1qrd A 2.4 BS02 CBD A 1 G149 H194 G149 H194 G149 Y155 H161 G149 Y155 H161 1.6.5.2 0000209,0002931,0003955,0004784,0005634,0005737,0005829,0006116,0006743,0006801,0006979,0007584,0008753,0009410,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 P05982 7568029 275 AVRRALIVLAHAERTSFNYAMKEAAVEALKKKGWEVVESDLYAMNFNPLISRNDITGEPKDSENFQYPVESSLAYKEGRLSPDIVAEQKKLEAADLVIFQFPLYWFGVPAILKGWFERVLVAGFAYTYATMYDKGPFQNKKTLLSITTGGSGSMYSLQGVHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARVQVLEGWKKRLETVWEESPLYFAPSSLFDLNFQAGFLLKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK 20gs A 2.45 BS01 CBD A 1 Y7 V10 R13 I104 Y108 G205 Y6 V9 R12 I103 Y107 G204 Y7 R13 Y6 R12 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 P09211 10452896 211 PYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 20gs B 2.45 BS01 CBD B 1 Y7 F8 V10 R13 I104 Y108 G205 Y6 F7 V9 R12 I103 Y107 G204 Y7 R13 Y6 R12 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 P09211 10452896 211 PYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 3vi7 A 2.0 BS02 CBD A 1 R14 M99 W104 A105 K107 K198 L199 R13 M98 W103 A104 K106 K197 L198 2.5.1.18,5.3.99.2 0000287,0001516,0004364,0004667,0005509,0005515,0005654,0005737,0005829,0006693,0007165,0007626,0009624,0010269,0016740,0016853,0042803,0043231,0046872,2000255 -logKd/Ki=7.39, IC50=40.4nM IC50=2E2nM O60760 22418579 201 PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGMSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL 3vi7 B 2.0 BS02 CBD B 1 R214 M299 W304 A305 K312 K398 L399 R13 M98 W103 A104 K111 K197 L198 2.5.1.18,5.3.99.2 0000287,0001516,0004364,0004667,0005509,0005515,0005654,0005737,0005829,0006693,0007165,0007626,0009624,0010269,0016740,0016853,0042803,0043231,0046872,2000255 IC50=2E2nM O60760 22418579 401 PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGMSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL 3w78 A 2.62 BS02 CBD A 1 A119 F125 Y127 E129 N130 G131 F172 A118 F124 Y126 E128 N129 G130 F171 1.6.5.-,1.7.1.17 0000166,0009055,0010181,0016491,0016652,0016655,0046872 C0STY1 24531489 302 TKVLFITANPNSAEGSFGMAVGEAFIEAYKNEHPQDEVVTIDLFNTTVPAIDADVFAAWGKFAAGEGFEALTEVQQQKVAAMNTNLETFMNADRYVFVTPMWNFSYPPVVKAYLDNVAIAGKTFKYTENGPVGLLEGKKALHIQATGGVYSEGAYAAVDFGRNHLKTVLGFVGVNDTEYIAVEGMNANPEKAQEIKEAAIANARELAKRF 3w78 A 2.62 BS03 CBD B 1 N104 V150 Y151 N187 A188 N103 V149 Y150 N186 A187 1.6.5.-,1.7.1.17 0000166,0009055,0010181,0016491,0016652,0016655,0046872 C0STY1 24531489 302 TKVLFITANPNSAEGSFGMAVGEAFIEAYKNEHPQDEVVTIDLFNTTVPAIDADVFAAWGKFAAGEGFEALTEVQQQKVAAMNTNLETFMNADRYVFVTPMWNFSYPPVVKAYLDNVAIAGKTFKYTENGPVGLLEGKKALHIQATGGVYSEGAYAAVDFGRNHLKTVLGFVGVNDTEYIAVEGMNANPEKAQEIKEAAIANARELAKRF 3w78 B 2.62 BS01 CBD A 1 N104 G149 V150 Y151 Y156 N187 A188 N103 G148 V149 Y150 Y155 N186 A187 1.6.5.