1iem A 2.3 BS01 CB4 A 1 S64 Y150 N152 Y221 A318 G320 S61 Y147 N149 Y218 A315 G317 S64 K67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 K64 Y109 A111 V118 Y147 G153 E269 K312 A315 3.5.2.6 0008800,0016787,0017001,0030288,0042597,0046677 -logKd/Ki=7.70, Ki=20nM P00811 11478888 964 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 1iem B 2.3 BS01 CB4 B 1 S64 K67 Y150 N152 A318 G320 S61 K64 Y147 N149 A315 G317 S64 K67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 K64 Y109 A111 V118 Y147 G153 E269 K312 A315 3.5.2.6 0008800,0016787,0017001,0030288,0042597,0046677 P00811 11478888 964 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 1jwv A 1.85 BS01 CB4 A 1 S70 Y105 S130 N132 G236 A237 A238 E240 S45 Y80 S105 N107 G211 A212 A213 E214 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0005515,0008800,0016787,0017001,0030655,0046677 P62593 12079336 300 HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAAERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1m40 A 0.85 BS01 CB4 A 1 S70 K73 Y105 S130 N132 G236 A237 G238 E240 S45 K48 Y80 S105 N107 G211 A212 G213 E214 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0005515,0008800,0016787,0017001,0030655,0046677 P62593 11996574 300 HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1yly A 1.25 BS01 CB4 A 1 S70 Y105 S130 N132 G236 S237 G238 D240 S45 Y80 S105 N107 G211 S212 G213 D214 S70 K73 S130 E166 K234 S237 S45 K48 S105 E141 K209 S212 3.5.2.6 0008800,0016787,0017001,0030655,0046677,0046872 -logKd/Ki=7.82, Ki=0.015uM Q9L5C7 15826180 2001 QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 1yly B 1.25 BS01 CB4 B 1 S70 Y105 S130 N132 G236 S237 G238 D240 S42 Y77 S102 N104 G208 S209 G210 D211 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677,0046872 Q9L5C7 15826180 2002 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 1ylz A 1.35 BS01 CB4 A 1 S70 Y105 S130 N132 G236 S237 G238 D240 S45 Y80 S105 N107 G211 S212 G213 D214 S70 K73 S130 E166 K234 S237 S45 K48 S105 E141 K209 S212 3.5.2.6 0008800,0016787,0017001,0030655,0046677,0046872 Q9L5C7 15826180 2001 QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 1ylz B 1.35 BS01 CB4 B 1 S70 N104 Y105 S130 N132 N170 G236 S237 G238 D240 S42 N76 Y77 S102 N104 N142 G208 S209 G210 D211 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677,0046872 Q9L5C7 15826180 2002 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 3mke A 1.75 BS03 CB4 A 1 M69 S70 D104 Y105 S130 N132 E166 N170 T235 G236 A237 M44 S45 D79 Y80 S105 N107 E141 N145 T210 G211 A212 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 -logKd/Ki=5.66, Ki=2.2uM Ki=2200nM P0AD64 21041505 1 SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR 4ua9 A 0.84 BS01 CB4 A 1 S70 Y105 S130 N132 G236 S237 G238 D240 S45 Y80 S105 N107 G211 S212 G213 D214 S70 K73 S130 E166 K234 S237 S45 K48 S105 E141 K209 S212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 2001 PTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ua9 B 0.84 BS01 CB4 B 1 S70 Y105 S130 N132 N170 G236 S237 G238 D240 S42 Y77 S102 N104 N142 G208 S209 G210 D211 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 301 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 5chm A 1.9 BS01 CB4 A 1 S64 K67 Y150 Y222 S317 G319 S58 K61 Y144 Y216 S311 G313 S64 K67 Y150 E271 K314 S317 S58 K61 Y144 E265 K308 S311 3.5.2.6 0008800,0016787,0017001,0030288,0046677,0046872 Q9L387 32349291 400 PLTATVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRATPGVLAAEAYGIKTGSADLLKFVEANMGYQGDAALKSAIALTHTGFHSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE 5glb A 1.6 BS01 CB4 A 1 S70 Y105 S130 N132 T226 G246 T247 S49 Y84 S109 N111 T195 G215 T216 S70 K73 S130 E166 K244 T247 S49 K52 S109 E145 K213 T216 3.5.2.6 0008800,0017001,0030655,0046677 Q2T5A3 27827433 401 GSHMRNVAAEQQLRELESTFDGRLGFVALDTATGARIAHRADERFPFCSTFKTMLSAAVLARSAGDAALLQRRIPYAKRDLVRYSPITEKHVGAGMTVAELCAATLQYSDNTAANLLIALLGGPQAVTAYARSIGDATFRLDRRETELNTAIPGDERDTTTPAAMAASVRRLLVGDALGTAQRAQLNAWMLGNKTGDARIRAGVPAGWRVADKTGTGDYGTGNDIGVAYPPDRAPIVFVVYTTMRSRNAQARDDVIASAARIAARAFV 5gld A 1.7 BS01 CB4 A 1 C69 S70 V103 R104 S130 N132 G256 T257 G258 D260 C48 S49 V82 R83 S109 N111 G208 T209 G210 D211 S70 K73 S130 K254 T257 S49 K52 S109 K206 T209 3.5.2.6 0008800,0017001,0030655,0046677 Q2T5A3 27827433 401 GSHMRNVAAEQQLRELESTFDGRLGFVALDTATGARIAHRADERFPFCSTFKTMLSAAVLARSAGDAALLQRRIPYAKRDLVRYSPITEKHVGAGMTVAELCAATLQYSDNTAANLLIALLGGPQAVTAYARSIGDATFRLDRRLPGDERDTTTPAAMAASVRRLLVGDALGTAQRAQLNAWMLGNKTGDARIRAGVPAGWRVADKTGTGDYGTGNDIGVAYPPDRAPIVFVVYTTMRSRNAQARDDVIASAARIAARAFV 6afn A 1.4 BS01 CB4 A 1 S70 K73 R104 Y105 S130 N132 G236 T237 G238 D240 S49 K52 R83 Y84 S109 N111 G215 T216 G217 D218 S70 K73 S130 E166 K234 T237 S49 K52 S109 E145 K213 T216 3.5.2.6 0008800,0017001,0030655,0046677 Q2T5A3 301 GSHMRNVAAEQQLRELESTFDGRLGFVALDTATGARIAHRADERFPFYSTFKTMLSAAVLARSAGDAALLQRRIPYAKRDLVRYSPITEKHVGAGMTVAELCAATLQYSDNTAANLLIALLGGPQAVTAYARSIGDATFRLDRRETELNTAIPGDERDTTTPAAMAASVRRLLVGDALGTAQRAQLNAWMLGNKTGDARIRAGVPAGWRVADKTGTGDYGTGNDIGVAYPPDRAPIVFVVYTTMRSRNAQARDDVIASAARIAARAFV 6afp A 1.398 BS01 CB4 A 1 C69 S70 K73 Y105 N132 E166 N170 T237 G238 D240 C48 S49 K52 Y84 N111 E145 N149 T216 G217 D218 S70 K73 S130 E166 K234 T237 S49 K52 S109 E145 K213 T216 3.5.2.6 0008800,0017001,0030655,0046677 Q2T5A3 301 GSHMRNVAAEQQLRELESTFDGRLGFVALDTATGARIAHRADERFPFCSTFKTMLSAAVLARSAGDAALLQRRIPYAKRDLVRYSPITEKHVGAGMTVAELCAATLQYSDNTAADLLIALLGGPQAVTAYARSIGDATFRLDRRETELNTAIPGDERDTTTPAAMAASVRRLLVGDALGTAQRAQLNAWMLGNKTGDARIRAGVPAGWRVADKTGTGDYGTGNDIGVAYPPDRAPIVFVVYTTMRSRNAQARDDVIASAARIAARAFV 6afp B 1.398 BS01 CB4 B 1 S70 K73 R104 Y105 S130 N132 N170 T237 G238 D240 S49 K52 R83 Y84 S109 N111 N149 T216 G217 D218 S70 K73 S130 E166 K234 T237 S49 K52 S109 E145 K213 T216 3.5.2.6 0008800,0017001,0030655,0046677 Q2T5A3 301 GSHMRNVAAEQQLRELESTFDGRLGFVALDTATGARIAHRADERFPFCSTFKTMLSAAVLARSAGDAALLQRRIPYAKRDLVRYSPITEKHVGAGMTVAELCAATLQYSDNTAADLLIALLGGPQAVTAYARSIGDATFRLDRRETELNTAIPGDERDTTTPAAMAASVRRLLVGDALGTAQRAQLNAWMLGNKTGDARIRAGVPAGWRVADKTGTGDYGTGNDIGVAYPPDRAPIVFVVYTTMRSRNAQARDDVIASAARIAARAFV 8sdr A 1.35 BS01 CB4 A 1 S90 Q146 Y177 G344 S345 N347 S62 Q118 Y149 G316 S317 N319 3.5.2.6 0008800,0017001,0030288 P24735 37850746 401 APADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLE 8sds A 1.63 BS01 CB4 A 1 S64 Q120 Y151 N153 S319 N321 S62 Q118 Y149 N151 S317 N319 3.5.2.6 0008800,0017001,0030288 P24735 37850746 401 APADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGHGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLE