4puz A 2.085 BS01 CG9 A 1 L377 S379 V385 A400 M448 A451 E452 G454 P455 L501 D512 L15 S17 V23 A38 M81 A84 E85 G87 P88 L134 D145 D494 A496 R498 N499 D512 K533 D127 A129 R131 N132 D145 K163 2.7.10.2 0004672,0004713,0005524,0006468 ic50=7.7nM -logKd/Ki=8.11, IC50=7.7nM IC50=377nM, EC50=125nM P43405 24779514 701 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 4puz B 2.085 BS01 CG9 B 1 L377 F382 V385 A400 M450 A451 E452 G454 P455 L501 L15 F20 V23 A38 M83 A84 E85 G87 P88 L134 D494 A496 R498 N499 D512 K533 D127 A129 R131 N132 D145 K163 2.7.10.2 0004672,0004713,0005524,0006468 ic50=7.7nM IC50=377nM, EC50=125nM P43405 24779514 701 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN