6b2p A 3.01 BS01 CJJ A 1 G18 V25 A38 M92 E93 Y94 V95 G97 M145 M155 G15 V22 A35 M89 E90 Y91 V92 G94 M142 M152 D138 K140 N143 D156 T179 D135 K137 N140 D153 T156 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.89, Ki<1.3nM Ki=<1.3nM P9WI81 29259738 301 PSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHN 6b2q A 2.88 BS01 CJJ A 1 I19 A20 V27 A40 M95 E96 V98 G100 L148 T158 I17 A18 V25 A38 M86 E87 V89 G91 L139 T149 D141 K143 N146 D159 T180 D132 K134 N137 D150 T158 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.05, Ki=9nM Ki=9.0nM P9WI83 29259738 301 PRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPS 6b2q B 2.88 BS01 CJJ B 1 I19 A20 V27 A40 M95 E96 V98 G100 L148 T158 I17 A18 V25 A38 M86 E87 V89 G91 L139 T149 D141 K143 N146 D159 T180 D132 K134 N137 D150 T163 2.7.11.1 0004672,0005524,0006468 Ki=9.0nM P9WI83 29259738 300 PRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPS 6b2q C 2.88 BS01 CJJ C 1 I19 A20 V27 A40 M95 E96 V98 G100 P102 L148 T158 D159 I17 A18 V25 A38 M88 E89 V91 G93 P95 L141 T151 D152 D141 K143 N146 D159 T180 D134 K136 N139 D152 T161 2.7.11.1 0004672,0005524,0006468 Ki=9.0nM P9WI83 29259738 300 PRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPS 6b2q D 2.88 BS01 CJJ D 1 I19 A20 V27 A40 K42 V98 G100 L148 T158 I17 A18 V25 A38 K40 V90 G92 L140 T150 D141 K143 N146 D159 T180 D133 K135 N138 D151 T160 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.05, Ki=9nM Ki=9.0nM P9WI83 29259738 300 PRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKVMGTAQYIAPEQALGSPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRP