GO:0009507 ... W0RYU5 36922595
    37129 7y7a:HO (4.3) BS04 CLA ? GO:0009507 ... W0RYU5 36922595
    37130 7y7a:HO (4.3) BS05 CLA ? GO:0009507 ... W0RYU5 36922595
    37131 7y7a:HZ (4.3) BS01 CLA ? GO:0009507 ... W0RYU5 36922595
    37132 7y7a:HZ (4.3) BS02 CLA ? GO:0009507 ... W0RYU5 36922595
    37133 7y7a:HZ (4.3) BS03 CLA ? GO:0009507 ... W0RYU5 36922595
    37134 7y7a:HZ (4.3) BS04 CLA ? GO:0009507 ... W0RYU5 36922595
    37135 7y7a:HZ (4.3) BS05 CLA ? GO:0009507 ... W0RYU5 36922595
    37136 7y7a:Hm (4.3) BS01 CLA ? GO:0009507 ... W0RYU5 36922595
    37137 7y7a:Hm (4.3) BS02 CLA ? GO:0009507 ... W0RYU5 36922595
    37138 7y7a:Hm (4.3) BS03 CLA ? GO:0009507 ... W0RYU5 36922595
    37139 7y7a:Hm (4.3) BS04 CLA ? GO:0009507 ... W0RYU5 36922595
    37140 7y7a:Hm (4.3) BS05 CLA ? GO:0009507 ... W0RYU5 36922595
    37141 7y7a:I7 (4.3) BS01 CLA ? GO:0009522 ... W0RZ51 36922595
    37142 7y7a:I7 (4.3) BS02 CLA ? GO:0009522 ... W0RZ51 36922595
    37143 7y7a:I7 (4.3) BS03 CLA ? GO:0009522 ... W0RZ51 36922595
    37144 7y7a:I7 (4.3) BS04 CLA ? GO:0009522 ... W0RZ51 36922595
    37145 7y7a:I7 (4.3) BS05 CLA ? GO:0009522 ... W0RZ51 36922595
    37146 7y7a:I9 (4.3) BS01 CLA ? GO:0005737 ... W0RYJ5 36922595
    37147 7y7a:IE (4.3) BS01 CLA ? GO:0005737 ... W0RYJ5 36922595
    37148 7y7a:IO (4.3) BS01 CLA ? GO:0005737 ... W0RYJ5 36922595
    37149 7y7a:IZ (4.3) BS01 CLA ? GO:0005737 ... W0RYJ5 36922595
    37150 7y7a:Im (4.3) BS01 CLA ? GO:0005737 ... W0RYJ5 36922595
    37151 7y7a:Io (4.3) BS01 CLA ? GO:0009522 ... W0RZ51 36922595
    37152 7y7a:Io (4.3) BS02 CLA ? GO:0009522 ... W0RZ51 36922595
    37153 7y7a:Io (4.3) BS03 CLA ? GO:0009522 ... W0RZ51 36922595
    37154 7y7a:Io (4.3) BS04 CLA ? GO:0009522 ... W0RZ51 36922595
    37155 7y7a:Io (4.3) BS05 CLA ? GO:0009522 ... W0RZ51 36922595
    37156 7y7a:J7 (4.3) BS01 CLA ? GO:0009507 ... W0RYG9 36922595
    37157 7y7a:J7 (4.3) BS02 CLA ? GO:0009507 ... W0RYG9 36922595
    37158 7y7a:J7 (4.3) BS03 CLA ? GO:0009507 ... W0RYG9 36922595
    37159 7y7a:J7 (4.3) BS04 CLA ? GO:0009507 ... W0RYG9 36922595
    37160 7y7a:Jo (4.3) BS01 CLA ? GO:0009507 ... W0RYG9 36922595
    37161 7y7a:Jo (4.3) BS02 CLA ? GO:0009507 ... W0RYG9 36922595
    37162 7y7a:Jo (4.3) BS03 CLA ? GO:0009507 ... W0RYG9 36922595
    37163 7y7a:Jo (4.3) BS04 CLA ? GO:0009507 ... W0RYG9 36922595
    37164 7y7a:K7 (4.3) BS01 CLA ? GO:0009507 ... W0RZ04 36922595
    37165 7y7a:K7 (4.3) BS02 CLA ? GO:0009507 ... W0RZ04 36922595
    37166 7y7a:K7 (4.3) BS03 CLA ? GO:0009507 ... W0RZ04 36922595
    37167 7y7a:K7 (4.3) BS04 CLA ? GO:0009507 ... W0RZ04 36922595
    37168 7y7a:K9 (4.3) BS01 CLA ? GO:0005737 ... W0RZ28 36922595
    37169 7y7a:K9 (4.3) BS02 CLA ? GO:0005737 ... W0RZ28 36922595
    37170 7y7a:KE (4.3) BS01 CLA ? GO:0005737 ... W0RZ28 36922595
    37171 7y7a:KE (4.3) BS02 CLA ? GO:0005737 ... W0RZ28 36922595
    37172 7y7a:KO (4.3) BS01 CLA ? GO:0005737 ... W0RZ28 36922595
    37173 7y7a:KO (4.3) BS02 CLA ? GO:0005737 ... W0RZ28 36922595
    37174 7y7a:KZ (4.3) BS01 CLA ? GO:0005737 ... W0RZ28 36922595
    37175 7y7a:KZ (4.3) BS02 CLA ? GO:0005737 ... W0RZ28 36922595
    37176 7y7a:Km (4.3) BS01 CLA ? GO:0005737 ... W0RZ28 36922595
    37177 7y7a:Km (4.3) BS02 CLA ? GO:0005737 ... W0RZ28 36922595
    37178 7y7a:Ko (4.3) BS01 CLA ? GO:0009507 ... W0RZ04 36922595
    37179 7y7a:Ko (4.3) BS02 CLA ? GO:0009507 ... W0RZ04 36922595
    37180 7y7a:Ko (4.3) BS03 CLA ? GO:0009507 ... W0RZ04 36922595
    37181 7y7a:Ko (4.3) BS04 CLA ? GO:0009507 ... W0RZ04 36922595
    37182 7y7a:L7 (4.3) BS02 CLA ? GO:0009507 ... W0S1Z0 36922595
    37183 7y7a:L7 (4.3) BS03 CLA ? GO:0009507 ... W0S1Z0 36922595
    37184 7y7a:L7 (4.3) BS04 CLA ? GO:0009507 ... W0S1Z0 36922595
    37185 7y7a:L7 (4.3) BS05 CLA ? GO:0009507 ... W0S1Z0 36922595
    37186 7y7a:L7 (4.3) BS06 CLA ? GO:0009507 ... W0S1Z0 36922595
    37187 7y7a:L7 (4.3) BS07 CLA ? GO:0009507 ... W0S1Z0 36922595
    37188 7y7a:L7 (4.3) BS08 CLA ? GO:0009507 ... W0S1Z0 36922595
    37189 7y7a:LO (4.3) BS01 CLA ? GO:0005737 ... W0RZ31 36922595
    37190 7y7a:LZ (4.3) BS01 CLA ? GO:0005737 ... W0RZ31 36922595
    37191 7y7a:Lo (4.3) BS02 CLA ? GO:0009507 ... W0S1Z0 36922595
    37192 7y7a:Lo (4.3) BS03 CLA ? GO:0009507 ... W0S1Z0 36922595
    37193 7y7a:Lo (4.3) BS04 CLA ? GO:0009507 ... W0S1Z0 36922595
    37194 7y7a:Lo (4.3) BS05 CLA ? GO:0009507 ... W0S1Z0 36922595
    37195 7y7a:Lo (4.3) BS06 CLA ? GO:0009507 ... W0S1Z0 36922595
    37196 7y7a:Lo (4.3) BS07 CLA ? GO:0009507 ... W0S1Z0 36922595
    37197 7y7a:Lo (4.3) BS08 CLA ? GO:0009507 ... W0S1Z0 36922595
    37198 7y7a:M7 (4.3) BS01 CLA ? GO:0009507 ... W0S1Z9 36922595
    37199 7y7a:M7 (4.3) BS02 CLA ? GO:0009507 ... W0S1Z9 36922595
    37200 7y7a:M9 (4.3) BS01 CLA ? GO:0009523 ... A0A5J4YYD7 36922595

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218