1hdc A 2.2 BS01 CBO A 1 S91 T92 G93 L148 Y152 M184 M189 T190 T193 S90 T91 G92 L147 Y151 M183 M188 T189 T192 G17 S139 Y152 K156 G16 S138 Y151 K155 1.1.1.53 0008202,0008207,0016491,0047044 Ki=1uM P19992 7866748 301 NDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGMKTVIPAMKDAGGGSIVNISSAAGLMGLALTSSYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGEPGEIAGAVVKLLSDTSSYVTGAELAVDGGWTTGPTVKYVMGQ 1hdc B 2.2 BS01 CBO B 1 S91 G93 L148 Y152 G183 T185 T193 W243 S90 G92 L147 Y151 G182 T184 T192 W241 G17 S139 Y152 K156 G16 S138 Y151 K155 1.1.1.53 0008202,0008207,0016491,0047044 Ki=1uM P19992 7866748 301 NDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGMKTVIPAMKDAGGGSIVNISSAAGLMGLALTSSYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGEPGEIAGAVVKLLSDTSSYVTGAELAVDGGWTTGPTVKYVMGQ 1hdc C 2.2 BS01 CBO C 1 G93 S139 L148 T149 Y152 M184 T185 T193 W243 G92 S138 L147 T148 Y151 M183 T184 T192 W241 G17 S139 Y152 K156 G16 S138 Y151 K155 1.1.1.53 0008202,0008207,0016491,0047044 Ki=1uM P19992 7866748 301 NDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGMKTVIPAMKDAGGGSIVNISSAAGLMGLALTSSYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGEPGEIAGAVVKLLSDTSSYVTGAELAVDGGWTTGPTVKYVMGQ 1hdc D 2.2 BS01 CBO D 1 S91 T92 G93 L148 T149 Y152 G183 M184 T193 S90 T91 G92 L147 T148 Y151 G182 M183 T192 G17 S139 Y152 K156 G16 S138 Y151 K155 1.1.1.53 0008202,0008207,0016491,0047044 Ki=1uM P19992 7866748 301 NDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGMKTVIPAMKDAGGGSIVNISSAAGLMGLALTSSYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGEPGEIAGAVVKLLSDTSSYVTGAELAVDGGWTTGPTVKYVMGQ 2bel A 2.11 BS02 CBO A 1 I121 S170 Y177 Y183 G216 L217 M233 I96 S145 Y152 Y158 G191 L192 M208 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=500nM, Ki=62nM P28845 1270 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLI 2bel B 2.11 BS02 CBO B 1 I121 S170 Y177 Y183 G216 L217 I95 S144 Y151 Y157 G190 L191 S170 Y183 K187 S144 Y157 K161 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=500nM, Ki=62nM P28845 1279 FRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILE 2bel C 2.11 BS02 CBO C 1 S170 Y177 Y183 G216 L217 S156 Y163 Y169 G202 L203 S170 Y183 K187 S156 Y169 K173 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=500nM, Ki=62nM P28845 1273 GRENLYFQGHMEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNP 2bel D 2.11 BS02 CBO D 1 I121 S170 Y177 Y183 G216 L217 M233 I97 S146 Y153 Y159 G192 L193 M209 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=500nM, Ki=62nM P28845 1279 MEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILE 7byi A 2.76 BS01 CBO B 1 L166 I183 L125 I142 2.1.2.1 0002082,0003682,0004372,0005515,0005634,0005737,0005739,0005743,0005759,0006544,0006545,0006563,0006564,0006730,0008284,0008732,0015630,0016597,0016740,0019264,0030170,0034340,0035999,0042645,0042802,0046653,0051262,0051289,0070062,0070129,0070536,0070552,1903715 P34897 601 GWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAGKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQAATPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH 7byi B 2.76 BS01 CBO B 1 E98 Y105 Y106 E56 Y63 Y64 2.1.2.1 0002082,0003682,0004372,0005515,0005634,0005737,0005739,0005743,0005759,0006544,0006545,0006563,0006564,0006730,0008284,0008732,0015630,0016597,0016740,0019264,0030170,0034340,0035999,0042645,0042802,0046653,0051262,0051289,0070062,0070129,0070536,0070552,1903715 P34897 601 WTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYGLAPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREAPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGGYLVSGGTDNHLVLVDLRPKGGGGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH 7byi B 2.76 BS02 CBO B 2 H171 L172 Y176 H129 L130 Y134 2.1.2.1 0002082,0003682,0004372,0005515,0005634,0005737,0005739,0005743,0005759,0006544,0006545,0006563,0006564,0006730,0008284,0008732,0015630,0016597,0016740,0019264,0030170,0034340,0035999,0042645,0042802,0046653,0051262,0051289,0070062,0070129,0070536,0070552,1903715 P34897 602 WTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYGLAPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREAPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGGYLVSGGTDNHLVLVDLRPKGGGGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH