3pch A 2.05 BS01 CHB M 1 G14 P15 R133 G14 P15 R133 Y79 V114 M122 H125 N127 Y79 V114 M122 H125 N127 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 -logKd/Ki=5.40, Ki=4uM P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pch B 2.05 BS01 CHB N 1 G14 P15 G14 P15 Y79 V114 Y79 V114 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 -logKd/Ki=5.40, Ki=4uM P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pch C 2.05 BS01 CHB O 1 G14 P15 G14 P15 Y79 V114 M122 H125 N127 Y79 V114 M122 H125 N127 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pch D 2.05 BS01 CHB P 1 G14 P15 R133 G14 P15 R133 Y79 V114 Y79 V114 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pch E 2.05 BS01 CHB Q 1 G14 P15 G14 P15 Y79 V114 M122 H125 N127 Y79 V114 M122 H125 N127 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pch M 2.05 BS02 CHB M 1 Y324 Y447 W449 R457 H460 H462 Q477 I491 Y24 Y144 W146 R154 H157 H159 Q174 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=4uM -logKd/Ki=5.40, Ki=4uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pch N 2.05 BS02 CHB N 1 Y324 Y447 W449 R457 H460 H462 Q477 I491 Y24 Y144 W146 R154 H157 H159 Q174 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=4uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pch N 2.05 BS03 CHB O 2 P322 I328 P22 I28 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=4uM P00437 9254599 551 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pch O 2.05 BS02 CHB O 1 Y324 Y447 W449 R457 H460 H462 Q477 I491 Y24 Y144 W146 R154 H157 H159 Q174 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=4uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pch P 2.05 BS02 CHB P 1 Y324 Y447 W449 R457 H460 I491 Y24 Y144 W146 R154 H157 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=4uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pch Q 2.05 BS02 CHB Q 1 Y324 Y447 W449 R457 H460 H462 I491 Y24 Y144 W146 R154 H157 H159 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=4uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pch Q 2.05 BS03 CHB R 2 P322 I328 P22 I28 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=4uM P00437 9254599 551 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pch R 2.05 BS02 CHB R 1 Y324 Y447 W449 R457 H460 H462 Q477 I491 Y24 Y144 W146 R154 H157 H159 Q174 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=4uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE