2rh1 A 2.4 BS03 CAU A 1 D113 V114 F193 W286 F289 F290 N293 N312 Y316 D85 V86 F165 W386 F389 F390 N393 N412 Y416 E1011 D1020 E212 D221 ?,3.2.1.17 0003796,0004930,0004941,0006940,0007186,0007189,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659,0097746 P00720,P07550 17962520 408 DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 2ycw A 3.0 BS01 CAU A 1 W117 D121 V122 F201 F307 N310 N329 Y333 W85 D89 V90 F169 F245 N248 N267 Y271 ? 0004930,0004935,0007186,0016020 P07700 21540331 400 AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDRASKRKRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAF 2ycw B 3.0 BS02 CAU B 1 W117 D121 V122 F201 F306 F307 N310 N329 Y333 W85 D89 V90 F169 F244 F245 N248 N267 Y271 ? 0004930,0004935,0007186,0016020 P07700 21540331 400 AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDRASKRKRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAF 4gbr A 3.993 BS01 CAU A 1 W109 D113 V114 F193 S203 W258 F261 F262 N265 N284 Y288 W81 D85 V86 F165 S175 W230 F233 F234 N237 N256 Y260 ? 0004930,0004941,0006940,0007186,0007189,0016020,0097746 Ki=0.030000nM P07550 23056231 500 DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 5d5a A 2.4826 BS03 CAU A 1 D113 V114 V117 F193 S203 F289 F290 N293 N312 Y316 D85 V86 V89 F165 S175 F389 F390 N393 N412 Y416 E1011 D1020 E212 D221 3.2.1.17 0003796,0004930,0004941,0006940,0007186,0007189,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659,0097746 P00720,P07550 26894538 1202 DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 5d5b A 3.8 BS03 CAU A 1 D113 V114 V117 F193 S203 F289 F290 N293 N312 Y316 D85 V86 V89 F165 S175 F389 F390 N393 N412 Y416 E1011 D1020 E212 D221 3.2.1.17 0003796,0004930,0004941,0006940,0007186,0007189,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659,0097746 P00720,P07550 26894538 1202 DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 5d6l A 3.2 BS03 CAU A 1 D113 V114 F193 S203 F289 F290 N293 N312 Y316 D85 V86 F165 S175 F389 F390 N393 N412 Y416 E1011 D1020 E212 D221 3.2.1.17 0003796,0004930,0004941,0006940,0007186,0007189,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659,0097746 P00720,P07550 28771236 1208 DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 5jqh A 3.2 BS01 CAU A 1 W1109 D1113 V1114 F1193 S1203 S1204 W1286 F1289 F1290 N1312 Y1316 W188 D192 V193 F272 S282 S283 W334 F337 F338 N360 Y364 E876 E10 3.2.1.17 0003796,0004930,0004941,0006940,0007186,0007189,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659,0097746 P00720,P07550 27409812 1401 NIFEMLRIDEFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLDKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLR 5jqh B 3.2 BS01 CAU B 1 W1109 D1113 V1114 F1193 S1203 F1289 F1290 N1293 N1312 Y1316 W197 D201 V202 F281 S291 F347 F348 N351 N370 Y374 3.2.1.17 0003796,0004930,0004941,0006940,0007186,0007189,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659,0097746 P00720,P07550 27409812 1401 GNIFEMLRIDVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLIDKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRR 5x7d A 2.703 BS04 CAU A 1 D113 V114 F193 S203 W286 F290 N293 N312 D83 V84 F163 S173 W384 F388 N391 N410 E1011 D1020 E210 D219 ?,3.2.1.17 0003796,0004930,0004941,0006940,0007186,0007189,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659,0097746 P00720,P07550 28813418 1206 VWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 6ps0 A 3.4 BS01 CAU A 1 T110 D113 V114 F193 S203 S207 W286 F289 F290 N293 N312 Y316 T80 D83 V84 F163 S173 S177 W384 F387 F388 N391 N410 Y414 ?,3.2.1.17 0003796,0004930,0004941,0006940,0007186,0007189,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659,0097746 -logKd/Ki=9.94, Ki=0.114nM D9IEF7,P07550 31709066 1201 VWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIWTLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL 7bvq A 2.5 BS02 CAU A 1 W1134 D1138 V1139 F1218 S1228 S1232 N1344 N1363 Y1367 W251 D255 V256 F335 S345 S349 N407 N426 Y430 3.2.1.17 0003796,0004930,0007186,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659 D9IEF7,P08588 33093660 1402 DYKDDDDANIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAASQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLC 7bvq B 2.5 BS01 CAU B 1 W1134 D1138 V1139 V1142 F1218 W1337 N1344 N1363 Y1367 W247 D251 V252 V255 F331 W396 N403 N422 Y426 3.2.1.17 0003796,0004930,0007186,0009253,0016020,0016798,0016998,0030430,0031640,0042742,0044659 D9IEF7,P08588 33093660 1401 DDDANIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAASQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLC 9ijd R 2.76 BS01 CAU R 1 W113 V121 S208 S212 F308 F309 N312 N332 Y336 W72 V80 S141 S145 F198 F199 N202 N222 Y226 P13945 39046191 401 ALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIWTLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCR