6b0z A 2.334 BS02 C81 A 1 R109 A111 R119 L120 W124 I128 I130 M259 S278 Y285 M291 R107 A109 R117 L118 W122 I126 I128 M251 S265 Y272 M278 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.018uM IC50=50nM O75874 29057061 502 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 6b0z A 2.334 BS03 C81 A 2 H132 C269 Q277 S278 H130 C261 Q264 S265 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.018uM IC50=50nM O75874 29057061 504 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 6b0z B 2.334 BS02 C81 B 1 R109 A111 I113 R119 L120 W124 I128 I130 W267 S278 V281 R107 A109 I111 R117 L118 W122 I126 I128 W263 S274 V277 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.018uM IC50=50nM O75874 29057061 502 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHADQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK 6b0z B 2.334 BS03 C81 D 2 Q277 V281 Q273 V277 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.018uM IC50=50nM O75874 29057061 504 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHADQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK 6b0z C 2.334 BS01 C81 A 2 Q277 V281 Q273 V277 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.018uM IC50=50nM O75874 29057061 504 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHADQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 6b0z C 2.334 BS03 C81 C 1 R109 A111 R119 L120 I128 I130 S278 M291 R107 A109 R117 L118 I126 I128 S274 M287 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.018uM IC50=50nM O75874 29057061 502 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHADQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 6b0z D 2.334 BS02 C81 D 1 R109 A111 R119 L120 W124 I128 I130 M259 A282 Y285 M291 R107 A109 R117 L118 W122 I126 I128 M252 A270 Y273 M279 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.018uM IC50=50nM O75874 29057061 502 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHARATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 6b0z D 2.334 BS03 C81 D 2 H132 V255 Q277 S278 V281 H130 V248 Q265 S266 V269 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 ic50=0.018uM IC50=50nM O75874 29057061 504 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHARATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