-,1.7.1.17 0000166,0009055,0010181,0016491,0016652,0016655,0046872 C0STY1 24531489 302 TKVLFITANPNSAEGSFGMAVGEAFIEAYKNEHPQDEVVTIDLFNTTVPAIDADVFAAWGKFAAGEGFEALTEVQQQKVAAMNTNLETFMNADRYVFVTPMWNFSYPPVVKAYLDNVAIAGKTFKYTENGPVGLLEGKKALHIQATGGVYSEGAYAAVDFGRNHLKTVLGFVGVNDTEYIAVEGMNANPEKAQEIKEAAIANARELAKRF 3w78 B 2.62 BS03 CBD B 1 A119 F125 Y127 E129 N130 G131 F172 A118 F124 Y126 E128 N129 G130 F171 1.6.5.-,1.7.1.17 0000166,0009055,0010181,0016491,0016652,0016655,0046872 C0STY1 24531489 302 TKVLFITANPNSAEGSFGMAVGEAFIEAYKNEHPQDEVVTIDLFNTTVPAIDADVFAAWGKFAAGEGFEALTEVQQQKVAAMNTNLETFMNADRYVFVTPMWNFSYPPVVKAYLDNVAIAGKTFKYTENGPVGLLEGKKALHIQATGGVYSEGAYAAVDFGRNHLKTVLGFVGVNDTEYIAVEGMNANPEKAQEIKEAAIANARELAKRF 3w78 C 2.62 BS02 CBD C 1 N104 G149 V150 Y151 N187 A188 N103 G148 V149 Y150 N186 A187 1.6.5.-,1.7.1.17 0000166,0009055,0010181,0016491,0016652,0016655,0046872 C0STY1 24531489 302 TKVLFITANPNSAEGSFGMAVGEAFIEAYKNEHPQDEVVTIDLFNTTVPAIDADVFAAWGKFAAGEGFEALTEVQQQKVAAMNTNLETFMNADRYVFVTPMWNFSYPPVVKAYLDNVAIAGKTFKYTENGPVGLLEGKKALHIQATGGVYSEGAYAAVDFGRNHLKTVLGFVGVNDTEYIAVEGMNANPEKAQEIKEAAIANARELAKRF 3w78 D 2.62 BS02 CBD D 1 N104 V150 Y151 N187 A188 N103 V149 Y150 N186 A187 1.6.5.-,1.7.1.17 0000166,0009055,0010181,0016491,0016652,0016655,0046872 C0STY1 24531489 302 TKVLFITANPNSAEGSFGMAVGEAFIEAYKNEHPQDEVVTIDLFNTTVPAIDADVFAAWGKFAAGEGFEALTEVQQQKVAAMNTNLETFMNADRYVFVTPMWNFSYPPVVKAYLDNVAIAGKTFKYTENGPVGLLEGKKALHIQATGGVYSEGAYAAVDFGRNHLKTVLGFVGVNDTEYIAVEGMNANPEKAQEIKEAAIANARELAKRF 4cf6 A 2.694 BS02 CBD A 1 G150 G151 M155 H195 G147 G148 M152 H192 G150 Y156 H162 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 P15559 25143260 1275 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLESQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKAR 4cf6 A 2.694 BS04 CBD B 1 P69 Y129 F233 G236 F237 P66 Y126 F230 G233 F234 G150 Y156 H162 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 P15559 25143260 1276 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLESQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKAR 4cf6 B 2.694 BS02 CBD A 1 P69 Y127 Y129 F179 F233 P66 Y124 Y126 F176 F230 G150 Y156 H162 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 P15559 25143260 1275 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLESQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 4cf6 B 2.694 BS04 CBD B 1 G150 S152 S154 H162 S192 H195 G147 S149 S151 H159 S189 H192 G150 Y156 H162 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 P15559 25143260 1276 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLESQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK